Comparison of the efficacy of Burch colposuspension, pubovaginal sling, and tension-free vagianal tape for stress urinary incontinence

배상욱 ( S. W. Bai ),( W. H. Sohn ),( D. J. Chung ),( J. H. Park ),( S. K. Kim ) 대한산부인과학회 2006 대한산부인과학회 학술대회 Vol.92 No.-

체외수정시술을 위한 과배란유도시 Highly Purified Follicle Stimulating Hormone (HP-FSH) 피하주사와 Follicle Stimulating Hormone 근육주사의 비교연구

배상욱,김진영,원종건,정창진,장경환,이병석,박기현,조동제,송찬호,Bai, S.W.,Kim, J.Y.,Won, J.G.,Jung, C.J.,Chang, K.H.,Lee, B.S.,Park, K.H.,Cho, D.J.,Song, C.H. 대한생식의학회 1997 Clinical and Experimental Reproductive Medicine Vol.24 No.1

The early studies demonstrated that the relative amount of FSH was important for stimulating normal ovarian activity and demonstrated the existence of a threshold level for FSH, above which follicular growth was activated. It was found that only a modest increase in circulating FSH level above the threshold (between 10 and 30%) was required to stimulate folliculogenesis. In addition, FSH is primary responsible for initiating estradiol production through the activation of the aromatase enzyme system in granulosa cells, follicular secretion and growth. LH on the other hand, plays a supportive role in ovarian steroidogenesis, stimulating the ovarian thecal cells to produce androgen, the precursor for estradiol synthesis. But there is now an increasing number of reports in the literature demonstrating an adverse effect of LH on fertility and miscarriage in infertile and fertile women. So HP-FSH is the drug of a highly purified FSH preparation which has a higher specific activity and far fewer impurities than FSH. This study was performed to evaluate the efficacy and safety of HP-FSH administered (SC; subcutaneous) versus FSH(IM; intramuscular) for ovulation induction. 20 candidates patients for ovulation induction were participated. All patients underwent pituitary desensitizing with a long gonadotropin-releasing hormone (GnRH) agonist protocol and ovulation induction was started with HP-FSH SC (10 patients; group I) or FSH IM (10 patients; group II). After ovulation, outcome of ovulation induction and local reaction of injection site were compared. There were no difference of outcome of ovulation in two groups except pregnancy rate/embryo transfer. Group I had a higher pregnancy rate/ embryo transfer than Group II (44.4% Vs 28.6%). Pain, redness, tenderness, bruising and itching when the injection received on the first 5 days of treated (50 SC and 50 IM injections) were assessed. There were no significant difference (P>0.05) in the incidence of tenderness, bruising and itching between the IM and SC injection. But IM injection (FSH) had a tendency of higher above incidence. The number of reports of pain, redness were significantly increased in IM injection group (P<0.05). These results indicate that SC administration of HP-FSH has been shown to be as effect for superovulation as traditional gonadotropins, with an improved safety profile due to the removal of extaneous proteins.

과배란유도 전 기저 난소 낭종이 체외수정시술 결과에 미치는 영향

배상욱,이경진,이병석,박기현,조동제,송찬호,Bai, S.W.,Lee, K.J.,Lee, B.S.,Park, K.H.,Cho, D.J.,Song, C.H. 대한생식의학회 1999 Clinical and Experimental Reproductive Medicine Vol.26 No.2

This study was performed to determine the significance of a baseline ovarian cyst on the response to controlled ovarian hyperstimulation and the outcome of IVF-ET. One hundred one patients who underwent IVF-ET were enrolled in this study. The outcome of 31 patients, who had an ovarian cyst of >10mm detected at ultrasound examination performed on day 3, was compared with that of 70 patients who underwent a similar protocol and did not have an ovarian cyst. E2 level on the day of hCG administration, the number of follicles, the number of oocytes retrieved, the number of embryo transferred and the pregnancy rate were evaulated. The E2 level on the day of hCG adminstration and the number of mature oocytes retrieved were lower in the group with a baseline cyst. The pregnancy rate also was significantly lower in the group with a cyst (21% versus 38%). Therefore a baseline ovarian cyst on cycle day 3 was associated with a poorer outcome after IVF-ET.

불임여성에서 자궁근종절제술 후 임신율에 관한 연구

원종건,배상욱,김진영,이지원,이병석,김정수,이경술,박기현,조동제,송찬호,Won, J.G.,Bai, S.W.,Kim, J.Y.,Yi, J.W.,Lee, B.S.,Kim, J.S.,Lee, K.S.,Park, K.H.,Cho, D.J.,Song, C.H. 대한생식의학회 1997 Clinical and Experimental Reproductive Medicine Vol.24 No.2

To evaluate the efficacy of transabdominal myomectomy in the management of infertile patients, and to analyze on the results of abdominal myomectomy in 38 infertile patients with no other detectable cause except myomas were undertaken at the Department of Obstetrics and Gynecology in Yonsei University Hospital from 1990 to 1996. The results are as follows; 1. Average age of patients was 31.1 years. The infertility duration ranged 12 months to 144 months, and average infertility period of patients was 29.4 months. 2. Fourteen of the 38 patients (8 of 23 patients with primary infertility, 6 of 15 patients with secondary infertility) conceived following myomectomy, with a pregnancy rate of 36.8%. 3. Patients with less than 4 years of infertility showed a higher pregnancy rate after myomectomy than those with more than 4 years of infertility (42.4% vs 0%, p<0.05). 4. Patients younger than 35 years showed significantly higher pregnancy rate than those older than 35 years (46.4% vs 9.0%, p<0.05). 5. The removal of a solitary myoma produced a significantly higher pregnancy rate than that of multiple myomas (47.8% vs 20.0%, p<0.05), and the size of the myomas did not influenced the pregnancy rate after myomectomy (p>0.1). 6. The average time period from operation to conception was 12.1 months. Eight of the 14 patients (57.1%) conceived in the first year after operation and 12 patients (85.7%) condeived within two years. In conclusion myomas are a possible cause of infertility and myomectomy can be strongly recommended with good success expectation for the infertile women if uterine myoma be considered as the main cause of infertility. And factors affecting the pregnancy rate after myomectomy in these patients are the age of the patient, the duration of infertiluty, and the number of myoma.

골다공증 환자에서 초음파와 DEXA 골밀도와의 상관관계

조은미,김진영,배상욱,박기현 대한폐경학회 1997 대한폐경학회지 Vol.3 No.2

As the human life becomes longer, Involutional osteoporosis is becoming increasingly recognized as a major health care problem. The incidence of osteoporotic fracture is rising in all countries and, if the current trends continue, then the prevalence of hip fractures will double over the next 20 years. Awareness of osteoporosis has coincided with the realization that osteoporosis can be prevented in part, not only with hormone replacement, but also with other interventions which prevent or delay the rate of bone loss. Much attention has focused on prevention and the use of physical and biochemical techniques which can assess the risk of osteoporotic fracture. Techniques for measuring bone mineral density have been widely accepted for the diagnosis and management of osteoporosis. These techniques are clinically feasible, and their fracture prediction capability has been proven in numerous studies. However, it has been demonstrated that bone strength and fracture risk are affected not only by the density of bone but also by other skeletal features including bone composition and microarchitecture. Theoretically, QUS(Quantitative Ultrasound) may reflect not only bone mass but also bone structure. In this study, we have examined the relationship between SI(Stiffness Index), SOS(The speed of sound), BUA(Broadband Ultrasound Attenuation) measured in the os calcic by QUS and BMD(Bone Mineral Density) measured in lumbar spine and femur neck by DEXA(Dual Energy X-ray Absorptiometry) in 18 marked osteoporotic patient. All QUS parameters poorly correlated with BMD measured in lumbar spine(SI; C.C.=0.2795, SOS; C.C.=0.0355, BUA; C.C.=0.3110) and in femur neck(SI; C.C.=0.2239, SOS; C.C.=0.0742, BUA; C.C. 0.3130) in contrast to good correlation in normal and mild osteoporotic women. Considering the report that at 2 standard deviations below the normal mean QUS has the maximum accuracy, these findings may imply that QUS reflect the disruption of the intrinsic trabecular architecture, the integrity of which plays a vital role in maintaining skeletal strength, so give better information about fracture risk in marked osteoporotic patients, QUS has the added advantages of being relatively inexpensive, rapid and radiation-free. With improved assessment of fracture risk, QUS may be a putatively acceptable screening procedure.