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박희붕(Hee Boong Park),이묘경(Myo Kyung Lee),홍정(Jeong Hong),정우희(Woo Hee Jung),황의호(Eui Ho Hwang),설준희(Joon Hee Sul) 대한두경부종양학회 1993 대한두경부 종양학회지 Vol.9 No.2
Histologically proven 465 cases of neck mass in children were analized for the determination of the nature of lesions. Pathologic specimens were obtained during 10 years from January 1981 to December 1989 at Severance Hospital, Yonsei University, College of Medicine. 1) Congenital lesion was most common in neonate(80%) and congenital lesion and inflamatory disease were common in infancy and inflammatory disease was most common in more than one year old children. Thyroglossal duct cyst was most common(35.4%) disease of the congenital lesion. followed by cytic hygroma(34%) and branchial cleft remnants(29.2%). 2) Benign tumors were discovered most frequently in adolescence (55.2%) and thyroid adenoma(23.7%) and epithelial tumor(21.1%) and hemangiomas(19.7%) were most common. Most common malignant tumors were malignant lymphoma (50%) and Hodgkin's disease and were present in the older children. Metastatic cancers were very rare and their primary sites were deductable in all cases. 3) Reactive hyperplasia of lymph node was most common in inflammatory disease(23.7%). Tuberculosis lymphadenitis was more common than nonspecific lymphadenitis. 4) Bilaterality of lesion was commonly seen in malignant disease(41.7%), reactive hyperplasia of lymph node (38.85%) and metastatic disease(33.3%). Size and duration of the masses were not helpful in the differential diagnosis of the cause of the masses. Pediatric neck mass must be evaluated with its characteristics. sites, bilaterality, size and its cange, duration and patient's age but any of these alone cant not be predicted its causes without biopsy or excision. Biopsy or excision can be done with few complication but biopsy of lymph node for diagnosis is carefully made because a large number of lymph node biopsy showed no definite diagnosis in these selected cases of patients.
갑상선 자극호르몬이 갑상선암세포의 VEGF, 신생혈관 형성, 성장, 침윤 및 전이에 미치는 영향
소의영,박희붕,김혜진,김현만<SUP>1<,SUP>,Euy Young Soh,M,D,Hee Boong Park,M,D,Hye Jin Kim,M,D,and Hyun Man Kim,M,D,<SUP>1<,SUP> 대한갑상선-내분비외과학회 2001 The Koreran journal of Endocrine Surgery Vol.1 No.1
Purpose: Vascular endothelial growth factor (VEGF) is a vascular endothelial cell specific mitogen and a major regulator of angiogenesis. VEGF secretion is activated in some thyroid cancers and that VEGF secretion is stimulated by TSH. So we postulated that TSH may promote growth and invasion in some thyroid cancers by stimulating VEGF secretion and angiogenesis. Methods and Results: We investigated the TSH effect for the VEGF secretion, endothelial cell proliferation and invasion in vitro with the primary cultured normal thyroid cell (NT-1) and thyroid cancer cell line (TPC-1). And to evaluate the relationship between TSH and VEGF, angiogenesis and tumor growth in vivo, we xenografted human dermal matrix inoculated with thyroid cells into nude mice or directly injected subcutaneously. For the study, mice were made hypothyroid (Group 1) by antithyroid hormone p.o, hyperthyroid (Group 2) by L-thyroxine injection and euthyroid (Group 3). One week after the treatment, significant difference were noted in T3, T4 and TSH level between each group, but the VEGF level showed significant difference in group 1 only compared with group 2 and 3. NT-1 or TPC-1 were seeded in the upper chamber of Transwell and HUVEC were cultured in lower chamber, and added different concentration of TSH. NT-1 and TPC-1 secreted VEGF under basal condition, but the level were similar. TPC-1 cells secreted significantly more VEGF than NT-1 after TSH (1, 10, 100 mIU/dl) stimulation, which were also parallel with the concentration of TSH. In low concentration of TSH (0, 1 mIU/dl), there were no difference of HUVEC proliferation between NT-1 and TPC 1. In high concentration of TSH (10, 100 mIU/dl), however, TPC-1 enhanced HUVEC proliferation than NT-1 significantly (p<0.05). Similar findings were noted in thyroid cell invasion. Invasion was higher in TPC-1 than in NT-1 in high concentration of TSH (10, 100 mIU/dl). In vivo study using the dermal matrix showed that number of blood vessels ingrowth were higher in Group 1 (25/HPF) than Group 2 (16/HPF) or Group 3 (17/HPF). But there was no difference between Group 2 and Group 3. Level of TSH and VEGF were also increased significantly in Group 1 compared with in Group 2 and Group 3. The size of tumor did not showed significant difference between each group during observation. The tumor from Group 1 (6.2 gm) were larger compared with Group 2 (5.1 gm) or Group 3 (5.6 gm), but this difference was not significant statistically (p>0.05). The number of blood vessels in tumor were also more increased in Group 1 and were commonly located in the peripheral portion of tumor. Conclusion: We conclude that thyroid cancer cell line secrete the VEGF and TSH secretion is more enhanced by the stimulation of TSH. And increased VEGF promote the vascular endothelial cell proliferation, invasion and angiogenesis in thyroid cancer. (Korean J Endocrine Surg 2001; 1:51-60)
갑상선 결절에 동반된 퇴행성 낭종의 재발과 낭액내 VEGF의 관련성
조은호,박희붕,김현만<SUP>1<.SUP>,이관우<SUP>1<.SUP>,정윤석<SUP>1<.SUP>,소의영,Eun Ho Cho,M.D.,Hee Boong Park,K.D.,Hyun Man Kim,M.D.<SUP>1<.SUP>,Kwan Woo Lee,M.D.<SUP>1<.SUP>,Yun Suk Jung,M.D.<SUP>1<.SUP> and Euy Young 대한갑상선-내분비외과학회 2002 The Koreran journal of Endocrine Surgery Vol.2 No.1
Purpose: VEGF, a potent angiogenic factor, increases vascular permeability and induces the fluid accumulation in the peritoneal and pleural cavities. This study is designed to know whether the VEGF concentration are associated with the formation of cystic fluid of thyroid nodules and the results of treatment. Methods: To know whether thyroid follicular cells produce VEGF, we measured the VEGF concentration in the conditioned medium after primary culture of the normal thyroid follicular cells (NT 1.0). Thirty seven patients, who had visited Ajou University Medical Center, were divided into two groups; group A (n=19) is patients whose cystic nodules disappeared completely with 1 or 2 times fine needle aspirations. In Group B (n=18), the cystic nodules recurred rapidly and required aspiration more than 3 times. Clinical records of patients were analyzed and compared with TSH and VEGF levels in cystic fluids. Results: The VEGF concentration in basal conditioned medium were 8.2⁑1.2 ng/ml in NT 1.0 and 8.2⁑0.6 ng/ml in thyroid cancer cell line (FTC-133). NT 1.0 was not affected by TSH stimulation. Mean concentration of TSH of all cystic fluids was 4.36μIU/ml (0.13∼21.7) and there was no difference between 2 groups. Mean concentration of VEGF of all cystic fluids was 140.7 ng/ml (11.1∼688.8). The VEGF concentration (287.9⁑289.6 ng/ml) in group B was significantly higher than that (104.2⁑97.1 ng/ml) in group A (P<0.05). Conclusion: This study suggests that thyroid follicular cells produce and secrete VEGF, and VEGF is related with the accumulation of cystic fluid in degenerative cysts of thyroid. Cysts with high VEGF concentration promote rapid reaccumulation of the cystic fluid and possibly necessitate operation in selected patients. (Korean J Endocrine Surg 2002;2:25- 30)
갑상선 질환(종양)에서 Cyclooxygenase-2의 발현에 대한 연구
이국종,박희붕,김지훈,정용식,주희재<SUP>1<,SUP>,소의영,Kug Jong Lee,M,D,Hee Boong Park,M,D,Ji Hoon Kim,M,D,Yong Sik Jeong,M,D,Hee Jae Joo,M,D,<SUP>1<,SUP> and Euy Young Soh,M,D 대한갑상선-내분비외과학회 2002 The Koreran journal of Endocrine Surgery Vol.2 No.2
Purpose: Thyroid tumor is one of the most common endocrine tumors, and yet little is known about its molecular process of development and progression. Cyclooxygenase (COX)- 2, the inducible form of the COX enzyme for prostaglandin synthesis, is up-regulated in gastrointestinal cancers and is a key mediator of epithelial cell growth. Regular intake of aspirin or other nonsteroidal antiinflammatory drugs (NSAIDs) is associated with a decreased incidence of colorectal, esophageal, gastric, and lung cancer. We sought to determine the involvement of COX-2 in human thyroid cancer. Methods: COX-2 protein was assayed in thyroid tissue of 64 which were inflammatory disease and benign tumor and malignant tumor with or without metastasis patients by using immunohistochemistry and Western Blot analysis. Results: COX-2 protein was not expressed in normal thyroid tissue. But COX-2 protein was expressed strongly in inflammatory tissue. Expression of COX-2 was very high in both benign and malignant tumor. There is no difference in pathology and malignant potential or existence of metastasis. Conclusion: There was no correlation between clinicopathological characteristics of thyroid tumor and intensity of COX-2 protein expression. In addition, there was no difference of expression of COX-2 between inflammatory thyroid disease and thyroid tumor. This study indicates that COX-2 protein over expression may contribute to an early event of gastric cancer development, and it further suggests that selective inhibition of COX-2 may provide a chemopreventive effect against thyroid cancer. (Korean J Endocrine Surg 2002;2:90-96)
이은현(Eun-Hyun Lee),박희붕(Hee Boong Park),김명욱(Myung Wook Kim),강승희(Sunghee Kang),이혜진(Hye-Jin Lee),이원희(Won-Hee Lee),전미선(Mison Chun) 대한방사선종양학회 2002 Radiation Oncology Journal Vol.20 No.4
목적 : 본 연구 목적은 암 환자의 삶의 질에 대한 국내 연구논문을 분석 평가하여 선행연구의 단점을 보완한 후속 연구의 방향을 제시하기 위함이다. 대상 및 방법 : 전남대학교 보건연구 정보센타, KoreaMed 및 의학연구정보센타의 DB Bank를 검색하여 ‘삶의 질’과 ‘암’이라는 용어가 포함된 논문 31편을 선정하였다. 선정된 연구논문을 암 부위, 삶의 질 정의에 대한 개념적 영역(domains), 사용된 독립변수(예측변수), 연구설계(단면적/종적연구), 측정의 주체(자가측정/대리측정), 사용된 도구(단일도구/일련의 도구 세트), 질문지 번역과정(번역-역번역), 신뢰도, 타당도, 점수계산방법 및 연구결과에 따라 분석하였다. 결과 : 전체 31편의 연구논문 중 약 반이 여러 종류의 암 환자를 대상으로 실시되었고, 삶의 질의 정의에 대해서는 많은 연구에서 다차원적으로 정의하였다. 연구설계는 약 30%의 논문만이 종적연구설계를 하여 삶의 질 변화에 대한 연구를 하였다. 삶의 질 측정도구로는 거의 전 연구에서 환자가 직접 측정하는 질문지 방법을 이용하였으나, 도구의 선택에 있어 신뢰도와 타당도에 대해서는 고려하지 않은 편이다. 또한 외국에서 개발된 질문지를 번역하여 사용할 때 변역-역번역 과정을 통해 한글로 번역한 도구는 하나도 없었다. 측정된 삶의 질 계산방법은 전부 전통적인 방법인 평균이나 합으로 계산하였다. 연구에서 삶의 질에 영향을 미치는 독립변수로 검정되었던 변수들은 다양하지 않았다. 결론 : 앞으로 암 환자의 삶의 질에 대한 국내 연구가 나아가야 할 방향은 치료과정에 따른 삶의 질 변화 파악을 위한 종적 연구설계의 시도와 신뢰도와 타당도가 수립된 적절한 측정도구의 사용, 그리고 삶의 질에 영향을 미치는 제 변수들에 대한 반복적 연구 및 새로운 변수 파악을 위한 연구라고 할 수 있다. Purpose : The purpose of the present study was to analyze and evaluate prior studies published in Korea on the cancer-related quality of life, in order to make recommendations for further research. Materials and Methods : A total of 31 studies were selected from three different databases. The selected studies were analyzed according to 11 criteria, such as site of cancer, domain, independent variable, research design, self/proxy rating, single/battery instrument, translation/back translation, reliability, validity, scoring, and findings. Results : Of the 31 studies, approximately half of them were conducted using a mixed cancer group of patients. Many of the studies asserted that the concept of quality of life had a multidimensional attribute. Approximately 30% were longitudinal design studies giving information about the changes in quality of life. In all studies, except one, patients directly rated their level of quality of life. With respect to the question-naires used for measuring the quality of life, most studies did not consider whether or not their reliability and validity had been established. In addition technique. All studies used sum or total scoring meth-ods when calculating the level of quality of life. The types of variables tested for their influence on quality of life were quite limited. Conclusion : It is recommended that longitudinal design studies be performed using methods of data collection whose validity and reliability has been confirmed, and studies be conducted to identify new variables having an influence on the quality of life.