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기분 장애 환자에서 나타나는 불특정 CAG 삼핵산 반복서열의 확장
손성은,임신원,이소영,황혜진,진동규,박정의,김도관,김이영 대한신경정신의학회 2000 신경정신의학 Vol.39 No.2
연구목적: 기분장애는 그 원인과 발생기전은 아직 밝혀져 있지 않고 있지만, 과거부터 유전적 요인이 질병의 발생과 중요한 연관성을 가지고 있다고 알려져 있다. 특히 양극성 정동장애는 가족력이 있는 경우에 발병될 가능성이 높고, 같은 가족 내에서 발생했을 때 세대가 내려감에 따라서 발병시기가 점차 빨라지며 증세가 심해지는 경향이 있어서 그 유전적 배경에 대해 많은 의문이 있어 왔다. 연구자들은 다양한 증상의 기분장애 환자들의 DNA에서 불특정 CAG 삼핵산 반복(trinucleotide repeat. TNR) 정도를 분석함으로써 TNR 확장이 기분장애의 유전과 관련되는지 살펴보았다. 방법: 환자 군은 DSM-Ⅲ-R 진단기준에 의거하여 양극성 정동장애(N=55), 주요우울장애(N=67) 환자들을 선발하였다. 정상인(N=89)은 정신과적 병력이 없고 다면성 인성검사상 정상의 profile을 나타내는 병원 종사자, 학생 및 건강의학센타 방문자들 중 선발하였다. TNR의 확장은 genomic DNA를 순수분리한 후, (CTG)₁□의 oligonucleotide를 □-□□P-ATP로 방사선 표지하여 반복서열 확장 탐지법(repeat expansion detection)으로 측정하였다. 집단간의 비교를 위해 Mann-Whitney U 검증을 실시하였다. 결과: DNA에서 관찰되는 불특정 CAG 삼핵산 반복 길이의 평균은 양극성 정동장애에서 169.8bp(S.D=58.6), 주요우울장애에서 167.5bp(S.D=63.9)로서 대조군 178.7bp(S.D=56.5)과 비교하였을 때 유의미한 차이는 관찰되지 않았다. 각각의 환자군을 가족력이 있는 군과 없는 환자군으로 나누어 대조군과 비교하였을 때도 유의미한 차이는 관찰되지 않았다. 결론: 불특정 CAG 삼핵산 반복서열 확장이 양극성 정동장애 환자와 주요우울장애 환자들의 유전 양식에 영향을 미친다는 가설을 뒷받침하지 않는다. Objectives: The genetic facotrs have been suggested for the etiology of mood disorders but the mode of inheritance is complex. Increased severity and an earlier onset of the bipolar and major depressive disorder over generations within families(Anticipation) were reported. In order to test the hypothesis that trinucleotide repeat expansions underlie the genetic basis of Bipolar and major depressive disorders, we have analyzed the extent of CAG reapeats in genomic DNA from mood disorder patients. Methods: 55 bipolar disorder, 67 major depressive disorder patients were recruited accord-ing to the DSM-Ⅲ-R criteria. 89 normal controls were recruited from the medical personnel, students and the visitors to the health services center who had no history of psychiatric illness and show normal profile of MMPI. The genomic DNA of patients and controls was analyzed by use of the (CTG)□ oligonucleotide and the repeat expansion detection(RED) method. The Mann-Whitney U test was used to compare the distribution of the number of CAG repeats among the groups. Results: when the bipolar disorder, major depressive disorder patients were compared with the control group, no significant differences were observed. Conclusions: Our results do not support the hypothesis that expanding CAG repeats are causing the observed genetic anticipation in bipolar disorders and major depressive disorders.
김영자,김영배,홍영규,양윤모,최규식,최인준,이경식,소의영,황영남,조승운 대한내과학회 1988 대한내과학회지 Vol.35 No.5
Solitary malignant schwannoma is a rare primary nerve sheath tumor and has been reported to occur in almost any anatomic location, most commonly in the extremities, but rarely in the retroperitoneum. The typical clinical presentation is that of a painless, slowly enlarging soft tissue mass, occasionally associated with a peripheral neuropathy. A high percentage of the patients experience local recurrence even after radical surgical therapy and the results of treatment with radiation and chemotherapy have also been disappointing. This paper presents a case of solitary malignant schwannoma occuring in the retroperitoneal cavity with a brief review of the pertinent literature. A 71 year-old male visited our medical hospital with the symptom of a progressive growing painless mass in the left upper abdomen of 2 months duration. Abdominal ultrasonography and CT scan highly suggested a pancreatic tail carcinoma or primary retroperitoneal tumor. Radical surgical resection was performed successfully and the histological findings were compatible with malignant schwannoma.
FCT 6 : Prevention of thyroidectomy scars in Asian adults with low-level light therapy
( Young Joon Park ),( Sang Jin Kim ),( Hyo Sang Song ),( Jeong Hun Lee ),( Euy Young Soh ),( You Chan Kim ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: Abnormal wound healing after thyroidectomy and a consequent scar is a common dermatologic consultation.Prevention of the possible hypertrophic scars and keloids is known to be challenging. Objectives: The objective of our study was to validate and confirm the efficacy and safety of low-level light therapy (LLLT) for the prevention of thyroidectomy scars on the neck. Methods: Fourty-one South Korean patients with linear surgical suture after thyroidectomy operation were treated with an 830/590nm light-emitting diode (Healite®). Each patient was treated daily of 60J/cm2(11 minutes) for a week starting on post-operation day one and treated 3 times per week for 3 more weeks. The control group consisted of 15 patients without any therapy except application of absorbent foam dressing. The scar prevention effects were evaluated at 1 month and 3 months after surgery.Colorimetric evaluation using a tristimulus color analyzer was done. The Vancouver Scar Scale (VSS), Global Assessment Score (GAS) and a subjective score ranging 1 to 4 was also measured. Results: The L* value and a* value decreased significantly on the 3 month follow up visit in the the treated groupcompared to the control group. Also, the average VSS and GAS was lower in the treated group. However, subjective measure did not show significant difference. Conclusion: LLLT using a 830/590nm light emitting diode may efficiently suppress the formation of thyroidectomy scars, and can be safely without noticeable side effects.
Kim, Young Hwa,Choi, Yong Won,Han, Jae Ho,Lee, Jeonghun,Soh, Euy Young,Park, So Hyun,Kim, Jang-Hee,Park, Tae Jun Neoplasia Press 2014 Neoplasia Vol.16 No.12
<P>B-RafV600E oncogene mutation occurs most commonly in papillary thyroid carcinoma (PTC) and is associated with tumor initiation. However, a genetic modification by B-RafV600E in thyrocytes results in oncogene-induced senescence (OIS). In the present study, we explored the factors involved in the senescence overcome program in PTC. First of all, we observed down-regulation of p-extracellular signal-regulated kinases 1/2 and up-regulation of dual specific phosphatase 6 (DUSP6) in the PTC with B-RafV600E mutation. DUSP6 overexpression <I>in vitro</I> induced extracellular signal-regulated kinases 1/2 dephosphorylation and inhibited B-RafV600E–induced senescence in thyrocytes. Although DUSP6 protein was degraded by B-RafV600E–induced reactive oxygen species (ROS), thyroid-stimulating hormone (TSH) stabilized DUSP6 protein by increasing Mn superoxide dismutase expression and inhibited B-RafV600E–induced senescence. Although serum TSH was not increased, its receptor was markedly upregulated in PTC with B-RafV600E. Furthermore, TSH together with DUSP6 reactivated Ras signaling, resulted in activation of Ras/AKT/glycogen synthase kinase 3β, and stabilized c-Myc protein by inhibiting its degradation. These observations led us to conclude that increased TSH signaling overcomes OIS and is essential for B-RafV600E–induced papillary thyroid carcinogenesis.</P>