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초음파 진단영상 대조도 개선을 위한 확률 경계 맵을 이용한 연구
최우혁,박원환,박성윤,Choi, Woo-hyuk,Park, Won-hwan,Park, Sungyun 대한한의진단학회 2016 大韓韓醫診斷學會誌 Vol.20 No.1
Ultrasonic imaging is the most widely modality among modern imaging device for medical diagnosis. Nevertheless, medical ultrasound images suffer from speckle noise and low contrast. In this paper, we propose probabilistic edge map for ultrasound image edge enhancement using automatic alien algorithm. The proposed method used applied speckle reduced ultrasound imaging for edge improvement using sequentially acquired ultrasound imaging. To evaluate the performance of method, the similarity between the reference and edge enhanced image was measured by quantity analysis. The experimental results show that the proposed method considerably improves the image quality with region edge enhancement.
홍문엽,박선동,박원환,Hong, Mun-Yeup,Park, Sun-Dong,Park, Won-Hwan 동국대학교 한의학연구소 1999 東國韓醫學硏究所論文集 Vol.8 No.1
금궤요략은 후한말기(後漢末期) 장기(張機)가 지은 임상의학(臨床醫學) 전문서적(專門書籍)으로써, 리(理) 법(法) 방(方) 약(藥)이 갖추어진 독창적(獨創的)인 변증론치체계(辨證論治體系)를 수립하고 있으며, 특히 복증(腹證)에 관한 내용을 중(重)히 다루고 있고, 방증변증(方證辨證)이 중심(中心)이 되어 복증(腹證)을 통한 변증(辨證)이 매우 발달되어 있어서 진단학(診斷學)의 발전(發展)에 크게 기여하였다. 이후 진단학(診斷學)의 발전(發展)은 진맥(診脈), 진설(診舌)을 위주로 했으며, 복진(腹診)의 운용(運用)에 대해서는 역사적으로 사회적인 특수한 배경으로 인하여 계속 발전되지 못하였다. 최근 한의학적(韓醫學的) 진단방법(診斷方法)과 치료방법(治療方法)이 매우 강조되어 활발한 연구가 계속 진행되면서 복증변증(腹證變證)에 관한 관심이 매우 집중되고 있기에, 복부진단(腹部診斷)에 관한 연구(硏究)의 한 방법(方法)으로써 금궤요략에 실려있는 상견복증(常見腹證)에 관련된 내용(內容)을 정리한 결과(結果) 약간의 지견(知見)을 얻었다. The subject of Abdominal syndrome in the field of Jin Kui Yao Lue takes a quarter of the whole research quantity, and has greatly contributed to the development of diagnoses due to the well-growth of syndrome differentiation through 'the differentiation of symptoms and signs based on prescriptions'-centered abdominal syndrome. Since then, while the diagnostic has been developed mainly in the field of pulse feeling and the inspection of the tongue, application of the abdominal diagnostic has not been continuously improved because of special historical and social environments. Recently, since interest in the differentiation of symptoms and signs based on abdominal syndrome has been raised by emphasis of Oriental diagnostic methods and. medical treatment which have led to the study of Abdominal Syndrome in Jin Kui Yao Lue. The following is the results of the study. 1. Jin Kui Yao Lue abdominal syndrome is categorized into all abdominal symptoms Epigastric symptoms, Hypochondrium symptoms, and Lower abdomen symptoms. 2. Subjective symptoms and Objective symptoms have been found in Abdominal syndrome, and Subjective symptoms have been more often than Objective symptoms. Both of the symptoms have been found more to co-exist in abdominal syndromes. 3. More cases of fullness of abdomen symptoms in All abdominal symptoms, a smaller number of cases in Taiyang disease, Yangming disease, disease involving all three yang, Tayin disease and Jueyin disease have been found, but there have not been found in Shaoyin disease. 4. More cases of Epigastric fullness and rigidity in Epigastric symptoms, Epigastric throbs in Palpitation symptoms, and sense of fullness-in-chest in Abdominal syndrome of chest and hypochondrium have been recognized. 5. Any regularity caused by abdominal symptoms has not been identified. 6. Diagnosis of the abdomen caused by abdominal symptoms has been identified in Epigastric fullness, Epigastric pain, Epigastric procrastination, Epigastric throb, fullness of abdomen and distension of lower abdomen.
사역산(四逆散)과 시호(柴胡)·감초(甘草) 배합추출물(配合抽出物)이 CCl<sub>4</sub>로 유도(誘導)된 간중독(肝中毒) 흰쥐에 미치는 영향(影響)
정성이,박선동,박원환,Jung, Sung Yi,Park, Sun Dong,Park, Won Hwan 동국대학교 한의학연구소 1996 東國韓醫學硏究所論文集 Vol.5 No.-
The purpose of this study is to observe the effect of Sayeuksan on serum reaction in $CCl^4$ treated rats. In this study the experimental rats divided four group (Control group, $CCl^4$ group, sayeuksan group, and shiho, kamcho group) Under the same condition control group were administered water, sample group were administered Sayeuksan for 8days. and then, both $CCl_4$ group and sample group were injeccted to abdomen with $CCl_4$ for 1days. The change of GOT GPT ${\gamma}$-GTP ALP LDH activity in blood serum. The obtained results are summarised as follows : 1. In the change of GOT GPT contents, as compared with control group sample group was significantly decreased. 2. In the change of ${\gamma}$-GTP contents as compared with control group, sample group was significantly decreased. 3. In the change of ALP contents, as compared with control group, sample group was significantly decreased. 4. In the change of LDH contents, as compared with contol group, sample group was significantly decreased.
대계 추출물의 할성산소 소거능 및 Cytochrome P450 효소 저해효과
김혁,이효승,박원환,문진영,Kim, Hyuck,Yi, Hyo-Seung,Park, Won-Hwan,Moon, Jin-Young 대한본초학회 2007 大韓本草學會誌 Vol.22 No.1
Objectives: Our previous studies have clearly demonstrated that the scavenging activity of reactive oxygen species (ROS), protective effect of lipid peroxidation (LPO), and inhibition of cytochrome P450 isozymes (CYPs) from the Circium japonicum aqua-acupuncture solution (CJAS). But, Circium japonicum water extracted solution (CJWS) was weakly reported in cardiovascular diseases such as oxidative stress-mediated atherosclerosis or its value evaluated. Methods: CJWS was assessed to determine the mechanism of its scavenging activity of ROS and inhibitory effect of CYP 2E1. Results: CJWS exhibited a concentration-dependent scavenger of DPPH and superoxide anions radicals using different assay systems. In addition, CJWS showed dose-dependent free radical scavenging activity, including hydroxyl radicals, peroxynitrite, and nitric oxide. The CJWS was also found to be effective in protecting rat liver homogenate against LPO. Futhermore, the CJWS showed significant inhibition of CYP 2E1 induced by pyrazol in a rat liver microsome. Conclusion : ROS and CYPs may play a role in several diseases, such as cardiovascular disease and heart failure. Our study demonstrated that the CJWS has excellent scavenging activity of ROS. Hence, it is worthwhile to investigate the potential effectiveness of CJWS in preventing oxidative stress-mediated cardiovascular diseases.
용담사간탕(龍膽瀉肝湯)에 의해 유도된 MAP kinases 활성화를 통한 간암 세포주 HepG2의 세포사멸
윤현정,김한성,허숙경,황성구,박원환,박선동,Yun, Hyun-Jeong,Kim, Han-Seong,Heo, Sook-Kyoung,Hwang, Seong-Goo,Park, Won-Hwan,Park, Sun-Dong 대한한의학방제학회 2007 大韓韓醫學方劑學會誌 Vol.15 No.2
The purpose of this study was to investigate the effect of Yong-dam-sa-gan-tang (YST) on apoptosis in HepG2 cells, First of all. to study the cytotoxic effect of methanol extract of YST on HepG2 cells, the cells were treated with various concentrations of YST and then cell viability was determined by XTT reduction method and trypan blue exclusion assay. YST reduced proliferation of HepG2 cells in a dose-dependent manner. To confirm the induction of apoptosis, HepG2 cells were treated with various concentrations of YST. The cleavage of poly AD P-ribose polymerase (P ARP), a substrate for caspase-3 and a typical sign of apoptosis, and the activation of caspase-3, procaspase-8 and procaspase-8 were examined by western blot analysis. YST decreased procaspase-3, procaspase-8 and procaspase-9 levels in a dose-dependent manner and induced the clevage of PARP. YST triggered the mitochondrial apoptotic signaling by increasing the release of cytochrome c from mitochondria to cytosol. Furthermore, YST also downregulated the anti-apoptotic Bcl-2 and upregulated the pro-apoptotic-Bax. Therefore, this result suggest that YST induced HepG2 cell death through the mitochondrial pathway. Sustained activation of the Ras/Raf/MEK/ERK cascade in cells results in a cell cycle arrest and has been implicated in the differentiation of certain cell types, in many cases acting to promote differentiation. YST decreased the activation of Ras/Raf/MEK/ERK cascade in a dose-dependent manner. These results suggest that YST is potentially useful as a chemo-therapeutic agent in HepG2.