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Glucose Oxidase에 의(依)하여 손상(損傷)된 배양척수감각신경절세포(培養脊髓感覺神經節細胞)에 대(對)한 음양곽(淫羊藿)의 효과(效果)
박승택,이호섭,윤용갑,박병림,Park Seung-Taeck,Lee Ho-Sub,Yun Yong-Gap,Park Byung-Rim 대한한의학방제학회 1999 大韓韓醫學方劑學會誌 Vol.7 No.1
척수감각신경절세포에 대한 산소자유기의 신경독성효과에 대한 기전을 규명하기 위하여 여러 농도의 Glucose Oxidase(GO)를 배양 척수 감각신경절세포에 처리한 후 GO의 독성효과를 분석하였으며 또한 GO에 의하여 유발된 신경독성에 대한 음양곽(Epimedium Koreanum Nakai)의 방어효과를 MTT assay법에 의하여 조사하여 다음과 같은 결론을 얻었다. GO는 신경세포에 처리한 농도와 시간에 비례하여 세포의 생존율을 유의하게 감소시켰으며, 또한 음양곽이 GO의 독성효과를 효과적으로 방어하였다. 이상의 결과로부터 산소자유기인 GO는 생쥐의 배양 척수감각신경절세포에 독성을 나타냈으며 음양곽과 같은 한약추출물이 GO의 독성을 방어하는데 효과적인 것으로 나타났다. To evaluate the neurotoxic effect of oxygen radicals in cultured mouse spinal dorsal root ganglion(DRG) neurons, cytotoxicity was determined by MTT assay after cultured DRG neurons were grown in the media containing various concentrations of glucose oxidase(GO). In addition, neuroprotective effect of herb extract, Epimedium Koreanum Nakai was examined by MTT assay in cultured DRG neurons. Cell viability of cultured DRG neurons was remarkably decreased by GO in dose- and time-dependent manner, and Epimedium Koreanum Nakai protected remarkably GO-induced neurotoxicity in these cultures. From the above results, it is suggested that oxygen radicals is toxic in cultured mouse DRG neurons, and herb extracts such as Epimedium Koreanum Nakai are effective in prevention of the neurotoxicity induced by oxygen radicals in cultured mouse DRG neurons.
박승택,윤향석,형근영,조정구,이강창,김원신,김형민,전병훈,윤용갑,Park Seung-Taeck,Yoon Hyang-Suk,Hyoung Keon-Young,Cho Chung-Gu,Lee Kang-Chang,Kim Won-Shin,Kim Hyung-Min,Jeon Byung-Hoon,Yun Young-Gap 대한한의학방제학회 1999 大韓韓醫學方劑學會誌 Vol.7 No.1
In order to eludidate the mechanism of oxidative stress in cultured spinal motor neurons damaged by oxygen free radicals, cytoxicity was assesed by MTT assay and NR assay after spinal motor neurons from mouse were cultured in media containing various concentrations of xanthine oxidase(XO) and hypoxanthine(HX) for 3 hours. In addition, neuroprotective effects of several herb extracts on oxidant-induced neurotoxicity were examined in these cultures, compared with nerve growth factors such as basic fibroblast growth factor(bFGF). XO/HX decreased cell viability in dose- and time dependent manners on cultured mouse spinal motor neurons, and MTT50 and NR50 values were measured at 20mU/ml XO and 0.1mM HX for 3 hours in these cultures. bFGF significantlt increased cell viability. In neuroprotective of herb extracts, Epimedium Koreanum Nakai(EK) and Alpinia oxphylla Mig(IJI) was very effective in the prevention of the neurotoxicity induced by XO/HX in cultured mouse spinal motor neurons. From the above results, it is suggested that XO/HX shows toxic effect in cultured mouse spinal motor neurons and selective herb extracts such as Epimedium Koreanum Nakai(EK) and Alpinia oxphylla Mig(IJI) were very effective in the increase of cell viability against the neurotoxicity induced by oxygen radicals in these cultures.
산소자유기에 의해서 유도된 신경독성에 대한 Iron-chelator의 영향에 관한 연구
박승택(PARK Seung Taeck) 대한체질인류학회 1995 대한체질인류학회지 Vol.8 No.2
산소자유기에 의한 신경독성에 대한 기전을 규명하기 위하여 배양 생쥐 적수 감각 신경절 세포에 효소 적으로 발생시킨 산소자유기를 노출시킨 뒤 산소자유기에 의하여 유도된 신경독성효과를 조사하고 또한 산소자유기에 의해 유발된 신경독성에 대한 iron-chelator의 방어효과를 MTT assay와 neurofilament enzymeimmuno assay(EIA)에 의하여 분석하였다. 배양 신경세포를 25mU/ml xanthine oxidase(XO)와 0.3mM hypoxanthine(HX)에 3시간 동안 노출시킨 결과 시간에 비례하여 유의한 세포수의 감소를 보였다. 또한 산소자유기에 의하여 중재된 신경독성에 대하여 iron-chelator인 TPEN은 유의하게 방어효과를 보인 반면 DFX는 뚜렷한 방어효과를 나타내지 않았다. 위의 결과로부터 산소자유기는 배양 생쥐 척수 감각신경절 세포에 독성을 보였고 또한 이같은 신경 독성에 절이 관여하고 있으며 TPEN과 같은 선택적인 iron-chelator가 신경 독성효과를 방어하는데 효과적인 것으로 나타났다.
산소자유기에 의해 저해된 배양 척수감각 신경절 세포에 대한 상피세포성장인자의 영향
박승택(Seung Taeck Park),김형룡(Hyung Ryong Kim),채한정(Han Jung Chae) 대한약학회 1997 약학회지 Vol.41 No.1
In order to elucidate the cytotoxic effect of oxygen radicals on cultured spinal dorsal root ganglion(DRG) neurons derived from mouse. the neurotoxic effect of oxygen radicals was examined after cultured DRG neurons were exposed to xanthine oxidase(XO) and hypoxanthine(HX)-oxygen radical generating system. In addition. neuroprotective effect of epidermal growth factor(EGF) against oxidant-induced neurotoxicity was also evaluated in these cultures. The results were, as follows: 1. Lethal concentration 50(LC50) was 35mU/ml XO and 0.1mM HX in cultured DRG neurons. 2. Oxygen radicals induced the morphological changes such as the decrease of cell number and loss of neurites in these cultures. 3. EGF increased the cell viability and neurofilament in neurons damaged by oxygen radicals. From above the results, it is suggested that oxygen radicals have a cytotoxic effect on cultured DRG neurons of neonatal mouse and selective neurotrophic factors such as EGF are, effective, in blocking the neurotoxicity induced by oxygen radicals in cultured spinal DRG neurons.
배양 흑색종세포에 있어서 NiSO₄의 세포독성 및 멜라닌화에 대한 감잎 추출물의 영향
박승택(Seung Taeck Park),이경완(Gyoung Wan Lee),서영미(Young Mi Seo) 인간식물환경학회 2014 인간식물환경학회지 Vol.17 No.2
To evaluate the effect of persimmon(Diospyros kaki Thunb.) leaves(PL) extract on the cytotoxicity and melanogenesis of nickel sulfate(NiSO₄), an environmental pollutant or an allergic contact dermatitis inducer, the colorimetric assay was performed to measure the cell viability and lactate dehydrogenase(LDH) activity as well as the tyrosinase activity and total amount of melanin in cultured B16/F10 melanoma cells. In this study, NiSO₄ significantly decreased cell viability in dose-dependent manner, and XTT₅₀ value was calculated at 106.7μM of NiSO₄. The cytotoxicity of NiSO₄ was revealed to be mid-toxic in these cultures by Borenfreund and Puerner’s toxic criteria. And also, vitamin E effectively prevented NiSO₄-induced cytotoxicity by the significant increase of cell viability. PL extract showed the antioxidative activity by the significant increase of cell viability and the decrease of LDH activity compared to positive control(NiSO₄). In the melanogenesis, PL extract significantly decreased both tyrosinase activity and total amount of melanin which were increased by NiSO₄-induced cytotoxicity. From these findings, it is suggested that the cytotoxicity of NiSO₄ is involved in oxidative stress, and PL extract effectively prevented the cytotoxicity and the melanogenesis induced by NiSO₄. Conclusively, natural component such as PL extract may be a putative resources for beauty or detoxification by the prevention of the toxicity and the melanogenesis of heavy metals related with oxidative stress such as NiSO₄.
DNCB에 의해 발생되는 세포독성에 대한 오이풀 추출물의 방어 효과
박승택 ( Seung Taeck Park ),강민정 ( Min Jung Kwang ),제갈승주 ( Seung Joo Jekal ),이재형 ( Jae Hyoung Lee ),윤미영 ( Mi Young Yoon ),표애자 ( Ae Ja Pyo ),임요섭 ( Yo Sup Rim ),정인주 ( In Ju Jung ) 대한미용학회 2013 대한미용학회지 Vol.9 No.2
The protective effect of Sanguisorba officinalis L. (SO) extract against 1-chloro-2, 4-dinitrobenzene (DNCB)-induced cytotoxicity was performed in cultured human skin fibroblasts (Detroit 551 cells). The DNCB remarkably lowered cellviability in a dose-dependent manner, and its XTT50 value was measured at 48.4 μM. Whereas, 20 and 30 μM pretreatment of catalase for 2 hours before 48.4 μM treatment of DNCB significantly raised the cell viability. And also, 70 and 90μg/mL pretreatment of SO extract for 2 hours before 48.4 μM treatment of DNCB significantly raised the cell viability. The SO extract had a considerable DPPH-radical scavenging activity and SOD-like activity. From these results, it is suggested that the cytotoxicity of DNCB may be correlated with oxidative stress, and also, SO extract effectively prevented DNCB-in duced cytotoxicity by antioxidative effect. Conclusively, the natural plant extract such as SO may be a putative resource for the prevention of the cytotoxicity induced by skin decoloric agent such as DNCB.
Chromium Trioxide로 유발된 세포손상에 대한 Lavender 오일의 항산화 효과
박승택 ( Seung Taeck Park ),유영월 ( Young Wall Ryu ),김선주 ( Sun Ju Kim ),김지원 ( Ji Won Kim ),서영미 ( Young Mi Seo ),박미순 ( Mi Soon Park ),김은주 ( Eun Ju Kim ),이화정 ( Hwa Jeong Lee ),정인주 ( In Ju Jung ) 대한미용학회 2011 대한미용학회지 Vol.7 No.2
The cell viability by XTT assay, DPPH-radical scavenging activity, superoxide dismutase (SOD)-like activity and lipid peroxidation were measured to evaluate the cell injury of chromium trioxide (CrO3) and the antioxidative effect of lavender (Lavendula angustifolia L.) oil on the cell injury induced by CrO3 in cultured C6 glioma cells. C6 glioma cells were then treated with the media containing 30~50 μM of CrO3 for 48 hours. The results of this study showed that CrO3 remarkably decreased cell viability in dose-dependent manner and the XTT50 value was appeared at 40.5 μM of CrO3. In the effect of antioxidant, SOD on CrO3-mediated cytotoxicity significantly increased the cell viability which was decreased by CrO3. Meanwhile, in the protective effect of lavender oil on the cytotoxicity induced by CrO3, it remarkably increased the cell viability damaged by CrO3-mediated cell injury and also showed the DPPH-radical scavenging activity, SOD-like activity and the inhibitory activity of lipid peroxidation. From these results, it is revealed that the cell injury by CrO3 was involved in oxidative stress and lavender oil was effective in the protection of CrO3-mediated cell injury by antioxidative effect.
회소돌기아교세포에 있어서 메틸수은에 의해 유도된 신경독성에 대한 glutathione의 영향
박승택(Seung Taeck Park),오재민(Jae Mm Oh),최민규(Mm Kyo ChOl),김정중(Jung Joong KIm),윤향석(Hyang Suk Yoon),정진원(Hyang Suk Yoon),박옥규(Jm Won Chung),전병훈(Ick Kyu Park),김원신(Byung Hun Jeon),정연태(Won SIn KIm) 대한체질인류학회 1997 해부·생물인류학 (Anat Biol Anthropol) Vol.10 No.1
에틸수은 (methylmecury, MM) 이 소의 배양 희소돌기아교세포에 미치는 신경독성효과를 규명하기 위하여 여러 농도의 methylmercuric chloride (MMC)가 들어있는 배양액에서 신경세포를 24시간 동안 배양한 다음 이에 대한 신경특성을 MTT 분석법에 의하여 조사하였으며 또한 MMC에 의한 옥성효과에 대하여 항산화제의 방어효과를 분석 하였다. MMC는 처리한 농도와 시간에 비례하여 소의 배양 희소돌기아교세포의 생존율을 강소시켰으며 glutathione이 MMC에 의해 유도된 신경독성을 방어하였다. 이상의 경파로 부터 MM은 소의 배양 희소돌기아교세포에 독성을 나타냈으며 glutathione과 같은 선택적인 항산화제가 MM에 의한 신경독성을 방어하는데 매우 효과적인 것으로 나타났다.
기계학습 기반의 뉴스 추천 서비스 구조와 그 효과에 대한 고찰
박승택(Seungtaek Park),성인재(Injae Sung),서상원(Sangwon Seo),황지수(Jisoo Hwang),노지성(JiSung Noh),김대원(Daewon Kim) 사이버커뮤니케이션학회 2017 사이버 커뮤니케이션 학보 Vol.34 No.1
본 논문에서는 카카오가 2015년 6월부터 다음 뉴스에 적용한 루빅스(RUBICS)의 구조와 성과를 고찰한다. 루빅스는 다양한 추천 알고리듬으로 구성된 앙상블(Ensemble) 추천 시스템이며, 각 이용자의 성향을 반영한 개인화 추천과 이용자 집단 내의 트렌드를 반영한 추천을 통합적으로 제공한다. 본 논문에서는 루빅스의 초기(콜드 스타트(Cold-Start) 이용자가 다수인 상황)에 주요 알고리듬으로 사용된 멀티암드밴딧(Multi-Armed Bandit) 중심의 뉴스 추천시스템을 설명한다. 이어 알고리듬 성능을 추적하고 개선하기 위해 사용한 성능평가 방법을 설명하고 이를 통한 점진적인 알고리듬 개선 프로세스에 대해 논의한다. 마지막으로 루빅스 도입 이전과 이후의 뉴스 서비스의 성과 지표 비교를 통해 루빅스의 효과를 설명한다. 루빅스가 다음 모바일 뉴스에 도입되기 전인 2015년 4월과 도입(2015년 6월) 후인 2015년 8월의 뉴스 소비를 비교한 결과, 루빅스가 적용된 후 일평균 클릭 수는 130% 증가했으며, 일평균 뉴스 이용자도 45% 늘었다. 또한 첫 화면에 노출되는 뉴스 콘텐츠의 양도 250% 증가하였다. 이는 루빅스가 이용자 경험의 개선을 통해 이용자의 증가와 뉴스 내의 다양성 확보에 효과가 있음을 보여준다. We study the structure of RUBICS (Real-time User Behavior Interactive Content recommender System) and its performance in the Daum mobile news service (the “News Service”). RUBICS has deployed in the News Service since June 2015. RUBICS is an ensemble recommender system consisting of various recommendation algorithms, which provides users with a combination of trend recommendation and personalized one. In this paper, we mainly explain a customized Multi-Armed Bandit (MAB) algorithm, which played a major role in the early version system where most users were in cold-start situations. Then, we explain our performance evaluation methods and test-procedures which were employed in order to improve the algorithms in our system. Finally, we discuss the impact of RUBICS on the News Service by comparing the KPIs of the service before and after deployment of RUBCIS. RUBICS increased the average number of clicks per day by 130% and the average number of news clickers per day by 45% between April 2015 and August 2015. Also, the number of news articles shown in the Daum mobile homepage increased by 250% during the same period. These results show that RUBICS is efficient in improving user experiences and therefore, can increase the number of active users in the News Service, and enhance diversity of news articles. We hereby wish to share our knowledge obtained from the development of RUBICS and seek to help build an open discussion for the usage of machine learning in the news recommendation service.