생리활성능을 지닌 사람 인터루킨 - 1β - 재조합 단백질의 대장균의 생산

박순희,박한길,나도선,최인성,정태화 ( Soon Hee Park,Han Kil Park,Doe Sun Na,In Seong Choe,Tai Wha Chung ) 생화학분자생물학회 1991 BMB Reports Vol.24 No.3

We produced human recombinant interleukin-1β in E. coli to study the mechanism (s) of its pleiotropic action(s), and to develop it as an anti-cancer or anti-inflammatory drug. We constructed expression vectors using lambda P_L promoter. Expression of hrIL-1β in E. coli was induced and the production of the protein was confirmed by Western blot assay. We also confirmed the presence of biological activity of recombinant IL-1β protein by demonstrating its growth promoting effect on mouse thymocytes.

학습코칭이 보건관련 전공 대학생의 자기주도학습능력 및 학업성취에 미치는 영향

박순희(Sun Hee Park),이은경(Eun Kyoung Lee),오명화(Myung Hwa Oh) 한국발육발달학회 2017 한국발육발달학회지 Vol.25 No.3

This study examined the effects of learning coaching on self-directed learning ability and academic achievement in college students. The questionnaire survey was conducted with 397 college students with team learning and team-based class experience. The effect relationship between main factors was analyzed. The results of the study were summarized as follows. First, learning coaching had a positive effect on academic achievement in college students. Second, learning coaching had a positive effect on self-directed learning ability in college students. Based on the results, this study suggested the methods for academic achievement in college students and presented the suggestions and limitations of the study.

당뇨병 환자의 자율신경병증 평가에 있어 24 시간 Holter Monitoring 을 이용한 Power Spectrum 의 Diurnal Variation 에 대한 연구

박순희(Sun Hee Park),박종욱(Chong Wook Park),김정식(Jeong Sik Kim),곽현철(Hyun Cheol Kwak),김광석(Kwang Suck Kim),오성주,김수길,원동준(Dong Jun Won),박정식(Jeong Sik Park) 대한내과학회 1997 대한내과학회지 Vol.53 No.4

Objective: We studied the efficacy of the power spectral and nonspectral analysis and its diurnal variations for the early detection of the diabetic autonomic neuropathy. Method: The spectral and nonspectral analysis of 24hour-Holter monitoring were done for both diabetic neuropathy patients and controls. We also made a comparative analysis of the diurnal variations between the patient and control groups by means of hourly power spectral analysis. Result: 1) The power spectral density of the diabetic neuropathy patients was below than that of the normal controls (P<0.05) (Table 2, Fig. 1). 2) The nonspectral analysis of the diabetic neuropathy patients was below than that of the normal controls except for the mean RR intervals (P<0.05) (Table 3). 3) Every hour-power spectral analysis showed a diurnal variation of day time (06:00 to 16:00) decrease in high frequency area of the normal controls. On the contrary, there was a disappearance of the diurnal variation in patient group. Conclusion: The power spectral and nonspectral analyses after 24hour-Holter monitoring and its diurnal variation in the diabetic patients are considered as good means of the early detection of autonomic neuropathy, but further study of its diagnostic value will be needed.

국제결혼이주가정 부모의 사회적 관계망이 아동의 심리사회적 적응에 미치는 영향

박순희(Park, Sun-Hee),이주희(Lee, Ju-Hee),안효자(An, Hyo-Ja),조원탁(Cho, Won-Tak) 한국지역사회복지학회 2010 한국지역사회복지학 Vol.0 No.33

본 연구의 목적은 국제결혼이주가정 부모의 사회적 관계망의 구조적, 기능적 특성이 어떠한지 살펴보고, 부모의 사회적관계망이 아동의 심리사회적 적응에 미치는 영향을 알아보기 위한 것이다. 이를 위해 광주?전남 지역에 거주하는 국제결혼이주가정 아동과 그 부모를 대상으로 조사를 실시하였다. 설문지는 기본사항과 부모용(남편용, 아내용), 자녀용으로 구성되어 있으며, 총 336부가 자료 분석에 사용되었다. 연구결과, 어머니의 사회적 관계망의 특성요인들이 다른 변인에 비해 상대적으로 영향력이 높은 것으로 나타난 반면 아버지의 사회적관계망은 유의한 영향력을 나타내지 못했다. 또한 부모의 사회적관계망의 특성이 아동의 심리사회적 적응에 긍정적 기능과 더불어 부정적 기능도 제공한다는 것을 확인하였다. 본 연구의 결과는 국제결혼가족을 지원함에 있어 구체적이고 다양한 지원기능의 개발이 요구되며, 다양한 측면에서 접근할 필요성을 강조한다. 따라서 지역사회의 공식적, 비공식적 모임 등을 활성화함으로써 사회적관계망을 구축하여 자녀양육 및 교육에 필요한 정보와 지지를 제공하는 역할을 수행할 수 있도록 해야 한다. The purpose of this study is to examine the structural and functional characteristics of parents" social network in international marriage families and the effects of parent"s social network on children"s psychosocial adjustment. In order to achieve this purpose, research was conducted with children and their parents in international marriage family residing in Gwangju and Jeonnam. A questionnaire consisted of basic information for parents(husband and wife respectively) and children and a total of 336 questionnaires were used for data analysis. As a result of this study, the characteristic factors of mother"s social network had a greater effect than other factors, whereas no significant effect was found in father"s social network. It was also demonstrated that the characteristics of parents" social network did not always have a supportive effect on psychosocial adjustment in children. The results of this study require to develop detailed and various supportive functions in supporting international marriage family and emphasize the need of approach in various aspects. Accordingly, a social network should be constructed to play a role of providing necessary information and support for child care and education by revitalizing formal and informal meetings in community.

쿠싱 증후군에서 골밀도와 골교체율의 변화

박순희(Sun Hee Park),김선욱(Sun Wook Kim),이선화(Seon Hwa Lee),박도준(Do Joon Park),박경수(Kyong Soo Park),김성연(Seong Yeon Kim),조보연(Bo Youn Cho),이홍규(Hong Kyu Lee) 대한내과학회 2000 대한내과학회지 Vol.58 No.5

Background : Although it is generally accepted that high serum glucocorticoid levels causes osteoporosis by suppressing the bone formation, conflicting results have reported on bone resorption. But, previous studies have been carried out in patients with glucocorticoid excess secondary to exogenous glucocorticoid treatment of disorders, which also affect bone turnover and mass by themselves. The purpose of this study were to assess the effect of glucocorticoid excess on bone mass and turnover not influenced by other diseases known to affect skeleton and by different gonadal status and sex and to study the reversibility of osteopenia after cure of Cushing's syndrome. Methods : We measured bone mineral density using dual energy X-ray absorptiometry(DEXA) in 28 patients with Cushing's syndrome before and after surgical cure. In addition, in the patients with Cushing's syndrome and 21 healthy premenopausal women matched for age, we measured biochemical bone markers. Results : 1) Marked osteopenia was present in most patients with active Cushing's syndrome. Lumbar spine BMD and Ward's triangle BMD were significantly lower than femoral neck BMD and femoral great trochanter BMD.(Z-score: lumbar spine -2.22±1.17, femoral neck -0.71±1.08, Ward's triangle -1.77±0.97, femoral great trochanter -0.64±0.71; mean±SD, p<0.05). In patients with active Cushing's syndrome, serum osteocalcin, a marker of osteoblastic function, was reduced(p<0.05), and bone resorption was increased, as indicated by increased urinary N-telopeptide(p<0.05). 2) Osteopenia was still in patients after surgical cure.(Z-score: lumbar spine -1.59±1.01, femoral neck -0.47±0.58, Ward's triangle -1.44±0.77, femoral great trochanter -0.42±0.61). In Cushing's syndrome patients after surgical cure, serum osteocalcin and urinary N-telopeptide were higher compared to controls but not stastistically significant(p>0.05). 3) When compared with pretreatment values, BMD after surgical cure of Cushing's syndrome was increased significantly(p<0.05). Serum osteocalcin was increased and urinary N-telopeptide was decreased significantly(p<0.05). Conclusion : These results show that compared to age matched control, premenopausal Cushing's syndrome patients have reduced bone formation, increased bone resorption, and reduced BMD, especially trabecular bone and that these abnormalities are improved after surgical cure.(Korean J Med 58:560-567, 2000)

다문화가족 자녀의 사회적응과 관련변인 연구

박순희(Park, Sun-Hee),조원탁(Cho, Won-Tak),이주희(Lee, Ju-Hee) 한국지역사회복지학회 2008 한국지역사회복지학 Vol.0 No.27

모델전공 여대생들의 운동 참여정도가 신체만족도 및 폭식증에 미치는 영향

박순희 ( Park Sun Hee ) 한국리듬운동학회 2018 한국리듬운동학회지 Vol.11 No.1

This research is to find out the effect of body satisfaction and bulimia on model major female students exercise participation level. To find out the result, I’ve used convenient sampling method for 250 participants’ survey from female students in 4 year university in Seoul major in model. Out of 250, I have applied 243 survey in this research. I used SPSS 18.0 statistic program frequency analysis, exploratory factor, path analysis. The tool for the body satisfaction which I have applied is from Orbach & Mikulincer (1998)’s The body investment scale. The tool for the excessive eating that I have applied is Thelen, Farmer, Wonderlich & Smith (1991)’s A revision of the bulimia test: The BULIT-R. To find our how much time they spent in exercising, I have generalized it. With all these research method, The conclusions were as follow First, the exercise participation rate of female students’ major in model had positive correlation to their body satisfaction(β=.258, p<.001). Second, the exercise participation rate had negative correlation to bulimia nervosa(β=-.603, p<.001). Third, body satisfaction had negative correlation to bulimia nervosa(β=-.190. p<.001).

다문화가족 아동의 특성과 사회적응

박순희(Sun Hee Park) 한국아동복지학회 2009 한국아동복지학 Vol.- No.29

본 연구는 다문화가족 아동이 지각하는 적응관련 요인인 자아정체성, 의사소통기술, 대인관계기술, 문화수용, 교사지지, 또래지지, 가족지지, 지역사회지지의 일반적 경향을 알아보고 인구사회학적 요인에 따라 적응관련요인 및 사회적응 수준에 차이가 있는가를 살펴보고, 다문화가족 아동의 사회적응에 영향을 미치는 요인은 무엇인가를 파악하고자 하였다. 이를 위해 광주·전남지역에 거주하는 다문화가족 아동 193명을 대상으로 설문조사를 실시하고 분석하였다. 연구결과는 다음과 같다. 첫째, 적응관련 요인들의 일반적 경향은 개인내적요인으로서 의사소통기술이 가장 낮고 문화수용이 가장 높게 나타났으며, 사회환경요인으로서 지역사회지지가 가장 낮고 가족지지가 가장 높게 나타났다. 둘째, 인구사회학적 요인에 따른 차이를 살펴본 결과 성별, 경제수준에 따라 적응관련 및 사회적응 수준에 차이가 있는 것으로 나타났다. 셋째, 다문화가족 아동의 사회적응에 영향을 주는 요인은 의사소통기술과 지역사회지지, 경제수준으로 나타났다. 인구사회학적 요인과 적응관련 요인을 모두 투입한 모델에서 경제수준은 유의성이 사라지고 의사소통기술과 지역사회지지가 높을수록 사회적응을 잘하는 것으로 나타났다. 이는 다문화가족아동의 사회적응은 가정의 경제적인 수준보다는 개인내적요인으로서 의사소통기술과 사회환경요인으로서 지역사회지지에 의해 영향을 받는 것을 의미한다. 따라서 다문화가족 아동의 사회적응 향상을 위해서는 경제적인 지원과 더불어 한국어의 미숙함과 이중문화 노출로 인해 나타날 수 있는 의사소통의 어려움과 스트레스를 잘 극복할 수 있도록 사회의 관심과 지지를 유도하고 원조하는 것이 필요하다. This research was intended to examine the general trends of adjustment-related factors perceived by children of multicultural families such as self identity, interpersonal relations skill, cultural acceptance, teacher support, peer support, family support, and community support, to investigate the difference in adjustment-related factor and social adjustment levels according to socio-demographic characteristics, and to understand the factors influencing social adjustment in children of multicultural families. To achieve this purpose, a questionnaire survey was conducted and analyzed in 193 children of multicultural families residing in Gwangju and Jeonnam. The results of study were as follows. First, for the general trend of adjustment-related factors, while a communication skill was the lowest and cultural acceptance was the highest in the personal internal factor, the community support was the lowest and the family support was the highest in the social environment factor. Second, for the difference associated with socio-demographic characteristics, it was found that there was a difference in adjustment-related factor and social adjustment levels according to sex, economic status. Third, the factors influencing social adjustment in children of multicultural families were a communication skill, community support, and economic status. However, in the model which was inputted by all socio-demographic and adjustment-related factors, the significance of economic status disappeared and as the communication skill and community support was increased, social adjustment became high. It suggested that social adjustment was influenced by a communication skill as the personal internal factor and community support as the social environment factor rather than family`s economic status in children of multicultural families. Accordingly, to improve the social adjustment in children of multicultural families, it is necessary to induce social concern and support to overcome the difficulty in communication and stress caused by a poor Korean skill and bicultural exposure as well as provide economic support.

IPA 분석을 통한 대학 모델과(科) 교육서비스품질 명료화(明瞭化)

박순희(Park Sun Hee),정선옥(Jung Sun Ok) 학습자중심교과교육학회 2021 학습자중심교과교육연구 Vol.21 No.23

목적 본 연구는 대학 모델과(科)의 교육서비스 품질 향상을 위해 학과운영 전반에 관한 문항을 구성하여 중요도-만족도 분석을 실시하였다. 이러한 분석을 통하여 학령기 학생 수 감소에 따른 대학의 내. 외적 환경변화에 대응하기 위한 교육서비스품질의 실증적 자료를 제시하는데 그 목적이 있다. 방법 위와 같은 연구목적 달성을 위해 국내 대학 모델과(科) 학생을 모집단으로 설정한 후 유목적적 표집을 통해 표집한 국내 5개 대학 모델과(科) 전공자 366명을 대상으로 설문조사를 실시하였으며, 요인분석과 신뢰도 분석을 통해 조사도구의 타당성을 확보하였고 이후 대응표본 t-검증과 IPA 매트릭스 분석을 실시하였다. 결과 결과적으로 1사분면에는 교수영역에 해당하는 항목들이 주로 위치하고 있었다. 2사분면에는 등록금과 취업관련 항목들이 포함되어 있었다. 3사분면에는 도서관, 셔틀버스, 주차, 기숙사 시설 등이 있었다. 마지막으로 4사분면에는 교수진의 휴. 보강처리, 최신 기자재 활용이 있었다. 결론 이 연구를 통해 대학 모델과(科)의 교육서비스 품질 향상을 위해서 우선 조치가 필요한 부분인 개선 시급 영역에는 장학금, 신속한 학생 민원처리, 학생행정에 학생의견 반영이 있음을 알 수 있었다. 또한, 등록금, 취업 등과 관련하여 학생의 의견을 충분히수렴할 필요가 있으며, 이와 같은 의견 수렴을 위한 적절한 방법에 관한 논의가 필요함을 확인할 수 있었다. Objectives This study was conducted to improve the quality of education service in the university model departments, questions on the overall operation of the department were composed and an importance-satisfaction analysis. Methods In order to achieve the above research goals, a survey was conducted on 366 students majoring in model at five domestic universities through a target sample, and after securing the validity of the survey tool through factor analysis and reliability analysis, the sample t-test and IPA matrix analysis were conducted. Results The results showed that items that correspond to the teaching area were primarily located in Quadrant I. Quadrant II included tuition and employment-related items. Quadrant III contained the library, shuttle bus, parking, dormitory facilities, and others. Finally, the handling of class cancellation and supplementation by the faculty as well as the utilization of the latest apparatus and materials were found in Quadrant IV. Conclusions Through this study, it was found that scholarships, rapid handling of student complaints, and reflection of student opinions in student administration are in areas where priority measures are needed to improve the quality of educational services of modeling major in the university.

모델 전공 대학생들에게 내재된 자기결정성,정서조절능력, 진로탄력성의 관계

박순희(Sun-Hee Park),정선옥(Sun-Ok Jung) 학습자중심교과교육학회 2024 학습자중심교과교육연구 Vol.24 No.2

목적 이 연구는 모델 전공 대학생들에게 내재된 자기결정성, 정서조절능력, 진로탄력성의 관계를 알아보기 위해 실시하였다. 방법 이를 위하여 국내 대학 모델 전공 대학생 206명(남자: 74명, 여자: 132명)이며, 편의표본추출법을 활용해 표본을 취합하였다. 이후 취합된 자료는 SPSS 22.0과 AMOS 21.0을 통해 빈도분석(frequency analysis), 기술통계(descriptive statistics), 탐색적 요인분석(exploratory factor analysis), 확인적 요인분석(confirmatory factor analysis), 내적 일관성계수((Cronbach's α) α), 상관관계(correlation analysis), 경로분석(path analysis), Hayes(2013)의 PROCESS macro 매개모형(mediation) 검증 기법을 활용한 부트스트래핑(bootstrapping)을 통해 매개효과 검증을 실시하였다. 모든 통계적 유의성은 α=.05를 기준으로 설정하였다. 결과 첫째, 관계성과 유능감이 정서조절능력에 정적인 영향을 미쳤다. 둘째, 관계성과 정서조절능력이 진로탄력성에 정적인 영향을 미쳤다. 셋째, 정서조절의 매개효과 검증에서는 관계성, 유능감과 진로탄력성의 관계에서 정서조절이 매개효과가 있음을 확인하였다. 결론 모델과(科) 대학생들의 유연한 진로변경과 진로 변경 적응력 향상을 위해 정서조절 관리와 긍정적인 대인관계 형성 함양에 대한 다각적인 논의가 필요함을 시사한다. Objectives This research was conducted to explore the relationship between Self-Determination, emotional reg-ulation ability, and career resilience among model major university students. Methods This research was conducted to explore the relationship between Self-Determination, emotional regu-lation ability, and career resilience among model major university students. The collected data were then analyzed using SPSS 22.0 and AMOS 21. The data were analyzed using frequency analysis, descriptive statistics, ex-ploratory factor analysis, confirmatory factor analysis, internal consistency coefficient ((Cronbach's α)α), correla-tion analysis, path analysis, and bootstrapping using Hayes' (2013) PROCESS macro mediation test technique. All statistical significance was set at α=.05. Results The results are as follows: First, connectedness and competence had a positive influence on emotional regulation ability. Second, connectedness and emotional regulation ability had a positive influence on career adaptability. Third, in the mediation analysis of emotional regulation, it was confirmed that emotional regulation played a mediating role in the relationship between connectedness, competence, and career adaptability. Conclusions These findings highlight the importance of multidimensional discussions on emotional regulation management and fostering positive relationships for enhancing the flexible career development of model major university students.