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국소마취제의 중추적 독성과 뇌부위별 dopamine 성 신경활동에 관한 연구
오귀옥,박병건,조남표,송요한,박수정 全北大學校 齒醫學硏究所 1987 전북치대논문집 Vol.5 No.1
Administration of convulsive dose of local anesthetics is believed to change the activity of central aminergic neuron in laboratory animals. In the present study. subconvulsive dose of lidocaine(25, 50 ㎎/㎏ i.p) was injected into rats after synthesis inhibition of catecholamine by α-methyltyrosine administration (250 ㎎/㎏ i.p), which were killed after 0, 2, 4 hours. Four brain parts were analyzed for dopamine by HPLC-electrochemical detection. Lidocaine induced the significant increase of dopamine concentration in striaturn (2, 4hr) and hypothalamus (4 hr), but dose-dependent effect was observed only in the striatum. Dopamine turnover rate was also decreased in the striatum and hypothalamus with statistical significance. However, hippocampus and frontal cortex showed no significant: change of dopamine concentration and turnover rate.