수종 식물의 Plasmin 저해 활성 검색

박미현,정현주,배기환,김영호,Park, Mi-Hyoun,Jung, Hyun-Ju,Bae, Ki-Hwan,Kim, Young-Ho 한국생약학회 1998 생약학회지 Vol.29 No.3

Binding of urokinase-type plasminogen activator to its cellular receptor accelerate production of plasmin from plasminogen on the cell surface. Plasmin can digest extracellular matrix components and basement membranes through activating certain proMMPs, which is related to the invasiveness to the cells. Plasmin also acts the regulation of blood coagulation and relates closely to cardiovascular diseases such as stroke and coronary occlusion. Therefore, its inhibitors may be useful as antimetastatic agents and to the treatment of cardiovascular diseases. To search for plasmin inhibitors from plant resources, we screened plasmin inhibitory activities with 76 methanol extract of plant species. Among them, three plant samples showed strong inhibitory activities (>70%) and thirteen plant samples showed more than 50% inhibitory activities of plasmin. Their inhibitory activities were not directly related with uPA inhibitory activites and cell viability.

중학생의 자유 탐구 보고서에 나타난 특징과 탐구 수행에 대한 학생들의 인식

박미현,차정호,김인환,Park, Mi-Hyun,Cha, Jeong-Ho,Kim, In-Whan 대한화학회 2012 대한화학회지 Vol.56 No.3

이 연구에서는 대구 지역 중학교 2학년 165명이 작성한 자유 탐구 보고서를 주제 영역, 탐구 가설, 그리고 탐구 변인의 측면에서 분석하였다. 여름방학이 시작되기 전 2시간 동안 오리엔테이션을 진행하면서 탐구 과정에 대해 소개하고, 주제를 탐색하도록 하였다. 여름방학 동안 학생들은 주제 선정, 실험설계 및 수행, 자료 수집 및 분석, 결과 보고서 작성 등의 과정을 스스로 진행하였다. 여름방학 후, 결과보고서를 제출받으면서 학생들이 주제 선정에서 활용한 자료의 출처, 가설의 정의, 그리고 탐구 과정에서 가장 어려운 단계에 대한 인식도 조사하였다. 보고서의 주제 영역은 물리, 화학, 생물, 지구과학, 생활 영역으로, 보고서에 기술된 가설은 예측 가설과 설명 가설로 분류하였고 가설의 정의에 대한 학생들의 인식과 비교하였다. 탐구 주제, 탐구 가설, 실험 설계 부분에 제시된 탐구 변인을 분석하여 범주형, 연속형, 불확실 유형으로 분류하였다. 연구 결과, 주제 영역 중 화학 영역의 보고서가 가장 많았고, 다음으로 생물과 생활 영역이 많았다. 전체 165개 보고서 중 130개에 탐구 가설을 포함하고 있었는데, 이들 중 대부분은 예측 가설에 해당하였다. 보고서에 제시된 탐구 변인을 분석한 결과, 탐구 주제와 탐구 가설에 기술된 독립 변인과 종속 변인은 불확실 유형이 많았다. 그러나 실험 설계 부분에 기술된 변인들은 불확실 유형이 많이 줄어들었고, 범주형 변인이 증가하였다. 탐구 수행 과정에서 가장 어려운 단계에 대한 질문에 학생들은 주제 선정 단계를 가장 많이 선택하였다. In this study, open inquiry reports of 165 eighth graders in Daegu were analyzed in terms of content area, the types of inquiry hypothesis, and the types of inquiry variables. Before summer vacation, students learned about inquiry process and explored their own inquiry topic for two class hours. During summer vacation, students performed open inquiry including problem selection, designing and performing experiment, data collection, data analysis, and writing report. After the vacation, students submitted their reports, and answered to additional survey regarding the source of inquiry idea, the definition of hypothesis, and the most difficult step of inquiry process. As a result, chemistry was the most dominant content area of the reports and biology and life science were the next. 130 out of 165 reports included inquiry hypotheses, and most of them were predictive hypotheses. In many reports, dependent and independent variables could not be identified because of their ambiguity. However, inquiry variables described in experimental design, which were mostly categorical variables, were clearer than those described in inquiry subject and inquiry hypothesis. The most difficult step of inquiry process for students was to generate an idea for open inquiry.

유아의 단기 종단적 친구관계 변화 유형에 대한 유아의 정서 조절과 어머니 친구관계 관여의 영향

박미현(Mi Hyun Park),박경자(Kyung Ja Park) 한국아동학회 2018 아동학회지 Vol.39 No.3

Objective: This two-wave study examined changes in kindergarteners friendship patterns and their associations with emotion regulation and parental involvement in friendship management. Methods: Participants were 275 5-year-old children (138 girls and 137 boys) attending kindergartens in Korea. Utilizing nomination methods, each child identified three children as his/her friends twice in 5 months. Teachers rated the children’s emotion regulation and mothers rated their involvement with children. The data were analyzed by descriptive statistics, t-tests, and logistic regressions. Results: Children were classified into five groups according to their friendship stability in 5 months; stable, fluid, gain, loss, friendless. Kindergarteners with higher emotion regulation were more likely to belong to stable, fluid, gain and loss friendship groups than the friendless kindergarteners. Children whose mothers reported higher mediation and supervision in children’s friendship establishment were more likely to belong to the friendship gain group than the friendless group. Children whose mothers expressed higher levels of concerns and advice to children were more likely to be in the fluid group than the gain one. Conclusion: Children’s dispositions to control emotions and the mothers’ involvement in children’s making friends facilitate children’s maintenance or making friendships.

유아교과 논리 및 논술 교육의 쟁점과 방향

박미현(Park, Mi hyun),최종문(Choi, Jong moon) 한국영유아교육지원학회 2016 영유아교육지원연구 Vol.1 No.1

본 연구의 목적은 유아교과 논리 및 논술교육의 쟁점과 방향을 알아보는 데 있다. 이를 위하여 유아교과 논리 및 논술교육 강의계획서 A, B, C 를 비교하여 교육목적, 교육내용, 교육주체, 교육방법에 대하여 검토하였다. 연구결과는 다음과 같다. 첫 번째로 유아교육에서 논리 및 논술은 유아교육학 전공학생들의 사고력과 표현력을 기르기 위해서 필요하다. 두 번째로 유아교육에서 사고력 향상과 표현력 신장을 위해 유아교과 논리 및 논술 교육을 가르쳐야 한다. 세 번째로 유아교육에서 논리 및 논술은 유아교육학 전공자로 교과 논리 및 논술교육이 가능한 유아교육전공자가 가르쳐야 할 것이다. 네 번째로 유아교육에서 논리 및 논술을 사고력, 표현력 향상에 도움이 되는 다양한 방법으로 가르쳐야 한다. 방법으로 토론을 통한 게임, 글쓰기, 영화에세이, 비판적 글읽기와 성찰적 글읽기 등이 있다. 결과적으로 유아교과 논리 및 논술교육과 관련된 문제해결을 위해 정체성과 방향성을 구체적으로 마련하여야 하며, 학생들의 수준을 반영한 다양한 교수-학습방법들의 개발과 적용이 이루어져야 한다. The purpose of this study was to explore directions and issues of logic and writing education in early childhood education. In order to investigate the issues and directions of the education, we analyzed syllabus A, B, C of logic and writing education. The results were as follows. First, why logic and essay writing education need in early childhood education? it is required to improve critical thinking abilities and expressive skills of students majoring in early childhood education. Second, what are you going to teach? Logic education and essay writing education should taught side-by-side. Third, who should teach? Teachers majoring in early childhood education have to teach logic and essay writing education. Fourth, how do you teach? it is required that students must learn to logical thought to give evidences for their arguments. There are discuss game, A4 writing, movie essay writing, critical reading, reflective reading, and so on. As a result, identity and orientation of logic and essay writing education should be provided on the basis of this condition. Also, various teaching-learning methods reflecting students’ levels should be developed and applied to the educational sites.

『일본서기』 고사본의 한국고유명에 가점된 성점의 형태적 연구

박미현(Mi-Hyun Park) 일본어문학회 2022 일본어문학 Vol.99 No.-

本稿は『日本書紀』古写本の韓国固有名に注記されている声点の形態を調査し、資料として提示し、考察したものである。特に韓国固有名の多くを網羅する兼右本を対象に圏点と線点の特徴を論じた。従来、線点は分註と萬葉仮名に、圏点は音読漢字と訓読漢字に注記されていると論じられているが、韓国系固有名に注記されている線点は分註より本文に多く見えており、日本固有名の線点の注記傾向と同様ではないことが明らかになった。 また音読と推定される韓国系官職名にも線点が注記されており、線点は萬葉仮名に注記されるという兼右本の傾向と必ずしも同じであるとは言えない。 なお、圏点と線点が混在する固有名を分析した結果、線点が優位に使用される用例および中立的に使用される用例が多数見えるため、線点の用例は萬葉仮名として注記された可能性があると言える。 以上のように、韓国系固有名は声点の形態においても日本固有名と同様ではないため、利用に注意が必要である。 In this paper, I analyse the forms of accent marks on Korean proper nouns in an old manuscripts of the Nihonshoki. In particular, I focus on the properties of ‘kenten’ marks (small circle marks) and ‘senten’ marks (line marks) in the Ken’u manuscript, which contains a number of Korean proper nouns. Previously, it has been argued that senten marks were used for ‘warichu’ and man’yogana, whereas kenten marks were used for kanji (both in on’yomi and kun’yomi). The senten marks used for Korean proper nouns, however, appear in the text, rather than in warichu, which indicates that their use is not the same as the use of senten marks for Japanese proper nouns. Also, senten marks are used even for Korean title names, which are presumed to be read in ondoku. This practice seems to be different from the tendency in the Ken’u manuscript that senten marks are used for man’yogana. Further, the analysis of proper nouns with kenten or senten marks reveals that there are many cases where senten marks are used dominantly or neutrally. This result suggests that the characters with senten marks might have been treated as man’yogana. Since Korean proper nouns differ from Japanese proper nouns in terms of the forms of senten marks, they need to be used precautiously.

유아의 친구관계 안정성에 대한 단기 종단적 탐색

박미현(Mi Hyun Park),박경자(Kyung Ja Park) 한국아동학회 2016 아동학회지 Vol.37 No.1

Objective: This two-wave study examined stability in kindergarteners’ friendship patterns over 5 months. Methods: Participants were 501 five-year-old children (262 girls and 239 boys) attending kindergartens in Seoul, Incheon, and Kyounggi provinces in Korea. Each child nominated three individuals as his/her friends in July, and again in December of 2013. Depending on the presence/absence of friendships and the mutuality of identifying friends, the children’s friendship patterns were categorized into five groups: stable, fluid, loss, gain, and friendless. The data were analyzed by descriptive statistics, and chi-square tests. Results: Results revealed stability, as well as changes in friendship patterns, among kindergarteners over the 5-month period. The stable friendships, those that maintained the same friend(s) in both waves, was 43.7%, the fluid friendships, those that changed friends over the 5 month period was 18%, the gain friendships, those who had newly developed friends in wave 2 was 17%, and the loss friendships, those who had friends at wave 1 but lost friends at wave 2, was 9.8%. The friendless, those that had no friends in both waves, was 11.5%. Conclusion: Results showed that kindergarteners were capable of maintaining and making new friends over a 5-month period.

초등학생 아동의 스트레스와 우울의 5년에 걸친 발달적 변화

박미현(Mi Hyun Park),박경자(Kyung Ja Park),김현경(Hyoun K Kim) 한국아동학회 2012 아동학회지 Vol.33 No.4

This study examined the developmental trajectories of perceived level of stress and depression in Korean youth using longitudinal data from the Korean Youth Panel Study (KYPS) of 2,844youth (1,524 boys) across 4th grade through 8th grade. Latent growth modeling indicated the presence of age-related, significant increases in stress and depression for both boys and girls. Girls experienced greater in stress and depression than did boys. Multiple group analysis indicated that there was no significant sex difference in effects of stress on depression. Overall, increases in stress were associated with increases in depression levels for both boys and girls. Conceptual and clinical implications of the findings were discussed.

평생교육 제도에 대한 한·일 비교연구

박미현(Park, Mi hyun),이미예(Lee, Mi ye),허균(Heo, Gyun) 동북아시아문화학회 2021 동북아시아문화학회 국제학술대회 발표자료집 Vol.2021 No.10

The lifelong education system has different aspects and systems depending on the various social and cultural backgrounds and educational ideologies of each country. Since many variables affect lifelong education, the diversity of institutions is even greater. Nevertheless, comparing and analyzing each country"s lifelong education support system can provide useful implications for developing Korea"s lifelong education system. Therefore, this study attempted to present implications for revitalizing lifelong education in Korea in the future by comparing and analyzing the lifelong education system in Korea and the lifelong education system in Japan. The implications derived from the results of this study are as follows. First, it is a clear direction for the lifelong education promotion system. Lifelong learning should proceed in the direction of pursuing social equity and integration. Low social groups such as the disabled, the poor, and low-wage workers, women, middle-aged, and non-advancing.It is necessary to ensure that as many people as possible receive educational opportunities and benefits, including unemployed youth and those with basic skills. Second, it is an active connection between the Lifelong Education Promotion Agency and the Regional Office of Education. Proximity to lifelong education is an important factor in providing educational opportunities, and the needs of local residents should be actively reflected in setting educational content. Therefore, it is necessary to prepare a plan to use local elementary, middle, and high school facilities as lifelong education facilities. Third, it is the establishment of an evaluation recognition system that can socially recognize lifelong learning. In the case of Korea, bachelor"s degrees are currently awarded under the credit bank system, but in Japan, courses up to graduate schools are also possible. At the same time as expanding this, it is necessary to actively consider introducing a system that can link the qualifications or completion contents acquired by high school dropouts and non-entering scholars with their educational background.

시ㆍ도 입장에서 모색한 한국민속예술축제 보완

박미현(Park Mi-Hyun) 한국민속학회 2009 韓國民俗學 Vol.50 No.-

이 글은 한국민속예술축제 점검과 전망을 시ㆍ도 입장에 두고 출발하였다. 전국 16개 시ㆍ도와 이북 5도 등 지역은 반세기 넘는 세월동안 축제와 함께 호흡하여왔다. 1958년 창설된 후 줄곧 서울서 열리던 축제가 1967년부터 지역을 순회하고, 1976년부터는 도청 소재지가 아닌 곳에서도 열리면서 더 가까워졌다. 전국민속예술경연대회에서 한국민속예술축제로 개칭된 1999년 이후 외형은 ‘축제’, 내용은 ‘경연’이라는 이중 구조로 인한 또 다른 한계에 부딪쳐 새로운 모색을 해야 되는 시점이어서 시ㆍ도 입장에서 성과와 문제점, 방향성을 찾아보았다. 전국 시ㆍ도 입장은 두 가지로 축약될 수 있다. 하나는 경연 방식으로 치러지는 한국민속예술축제에 ‘참가 선수’입장으로 참여하는 것이고, 또 다른 하나는 매년 순회하는 축제 개최지로서 측면이 있다. 시ㆍ도는 급격히 사라지는 지역 민속예술 발굴ㆍ보존ㆍ계승이라는 축제 취지에 따라 의무적으로 경연에 참가하고 있는데, 시ㆍ도 민속예술대표단은 민속예술 전승 주체이면서 심사 평가를 받는 대상으로서 객체가 되는 모순된 입장에 처해있다. 축제를 존재케 하는 민속예술 전승 핵심 역할을 수행하는 주인공 자리와 문화체육관광부를 비롯한 관 주도로 짜놓은 행사에 초청된 손님으로서 주변적 위치로 동시에 호명되고 있는 것이다.‘축제’의 외피로 바뀐 뒤에도 여전히 시ㆍ도는 ‘참가선수’ 로 대상화됨으로써 주체적이고 능동적인 위치를 갖지 못한 것은 한국민속예술축제 역사의 어두운 면이기도하다. 중앙정부와 공동 주최하는 개최지로서의 시ㆍ도와 시군 입장에서 살펴본 결과 민속예술 보존과 전승이라는 고유 목적 이외에 개최지 문화의 자긍심 제고와 참가단과 관람객 유치를 통한 특산물 판매와 지역 경제 수익 제고, 관광객 유인 등의 효과를 점점 중시하고 있는 것으로 나타났다. 지역축제와 연계하고 부대 프로그램을 활성화하며 자매결연도시 인원 동원 등의 행정 변화는 이 같은 추세를 반영하고 있다. 이 같은 시ㆍ도 입장에서 무형문화재 인정과 보존, 민속예술 전승자로서 자긍심 계발, 마을 구심체 역할, 실생활에 도움 주는 관광문화 자산 확보 등을 축제 성과로 꼽을 수 있었다, 문제점으로 전승 주체자의 객체화와 단절화, 텅 빈 관중석과 운동장 경연환경, 빈약한 일회적 지원과 제도를 지적하였다. 보완점으로 민중 곧 지역민이 주체가 되어 생산하고 매개하며 전승할 수 있는 민속예술 본질 회복과 비일상적인 일회성 이벤트가 아니라 삶의 일상이 되는 전승여건, 연행될 때 객석 관중과 부담 없이 어우러질 수 있는 환경을 만드는데 방향성을 두고 민속예술 일상성 회복과 현장 심사제, 도농교류나 마을축제 연계, 심사위원 전문가 풀제, 긴장감과 활력 제공하는 시상제 유지, 중앙정부 제도적 장치와 지원 제도를 제안하였다. 한국민속예술축제는 중앙정부의 행정력을 발휘하여 민속예술을 지키고 가꿔가는 관 주도 사업으로 단순히 볼거리 제공 축제나 이벤트 형태와 달라야 하며 지역민속 보존과 전승 동력을 촉진하는데 초점이 맞춰져야한다는 측면에서 시ㆍ도 입장과 지역적 욕구 수렴에 우선할 필요가 있다는 점을 강조하였다. 한편 축제 폐지론 이유 중 하나인 소재 고갈 논란에 대해서는 강원지역 사례를 집중분석한 결과 제한된 전문 인력과 고증에서 오는 문제점으로 파악하였다. 시ㆍ도 입장에서는 예선 성격으로 치러지는 시ㆍ도민속예술축제가 한국민속예술축제와 떼려야 뗄 수 없는 관계로 더 열악한 환경에 처해있기도 하므로 두 축제의 유기적 관계를 고려한 동반 개선 방안 마련이 중요함을 피력하였다. This writing focuses on the standpoint of city and province concerning examination and prospect of Korea Folk Art Festival. 16 cities and provinces nationwide as well as 5 provinces in the North celebrated the festival together for more than half a century. After its establishment in 1958, the festival, held mostly in Seoul mostly, began its nationwide tour in 1967. From 1976, the festival became closer by opening itself in places that are not necessarily capital cities. After it changed its name from National Folk Art Competition to Korea Folk Art Festival in 1999, it reached another breaking point due to the dual structure of “festival” on the outside, and “competition” on the inside. Therefore, it is time to seek for a new solution. The results, weaknesses, and future direction from the standpoint of cities and provinces are examined. The position of cities and provinces nationwide can be summarized into two standpoints. First, cities and provinces can participate as “competitors” at Korea Folk Festival, which will be held in competition format. Second, cities and provinces can be viewed as sites of annual tour of the festival. Cities and provinces participate in the competition mandatorily in order to discover, conserve and inherit regional folk art, which is rapidly disappearing. City-province Folk Art delegation is the principle agent transmitting Folk Art as well as subject of evaluation at the same time. The paradox is that on the one hand, they play the principle role of transmitting the Folk Art and organizing the festival, and on the other hand, they are also invited as guests at the festival. The fact that city-province didn’t get active position by remaining as “competitors” even after the competition became a “festival” is the dark side of the Korea Folk Art Festival’s history. After examining from the perspective of city-province as the site sponsoring jointly with the central government, and of city-district, various effects including raising the pride about the culture of the site, raising economic profit by selling special products of region, attracting tourists, and more seem to be considered increasingly important apart from traditional purpose, such as conservation and transmission of Folk art. The administrative changes like liaison with local festivals, activation of troop programs, and mobilization of people in sister-city affiliation reflects this type of trend. The fruitful outcomes of the festival from the perspective of city-province include certification and conservation of intangible cultural assets, development of pride as folk art successor, playing crucial role in the area, securing touristic and cultural property benefiting the real life, and more. In contrast, the drawbacks of the festival are objectification and separation of principle agent of transmission, empty seats and stadium environment, as well as poor one-time support and policy. In order to supplement for the shortcomings, it’s been suggested that the local residents should be the principle agent. Restoring the essence of Folk art, transmission condition in everyday life, promoting environment in which all people get joined together should be focused. Also, restoration of ordinaries of Folk art, field screening policy, liaison of local festival or agricultural exchange, inviting professional judges, maintaining award policy to provide vitality, institutional measure and support of central government have been suggested. It’s been argued that Korea Folk Art Festival must be different from simple festival or event and central government should display its administrative power to protect Folk art. Moreover, it’s been emphasized that the priority should be on responding to the desire of the region and the perspective of city-province in order to facilitate regional folk conservation and transmitting power. On the other side, a focused analysis of Gang-Won area case in response to one of the reasons in

스트레스로 인한 뇌조직의 산화적 손상에서 Vitamin E의 방어 효과

박미현(Park Mi Hyun),강상모(Kang Sang Mo),정혜영(Jung Hye Young),홍성길(Hong Seong Gil) 韓國營養學會 2003 Journal of Nutrition and Health Vol.36 No.6