http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
박무석,( Moo Suk Park ),( Young Sam Kim ),( Young Ae Kang ),( Ji Ye Jung ),( Eun Young Kim ),( Se Kyu Kim ),( Joon Chang ),( Ivor Douglas ) 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-
Injurious mechanical ventilation (MV) induces and amplifies lung injury, in part through Wnt/β-catenin signaling. Wnt-7a is required for normal lung epithelial barrier integrity but its role in the progression of VILI is unknown. Male (6-8 weeks) Wnt-7a knockout (KO) or wild type (WT) mice were subjected to MV with injurious (Vt 24 ml/kg; PEEP 0) strategy for 3hours. Lung mechanics and pulse oximetry were monitored. Terminal BAL and lung tissues harvesting was performed for semiquantitative lung injury scoring on H&E sections. Whole lung protein lysates were subjected to PAGE and immunoblotting for MAPK proteins, MKP-1, GSK-3β and β-catenin. Wnt-7a KO mice were significantly protected against injurious MV (Cstat % of baseline at 3 hrs KO (n=5): 104.8±27.4% vs. WT (n=4): 69.1±20.8%; P<0.05). Total BAL cell counts were comparable (KO: 7.9±2.1×104 vs. WT: 8.3±1.3×104 cell/ml, P=0.76). Lung injury scores (LIS) were lower in KO group than that of WT group (5.1±1.1 vs 6.3±0.7, P=0.07). There was similar significant induction of cytokine expression adjusted by tubulin between WT and KO mice. Whole lung activated β-catenin was lower and total GSK-3β expression were significantly increased in KO vs WT after injurious MV (0.36-fold, P=0.004 and 3-fold, P=0.01 respectively). pERK1/2 (4.7-fold, P<0.01) expression was increased relative to total MAPK levels in KO lungs vs WT. In conclusion Wnt-7a is required for β-catenin dependent lung injury progression and deficiency is associated with β-catenin/GSK stabilization and ERK activation.
박무석 ( Moo Suk Park ),박민찬 ( Min Chan Park ),송정식 ( Jung Sik Song ),박용범 ( Yong Beom Park ),이수곤 ( Soo Kon Lee ),김세훈 ( Se Hoon Kim ),양우익 ( Woo Ick Yang ) 대한류마티스학회 2000 대한류마티스학회지 Vol.7 No.3
Systemic lupus erythematosus (SLE) is an autoimmune disease with a loss of the control over B lymphocytes which is normally exerted by T-suppressor cell. The thymus play a central role in regulating and controlling immune reaction through its effects on T cell differentiation of both T helper and T suppressor cells. Tumors of the thymus are rare but have been reported in concur rence with a variety of autoimmune diseases, including most frequently myasthenia gravis and rarely SLE and other disorders. The association of thymoma and SLE is very rare, fewer than 10 case reports in the world literature. The woman had been thymectomized because of incidental thymoma. After two years, she was diagnosed as SLE with features of arthritis, leukopenia, high titer of ANA, positivity of anti-dsDNA and hypocomplementemia. We report here one case of concurrent SLE and thymoma.
박무석 ( Moo Suk Park ),신동환 ( Dong Hwan Shin ),정경영 ( Kyung Young Chung ),정재희 ( Jae Hee Cheong ),정재호 ( Jae Ho Chung ),김도훈 ( Do Hoon Kim ),김세규 ( Se Kyu Kim ),장준 ( Joon Chang ),김주항 ( Joo Hang Kim ),김성규 ( Su 대한내과학회 2002 대한내과학회지 Vol.63 No.5
Background : To define the final outcome of large cell carcinoma (LCC) after surgical treatment, we reviewed the histopathology, clinical features and follow-up results of 28 cases. Methods : We retrospectively reviewed 28 patients with LCC who underwent surgical resection during the last 15 years from 1986 to 2001 in Severance Hospital. We evaluated clinical data, radiologic findings, pathologic findings, treatment modalities, and survival. Results : The prevalence of LCC was 2.9% (29 cases) among the surgically resected cases in primary lung cancer (1003 cases) during 15 years. The mean age was 59 years old and twenty five cases were male. There were 23 smokers and the average pack year was 33. The cough was the most frequent symptom. Fifteen cases were located in the peripheral part of the lung. Twenty cases consisted of lobulated mass. In chest CT scan, twenty six cases had necrotic portions which appeared to be lower density. Postoperative stage was IA in 1 case (3.6%), IB in 11 cases (39.3%), IIB in 8 cases (28.5%), IIIA in 7 cases (25%), and IV in 1 case (3.6%). Preoperative and postoperative stage concordance rate was 43%. Median survival time was 54.5 months and 5 year-survival rate was 45%. Conclusion : Our results suggest that LCC in the lung is predominant in male and is equally located in the central and peripheral parts of the surgically resected cases. To define the treatment outcome and risk factors of LCC of the lung, further multicenter studies are needed. (Korean J Med 63:496-506, 2002) Key Words : Carcinoma, Large cell, Diagnosis, Treatment outcome
박선철 ( Seon Cheol Park ),박병훈 ( Byung Hoon Park ),신상윤 ( Sang Yun Shin ),전한호 ( Han Ho Jeon ),정경수 ( Kyung Soo Chung ),박준철 ( Jun Chul Park ),정재헌 ( Jae Heon Jeong ),권지은 ( Ji Eun Kwon ),박무석 ( Moo Suk Park ) 대한결핵 및 호흡기학회 2007 Tuberculosis and Respiratory Diseases Vol.63 No.3
Lymphangioleiomyomatosis (LAM) is a rare disease that affects females of reproductive age. It is characterized by the abnormal proliferation of smooth muscle cells in the lung and along the axial lymphatics. We report a case of lymphangioleiomyomatosis presenting as a lung mass. The patient visited the emergency room because of dyspnea upon exertion. The chest X-ray showed a lung mass in the right lower lung field and a pneumothorax in the left lung. Chest computed tomography revealed a 5 x 3 cm sized mass in the right lower lobe and multiple thin-walled small cysts scattered in both lungs. Transbronchial biopsy of the lung mass was performed. The biopsy specimen showed atypical smooth muscle cell proliferation and cystic dilatation of the terminal bronchioles, which confirmed the diagnosis of lymphangioleiomyomatosis. To the best of our knowledge, this is the first case of lymphangioleiomyomatosis presenting as a lung mass. (Tuberc Respir Dis 2007; 63: 289-293)
중환자실에서 지속성 신대체요법을 받은 신부전 환자의 칼로리와 단백질 공급 현황
이호선 ( Ho Sun Lee ),박무석 ( Moo Suk Park ),나성원 ( Sung Won Na ),이재길 ( Jae Gil Lee ),유태현 ( Tae Hyun Yoo ),고신옥 ( Shin Ok Koh ) 대한영양사협회 2009 대한영양사협회 학술지 Vol.15 No.4
Forty-two percent of the patients with renal failure that requires continuous renal replacement therapy (CRRT) have been reported to have severe malnutrition, and preexisting malnutrition is a statistically significant and independent predictor of negative hospital outcomes. We performed this study to evaluate the appropriateness of the calorie and protein provided for the critically ill patients who require CRRT. One hundred forty-nine patients who received CRRT were enrolled. The demographic data, the length of the ICU stay and the mortality were recorded. The calorie/protein intake and the blood urea nitrogen (BUN), albumin and creatinine levels were used as nutritional parameters. The mean daily calorie intake during CRRT was 16.1±7.4 kcal/kg, which was 64% of the recommended intake. Only 10% of the patients received the recommended caloric intake and the ratio of the enteral and parenteral calories was 26%/74%. The mean protein intake was 0.58±0.34 g/kg, which was 38% of the recommended intake. The calorie and protein intakes at the termination of CRRT were significantly increased compared to the initial day of treatment, but they stayed under the recommended intake. The BUN, creatinine and albumin levels were significantly increased in the survival group (odds ratio for albumin: 2.73; creatinine: 2.43). A strategy to increase the nutrition provision is needed to improve the nutritional statuses and clinical outcomes of the critically ill patients who require CRRT.
국내 민간병원에서 치료한 다제내성결핵 환자의 치료 결과 및 예후 인자
박진경 ( Jin Kyeong Park ),고원중 ( Won-Jung Koh ),김덕겸 ( Deog Kyeom Kim ),김은경 ( Eun Kyung Kim ),김유일 ( Yu Il Kim ),김희진 ( Hee Jin Kim ),김태형 ( Tae-Hyung Kim ),김재열 ( Jae Yeol Kim ),박무석 ( Moo Suk Park ),박이내 ( I- 대한결핵 및 호흡기학회 2010 Tuberculosis and Respiratory Diseases Vol.69 No.2
Background: The increasing rate of drug-resistant tuberculosis (TB) is a threat to the public health and TB control. In Korea, about 75~80% of TB patients are treated in private hospitals and the rate has been continuously increasing since 2000. Methods: On a retrospective basis, we enrolled 170 newly diagnosed with or retreated for multidrug-resistant TB (MDR-TB) in 2004 from 21 private hospitals. We extracted the following demographics and treatment history from patient medical records: initial treatment outcomes, cumulative survival rates, treatment outcomes, and prognostic factors. Results: Of the 170 patients, the majority were male (64.1%), the mean age was 44.5 years old, and mean body-mass-index was 20.2kg/m2. None of the patients tested positive for HIV. Eleven (6.5%) were confirmed to have extensively drug-resistant TB (XDR-TB) at treatment initiation. Treatment success rates were not different between XDR-TB (36.4%, 4/11) and non-XDR MDR-TB (51.6%, 82/159). Default rate was high, 21.8% (37/170). Far advanced disease on X-ray was a significant negative predictor of treatment success; advanced disease and low BMI were risk factors for all-cause mortality. Conclusion: In private hospitals in Korea, the proportion of XDR-TB in MDR-TB was comparable to previous data. The treatment success rate of MDR-/XDR-TB remains poor and the failure rate was quite high. Adequate TB control policies should be strengthened to prevent the further development and spread of MDR-/XDR-TB in Korea.
한국 성인을 대상으로 한 미국 및 유럽 폐활량 검사 재현성 기준의 유용성
박병훈 ( Byung Hoon Park ),박무석 ( Moo Suk Park ),정우영 ( Woo Young Jung ),변민광 ( Min Kwang Byun ),박선철 ( Seon Cheol Park ),신상윤 ( Sang Yun Shin ),전한호 ( Han Ho Jeon ),정경수 ( Kyung Soo Jung ),문지애 ( Ji Ae Moon ),김 대한결핵 및 호흡기학회 2007 Tuberculosis and Respiratory Diseases Vol.63 No.5
연구배경: 본 연구를 통해 2005년도 ATS/ERS 폐활량검사 지침에서 제시한 재현성 기준을 한국 성인들에게 적용할 수 있는 지와, 한국 성인들의 폐활량 검사 시 재현성에 영향을 미치는 요인들을 알아보고자 하였다. 방 법: 국민건강영양조사, COPD 코호트, 지역사회 코호트로부터 얻은 성인 4,663명의 폐활량검사 결과를 이용하여 dFVC 및 dFEV1를 계산하여 분포를 알아보고, 1994년도 ATS 지침 및 2005년도 ATS/ERS 지침을 만족하는 검사의 비율을 비교하였다. 다중회귀분석을 통해 개인적 특성 및 재현성 기준의 변화가 재현성에 영향을 미치는가를 알아보았다. 결 과: 폐활량검사를 시행한 사람들 중 95% 이상이 150ml 이내의 재현성 기준을 만족시켰다. 1994년도 ATS 지침에 따라 검사를 시행한 경우 재현성을 만족하지 않는 경우가 증가하였다. 다중회귀분석 결과 재현성에 영향을 주는 요인들은 신장, 연령, 체중, 폐쇄성폐질환 여부, 재현성 기준의 변화 등이었으나 재현성에 영향을 미치는 정도는 매우 작았다(0.5∼3.0%). 결 론: 한국인에게도 2005년도 ATS/ERS에서 제시한 재현성 기준을 적용할 수 있을 것으로 생각하며, 이를 위해서는 변경된 재현성 기준에 대한 지속적인 홍보와 검사자 들에 대한 교육 및 정도 관리가 필요하다. Background: The objective of this study was to evaluate the clinical applicability of the repeatability criteria recommended by the American Thoracic Society/European Respiratory Society (ATS/ERS) spirometry guidelines and to determine which factors affect the repeatability of spirometry in Korean adults. Methods: We reviewed the spirometry data of 4,663 Korean adults from the Korean National Health and Nutritional Examination Survey (KNHANES) Chronic Obstructive Pulmonary Disease Cohort (COPD cohort) and the Community-based Cohort Study VI-Fishing village/Islands (community cohort). We measured the anthropometric factors and differences between the highest and second-highest FVC (dFVC) and FEV1 (dFEV1) from prebronchodilator spirometry. Analyses included the distribution of dFVC and dFEV1, comparison of the values meeting the 1994 ATS repeatability criteria with the values meeting the 2005 ATS/ERS repeatability criteria, and the performance of linear regression for evaluating the influence of subject characteristics and the change of criteria on the spiro-metric variability. Results: About 95% of subjects were able to reproduce FVC and FEV1 within 150 ml. The KNHANES based on the 1994 ATS guidelines showed poorer repeatability than the COPD cohort and community cohort based on the 2005 ATS/ERS guidelines. Demographic and anthropometric factors had little effect on repeatability, explaining only 0.5 to 3%. Conclusion: We conclude that the new spirometry repeatability criteria recommended by the 2005 ATS/ERS guidelines is also applicable to Korean adults. The repeatability of spirometry depends little on individual characteristics when an experienced technician performs testing. Therefore, we suggest that sustained efforts for public awareness of new repeatability criteria, quality control of spirograms, and education of personnel are needed for reliable spirometric results. (Tuberc Respir Dis 2007;63:405-411)