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피롤리딘의 개환과 N-프로텍티드 아미노 케톤의 형성; 5-아미노-2-펜타논 유도체의 합성
박명숙,Park, Myung-Sook 대한약학회 1996 약학회지 Vol.40 No.3
The base-induced elimination of N-protected 2-(bromomethyl)pyrrolidines 12a-c with KHMDS in THF at -78$^{\circ}C$ for 1h gave exocyclic enamines 13a-c. The acidic catalyzed pr otonation on ${\beta}$-carbon atom of 2-(methylene)pyrrolidines 13a-c with $H_3PO_4$ formed endocyclic N-iminium intermediates 14(or 15). Nucleophilic attack of alpha-carbon atom and hydrolysis of N-iminium ion gave carbocationic adduct (aminoalcohol) 16 from which 5-amino-2-pentanones 17a-c were formed after deprotonation.
Silver Oxide를 이용한 1,2-벤조티아진 유도체의 비대칭 중합체 합성 및 결정 구조
박명숙,Park, Myung Suk 대한화학회 1998 대한화학회지 Vol.42 No.6
새로운 비대칭 중합체인 7,7'-substituted (or H)-4-oxo-2,2'-dialkyl-1,2',2,2'-dibenzothiazine-3,3'-dicarboxylic acid methyl ester-1,1,1',1'-tetraoxide 3,4'-yl ethers 2a-d를 silver oxide($Ag_2O$)를 이용한 산화적인 중합반응에 의해 7-substituted (or H)-4-hydroxy-2-alkyl-1,2-benzothiazine-3-carboxylic acid methyl ester 1,1-dioxide 1a-d로부터 합성하였다. 4-Oxo-e,e'-dialkyl-1,1',2,2'-dibenzothiazine-3,3'-dicarboxylic acid methyl ester-1,1,1',1'-tetraoxide 3,4'-yl ether 2c의 구조를 X-ray 결정 구조 분석에 의해 확인하였다. Y의 혼입량, 소결 온도 및 냉각 속도를 실험 인자로 설정하여 BSYT의 상온비저항을 위한 모델식을 반응표면분석법으로 구하였다. 그 결과 Y의 혼입량 변화가 상온비저항에 가장 크게 영향을 미치며, Y의 함량이 약 0.24 mol% 일 때 상온비저항은 최소값을 나타내었다. 실제 실험으로부터 구한 상온비저항 값과 모델식으로부터 계산한 상온비저항 값을 비교한 결과 잘 일치함을 확인하였다. New asymmetric dimer, 7,7'-substituted (or H)-4-oxo-2,2'- dialkyl-l,l',2,2'-dibenzothiazine-3,3'dicarboxylic acid methyl ester-1,1,1',1'-tetraoxide 3,4'-yl ethers 2a-d were synthesized through the oxidative dimerization of 7-substituted (or H)-4-hydroxy-2-alkyl-1,2-benzothiazine-3-carboxylic acid methyl ester 1,1-dioxides la-d using silver oxide($Ag_2O$). 4-Oxo-2,2'-dialkyl-1,1'2,2'-dibenzothiazine-3,3'-dicarboxylic acid methyl ester-1,1,1',l'-tetraoxide 3,4'-yl ether 2c was identified by X-ray crystal structure determination.
산화은을 이용한 O-알킬화 반응; 새로운 4-알킬옥시-2-페닐카복사미딜-1-토실피롤리딘 유?체의 합성
박명숙,Park, Myeong Suk 대한화학회 2001 대한화학회지 Vol.45 No.6
새로운 COZ-2저해제를 개발하기 위하여 4-hydroxy L-proline의 1-위치에 arylsulfonyl기 2-위치에 arylcarboxamidyl기, 그리고 4-위치의hydroxy에 alkyl기를 도입한 새로운 후보 화합물을 합성하였다. 4-Hydroxy L-proline 1을 출발 물질로 하여 N-tosylation으로 1-위치에 4-methylphenylsulfonyl기를 도입하였고 esterification으로 carboxylic acid를 protection하였다. 4-위치의 O-alkyl-(or aralkyl)ation을 위해서 촉매로 silver oxide를 사용하여 다양한 유도체 4b-d로 전환시키는 데 성공하였다. Carboxylic acid기의 deprotection을 위해서 간편한 base-hydrolysis의 과정을 거쳐 4-alkyloxy-1-tosyl L-prolines 5b-d를 얻었다. 최종 목적 화합물인 1,2,4-치환된 pyrrolidine derivatives, 4-alkyloxy-2-phenylcarboxamidyl-1-tosyl pyrrolidines 6a-d 4종은 DCC를 사용하여 3 및 5b-d와 aniline과의 축합 반응으로 합성하였다. For the development of new COX-2 inhibitor, novel compound were synthesized through induction an arylsulfonyl group to 1-position, an arylcarboxamidyl group to 2-position and an alkyl group to 4-position of L-proline. We started from 4-hydroxy-L-proline, the 4-methylphenylsulfonyl of 1-position was introduced through N-tosylation and the carboxylic acid group was protected by esterification. We sucessfully converted to a various derivatives 4b-d for O-alkyl-(or aralkyl)ation of 4-position using silver oxide as catalysis. The 4-alkyloxy-1-tosyl L-prolines 5b-d were synthesized through base-hydrolysis for the deprotection of carboxylic acid. Final compound 1,2,4-substituted pyrrolidines, 4-alkyloxy-2-phenylcarboxamidyl-1-tosyl pyrrolidines 6a-d were synthesized through the condensation of arylamine with 3 and 5b-d using DCC.
박명숙(Park, Myung-Sook),최스미(Choi-Kwon, Smi),한정희(Han, Jung-Hee) 한국재활간호학회 2015 재활간호학회지 Vol.18 No.1
Purpose: This study attempted to adapt evidence-based oral health care guidelines for nursing home residents in South Korea. Methods: The manual for guideline adaptation, version 2.0, developed by the Korean National Evidence-based Healthcare Collaborating Agency was applied. On the basis of a comprehensive literature review of current research and multidisciplinary panel discussion on adapting such guidelines, we developed evidence-based guidelines for oral health at nursing homes. Results: The guidelines have three domains: oral assessment, oral hygiene care, and support and facilities. Oral assessment includes recommendations on the frequency of and tools for conducting oral health assessment. Oral hygiene care involves recommendations for care of natural teeth, denture care, xerostomia, and behavioral problems. Support and facilities refer to six components of the support system provided by facilities to encourage oral hygiene care among nursing home residents. Conclusion: These adapted guidelines could be an effective method to improve oral hygiene among nursing home residents.
결혼이주여성의 아동학대 발생위험성에 영향을 미치는 요인
박명숙(Park, Myung-Sook),이재경(Lee, Jaekyoung) 한국사회복지학회 2014 한국사회복지학 Vol.66 No.2
본 연구는 결혼이주여성의 아동학대 발생위험에 영향을 미치는 요인으로 양육스트레스, 문화적응스 트레스, 사회적지지의 구조적관계를 검증하는데 목적이 있다. 선행연구들을 바탕으로 가설모형을 설정 한 후, 전국을 표본으로 결혼이주여성 195명에 대한 설문결과를 분석하였다. 분석결과 아동학대에 직 접효과를 갖는 변수는 양육스트레스였고, 문화적응스트레스는 양육스트레스를 매개로 간접효과를 갖는 것으로 나타났다. 이와 함께 사회적지지는 아동학대에 영향을 미치는 양육스트레스에 대해 문화적응스 트레스를 매개로 간접효과를 갖는 것으로 나타났다. 사회적지지는 아동학대에 직접적인 영향을 미치지 않았으나, 아동학대에 영향을 미치는 위험요인들을 상쇄시키는 보호요인으로 기능하였다. 이와 같은 연구결과에 근거하여 사회복지에 대한 실천적, 정책적 함의를 제안하였다. This study was designed to explore the structural relationship of social support, acculturative stress and parenting stress which influenced child abuse among married immigrant women in Korea. For study 195 married immigrant women participated and structured questionnaire was used. This study identified that the variable of parenting stress directly affected child abuse and the variable of acculturation stress indirectly affected child abuse with a variable of parenting stress as a mediator variable. In addition, the variable of social support indirectly affected parenting stress with a variable of acculturation stress as a mediator variable. Also, the variable of social support did not directly affect child abuse, but it was verified as a protective factor to reduce the risk of child abuse. This study suggested the social interventions to prevent child abuse among multi-cultural families based on the study results.