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위양성 양수 Acetylcholinesterase 를 보인 정상 임신 1 예
김연희(Youn Hee Kim),이지현(Jee Hyun Lee),문희봉(Hee Bong Moon),오준환(Jun Hwan Oh),이귀세라(Gui Se Ra Lee),이종승(Chong Seung Yi),신종철(Jong Chul Shin),김수평(Soo Pyung Kim) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.2
Maternal serum α-fetoprotein (AFP) has been used for a long time for the prenatal diagnosis of neural tube defects in women at midtrimester of gestation. But AFP is elevated not only in cases of neural tube defects, but also in fetus with congenital nephrosis, abdominal wall defects, fetal demise, low birth weight or simply erroneously calculated gestational age. So, when maternal serum AFP is increased, gestational age of the fetus must be re-evaluated and targeted ultrasonographic evaluation is indicated to rule out neural tube defects. If NTDs are suspected or ultrasound is non-diagnostic, amniotic fluid AFP are measured and when AF-AFP is elevated, the presence or absence of acetylcholinesterase should be evaluated. The detection rate of open neural tube defects using amniotic acetylcholiesterase is reported to be as high as 96 to 99% with a 0.06% and 0.14% of false positive rate in amniotic fluids non-contaminated and contaminated by blood, respectively. We report a case with elevated mid-trimester MS-AFP, AF-AFP and positive amniotic acetylcholin- esterase, but in which repeated sonographic findings were normal, and result in delivery of a heathy baby without anomalies.
김진휘(Jin Hwi Kim),문희봉(Hee Bong Moon),안현영(Hyun Young Ahn),이지현(Jee Hyun Lee),김사진(Sa Jin Kim),신종철(Jong Chul Shin),김수평(Soo Pyung Kim),이현정(Hyun Jeong Lee) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.8
There is high prevalence of HBV infection in Asian countries including South Korea. In fact, 8% of Koreans are HBV carriers, and 20-25% of them progress to liver cirrhosis. Liver cirrhosis, known to be the last stage of chronic liver diseases, is the most prominent cause of death in Korean males in their forties. However, women participation to social activities increased and also increased psychological stress that changed life style now days, and due to increased alcohol consumption liver disease has become a serious problem in korean women population. But as liver cirrhosis usually occurs after the menopause, and decreased fertility in cirrhotic patients, pregnancy in women with liver cirrhosis is rare. However, improved general care increased pregnancy rates and reports of pregnancy in women with liver disease worldwide. Studies on the effect of liver cirrhosis on pregnancy and the effect of pregnancy on the clinical progression of liver cirrhosis have not been well established, and the continuation of pregnancy in a patient with liver cirrhosis has been controversial. Recently, it has become favorable for the argument that pregnancy can be kept as long as liver function is maintained at certain level and portal hypertension is mild. The most common and fatal maternal complication is gastrointestinal hemorrhage. It increases maternal mortality and intrauterine developmental defect resulting in neonatal morbidity. Although South Korea is an area of high prevalence of HBV infection, there are few reports of pregnancies in women with liver cirrhosis. Recently, we have experienced the 3 cases of pregnancies in women with progressive liver cirrhosis who became pregnant. Although thrombocytopenia and increased coagulopathy complicated the pregnancy course, all women delivered healthy babies and were discharged in good condition.
간세포 성장인자가 HT 세포주에서 matrix metalloproteinase 의 발현에 미치는 영향
신종철(Jong Chul Shin),문희봉(Hee Bong Moon),이지현(Jee Hyun Lee),양동은(Dong Eun Yang),이귀세라(Gui Se Ra Lee),이영(Young Lee),이종승(Jong Seong Lee),김창이(Chang Yi Kim),김수평(Soo Pyung Kim) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.12
Objective : This study was performed to investigate the influence of hepatocyte growth factor (HGF) on matrix metalloproteinase (MMP), which are related in the lysis process of tissue during the invasion of trophoblasts. Method : HT cell line was treated with recombinant HGF (rHGF) of different concentration (0, 10, 50 and 100 ng/mL) and was cultured for 24 hours to check the changes in the expression of MMP-2 and MMP-9. Also, HT cell line was treated with recombinant HGF 50 ng/mL and was cultured for 24, 36, 48, and 72 hours to check the changes in the expression of MMPs according to the different time span. Total RNA were extracted from each cultured sample and RT-PCR and Western blotting were used to analyze the expression of MMP-2 and MMP-9. Results : MMP-2 mRNA expression with treated rHGF showed increase of 2, 2.5 and 2.2 times with the increase of concentration level of 10, 50 and 100 ng/mL accordingly, while MMP-2 protein expression were increased 1.4 and 1.5 times in 50 ng/mL and 100 ng/mL of rHGF respectively compared with that of normal control. MMP-9 mRNA showed no significant changes in its expression with all different levels of concentration, while MMP-9 protein showed 1.5 times increase with 10 ng/mL rHGF but 0.4 times decrease with 100 ng/mL. MMP-2 mRNA expression treated with recombinat HGF were increased 1.6 times with 24 hour culture and 2.3 times with 36 hour culture. MMP-2 protein showed 1.9 times increase only for the case of 24 hour culture. MMP-9 mRNA expression of recombinant HGF-treated groups was decreased 0.7 times compared with that of control group in 36 hours. MMP-9 protein expression were increased by 1.2, 1.6 and 1.9 times as culture time increase to 36, 48, and 72 hours accordingly, compared with that of normal control. Conclusion : This result suggests that the HGF might partially regulate the invasion of trophoblasts through MMP-2 and MMP-9.
주하경(Ha Kyong Joo),박윤희(Yoon Hee Park),이지현(Jee Hyun Lee),문희봉(Hee Bong Moon),김사진(Sa Jin Kim),이종승(Chong Seung Yi),신종철(Jong Chul Shin),김수평(Soo Pyung Kim) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.10
Trisomy 18 is the second most common chromosomal anomaly that reach to live birth after Down syndrome. Several methods were proposed to screen patients on the risk of Edward syndrome like maternal serum levels using total human chorionic gonadotropin (hCG), alpha-fetoprotein (AFP) and unconjugated estriol (uE3), or free beta hCG with AFP, but the serum screening has only 50-60% detection rate with a 1-2% of false positive rate. So to cover the limitations that serum marker has, detailed ultrasound examination is also necessary and sensitivities of 65-70% were reported. We report a case of trisomy 18 fetus in which second trimester triple markers of maternal serum was normal, but by detailed ultrasound examination, unilateral radius aplasia was diagnosed cytogenetic study confirmed the fetus as trisomy 18.
오민정(Min Jeong Oh),박윤희(Youn Hee Park),최성권(Soung Kwon Choi),최윤경(Yoon Kyong Choi),이지현(Jee Hyun Lee),문희봉(Hee Bong Moon),김사진(Sa Jin Kim),신종철(Jong Chul Shin),김수평(Soo Pyung Kim) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.11
Objective : Our purpose was to determine the effectiveness of transabdominal amnioinfusion in the pregnant women with preterm premature rupture of the membranes (PPROM). Methods : Between March 1997 and June 1999, 54 pregnancies of 26 weeks to 36 weeks of gestation complicated with preterm premature rupture of the membranes were admitted at our institution, 23 patients were excluded from study due to incomplete data, loss follow up or medical diseases was combined. Among included 31 cases were randomly selected either for amnioinfusion (n=16) or expectant management (n=15). After hospitalization, all patients were assessed for fetal heart rate abnormalities, fetal lung maturity and chorioamnionitis. Labor induction was not performed until progressive labor and chorioamnionitis occurred. Amnioinfusion was done through transabdominal catheter and infused group was managed with prophylactic antibiotics and conservative group were treated by hydration and antibiotics. Results : The median interval from PPROM and delivery was significantly increased in amnioinfused group compared to expectant group (11.19±11.52 days vs 3.67±5.59 days, p=0.02). There were no differences in 1 minute and 5 minutes Apgar score. However, the duration of incubator treatment and oxygen supplementation were more necessary in expectant group compared to amnioinfused group (p=0.01, respectively). Respiratory distress syndrome was more frequent in expectant group although it did not show statistical significance (20% vs 6%, p<0.25). There was no differences in mode of delivery, birth weight and maternal clinical characteristics between two groups. Conclusion : Our results suggest that active management using transabdominal amnioinfusion in pregnancies complicated with PPROM may give a chance to gain minimal time to accelerate lung maturation and thus improve neonatal outcome without increasing complications.
증례 보고 : 일측 에드워드 증후군을 동반한 쌍태 임신 1예
이동현(Dong Hyun Lee),이지현(Jee Hyun Lee),문희봉(Hee Bong Moon),김사진(Sa Jin Kim),이종승(Chong Seung Yi),신종철(Jong Chul Shin),김수평(Soo Pyung Kim) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.9
Chromosomal anomaly is common in twin pregnancies and when it is complicated with discordancy of fetal chromosomal trisomy, optimal management is difficult to decide. Genetic counseling is necessary and delicate management is required to prevent complications like preterm birth of the normal fetus. Although Edward syndrome the second most common trisomy that reaches to live birth after Down syndrome, its loss rate after second trimester reaches to almost 86% resulting in fetal death in utero, and 90% of the few who survive to term die in the first year of life. When twin pregnancy is discordant for Edward syndrome, fetal death in utero of the anomalous baby occurs frequently. One fetal death in twin pregnancy, reaching the third trimester may increase the risk of mortality and morbidity to both surviving fetus and mother. We present a case of twin pregnancy discordant for trisomy 18 that close follow up result in the delivery of a full term healthy boy, although fetal death in utero occurred in trisomy fetus at 34 weeks in gestation with literatures.
산전 초음파로 진단된 태아 일측 신결여 및 반대측 신저형성증
김민정 ( Min Jeong Kim ),안현영 ( Hyun Young Ahn ),이지현 ( Jee Hyun Lee ),문희봉 ( Hee Bong Moon ),이귀세라 ( Gui Se Ra Lee ),김사진 ( Sa Jin Kim ),신종철 ( Jong Chul Shin ),나종구 ( Gong Gu Ra ) 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.4
Renal agenesis is a disorder characterized by the congenital absence of one or both kidneys due to complete failure of the kidney to form. The syndrome of renal agenesis is severe oligohydramnios, amnion nodosum, flattened face, low-set and floppy ears, a
배양된 영양배엽세포에서 저산소 상태가 혈관내피 성장인자, 섬유아세포 성장인자에 미치는 영향
이영 ( Young Lee ),신종철 ( Jong Chul Shin ),양동은 ( Dong Eun Yang ),문희봉 ( Hee Bong Moon ),이귀세라 ( Gui Sera Lee ),김사진 ( Sa Jin Kim ),이종승 ( Jong Seung Lee ),김창이 ( Chang Ee Kim ),김수평 ( Soo Pyung Kim ) 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.3
Objective : To investigate whether the hypoxic condition influences on the expression of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) mRNA in the cultured human trophoblast. Methods : Trophoblasts were isolated from
새로 발생한 13 q32.2 → qter 결손과 동반된 13 번 환상염색체 환아 1 예
황성진(Seong Jin Hwang),이지현(Jee Hyun Lee),박인양(In Yang Park),문희봉(Hee Bong Moon),오준환(Joon Hwan Oh),이귀세라(Gui Se Ra Lee),이종승(Chong Seung Yi),신종철(Jong Chul Shin),김수평(Soo Pyung Kim) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.2
We report a case of ring chromosome 13 with a distal deletion of 13q32.2→qter observed in a fetus who was referred to our institution at term due to severe growth restriction and multiple congenital malformations on ultrasonographic examination. This boy was born by vaginal delivery at 39 weeks in gestation. His weight, head circumference and height were less than the 3 percentile of gestational age. Apgar score was 7 at 1 minute and 9 at 5 minutes. He showed microcephaly, large forehead, low set ears, hypertelorism, flat nasal bridge, and micrognathia. The genitalia was ambiguous, showing severe hypoplasia of the penis. The anus was ectopic, displaced anteriorly from its normal position but with a normal opening and function. Neurologic examination was normal. Echocardiogram done at 2 weeks of life showed a persistent foramen ovale and a ventriculoseptal defect (type II) with increased pulmonary hypertension. MRI examination of the brain showed poorly demarcating corpus callosum suspecting agenesis of corpus callosum. Also, cerebellar vermis was small and hypoplastic, mimicking a variant form of Dandy-Walker malformation. MRI of the pelvis showed a tubular structure in pelvic cavity, suspicious of uterine remnant, between urinary bladder and rectum, and a inguinal hernia was noted in the left side. In the abdominal cavity enlarged adrenal glands were noted, and hormonal study showed elevated 17-α-OH-progesterone (168.9 ng/ml) with normal 17-KS and 17-OHCS levels. Gastrointestinal and urogenital system were otherwise normal. Cytogenetic analysis of the parents were both normal but the newborn showed 46, XY, r(13), de novo, with deletion points q32.2→qter. Our findings are in line with previous reports about chromosome 13 deletions, in which loss of the critical point leads to major malformations like brain anomalies and ambiguous genitalia.