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위양성 양수 Acetylcholinesterase 를 보인 정상 임신 1 예
김연희(Youn Hee Kim),이지현(Jee Hyun Lee),문희봉(Hee Bong Moon),오준환(Jun Hwan Oh),이귀세라(Gui Se Ra Lee),이종승(Chong Seung Yi),신종철(Jong Chul Shin),김수평(Soo Pyung Kim) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.2
Maternal serum α-fetoprotein (AFP) has been used for a long time for the prenatal diagnosis of neural tube defects in women at midtrimester of gestation. But AFP is elevated not only in cases of neural tube defects, but also in fetus with congenital nephrosis, abdominal wall defects, fetal demise, low birth weight or simply erroneously calculated gestational age. So, when maternal serum AFP is increased, gestational age of the fetus must be re-evaluated and targeted ultrasonographic evaluation is indicated to rule out neural tube defects. If NTDs are suspected or ultrasound is non-diagnostic, amniotic fluid AFP are measured and when AF-AFP is elevated, the presence or absence of acetylcholinesterase should be evaluated. The detection rate of open neural tube defects using amniotic acetylcholiesterase is reported to be as high as 96 to 99% with a 0.06% and 0.14% of false positive rate in amniotic fluids non-contaminated and contaminated by blood, respectively. We report a case with elevated mid-trimester MS-AFP, AF-AFP and positive amniotic acetylcholin- esterase, but in which repeated sonographic findings were normal, and result in delivery of a heathy baby without anomalies.
김진휘(Jin Hwi Kim),문희봉(Hee Bong Moon),안현영(Hyun Young Ahn),이지현(Jee Hyun Lee),김사진(Sa Jin Kim),신종철(Jong Chul Shin),김수평(Soo Pyung Kim),이현정(Hyun Jeong Lee) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.8
There is high prevalence of HBV infection in Asian countries including South Korea. In fact, 8% of Koreans are HBV carriers, and 20-25% of them progress to liver cirrhosis. Liver cirrhosis, known to be the last stage of chronic liver diseases, is the most prominent cause of death in Korean males in their forties. However, women participation to social activities increased and also increased psychological stress that changed life style now days, and due to increased alcohol consumption liver disease has become a serious problem in korean women population. But as liver cirrhosis usually occurs after the menopause, and decreased fertility in cirrhotic patients, pregnancy in women with liver cirrhosis is rare. However, improved general care increased pregnancy rates and reports of pregnancy in women with liver disease worldwide. Studies on the effect of liver cirrhosis on pregnancy and the effect of pregnancy on the clinical progression of liver cirrhosis have not been well established, and the continuation of pregnancy in a patient with liver cirrhosis has been controversial. Recently, it has become favorable for the argument that pregnancy can be kept as long as liver function is maintained at certain level and portal hypertension is mild. The most common and fatal maternal complication is gastrointestinal hemorrhage. It increases maternal mortality and intrauterine developmental defect resulting in neonatal morbidity. Although South Korea is an area of high prevalence of HBV infection, there are few reports of pregnancies in women with liver cirrhosis. Recently, we have experienced the 3 cases of pregnancies in women with progressive liver cirrhosis who became pregnant. Although thrombocytopenia and increased coagulopathy complicated the pregnancy course, all women delivered healthy babies and were discharged in good condition.
간세포 성장인자가 HT 세포주에서 matrix metalloproteinase 의 발현에 미치는 영향
신종철(Jong Chul Shin),문희봉(Hee Bong Moon),이지현(Jee Hyun Lee),양동은(Dong Eun Yang),이귀세라(Gui Se Ra Lee),이영(Young Lee),이종승(Jong Seong Lee),김창이(Chang Yi Kim),김수평(Soo Pyung Kim) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.12
N/A Objective : This study was performed to investigate the influence of hepatocyte growth factor (HGF) on matrix metalloproteinase (MMP), which are related in the lysis process of tissue during the invasion of trophoblasts. Method : HT cell line was treated with recombinant HGF (rHGF) of different concentration (0, 10, 50 and 100 ng/mL) and was cultured for 24 hours to check the changes in the expression of MMP-2 and MMP-9. Also, HT cell line was treated with recombinant HGF 50 ng/mL and was cultured for 24, 36, 48, and 72 hours to check the changes in the expression of MMPs according to the different time span. Total RNA were extracted from each cultured sample and RT-PCR and Western blotting were used to analyze the expression of MMP-2 and MMP-9. Results : MMP-2 mRNA expression with treated rHGF showed increase of 2, 2.5 and 2.2 times with the increase of concentration level of 10, 50 and 100 ng/mL accordingly, while MMP-2 protein expression were increased 1.4 and 1.5 times in 50 ng/mL and 100 ng/mL of rHGF respectively compared with that of normal control. MMP-9 mRNA showed no significant changes in its expression with all different levels of concentration, while MMP-9 protein showed 1.5 times increase with 10 ng/mL rHGF but 0.4 times decrease with 100 ng/mL. MMP-2 mRNA expression treated with recombinat HGF were increased 1.6 times with 24 hour culture and 2.3 times with 36 hour culture. MMP-2 protein showed 1.9 times increase only for the case of 24 hour culture. MMP-9 mRNA expression of recombinant HGF-treated groups was decreased 0.7 times compared with that of control group in 36 hours. MMP-9 protein expression were increased by 1.2, 1.6 and 1.9 times as culture time increase to 36, 48, and 72 hours accordingly, compared with that of normal control. Conclusion : This result suggests that the HGF might partially regulate the invasion of trophoblasts through MMP-2 and MMP-9.
주하경(Ha Kyong Joo),박윤희(Yoon Hee Park),이지현(Jee Hyun Lee),문희봉(Hee Bong Moon),김사진(Sa Jin Kim),이종승(Chong Seung Yi),신종철(Jong Chul Shin),김수평(Soo Pyung Kim) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.10
Trisomy 18 is the second most common chromosomal anomaly that reach to live birth after Down syndrome. Several methods were proposed to screen patients on the risk of Edward syndrome like maternal serum levels using total human chorionic gonadotropin (hCG), alpha-fetoprotein (AFP) and unconjugated estriol (uE3), or free beta hCG with AFP, but the serum screening has only 50-60% detection rate with a 1-2% of false positive rate. So to cover the limitations that serum marker has, detailed ultrasound examination is also necessary and sensitivities of 65-70% were reported. We report a case of trisomy 18 fetus in which second trimester triple markers of maternal serum was normal, but by detailed ultrasound examination, unilateral radius aplasia was diagnosed cytogenetic study confirmed the fetus as trisomy 18.
오민정(Min Jeong Oh),박윤희(Youn Hee Park),최성권(Soung Kwon Choi),최윤경(Yoon Kyong Choi),이지현(Jee Hyun Lee),문희봉(Hee Bong Moon),김사진(Sa Jin Kim),신종철(Jong Chul Shin),김수평(Soo Pyung Kim) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.11
N/A Objective : Our purpose was to determine the effectiveness of transabdominal amnioinfusion in the pregnant women with preterm premature rupture of the membranes (PPROM). Methods : Between March 1997 and June 1999, 54 pregnancies of 26 weeks to 36 weeks of gestation complicated with preterm premature rupture of the membranes were admitted at our institution, 23 patients were excluded from study due to incomplete data, loss follow up or medical diseases was combined. Among included 31 cases were randomly selected either for amnioinfusion (n=16) or expectant management (n=15). After hospitalization, all patients were assessed for fetal heart rate abnormalities, fetal lung maturity and chorioamnionitis. Labor induction was not performed until progressive labor and chorioamnionitis occurred. Amnioinfusion was done through transabdominal catheter and infused group was managed with prophylactic antibiotics and conservative group were treated by hydration and antibiotics. Results : The median interval from PPROM and delivery was significantly increased in amnioinfused group compared to expectant group (11.19±11.52 days vs 3.67±5.59 days, p=0.02). There were no differences in 1 minute and 5 minutes Apgar score. However, the duration of incubator treatment and oxygen supplementation were more necessary in expectant group compared to amnioinfused group (p=0.01, respectively). Respiratory distress syndrome was more frequent in expectant group although it did not show statistical significance (20% vs 6%, p<0.25). There was no differences in mode of delivery, birth weight and maternal clinical characteristics between two groups. Conclusion : Our results suggest that active management using transabdominal amnioinfusion in pregnancies complicated with PPROM may give a chance to gain minimal time to accelerate lung maturation and thus improve neonatal outcome without increasing complications.
TL 세포주에서 matrix metalloproteinase-2의 발현에 있어서 산화질소 및 interleukin-1β의 역할
이재동 ( Jae Dong Lee ),신종철 ( Jong Chul Shin ),양동은 ( Dong Eun Yang ),문희봉 ( Hee Bong Moon ),이지현 ( Jee Hyun Lee ),안현영 ( Hyun Young Ahn ),이귀세라 ( Gui Se Ra Lee ),김사진 ( Sa Jin Kim ),김수평 ( Su Pyung Kim ) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.12
목적 : 영양배엽세포는 태반의 형성과정에서 중요한 역할을 하며, 이 과정에서 영양배엽세포의 적절한 침습이 필요하다. 한편, 세포외 조직분해에 관여하는 물질 중에 matrix metalloproteinase-2 (이하 MMP-2) 및 MMP-9는 영양배엽세포의 침습과정에서 중요한 역할을 하는 것으로 알려져 있다. 임신말기의 인간태반으로부터 얻은 TL 세포주를 이용하여 임신유지에 다양하게 관여하는 것으로 알려진 nitric oxide (이하 NO)와 int Objective : We studied to investigate whether nitric oxide (NO) and IL-1β modulate MMP-2 and MMP-9 using TL cell line obtained from the normal term placenta. Methods : After culturing TL cell line for 4 hours, we treated 0.1 mM of SNAP (NO donor) and 50 n
태아에서 발생한 양성 낭성 복막 중피종 ( Benign cystic peritoneal mesothelioma ) 1 예
고현선(Hyun Sun Ko),강대호(Dae Ho Kang),이지현(Jee Hyun Lee),문희봉(Hee Bong Moon),노승혜(Seung Hye Rho),백은정(Eun Jung Baik),정대영(Dae Young Chung),신종철(Jong Chul Shin),김수평(Soo Pyg Kim) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.10
It is stated in many reports that the most frequent cause among abdominal masses in fetus and neonates is congenital renal lesion including hydronephrosis and multicystic kidneys. Other causes are masses originated from gastrointestinal tract, retroperitoneum, or female genital tract. Which almost are benign but about 2% of cases have malignant course. Benign cytic peritoneal mesotheliomas are tumors of peritoneum characterized by thin-walled cyst lined by benign mesothelial cells. Despite the marked tendency to occur, no malignant degeneration or metastasis was reported. It occurs predominantly in females of reproductive age and is rare in male. We experienced a case of male fetus with a huge abdominal mass and severe secondary hydronephrosis which result to be a benign cytic peritoneal mesothelioma, a rare entity in male fetus and rarer in fetal period
정상 임신과 비정상 임신의 초기 혈중 CA - 125 수치에 관한 연구
노덕영(Duck Yeong Ro),김도강(Do Kang Kim),김수평(Soo Pyung Kim),문희봉(Hee Bong Moon),강규섭(Gyu Sub Kang),황지영(Jee Young Hwang),신봉영(Bong Young Shin),장병우(Byeung Woo Jang) 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.11
N/A A prospective study was initiated to compare maternal serum concentration of CA-125 during the first trimester of normal and abnormal pregnancies. Serum specimens were obtained from 87 women with a normal intrauterine pregnancy and 47 women with abnormal pregnancies which were ended in spontaneo abortion or pathologically confirmed to be missed abortion. In normal pregnancies, the mean serum CA-125 concentrations were increased significantly from amenorhea 6 weeks (139.838.7 IU/ml), and were higher statistically than the values tested in the same weeks of abnormal pregnancies. In abnormal pregnancies serum CA-125 concentations were relatively lower than those of normal pregnancies. But these differences were not statistically significant except the values tested in amenorhea 6weeks. So serum levels of CA-125 may not be proved useful in monitoring of early pregnancies outcome.
산전 초음파로 진단된 태아 일측 신결여 및 반대측 신저형성증
김민정 ( Min Jeong Kim ),안현영 ( Hyun Young Ahn ),이지현 ( Jee Hyun Lee ),문희봉 ( Hee Bong Moon ),이귀세라 ( Gui Se Ra Lee ),김사진 ( Sa Jin Kim ),신종철 ( Jong Chul Shin ),나종구 ( Gong Gu Ra ) 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.4
Renal agenesis is a disorder characterized by the congenital absence of one or both kidneys due to complete failure of the kidney to form. The syndrome of renal agenesis is severe oligohydramnios, amnion nodosum, flattened face, low-set and floppy ears, a