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신종철(Jong Chul Shin),문희봉(Hee Bong Moon),이지현(Jee Hyun Lee),양동은(Dong Eun Yang),이귀세라(Gui Se Ra Lee),이영(Young Lee),이종승(Jong Seong Lee),김창이(Chang Yi Kim),김수평(Soo Pyung Kim) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.12
N/A Objective : This study was performed to investigate the influence of hepatocyte growth factor (HGF) on matrix metalloproteinase (MMP), which are related in the lysis process of tissue during the invasion of trophoblasts. Method : HT cell line was treated with recombinant HGF (rHGF) of different concentration (0, 10, 50 and 100 ng/mL) and was cultured for 24 hours to check the changes in the expression of MMP-2 and MMP-9. Also, HT cell line was treated with recombinant HGF 50 ng/mL and was cultured for 24, 36, 48, and 72 hours to check the changes in the expression of MMPs according to the different time span. Total RNA were extracted from each cultured sample and RT-PCR and Western blotting were used to analyze the expression of MMP-2 and MMP-9. Results : MMP-2 mRNA expression with treated rHGF showed increase of 2, 2.5 and 2.2 times with the increase of concentration level of 10, 50 and 100 ng/mL accordingly, while MMP-2 protein expression were increased 1.4 and 1.5 times in 50 ng/mL and 100 ng/mL of rHGF respectively compared with that of normal control. MMP-9 mRNA showed no significant changes in its expression with all different levels of concentration, while MMP-9 protein showed 1.5 times increase with 10 ng/mL rHGF but 0.4 times decrease with 100 ng/mL. MMP-2 mRNA expression treated with recombinat HGF were increased 1.6 times with 24 hour culture and 2.3 times with 36 hour culture. MMP-2 protein showed 1.9 times increase only for the case of 24 hour culture. MMP-9 mRNA expression of recombinant HGF-treated groups was decreased 0.7 times compared with that of control group in 36 hours. MMP-9 protein expression were increased by 1.2, 1.6 and 1.9 times as culture time increase to 36, 48, and 72 hours accordingly, compared with that of normal control. Conclusion : This result suggests that the HGF might partially regulate the invasion of trophoblasts through MMP-2 and MMP-9.
오민정(Min Jeong Oh),박윤희(Youn Hee Park),최성권(Soung Kwon Choi),최윤경(Yoon Kyong Choi),이지현(Jee Hyun Lee),문희봉(Hee Bong Moon),김사진(Sa Jin Kim),신종철(Jong Chul Shin),김수평(Soo Pyung Kim) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.11
N/A Objective : Our purpose was to determine the effectiveness of transabdominal amnioinfusion in the pregnant women with preterm premature rupture of the membranes (PPROM). Methods : Between March 1997 and June 1999, 54 pregnancies of 26 weeks to 36 weeks of gestation complicated with preterm premature rupture of the membranes were admitted at our institution, 23 patients were excluded from study due to incomplete data, loss follow up or medical diseases was combined. Among included 31 cases were randomly selected either for amnioinfusion (n=16) or expectant management (n=15). After hospitalization, all patients were assessed for fetal heart rate abnormalities, fetal lung maturity and chorioamnionitis. Labor induction was not performed until progressive labor and chorioamnionitis occurred. Amnioinfusion was done through transabdominal catheter and infused group was managed with prophylactic antibiotics and conservative group were treated by hydration and antibiotics. Results : The median interval from PPROM and delivery was significantly increased in amnioinfused group compared to expectant group (11.19±11.52 days vs 3.67±5.59 days, p=0.02). There were no differences in 1 minute and 5 minutes Apgar score. However, the duration of incubator treatment and oxygen supplementation were more necessary in expectant group compared to amnioinfused group (p=0.01, respectively). Respiratory distress syndrome was more frequent in expectant group although it did not show statistical significance (20% vs 6%, p<0.25). There was no differences in mode of delivery, birth weight and maternal clinical characteristics between two groups. Conclusion : Our results suggest that active management using transabdominal amnioinfusion in pregnancies complicated with PPROM may give a chance to gain minimal time to accelerate lung maturation and thus improve neonatal outcome without increasing complications.
이재동 ( Jae Dong Lee ),신종철 ( Jong Chul Shin ),양동은 ( Dong Eun Yang ),문희봉 ( Hee Bong Moon ),이지현 ( Jee Hyun Lee ),안현영 ( Hyun Young Ahn ),이귀세라 ( Gui Se Ra Lee ),김사진 ( Sa Jin Kim ),김수평 ( Su Pyung Kim ) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.12
목적 : 영양배엽세포는 태반의 형성과정에서 중요한 역할을 하며, 이 과정에서 영양배엽세포의 적절한 침습이 필요하다. 한편, 세포외 조직분해에 관여하는 물질 중에 matrix metalloproteinase-2 (이하 MMP-2) 및 MMP-9는 영양배엽세포의 침습과정에서 중요한 역할을 하는 것으로 알려져 있다. 임신말기의 인간태반으로부터 얻은 TL 세포주를 이용하여 임신유지에 다양하게 관여하는 것으로 알려진 nitric oxide (이하 NO)와 int Objective : We studied to investigate whether nitric oxide (NO) and IL-1β modulate MMP-2 and MMP-9 using TL cell line obtained from the normal term placenta. Methods : After culturing TL cell line for 4 hours, we treated 0.1 mM of SNAP (NO donor) and 50 n
신진웅(Jin Woong Shin),이종승(Jong Seung Lee),문희봉(Hee Bong Moon),안상권(Sang Kwon Ahn),변태섭(Tae Sup Byeun),장병우(Byeung Woo Jang),노덕영(Duck Yeong Ro),김도강(Do Kang Kim),김수평(Soo Pyung Kim) 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.11
N/A A retrospective study was conducted to evaluate the clinical outcomes of midtrimester emergency cervical cerclage in patients with painless cervical dilatation with/without prolapsed amniotic sac, including cases of no previous history of cervical incompetence. 10 patients including 1 twin pregnancy were teviewed for study, All had received emergency cervical cerclage with Macdonald operation or Shirodka operation at 18 to 31 weeksgestation. The procedures were carried out without serious complication except for one patient who had received re-operation 3 days after Macdonald operation because of re-protrusion of amniotic sae. The mean procedure to delivery internal was 8.9+5.3 (range 1 to 17) weeks. The mean gestational age at delivery was 32.4+5.6 (range 22 to 39+6) weeks for the entire group, 36.1+2.6 (range 32+4 to 39+6) weeks for the 6 who achived viability, and 27.6+5.0 (range 22 to 29+4) weeks for the 3 who died during the neonatal period. 1 died during gestation and was delivered at 33+6 weeksgestation. The mean birthweight was 2181.6+971.6 (range 498 to 3500)g for the entire group, and 2712.9+ 571.5 (range 1860 to 3500)g for the 7 infants who lived until after neonatal period. The total survival rate for 11 babies was 64%. This study demonstrates that midtrimester emergency cervical cerclage for the patients who have dilated cervix with/without prolapsed amniotic sac is valuable method to try in the cases predicted they would lost the baby with conservative treatment only.
이영 ( Young Lee ),신종철 ( Jong Chul Shin ),양동은 ( Dong Eun Yang ),문희봉 ( Hee Bong Moon ),이귀세라 ( Gui Sera Lee ),김사진 ( Sa Jin Kim ),이종승 ( Jong Seung Lee ),김창이 ( Chang Ee Kim ),김수평 ( Soo Pyung Kim ) 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.3
목적 : 임신초기 인간의 태반에서 분리하여 배양한 영양배엽세포에서의 VEGF 및 bFGF유전자의 mRNA발현에 저산소상태가 미치는 영향을 연구하고자 시행하였다. 연구 방법 : 임신초기 (6-10주)에서 얻은 태반조직 5예를 이용하여 영양배엽세포를 분리한 후 정상산소상태 (5% CO2, 95% humid air in incubator) 및 저산소상태 (MERCK, 1% O2, 99% CO2)에서 각각 24시간, 48시간 및 72시간씩 배양하였다. 각각의 Objective : To investigate whether the hypoxic condition influences on the expression of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) mRNA in the cultured human trophoblast. Methods : Trophoblasts were isolated from
노덕영(Duck Yeong Ro),김도강(Do Kang Kim),김수평(Soo Pyung Kim),문희봉(Hee Bong Moon),강규섭(Gyu Sub Kang),황지영(Jee Young Hwang),신봉영(Bong Young Shin),장병우(Byeung Woo Jang) 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.11
N/A A prospective study was initiated to compare maternal serum concentration of CA-125 during the first trimester of normal and abnormal pregnancies. Serum specimens were obtained from 87 women with a normal intrauterine pregnancy and 47 women with abnormal pregnancies which were ended in spontaneo abortion or pathologically confirmed to be missed abortion. In normal pregnancies, the mean serum CA-125 concentrations were increased significantly from amenorhea 6 weeks (139.838.7 IU/ml), and were higher statistically than the values tested in the same weeks of abnormal pregnancies. In abnormal pregnancies serum CA-125 concentations were relatively lower than those of normal pregnancies. But these differences were not statistically significant except the values tested in amenorhea 6weeks. So serum levels of CA-125 may not be proved useful in monitoring of early pregnancies outcome.
안현영(Hyun Young Ahn),정대영(Dae Young Jung),백은정(Eun Jung Baik),이형근(Hyung Geun Lee),문희봉(Hee Bong Moon),이지현(Jee Hyun Lee),김석찬(Seok Chan Kim),신종철(Jong Chul Shin),나종구(Jong Goo Rha),김수평(Soo Pyung Kim) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.6
N/A Objectives: To analyze chromosomal abnormalities according to patients age and indications of patients in midtrimester amniocentesis for prenatal genetic diagnosis. Methods: We retrospectively analyzed 1,565 cases of midtrimester prenatal genetic amniocentesis cases which were done in the cytogenetics laboratory at Kangnam St. Hospital, Catholic University Medical College from November1997 to May 2000. Results: In 1,565 cases, the most common maternal and gestational age distributions were 35 to 39 years old and 17 to 17+6 weeks (32.78Vo and 2l.47%, respectively). Abnormal maternal serum markers were the most common indication for amniocentesis (43.64%), and followed by advanced maternal age (40.45%) and abnormal ultrasonographic findings (3.64%). The overall incidence of chromosomal abnormalities was 4.47% (70 cases), of which numerical abnormalities and structural abnormalities were 1.86% (29 cases) and 2.61% (41 cases), respectively. Among the autosomal abnormalities, Down syndrome was most common (10 cases, 0.65%), and followed by Edward syndrome (9 cases, 0.59%). Among the sex chromosomal abnormalities, both of 47,XXX and 47,XXY were most common (3 cases, 0.20%, respectively). Chromosomal abnormalities were most frequently noted in the maternal age of 25 to 29 years old (5.10%), 30 to 34 years old (4.82%), 40 to 44 years old (4.31%), and followed by 35 to 39 years old (3.90%). On the other hand, chromosomal abnormalities were most frequently noted in abnormal ultrasonographic findings (7.02%), previous history of aneuploidy (5.88%), and followed by advanced maternal age (3.95%). Conclusion: This study suggested that although advanced maternal age is still important indication in midtrimester amniocentesis for prenatal diagnosis, abnormal maternal serum markers and ultrasonographic findings might be also important as indications. Therefore, they should be considered in prenatal genetic counseling.
이정원 ( Chung Won Lee ),김정 ( Jeong Kim ),김수연 ( Sue Yeon Kim ),천소희 ( So Hee Cheon ),장동규 ( Tong Gyu Chang ),최주혁 ( Joo Hyuk Choi ),서경윤 ( Kyoung Yun Seo ),문희봉 ( Hee Bong Moon ),고영미 ( Young Me Koh ),김창이 ( Ch 대한산부인과학회 2005 Obstetrics & Gynecology Science Vol.48 No.1