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최서열,이승호,명나혜,이영석,유지숙,Choi, Seo Yeol,Lee, Seung-Ho,Myung, Na-Hye,Lee, Young-Seok,Yu, Jeesuk 대한유전성대사질환학회 2016 대한유전성대사질환학회지 Vol.16 No.2
멜라스 증후군은 사립체 질환 중의 하나로서, 증상발현 시기 및 임상 양상이 매우 다양하여 의심하지 않으면 진단이 늦어지는 경우가 있을 수 있다. 연구자들은 임상경과를 달리하는 두 증례를 경험하였기에 보고하는 바이다. 증례 1에서는 두통과 시야 흐림, 경련 등이, 증례 2에서는 성장장애, 난청, 시야 흐림, 경련 등이 초기 증상으로 나타났으며, 증례 1은 현재도 일상 생활이 가능한 정상적인 활동도를 보이는 반면에, 증례 2의 경우에는 심각한 뇌손상을 받은 후에 진단되어 예후가 불량하였다. 멜라스 증후군의 치료는 대증적으로 이루어지게 되며, 약물적인 치료 중 코엔자임 Q10, L-아르지닌 등을 사용하였을 때 성공적인 결과를 얻을 수 있다. 질환의 초기에는 비특이적인 경우가 많음으로 관심과 의심을 통하여 멜라스 증후군을 조기 진단하는 것이 매우 중요하다고 할 수 있으며, 조기 진단과 적절한 교육 및 지지적인 치료를 통해 임상경과를 좋게 만들 수 있도록 노력하는 것이 예후에 중요하다고 할 수 있겠다. Mitochondrial encephalopathy, lactic acidosis, and stroke-like episode (MELAS) syndrome is one of mitochondrial encephalopathy. As the early clinical manifestations can be variable, it is important to suspect the disease, especially in patients with multiple organ dysfunctions. A boy was diagnosed with epilepsy when he was 9 years old. Two years later, severe headache and blurred vision developed suddenly. On examination, left homonymous hemianopsia was detected with corresponding cerebral parenchymal lesions in right temporo-occipito-parietal areas. MELAS syndrome was confirmed by genetic test, which showed m.3243 A>G mitochondrial DNA mutation. Multivitamins including coenzyme Q10 were added to anticonvulsant. He experienced 4 more events of stroke-like episodes over 5 years, but he is able to perform normal daily activities. A 13-year-old boy was brought to the hospital due to suddenly developed respiratory arrest and asystole associated with pneumonia. Past medical history revealed that he had multiple medical problems such as epilepsy, failure-to-thrive, optic atrophy, and deafness. He has been on valproic acid as an anticonvulsant which was prescribed from local clinic. He recovered after the resuscitation, but his cognition and motor function were severely damaged. He became bed-ridden. He was diagnosed with MELAS syndrome by brain MRI, muscle biopsy, and clinical features. Genetic test did not reveal any mitochondrial gene mutation. Four years later, he expired due to suddenly developed severe metabolic acidosis combined with hyperglycemic hyperosmolar nonketotic coma. The clinical features of MELAS syndrome are variable. Early diagnosis before the presentation to the grave clinical course may be important for the better clinical outcome.
Helicobacter pylori성 위염에 대한 Mastic Gum의 효과
노임환 ( Im Hwan Roe ),남승우 ( Seung Woo Nam ),명나혜 ( Na Hye Myung ),김정택 ( Jung Taik Kim ),신지현 ( Ji Hyun Shin ) 대한소화기학회 2003 대한소화기학회지 Vol.41 No.4
Background/Aims: Mastic, a natural resin obtained from the Pistacia lentiscus tree, has been reported to have an antimicrobial activity against Helicobacter pylori (H. pylori). We investigated the effects of mastic containing chewing gum on the subjects with H. pylori-infected gastritis. Methods: A double blind clinical trial was carried out on forty-eight volunteers with H. pylori infected gastritis. They were divided into age and sex matched two groups and then treated with the chewing gum containing mastic (1 mg/piece) and placebo, 3 times for 15 minutes a day before meals for 90 days. The 13C-urea breath test and upper gastrointestinal endoscopy with biopsy for rapid urease test and histologic examination were performed at 0, 30, and 90 days after treatment in all subjects including 15 H. pylori-negative controls. Results: All subjects were well compliant. The treatment with mastic gum led to significant decrease in △13C(‰) values. The △13C(‰) value measured at 90 days was significantly lower than those at 0 and 30 days (p=0.033, p=0.034, respectively). Moreover, significant improvement was observed in active gastric inflammation at 90 days compared to before the treatment (p=0.004). Placebo group did not show any changes in △13C(‰) values and active inflammatory scores according to treatment duration. Conclusions: Mastic gum has a beneficial effect on H. pylori-infected gastritis, and can be considered as one of novel treatments. (Korean J Gastroenterol 2003;41:277-283)
관련성 위장질환 치료를 위한 계란항체 ( Immunoglobulin Yolk ) 의 기대 효과
노임환(Im Hwan Roe),남승우(Seung Woo Nam),양미라(Mie Rha Yang),명나혜(Na Hye Myung),김정택(Jung Taik Kim),신지현(Ji Hyun Shin) 대한소화기학회 2002 대한소화기학회지 Vol.39 No.4
Background/Aims: The importance of eggs as a source of specific antibodies (IgY) is well recognized. We investigated the efficacy of specific anti-Helicobacter pylori (H. pylori) IgY antibody against H. pylori infection. Methods: Specific anti-H. pylori IgY was obtained from the hens which were immunized with whole cell lysate (200 킽/mL) of H. pylori. Specific IgY was recognized by SDS-PAGE and the activity was determined by ELISA. After administration of specific IgY, the growth changes of H. pylori, the response of H. pylori-infected KATO III and AGS cell, and in vivo effect of IgY on H. pylori-infected gerbil model were determined. Results: Specific IgY inhibited the growth of H. pylori by 90% within 6 hours in contrast to no inhibitory effect on the growth of E. coli or L. salivarius. After treating with 10 mg/mL of specific IgY, H. pylori-infected (107 CFU/mL) KATO III and AGS cell did not proliferate. Bacterial adhesion was definitely decreased in H. pylori-infected AGS cell treated with 10 mg/mL of IgY. Oral administration of 10 mg/mL of IgY daily for 30 days remarkably inhibited gastric inflammation in H. pylori-infected gerbil, whereas 1 mg/mL of IgY did not reduce gastric inflammation. Conclusions: Specific anti-H. pylori IgY might provide promising effects on the H. pylori-associated gastric diseases. (Korean J Gastroenterol 2002;39:260-268)
Helicobacter pylori 양성 위염에서 위축 진행과 myeloperoxidase 유전자 다형성의 관련성
이만용 ( Man Yong Lee ),노임환 ( Im Hwan Roe ),권나영 ( Na Young Kwon ),신기철 ( Ki Chul Shin ),장효식 ( Hyo Shik Chang ),송승호 ( Seung Ho Song ),남승우 ( Seung Woo Nam ),김정원 ( Jung Won Kim ),명나혜 ( Na Hye Myung ),신지현 ( J 대한내과학회 2003 대한내과학회지 Vol.64 No.3
Background : Helicobacter pylori (H. pylori) infection is characterized by extensive infiltration of enutrophils and induces atrophic gastritis, however, the host factors governing the development of atrophy have not been defined, Myeloperoxidase (MPO) in
궤양성 대장염으로 Infliximab 치료 중인 환자에서 발생한 Mycobacterium gordonae 폐질환
최지성 ( Ji Sung Choi ),배종욱 ( Jong Wook Bae ),이상원 ( Sang Won Lee ),최규호 ( Gyu Ho Choi ),신정은 ( Jeong Eun Shin ),명나혜 ( Na Hye Myung ),박재석 ( Jae Seuk Park ) 대한내과학회 2015 대한내과학회지 Vol.89 No.4
Tumor necrosis factor-α (TNF-α) is a key component of the host defense against mycobacterial infection. Mycobacterium gordonae (M. gordonae) is one of the least virulent mycobacteria, and is generally considered non-pathogenic if detected from a clinical specimen. Here, we report a rare case of pulmonary M. gordonae infection in a patient with ulcerative colitis who had been treated with infliximab, a TNF-α antagonist. M. gordonae infection was treated successfully with clarithromycin, rifampin, and ethambutol. We believe this to be the first report of M. gordonae pulmonary disease associated with TNF-α antagonist treatment. (Korean J Med 2015;89:452-456)
이문숙(Moon Sook Lee),노임환(Im Hwan Roe),이만용(Man Yong Lee),이재현(Jai Hyun Lee),남승우(Seung Woo Nam),이명인(Myung In Lee),김미례(Mi Rae Kim),신지현(Ji Hyun Shin),명나혜(Na Hye Myong) 대한소화기학회 2001 대한소화기학회지 Vol.37 No.6
Background/Aims: Antrum has been proposed for the best biopsy site to diagnose Helicobacter pylori (H. pylori) infection. The aim of this study was to determine the best biopsy site for maximum diagnostic yield. Methods: H. pylori infection was determined by rapid urease test and histology from the biopsy specimens obtained from 992 patients (652 gastritis, 130 gastric ulcer, 148 duodenal ulcer, and 62 gastric adenocarcinoma). Three biopsy specimens were obtained from each of three biopsy sites (the antral greater curvature, mid-body greater curvature, and fundus). Results: H. pylori positivity was significantly higher in mid-body than in antrum or fundus (52.8% vs. 40.0%, 40.3%). The diagnostic yield from the mid-body alone was not significantly different from those of any combinations of other two biopsy sites. The results of rapid urease test were very similar to those of histologic diagnosis. H. pylori positivity in the patients with gastric ulcer and gastric cancer was significantly higher in mid-body than in antrum (55.4%, 45.2% vs. 26.9%, 27.4%). In duodenal ulcer patients, the positivity was significantly higher in mid-body than in antrum or in fundus (68.9% vs. 54.7%, 56.2%). Conclusions: The greater curvature of mid-body, not the antrum, is the best site to diagnose H. pylori infection irrespective of the kinds of gastroduodenal diseases. (Korean J Gastroenterol 2001;37:406-411)