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당뇨병성 케톤산증을 동반한 십이지장소마토스타틴종 1 예
남문석(Moon Suk Nam),이은직(Eun Jig Lee),조재화(Jae Hwa Cho),이홍우(Hong Woo Lee),정준근(Jun Keun Chung),김경래(Kyung Rae Kim),이현철(Hyun Chul Lee),이희대(Hy De Lee),김기황(Ki Hwang Kim),정현주(Hyeon Joo Jeong),허갑범(Kap Bum Huh) 대한내과학회 1995 대한내과학회지 Vol.48 No.6
The syndrome induced by excessive somatostatin secretion in somatostatinoma is characterized by steatorrhea, hypochlorhydria, cholelithiasis, and mild non-ketotic hyperglycemia. Since the first case of pancreatic somatostatinoma reported by Larsson et al in 1977, approximately 25 cases of pancreatic somatostatinama have been reported. Extrapancreatic somatostatinoma(mainly gastrointestinal somatostatinoma) was relatively rare, and first described by Kaneko et al in 1979. Gastrointestinal somatostatinomas are somewhat different from pancreatic somatostatinomas. Somatostatinoma syndrome is rarely seen in gastrointestinal somatostatinoma because of its low level of somatostatin. Due to the fact that somatostatin inhibits the secretion of insulin and glucagon simultaneously, the absence of diabetic ketoacidosis has been regarded. Jackson et al first described the diabetic ketoacidosis in the patient with malignant extrapancreatic somatostatinoma originated from the lung. As far as we can determine, intestinal somatostatinoma presenting with diabetic ketoacidosis has not been reported previously. In our case, the increased circulating level of somatostatin was detected and fasting insulin and C-peptide levels were suppressed, but plasma glucagon was not suppressed below normal level. Diabetic ketoacidosis was promptly corrected with insulin replacement and supportive fluid therapies, and after operation, the hyperglycemia was disappeared without insulin replacement. The mass was located at the second portion of duodenum and oval shaped, solid mass was seperated from the head of pancreas by a thick fibrous capsule. Light microscopic examination revealed that each tumor cells were polygonal shaped and had plenty of finely granular cytoplasm. The immunohistochemical stainings of tumor cells showed positive immunoreactivity for chromogranin and somatostatin but insulin, glucagon, calcitonin, and serotonin were negatively stained. The electronicroscopy of tumor cells showed electron-dense secretory granules and tonofilament bundles in cytoplasm. We presented a case of duodenal somatostatinoma in whom the diagnosis was recognized after presentation with diabetic ketoacidosis.
남문석(Moon Suk Nam),정준표(Jun Pyo Chung),이홍우(Hong Woo Lee),오제열(Je Yol Oh),박효진(Hyo Jin Pack),이관식(Kwan Sik Lee),이상인(Sang In Lee),박인서(In Suh Park),이안나(An Na Lee),송경순(Kyung Soon Song) 대한소화기학회 1994 대한소화기학회지 Vol.26 No.2
Behcets disease is a systemic disease involving skin, joint, gastrointestinal tract, vascular and nervous systems, characterized by recurrent oral and genital ulcerations and ocular in- flammation. The intestinal Behcets disease has nonspecific abdominal symptoms of colicky pain, constipation, diarrhea, nausea, vomiting, and malabsorption. Therefore, we need to dif- ferentiate with other diseases having nonspecific abdominal symptoms. We have experienced a case of lead intoxication after ingestion of herbal pills believed to contain lead compounds. A 40 year-old female with known Behcet's disaese was admitted due to acute colicky abdominal pain. The cause of abdominal pain and anemia was investigated and intestinal Behcets disease was ruled out. The diagnosis of lead intoxication was made by careful history, clinical manifestations, and various laboratory findings including peripheral blood smear, bone marrow aspiration and biopsy, serum lead and free erythrocyte protoporphyrin levels. W e also used lead mobilization test for measure of chelatable lead level. The treatment was performed with 4 courses of EDTA infusion therapy and the clinical symptoms and chemical data associated with lead intoxication improved.(Korean J Gastroen- terol 1994; 26: 399 404)
실크단백질 효소 가수분해물이 OLETF Rat의 혈당, 혈중 인슐린과 렙틴분비에 미치는 영향
이영숙,박민정,최지은,김지영,남문석,정윤화,Lee, Young-Sook,Park, Min-Jeong,Choi, Ji-Eun,Kim, Ji-Young,Nam, Moon-Suk,Jeong, Yoon-Hwa 한국식품영양과학회 2007 한국식품영양과학회지 Vol.36 No.6
본 연구는 누에고치를 가수분해하여 얻은 실크단백질 효소 가수분해물이 비만형 당뇨병 모델인 OLETF 쥐의 당뇨병 개선에 미치는 영향을 조사하였다. 27주령의 OLETF 쥐를 당뇨대조군과 실크단백질 효소 가수분해물 0.5%, 0.8% 섭취군으로 나누어 19주 동안 음수로 섭취시켰다. 19주 동안 실험동물의 체중, 식이 섭취량, 음수 섭취량을 측정하고, 매주 2회씩 비공복과 공복 혈당변화를 관찰하였으며, 19주 후 모든 동물을 희생시킨 후 혈액을 채취하여 혈청지질과 인슐린 및 렙틴의 농도를 분석하였다. 당뇨대조군의 체중은 실크단백질 효소 가수분해물 섭취군에 비해 크게 감소하는 경향을 보였고, 총 콜레스테롤은 농도 의존적으로 그 수치가 낮아지는 경향을 보였으나 유의적 차이는 없었다. 또한 중성지질이나 HDL-cholesterol 함량 변화에도 큰 영향을 미치지 못하였다. 실크단백질 효소 가수분해물 섭취군은 대조군에 비하여 혈당 상승이 유의적으로 억제되었다. 17주 후 내당능 측정결과 실크단백질 효소 가수분해물 섭취군의 최고 혈당치가 농도 의존적으로 낮게 나타나는 경향을 보였으며 회복도 빨랐다. 인슐린과 렙틴은 농도 의존적으로 증가하였으며, 유의적인 차이를 보였다. 실크단백질 효소 가수분해물의 섭취는 인슐린과 렙틴의 대사에 관여하여 혈당상승을 억제하는 것으로 사료된다. This study was performed to investigate the effect of silk protein hydrolysates hydrolyzed by protease on blood glucose level, serum insulin and leptin secretion in the OLETF rats. Twenty seven week-old-male OLETF rats were divided in three groups: diabetic control, 0.5% and 0.8% silk protein hydrolysates groups that were fed daily for 19 weeks. Body weight increased in the 0.5% and 0.8% silk protein hydrolysates fed groups compared with diabetic control group. Food and water intake were not different among diabetic and silk protein hydrolysates groups. In random state, the blood glucose levels in silk protein hydrolysates fed groups were lower than diabetic control group; however, the blood glucose in the three groups were not different in fasting state. Also silk protein hydrolysates improved the glucose tolerance in OLETF rat. The silk protein hydrolysates did not influence serum lipids while serum insulin and leptin levels were increased in the experimental OLETF rats. These results suggested that the administration of silk protein hydrolysates solution reduced significantly (p<0.05) an increasing rate of blood glucose level by stimulating the insulin secretion and increasing the serum leptin level.