http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
소아에서 연령군에 따른 집먼지진드기 주항원 ( Der f 1 과 Der f 2 ) 에 대한 특이 IgE 항체의 변화
남동호(Dong Ho Nahm),박중원(Jung Won Park),홍천수(Chein Soo Hong),이수영(Soo Young Lee),이기영(Ki Young Lee) 대한소아알레르기호흡기학회 1995 소아알레르기 및 호흡기학회지 Vol.5 No.2
N/A To evaluate the early IgE antibody response to house dust mite in child, we measured the specific IgE antibodies to whole body extract (WBE), of D. farinae, and two major allergens, Der f I and Der f II by ELISA (enzyme-linked immunosorbentassay) in sera from 173 children less than 16 years old who visited Allergy Clinic in Severance Hospital with the chief complains of respiratory and/or dermatologic allergic disease. 1. The levels of WBE specific IgE antibody were steadily increased accoding to the increase of age groups, and there was the significant difference between less than four years of age groups, (0.062±0.129 vs 0.500±0.361; t-test, p<0.05). 2. The levels of Der f I and Der f II specific IgE antibodies were also steadily increased by age, and there were noted significant differences between before and after years of age groups (in Der f I: 0.027±0.030 vs 0.082±0.076, in Der f II; 0.334±0.267 vs respectively, t-test, p<0.05). 3. In all age groups over 4 year, the responses of specific IgE antibody to Der f II were significantly higher than the responses to Der f L. In conclusion, these results suggest that IgE antibody response to house dust mite significantly rise after 4 year of age and Der f II may be more important than Der f I in the development of early IgE response to house dust mite antigen in Korean children.
전신성 홍반성 낭창 환자 혈청내 항뇌신경세포 항체에 관한 연구
남동호(Dong Ho Nahm),박중원(Jung Won Park),홍천수(Chein Soo Hong),조상래(Sang Nae Cho),김태승(Tae Seung Kim) 대한내과학회 1992 대한내과학회지 Vol.43 No.4
Background: Neuropsychiatric disorders caused by lupus activity occur during the course of the illness in about 50% of patients with systemic lupus erythematosus (SLE). And neuropsychiatric disorder is a poor prognostic sign and frequent cause of death in lupus patients. Recently some evidences suggest that autoantibodies directed against neuronal cell may have pathogenic significance in neuropsychiatric lupus. The present study was undertaken to characterize further nature of antineuronal antibody in SLE sera and to prove the association between antineuronal antibody and neurapsychiatric disorders in lupus. Methods: Sera from 61 patients with SLE (female 58, male 3) and 20 health control were examined for IgG antineuronal antibody by indirect immunofluorescence method using the frozen section of human brain (cortical portion of parietal lobe), Absortion experiments with 10 sera of high antineuronal antibody titer (≥1:10) by cardiolipin, asialoGM1, CNS neurofilament, myelin basic protein, ceramide and galactocerebroside were done to evaluate cross-reaction between purifed protein and lipid antigens and fluorescent IgG antineuronal antibody. Results: Fluorescent lgG antineuronal antibody was detected in 64% (39/61) of SLE patients and 5% (1/20) in health control, 3 types of fluorescent patterns of neuronal staining were observed. Those were homogenous pattern (21 cases), ring pattern (3 cases) and mixed pattern (18 cases). SLE patients with neuropsychiatric disorders had high titer (≥l:10) of fluorescent IgG antineuronal antibody more frequently than those without neuropsychiatric disorders (14/29, 48% vs 4/32, 12.5%; p<0.05). Lymphocyte counts of the peripheral blood in SLE patients with neuropsychiatric disorders were significantly lower than those of SLE patients without neuropsychiatric disorder (788/mm3 vs 1453/ mm3; p<0.05). Absorption experiments showed the significant changes in immunofluorescent patterns or immunofluorescent grades by asialo GM1, CNS-neurofilament and cardiolipin. Conclusion: IgG antineuronal antibody was high titer in neuropsychiatric lupus and absorption experiment suggested the cross-reactivity of antineuronal antibody with cardiolipin, asialo GM1, CNS-neurofilament.
아토피성 및 비아토피성 기관지천식 환자의 혈청내 항행항체 및 항갑상선 자가항체의 양성률 비교
남동호(Dong Ho Nahm),김선신(Sun Sin Kim),이수걸(Soo Keol Lee),박해심(Hae Sim Park) 대한천식알레르기학회 2000 천식 및 알레르기 Vol.20 No.2
Background and objectives : There have been several reports showing increased prevalences of various autoantibodies in non-atopic asthma compared to atopic asthma. And the possible involvement of autoimmune mechanisms in the pathogenesis of non-atopic asthma has been suggested. To evaluate this hypothesis, we compared the prevalence of circulating autoantibodies in sera from patients with non-atopic and atopic asthma. Subjects and methods : Sera samples from 23 patients with non-atopic asthma showing no visible skin reaction to 50 common inhalant allergens and serum total IgE levels below 200 IU/ml, 23 patients with atopic asthma who showing positive skin prick tests and positive allergen bronchoprovocation tests, 34 age-matched healthy volunteers, and 20 patients with systemic lupus erythematosus were enrolled. We screened IgG antinuclear antibody by indirect immunofluorescence test using HEp-2 cell, and IgG autoantibodies to thyroglobulin and thyroid peroxidase by radioimmunoassay. Results IgG antinuclear antibodies were found in 1 (3%) of 34 healthy volunteers, 3 (13%) of 23 patients with non-atopic asthma, none of 23 patients with atopic asthma, 19 (95%) of 20 patients with systemic lupus erythematosus. IgG autoantibodies to thyroglobulin or thyroid peroxidase were found in 2 (6%) of 34 healthy volunteers, 2 (9%) of 23 patients with non-atopic asthma, 1 (4%) of 23 patients with atopic asthma, and 4 (25%) of 20 patients with systemic lupus erythematosus. Conclusion : There was no evidence for increased prevalence of autoantibodies to nuclear and thyroid antigen in sera from atopic and non-atopic asthmatics compared to healthy controls.
이동훈 ( Dong Hun Lee ),도은진 ( Eun Jin Doh ),이진영 ( Jin Young Lee ),박양 ( Yang Park ),오재원 ( Jae Won Oh ),이미희 ( Mi Hee Lee ),홍수종 ( Soo Jong Hong ),이소연 ( So-yeon Lee ),박준수 ( Joon Soo Park ),남동호 ( Dong-ho Nahm 대한천식알레르기학회 2016 Allergy Asthma & Respiratory Disease Vol.4 No.4
Purpose: The effective management of atopic dermatitis (AD) adjusted to individual clinical courses and demands can be challenging to both patients and physicians. Understanding of actual situations, experienced and perceived by patients with AD and their caregivers, is essential to improve clinical outcomes and satisfaction in real practice.Methods: This multicenter survey was conducted in patients with AD or their caregivers from 9 centers with questionnaires on diagnosis and management of AD.Results: A total of 324 patients and caregivers participated in the study. Most of the AD cases were initially diagnosed by physicians (80.6%), followed by self-diagnosis. Patients and caregivers thought that allergic substances, such as house dust mites, food, and pollutants, are responsible for AD development; moisturization, environmental control, and improvement of the body constitution are important for AD management. Allergy tests were performed in 194 patients (59.9%), but allergen avoidance strategy was instructed in only 81 subjects (41.8%). Major topical medications were steroids (81.8%) and topical immunomodulators (34.3%), while systemic medications were steroids (42.6%), antihistamines (36.4%), and cyclosporins (2.8%). One hundred eighty-one subjects (55.9%) had received complementary alternative medicine, including Oriental medicine. Many subjects desired to receive individualized management, use of specialized institutions for AD as well as evidence-based, effective, sustainable treatment.Conclusion: Our findings suggest that there may still be an unmet need for patients with AD in real practice. Personalized, evidence-based, and multidisciplinary approaches, including patient education, should be implemented for good outcomes. (Allergy Asthma Respir Dis 2016:4:271-275)
강지원,남동호,서경식,김희연,박해심 ( Ji Won Kang,Dong Ho Nahm,Kyung Sik Suh,Hee Yeon Kim,Hae Sim Park ) 대한천식알레르기학회 1998 천식 및 알레르기 Vol.18 No.3
Objective '. In order to confirm the local production of total and specific IgE antibodies in the nasal polyp tissues. Material and method: We measured total IgE and house dust mite(Dermatophagoides pteronpssinus .' DP)-specific IgE antibody using enzyme-linked immunosorbent assay(ELISA) in the supernatant of nasal polyp homogenates from 72 subjects undergoing nasal polypectomy. The subjects were divided into three groups according to skin reactivity to DP: 20 strongly atopic subjects to group I(mean wheal diameter) 3mm), 19 weakly atopic subjects to group II (mean wheal diameter 1-3mm) and 33 negative skin responders to group III. Result: Group I showed significantly higher levels of total and DP-specific IgE levels in the nasa
Toluene diisocyanate 에 의한 직업성천식 환자의 객담내 호중구 활성화의 증거
김희연,남동호,박해심 ( Hee Yeon Kim,Dong Ho Nahm,Hae Sim Park ) 대한천식알레르기학회 1998 천식 및 알레르기 Vol.18 No.3
Background: Toluene diisocyanate (TDI) is the most prevalent agent to cause occupational asthma (OA) in Korea. The pathogenic mechanism of TDI-induced OA is still unclear. Involvement of both immunological and non-immunologicaI mechanisms have been suggested. Objeetive '. To evaluate a possible role of neutrophil in the development of TDI-asthma. Object and method: Myeloperoxidase (MPO) as a neutrophil activation marker in both serum and induced sputum, and IL-8 in induced sputum were measured. Induced sputa and sera were collected from 15 TDI-induced OA patients (classified to group I) during TDI- bronchoprovocation test and were compared with those from 11 asthmatic subjects with negative TDI-bronchoprovocation test (group II). MPO levels were measured by radioimmunoassay, IL-8 levels, by enzyme linked immunosorbent assay and albumin levels, by nephelometry. Sputum MPO and IL-8 levels were presented as a ratio to albumin. Result: Serum MPO level tended to decrease during the TDI-bronchoprovocation test in two groups, but no statistical significance was reached (p>0.05). However, the ratios of MPO (the ratio of MPO level measured at 30 min to MPO level at baseline, and the ratio MPO level measured at 360 min to MPO baseline) in group I were significantly lower than group II (p=0.004, p=0.03 respectively). The IL-8/albumin and MPO/albumin levels in induced sputum from group I were significantly increased after the TDI-bronchprovocation test in comparison to the baseline value which was obtained before the bronchoprovocation test (p=0.0l, p=0.02 respectively). There was a significant correlation between the percent increase of IL-8/albumin and the MPO/albumin in induced sputum (r=0.89, p<0.05). Conclarsiog '. These findings suggest a possible involvement of neutrophil in the development of bronchoconstiction after the TDI exposure, and IL-8 might contribute to neutrophil recruitment to airway mucosa. Further investigation will be needed to investigate mechanism of neutrophil activation in the pathogenesis af TDI-induced OA.
환삼덩굴 화분증 : 천식유발시험상 확진된 환자들의 임상적 특징
박해심,최소연,남동호,김희연 (Hae Sim Park,So Yeon Coi,Dong Ho Nahm,Hee Yeon Kim) 대한천식알레르기학회 1998 천식 및 알레르기 Vol.18 No.1
Baekground: Hop Japanese (Hop J) pollens are abundant in the air of Korea during the autumn season. Their significances as a source of allergenic sensitization have been underestimated in this country. Msterial and Method; In other to observe clinical features of Hop J-sensitive asthmatic patients in this country, skin prick test with Hop J pollen was performed. The serum specific IgE antibodies to Hop J pollen antigen were detected by enzyme linked immunosorbent assay (ELISA) in positive responders (>2+ of A/H ratio) on skin prick test. To confirm the respiratory sensitization, bronchoprovocation test was performed in 17 asthmatic patients sensi- tive to this pollen. Result: Ten asthmatic subjects showed a significant bronchoconstriction following the inhalation of Hop J pollen extract (6 early and 4 dual astmatic responses) and all of them had high serum specific IgE bindings, with minimal bindings in negative responders. They have suffered from seasonal aggravation of asthmatic symptoms with or without rhinitis, and/or conjunctivitis symptoms. The skin reactivity to Hop J had more than 5+ of A/H ratio on skin prick test in nine positive responders, whlie negative responders showed from 1+ to 3+ response. Moreover, four (40%) asthmatic subjects showed a positive response to only the Hop J pollen on skin prick test and an isolated positive asthmatic response to the Hop J bronchoprovocation test. Conelusion'. We believe that the Hop J pollen should be considered as an allergen during the Autumn season, and thus included in skin test batteries in this area. Some labelled having intrinsic asthma or rhinitis might be sensitized to this pollen or other unknown allergens.