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RISS 인기검색어
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- 저자 : 나병규(Byung Kyu Na) (검색결과 4 건)
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포스터 발표 : 대장 ; 대장암 수술후의 대장선종의 발생양상
나병규 ( Byung Kyu Na ),양현웅 ( Hyeon Uoong Yang ),서숭원 ( Soong Won Seo ),성재규 ( Sung Jae Kyu ),이병석 ( Byung Seok Lee ),정현용 ( Hyun Yong Jeong ) 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
〈목적〉 대장 직장암의 근치수술후 대장내시경 검사를 이용한 추적 검사를 통해 대장 선종의 발생 양상을 분석함으로써 대장직장암 환자에서의 대장선종 발생의 특징을 알아보고자 하였다. 〈방법〉 1998년 3월부터 2001년 2월가지 충남대학교병원에서 대장직장암으로 근치적 절제술을 시행 받은 환자중 수술전가 수술후에 대장내시경을 받았던 130명의 환자를 대상으로 의무기록을 통한 후향적 조사를 하였다. 〈결과〉 남자는 80명, 여자는 50명이었고 평균 연령은 5
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위암에서의 진단 방법들의 유용성 평가 : 수술 전후의 병기 결정의 비교
최재홍(Jae Hong Choi),나병규(Byung Kyu Na),오상우(Sang Woo Oh),이지현(Jee Hyun Lee),정상무(Sang Moo Jung),박선미(Seon Mee Park),윤세진(Sae Jin Yun),김승택(Sung Taek Kim),이복희(Pok Hee Lee) 대한내과학회 1997 대한내과학회지 Vol.53 No.2
Backgroud: Gastric cancer remains the main cause of cancer-related death in Korea. Accurate preoperative staging of gastric cancer is essential to predict prognosis and to plan optimal treatment. Although there are many reports dealing with the diagnostic values of conventional methods, controversies are still present especially in the field of preoperative staging. In this study, we evaluated the accuracy of gastroscopy and upper gastrointestinal series(UGI) for diagnosis of gastric cancer, and determined the usefulness of ultrasonography and computed tomography for preoperative staging. Methods : One hundred twenty-three patients, who underwent operation from Aug. 1991 to Mar. 1995 under the diagnosis of gastric cancer were analyzed. We excluded 15 patients because their postoperative definitive stagings were undetemined. Results : 1) Among 123 patients, the proportion of early gastric cancer was 26.0%(32/123) and that of the advanced gastric cancer was 74.0%(91/123). 2) The sensitivity of endoscopic diagnosis of gastric cancer was 96.7%(119/123), and the accuracy to determine the depth of invasion was 82.9% (102/123). 3) The sensitivity of UGI study for gastric cancer was 89.9%(98/109), and the accuracy to determine the depth of invasion was 61.5%(61/109). 4) The sensitivity of abdominal ultrasonography to detect the tumor was 11.3%(8/71), the accuracy to determine the T stage was 29.2%(28/96), and the sensitivity and specificity to detect lymph node metastasis was 13.6%(8/59), 100%(37/37), respectively. 5) The sensitivity of abdominal CT to detect the tumor was 74.3%(26/35), the accuracy to determine the T stage was 32.5%(13/40), and the sensitivity and specificity to detect lymph node metastasis were 34.5%(9/29), 72.7%(8/11), respectively. 6) The accuracy of preoperative staging was 45.5%(56/123). The 49.6%(62/123) of gastric cancer was downstaged, whereas only 4.1%(5/123) was overstaged. Conclusion: Our results show that high accuracy for diagnosis of gastrie cancer with the gastroscopy and UGI. However preoperative staging with ultrasonography and computed tomograpy was often underestimated, which could be concluded that the usefulness of the radiologic methods was limited.
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만성 활동성 C형 간염 환자에서 알파 인터페론 2b 투여에 의한 HCV-RNA의 소실
이경태,김연수,문희석,박기오,이엄석,김선문,양현웅,서승원,성재규,나병규,이승민,이병석,김남재,이헌영 충남대학교 의과대학 지역사회의학연구소 2001 충남의대잡지 Vol.28 No.1
Background/Aims : Interferon-alpha is the most effective agent for the treatment of chronic active hepatitis C(CAH-C). The purpose of this study are to evaluate the efficacy of alpha-interferon therapy for the CAH-C and to clarify the correlations between the biochemical and anti-viral responses. Methods : The presence of serum hepatitis C virus(HCV) with increased serum ALT(Alanine aminotransferase) activities were monitored in 18 patients with CAH-C confirmed by serologic studies and liver biopsy from July 1992 to July 1998. The patients were treated with interferon alpha 2b for 6 months and the other eight patients were selected as the control group. Results : The serum ALT levels became within normal limit in 9 of 10 patients(90%) after interferon treatment (End-of-treatment response;ETR). Sustained responses(SR) were achieved in 7 cases(70%) for follow-up period of 18 to 24 months (SR-12month). Two cases were relapsed responders who showed elevated ALT levels within 1-2 months after cessation of interferon therapy and the other case was a non-responders (NR). In all 7 sustained responders (SR), HCV-RNAs were negative at the end of the treatment. But HCV-RNA reappeared in the serum in the case of the relapsed responders during follow-up period after treatment. While none of 8 patients, control group showed normal ALT levels during 18-24 months follow-up period, and the HCV-RNA states did not change in all the control group. Conclusion : This study suggest that the 3 million units of interferon alpha 2b, T.I.W.(three times a week) for 6-month course is effective in the treatment of CAH-C, especially in younger age and shorter duration of disease. The disappearance of serum HCV-RNA is closely associated with the normalization of serum ALT levles, so that the serial measurement of HCV-RNA may be a reliable marker in the efficacy of interferon treatment and predicting relapse.
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양현웅,김연수,문희석,박기오,이엄석,김선문,서승원,성재규,나병규,이승민,이병석,김남재,이헌영 충남대학교 의과대학 지역사회의학연구소 2001 충남의대잡지 Vol.28 No.1
Background/Aims : Wilson's disease in an autosomal recessive genetic disorder which is characterized by hepatic and neurologic manifestations due to defect in copper metabolism. The progression of hepatic damage and critical neurologic complication can be prevented by early diagnosis and treatment. Our study investigated the usefulness of clinical manifestations and laboratory findings in Wilson's disease to early diagnosis of wilson's disease. Method : We investigated the 10 patients who are diagnosed as Wilson's disease at Chungnam national university Hospital during the recent 5 years for clinical manifestation, laboratory findings and treatment. Results : 1. Females are 9 patients(90%) among 10 objective patients and the median age of patients is 30.2±14 years. The second and third decade are the more common prevalent and 5 patients(50%) have family history. 2. The clinical manifestations of Wilson's disease at time of diagnosis are hepatic manifestation in 9 patients (90%) except presymptomatic patient and the psycho-neurologic manifestations are appeared in 5 patients(50%). Three patients have the secondary amenorrhea, hemolytic anemia and recurrent spontaneous abortions in each case. 3. The serum ceruloplasmin concentrations were lower than 20mg/dl in 8 patient(80%) including presymptomatic patient and the 24 hours urine copper excretion is above 100μg/24hrs in 7 patients(70%). 4. Seven patients(70%) with symptomatic Wilson's disease have the detectable Kayser-Fleischer ring in slit lamp examinations but one presymptomatic patient has no Kayser-Fleischer ring. 5. The serum level of ceruloplasmin is increased in 3 patients (42.8%) among 7 patients who are had been treated by penicillamine(one patient is not followed up serum ceruloplasmin) and the 24 hours urine copper excretion was decreased in 6 patient(75%) among 8 patients treated by penicillamine. 6. Five patients died with hepatic failure related to uncompensated liver cirrhosis. Conclusion : The slit lamp examination should be recommended in patients with hepatic and neurologic disease of unknown etiology and sibling of the patients wilson's disease. The irrerersible damage of organs would be prevented by aggressive treatment at early state in patients diagnosed as Wilson's disease.
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