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Cyclosporine 저항성 만성 자발성 두드러기환자에서 Omalizumab 치료에 대한 단일기관 후향적 연구
김학준 ( Hak-jun Kim ),김우일 ( Woo-il Kim ),신기혁 ( Kihyuk Shin ),손진화 ( Jin-hwa Son ),이원구 ( Won-ku Lee ),김훈수 ( Hoon-soo Kim ),김병수 ( Byungsoo Kim ),김문범 ( Moon-bum Kim ),고현창 ( Hyun-chang Ko ) 대한피부과학회 2021 대한피부과학회지 Vol.59 No.3
Background: Cyclosporine is a recommended third-line treatment for chronic spontaneous urticaria (CSU) that is resistant to H1-antihistamines according to the EAACI/GA<sup>2</sup>LEN/EDF/WAO guidelines for management of urticaria. However, some patients with refractory urticaria do not respond to cyclosporine or antihistamines. Omalizumab, a humanized anti-immunoglobulin E antibody, has been shown to be effective and safe for antihistamine-resistant CSU. However, there are few reports on the efficacy of omalizumab in patients with CSU who are resistant to cyclosporine. Objective: To evaluate the efficacy of omalizumab in patients with cyclosporine-resistant CSU. Methods: Recalcitrant CSU patients who had symptoms (seven-day urticaria activity score, UAS7≥7) despite being administered cyclosporine (3∼5 mg/kg/day) and H1-antihistamine at up to a four-fold increased dose for 4 weeks were included in this study. Omalizumab was administered at 150 mg or 300 mg by subcutaneous injection every 4 weeks. Efficacy was assessed using UAS7 12 weeks after the initial administration of omalizumab. Results: A total of 28 patients (18 women, 10 men) with an average age of 43.8 years were included in the study. The mean duration of CSU was 40.0 (2∼288) months, and the mean UAS7 at baseline was 14.2 (9∼35) months. Overall, 22 patients (78.6%) showed a complete (UAS7=0) or partial response (0<UAS7≤6) at 12 weeks. Patients who were administered 300 mg of omalizumab had a more complete response (9/15, 60%) than those who were treated with 150 mg (3/13, 23.1%). Conclusion: Omalizumab is an effective therapy for CSU patients who do not respond to cyclosporine. (Korean J Dermatol 2021;59(3):175∼180)
중등증-중증의 한국인 건선 환자에서 Secukinumab의 효과와 안전성에 관한 연구
하대룡 ( Dae-lyong Ha ),김우일 ( Woo-il Kim ),양민영 ( Min-young Yang ),이원구 ( Won-ku Lee ),김태욱 ( Taewook Kim ),박성민 ( Sungmin Park ),이현주 ( Hyun Joo Lee ),김건욱 ( Gun-wook Kim ),김훈수 ( Hoon-soo Kim ),고현창 ( Hyun-cha 대한피부과학회 2019 대한피부과학회지 Vol.57 No.1
Background: Secukinumab, a fully human monoclonal antibody that targets interleukin (IL)-17A, which is a central cytokine in the pathogenesis of psoriasis, has emerged as a promising treatment for moderate to severe psoriasis. However, to date, there are no real-world data for secukinumab in Korean patients with psoriasis. Objective: To assess the clinical efficacy and safety of secukinumab in Korean patients with psoriasis. Methods: Prospective data were gathered during follow-up from 28 consecutive patients with chronic plaque-type psoriasis treated with secukinumab for minimum of 12 weeks at a single referral center. Patient demographics, Psoriasis Area Severity Index (PASI) score, Physicians’ Global Assessment (PGA), Dermatologic Life Quality Index (DLQI), and adverse events were investigated. Results: The mean PASI score was significantly decreased after the induction period of secukinumab treatment (paired t-test, p<0.05). Of the 28 patients, 17 (60.7%) had obtained near complete clearance (PASI 90) at the last follow-up visit. No unexpected adverse events, other than nasopharyngitis, were observed. Conclusion: Secukinumab can be of benefit for the treatment of Korean patients with psoriasis, as the treatment was associated with a rapid and satisfactory response and safety profile. (Korean J Dermatol 2019;57(1):9∼14)
DNA chip에 의한 연구에 따른 길경 수용액 추출물이 NCI-H460 인체 폐암세포의 성장 및 유전자 발현에 미치는 영향
김훈,박동일,Kim, Hoon,Park, Dong-Il 대한한방안이비인후피부과학회 2006 한방안이비인후피부과학회지 Vol.19 No.2
Objectives : We studied Effect of Platycodon grandiflorum on Lung carcinoma Methods : By using cDNA microarray technique, we analyzed the effects of AEPG(aqueous extract of Platycodon grandiflorum) on the gene expression profile. Results : Out of 384 genes screened associated with growth inhibition of carcinoma cell, 9 genes were founded to be affected in their expression levels by more than 1.2-fold after treatment with AEPG. And 67 genes were changed the expression level 0.5 times more than that of reference RNA after treatment of AEPG. Conclusions: These findings suggest that P. grandiflorum has strong potential for development as an agent for prevention and treatment against human lung cancer.
인체폐암세포에서의 prostaglandin E2 생성과 Telomere 활성에 미치는 청조구폐탕의 영향에 관한 연구
김훈,박동일,Kim, Hoon,Park, Dong-Il 대한한방안이비인후피부과학회 2006 한방안이비인후피부과학회지 Vol.19 No.2
Objective : The effect of water extract of Chungjogupae-tang (CJGPT) was investigated on the growth of human lung carcinoma A549 cells. Methods : MTT assay and fluorescent microscope performed to compare and examine the efficacy of CJGPT treatment on the cytostaticity of lung cancer cells in proportion to time and doses, and DAPI staining and Western blot analysis were used to examine their effect on apoptosis. In addition the quantitative RT-PCR was used to examine to lung cancer cells growth and Progtaglandin E2 and Telomerase activity were measured Results : Exposure of A549 cells to CJGPT resulted in the growth inhibition and apoptosis in a dose-dependent manner as measured by MTT assay and fluorescent microscope. The antiuoliferative effect by CJGPT treatment in A549 cells was associated with morphological changes such as membrane shrinking and cell rounding up. CJGPT treatment resulted in an up-regulation of cyclin-dependent kinase inhibitor p21(WAF1/CIPl) in a p53-independent fashion. We found that CJGPT treatment decreased the levels of cyclooxygenase (COX)-2 and inducible nitric oxide synthease (iNOS) expression without significant changes in the expression of COX-1, which was correlated with a decrease in protaglandin E2 (PGE2) synthesis. CJGPT treatment also inhibited the levels of human telomerase reverse transcriptase (hTERT) and telomerase-associated protein (TEP)-1 mRNA expression, however the activity of telomerase was slightly increased by CJGPT treatment. Conclusion : These findings suggested that CJGPT-induced inhibition of human lung carcinoma A549 cell growth was connected with the induction of apoptotic cell death and the results provided important new insights into the possible molecular mechanisms of the anti-cancer activity of CJGPT.