마황약침(麻黃藥鍼)이 비만 유발 생쥐의 지방대사에 미치는 영향

김효재,김은지,한양희,Kim, Hyo-jae,Kim, Eun-ji,Han, Yang-hee 대한한방내과학회 2016 大韓韓方內科學會誌 Vol.37 No.4

Objectives: This study aimed to investigate the impact of Ephedra sinica pharmacopuncture on the weight and lipid metabolism of obese mice.Methods: Obesity was induced in male C57BL/6 mice by a 60% fat diet. The animals were divided into three groups (n=5) fed a normal diet, high-fat diet, and high-fat diet with Ephedra sinica pharmacopuncture. After 13 wk, fasting blood sugar levels were measured in each group, and oral glucose tolerance tests were conducted. After 15 wk, body weight, epididymal fat pad weight, subcutaneous fat pad weight, and serum lipid and gene expression of hormone sensitive lipase (HSL), adipose triglyceride lipase (ATGL), monoacylglycerol lipase (MGL), perilipin, and peroxisome proliferator-activated receptor (PPAR)-γ were measured in each group.Results: In the Ephedra group, body weight, fasting blood sugar, and oral glucose tolerance were significantly decreased. In addition, in the Ephedra group, the gene expression of HSL was significantly increased, whereas that of perilipin was significantly decreased.Conclusions: These results provide evidence that E. sinicapharmacopuncture affects obesity and obesity-induced metabolic syndrome, including insulin resistance and dyslipidemia, by activating lipolysis via the HSL pathway in adipose tissue.

Aneurysmal Subarachnoid Hemorrhage Following Intravenous Thrombolysis in Acute Ischemic Stroke

김효재,강동화,권순억,Jong S. Kim,전상범 대한신경집중치료학회 2017 대한신경집중치료학회지 Vol.10 No.2

Background: An incidental finding of unruptured aneurysm, which is a contraindication to the recombinant tissue plasminogen activator (rtPA), is common in patients with acute ischemic strokes. However, reports describing the rupture of intracranial aneurysm following the administration of rtPA are extremely rare. Case Report: A 51-year-old man presented to the emergency room with global aphasia. A computed tomography (CT) of the brain revealed no intracranial hemorrhage. Since global aphasia occurred in an hour, rtPA was administrated intravenously. A CT angiography was performed 2 hours after an infusion of rtPA, which despite the absence of neurological deterioration and blood pressure surge, revealed subarachnoid hemorrhage in the right cerebral hemisphere, in addition to a 3-mm saccular aneurysm with a bleb in the right middle cerebral artery. Conclusions: Aneurysmal subarachnoid hemorrhage can develop following the infusion of rtPA. Hence, unruptured aneurysm may not simply be an “incidental finding” in stroke patients receiving rtPA.

후박(厚朴)이 ob/ob 마우스의 대사성 염증과 인슐린 저항성에 미치는 영향 및 관련기전에 대한 연구

김효재,김은지,마영훈,한양희,Kim, Hyo-jae,Kim, Eun-ji,Ma, Young-hoon,Han, Yang-hee 대한한방내과학회 2018 大韓韓方內科學會誌 Vol.39 No.4

Objective: This study was undertaken to investigate how magnolia bark extract affects ob/ob mouse in terms of metabolic inflammation and insulin resistance. Methods: Leptin-deficient ob/ob mice were divided into 2 groups (n=5): a normal saline treatment (=control) and magnolia bark treatment. Wild type mice were the lean group (n=5). After 5 weeks, we measured fasting blood sugar (FBS) and conducted oral glucose tolerance tests (OGTTs) in each group. After 6 weeks, we measured body weight, epididymal fat pad weight, liver weight, serum glucose, serum insulin, and gene expression of tumor necrosis factor-${\alpha}$, interferon-${\gamma}$, and interleukin-6. We characterized the phenotype of adipose tissue macrophages (ATMs) and analyzed fractions of the phenotype in each group by flow cytometry. Results: In the magnolia bark group, fasting blood sugar, oral glucose tolerance levels, and insulin resistance (HOMA-IR) were significantly decreased. The population and proportion of ATMs among leukocytes in adipose tissue were significantly decreased in the magnolia bark group. The population and proportion of M1 type ATMs among ATMs were significantly decreased in the magnolia bark group. Gene expression of tumor necrosis factor-${\alpha}$ was significantly decreased in the magnolia bark group. Conclusions: These results support a positive effect of magnolia bark on metabolic diseases such as insulin resistance and metabolic inflammation in leptin-deficient ob/ob mice.

한국군의 익상견갑골증

김은진 ( Eun Jin Kim ),김경은 ( Kyoung-eun Kim ),김한선 ( Hanseon Kim ),김효재 ( Hyojae Kim ) 국군의무사령부 2014 대한군진의학학술지 Vol.45 No.1

Objective: To evaluate the etiology, clinical and electrodiagnostic manifestation of winged scapula in Korean soldiers. Method: Reports of conscripts with winged scapula were reviewed retrospectively on details associated with the condition onset, symptoms, signs, and electrodiagnostic study results. Results: We identified 36 patients with winged scapula. The causal events were backpack carriage in 10, closed trauma in 10, surgical trauma in 4, osteochondroma in 1, and idiopathic in 11 patients. The accessory nerves were affected in 16, the long thoracic nerves in 12, the upper brachial plexus in 5, and the dorsal scapula nerve in 3 patients. Poor outcome was rated as 14 (37.8%) and good outcome rated as 20 (54.1%) patients. Conclusion: The winged scapula was most commonly caused by nerve compression associated with backpack carriage in Korean soldiers. Careful physical examination for winged scapula should be performed in patients with shoulder problems associated with backpack carriage.

태양전지 묘듈용 솔드 합금의 산화 특성

김효재(Hyo Jae Kim),이영은(Young Eun Lee),이구(Gu Lee),강기환(Gi Hwan Kang),최병호(Byung Ho Choi) 한국태양에너지학회 2014 한국태양에너지학회 논문집 Vol.34 No.1

Photovoltaic(PV) cell is considered as one of the finest ways to utilize the solar power. A study of improving solar cell"s efficiency is important because the lifetime of solar cell is determined by photovoltaic module technology. Therefore, oxidation (and/or corrosion) of solder materials will be one of the primary yield and long-term reliability risk factor. Recently, the development of lead-free solder alloy has been done actively about lead-free solder alloys of the thermodynamic and mechanical properties. However, the oxidation behavior have rarely been investigated. In this study, the oxidations of 60 wt% Sn-40 wt% Pb, 62 wt% Sn–36 wt% Pb-2 wt% Ag, 50wt% Sn-48 wt% Bi-2wt% Ag alloys for the interconnect ribbon after exposure in atmosphere at 100℃ for several times were investigated. The wettability of 62 wt% Sn-36 wt% Pb-2wt% Ag and 50 wt% Sn-48 wt% Bi-2 wt% Ag solders was also studied to compare with that of 60 wt% Sn-40 wt% Pb alloy. The result showed that the zero cross time and the wetting time of 50 wt% Sn-48 wt% Bi-2 wt% Ag solder were better than other two samples. The surface of tested samples was analyzed by XPS. The XPS result showed that in all samples, SnO grew first and then the mixture of SnO and SnO₂ was detected. SnO₂ grew predominantly for the long time aging. Moreover XPS depth profile analysis has found surface enrichment of tin oxide.

복잡계의 행위자기반모형을 활용한 종합병원의 응급실 공간구조 분석에 관한연구

김효재 ( Hyojea Kim ),공순구 ( Soonku Kong ),홍기섭 ( Gisuop Hong ) 한국공간디자인학회 2018 한국공간디자인학회논문집 Vol.13 No.5

(Background and Purpose) Amid Korea’s social growth and expanding membership in the international community, the country is facing threats of epidemic from various diseases and infections. In the 2000s, the need for emergency services became critical in the wake of the swine flu and Middle Eastern Respiratory Syndrome (MERS) outbreak. In particular, the MERS outbreak in 2015 caused problems in the emergency medical system, causing serious social and economic confusion among infected patients, medical staff, and general patients. The government planned to analyze the spatial structure of emergency medical institutions to reduce the damage of outbreaks of various infectious diseases across emergency rooms operated in Korea, and create a structure that can respond to such outbreaks. This study selected an emergency medical institution in the Seoul Metropolitan Area as an example and analyzed how the space structure in the emergency room is constructed based on the model of a complex network. (Method) We used complex network model to identify problems in the spatial composition of the selected emergency medical institution. The proposed solution presented the criteria as a model for complex networks. We then analyzed the programs and the final outcome. The research method also included a direct visit to the emergency room of a general hospital in Korea, and an analysis was conducted by comparing X with the information from the survey, yearbook data, document, and web survey with the person in charge. (Results) The spatial structure system of an emergency medical institution was analyzed to be lacking in terms of the general medical system and the medical system for infected patients. The spatial structure and medical services for general emergency patients were being conducted together. In addition, the spatial structure inside the emergency room allowed for area-based communication of various types of treatment systems, and the combined flow of infected patients, general patients, medical staff, and general staff rendered these people susceptible to infection. Therefore, a more specialized space is required to separate the circulation system of general emergency and infected patients. (Conclusions) The research was intended to propose a form of spatial organization that can respond to the spatial composition of general emergency patients, medical staff, caregivers, and infected patients by drawing the composition and identifying the problems of the spatial structure of emergency rooms across the nation. This study used the analytical framework of behavioral magnetic model of complex systems to present basic data on effective and reasonable spatial composition.

구인회와 『문장』 기획의 연속성 연구

김효재 ( Kim Hyo-jae ) 대구가톨릭대학교 인문과학연구소 2023 인문과학연구 Vol.- No.49

The purpose of this study is to investigate the continuity between Guinhoe’s and literary magazine Munjang’s plan. To this end, this paper tried to track their continuity, focusing on the writings of Ri Sang, who was the editor of the magazine Poetry and Novel, and Lee Tae-joon, who was the editor of Sentence. Guinhoe’s response to the 1935 Paris International Writers' Association's banner of cultural advocacy requires an active re-evaluation of artists who were classified as art-oriented without being hit by Japanese fascism. In addition, the linguistic experiment shown by a group of writers in the 1930s needs to be defined as the constant struggle of artists facing the ecological and linguistic crisis of the colony. Through this work, based on the awareness of the problem, it was confirmed that two editors, Ri Sang and Lee Tae Joon had a common perception of the role of editor as a ‘midwife’ in supporting the creation of artists and publishing literary magazines that contribute to Joseon(Korean) Literature and culture as aesthetic practices in response to Japanese fascism.

3차원 다공성 구조체의 물리적 자극에 의한 세포 기능 향상 연구

김효재(Hyojae Kim),정진무(Jinmu Jung),오종현(Jonghyun Oh) 대한전기학회 2021 정보 및 제어 심포지엄 논문집 Vol.2021 No.4

1950년대 종합지 『새벽』의 정신적 지향(1)

김효재(Kim, HyoJae) 한국현대문학회 2015 한국현대문학연구 Vol.0 No.46

3차원 다공성 구조체의 물리적 자극에 의한 세포 기능 향상 연구

김효재(Hyojae Kim),정진무(Jinmu Jung),오종현(Jonghyun Oh) 대한전기학회 2021 대한전기학회 워크샵 Vol.2021 No.4