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      • SCISCIESCOPUS

        The novel herbal cocktail MA128 suppresses tumor growth and the metastatic potential of highly malignant tumor cells

        KIM, AEYUNG,IM, MINJU,YIM, NAM-HIU,HWANG, YOUN-HWAN,YANG, HYE JIN,MA, JIN YEUL Spandidos Publications 2015 ONCOLOGY REPORTS Vol.34 No.2

        <P>MA128, a novel herbal medicine, was previously identified and its effectiveness in the treatment of asthma and atopic dermatitis (AD) was demonstrated. In particular, post-inflammatory hyperpigmentation (PIH) in AD mice was improved by treatment with MA128. In addition, MA128 exhibited anti-melanogenic activity by inhibiting tyrosinase activity via the p38 MAPK and protein kinase A signaling pathways in B16F10 cells. In the present study, we examined whether oral administration of MA128 suppressed the in vivo tumor growth of HT1080 cells in athymic nude mice. The results showed that the daily oral administration of 75 and 150 mg/kg MA128 suppressed the tumorigenic growth of HT1080 cells efficiently. Since metastasis is a major cause of cancer-associated mortality and the greatest challenge during cancer treatment, we investigated the effect of non-toxic concentrations of MA128 on the metastatic potential of HT1080 cells. MA128 inhibited anchorage-independent colony formation, migration and invasion. Matrix metalloproteinase-9 (MMP-9) activity under resting and PMA-stimulated conditions was decreased in a dose-dependent manner by MA128 in HT1080 cells. In addition, the daily oral administration of MA128 at doses of 75 and 150 mg/kg efficiently blocked the lung metastasis of B16F10 cells that had been injected into the tail veins of C57BL/6 mice. In particular, none of the mice treated with MA128 exhibited systemic toxicity, such as body weight loss or liver and kidney dysfunction. MA128 also inhibited tumor-induced angiogenesis. Taken together, the results suggest that MA128 is a potential therapeutic agent and a safe herbal medicine for controlling malignant and metastatic cancer.</P>

      • Anti-melanogenic activity of the novel herbal medicine, MA128, through inhibition of tyrosinase activity mediated by the p38 mitogen-activated protein kinases and protein kinase signaling pathway in B16F10 cells

        Kim, Aeyung,Ma, Jin Yeul Medknow PublicationsMedia Pvt Ltd 2014 Pharmacognosy magazine Vol.10 No.39

        <P><B>Background:</B></P><P>Recently, our research group developed MA128, a novel herbal medicine, and demonstrated that MA128 is effective for the treatment of asthma and atopic dermatitis (AD). In particular, postinflammatory hyper-pigmentation in AD mice was improved with MA128 treatment. Thus, in this study, we determined the effect of MA128 on melanogenesis and its underlying mechanism in murine B16F10 melanoma cells.</P><P><B>Materials and Methods:</B></P><P>After treatment with MA128 at 100 and 250 μg/mL and/or alpha-melanocyte stimulating hormone (α-MSH) (1 μM), cellular melanin content and tyrosinase activity in B16F10 cells were measured. Using western blotting, expression levels of tyrosinase, tyrosinase-related protein-1 (TRP-1), TRP-2, microphthalmia-associated transcription factor (MITF), and activation of c-AMP-dependent protein kinase (PKA), c-AMP-related element binding protein (CREB) and mitogen-activated protein kinases (MAPKs) were examined.</P><P><B>Results:</B></P><P>MA128 significantly inhibited melanin synthesis and tyrosinase activity in a resting state as well as α-MSH-stimulating condition, and significantly decreased the expression of tyrosinase, TRP-1, TRP-2 and MITF. In addition, phosphorylation of PKA and CREB by α-MSH stimulation was efficiently blocked by MA128 pretreatment. Moreover, MA128 as an herbal mixture showed synergistic anti-melanogenic effects compared with each single constituent herb.</P><P><B>Conclusion:</B></P><P>MA128 showed anti-melanogenic activity through inhibition of tyrosinase activity mediated by p38 MAPK and PKA signaling pathways in B16F10 cells. These results suggest that MA128 may be useful as an herbal medicine for controlling hyper-pigmentation and as a skin-whitening agent.</P>

      • KCI등재후보

        Oral Administration of Novel Oriental Medicine, KIOM-C, Protect against Influenza Virus

        Jin Yeul Ma, Eun Ha Kim, Jun Han Lee, Min-Suk Song, Yun Hee Baek, Young Ki Choi 충북대학교 동물의학연구소 2012 Journal of Biomedical and Translational Research Vol.13 No.2

        The influenza virus is an important respiratory risk affecting humans, and effective treatments are needed. Some oriental medicines are currently applied for treatment of common colds as well as influenza infection. Previous studies have reported that the therapeutic properties of MA-128 are effective for treatment of psoriasis antiasthmatic and atopic dermatitis. In this study, we investigated the therapeutic properties of the novel herbal medicine, MA-128, for treatment of influenza virus infection by oral administration. MA-128 is an active natural biological compound from herbal-marine origin. The results showed that oral administration of MA-128 in mice could confer a survival benefit against Type A influenza virus infection. Daily oral administration of MA- 128 resulted in delayed death in infected mice for three days against mouse adapted H3N2 (A/Philippines/2/82). However, it protected more than 60% of mice from lethal infection of 2009 pandemic H1N1 (A/Korea/CJ01/2009) influenza virus. In addition, lung viral titers were significantly reduced at seven days post infection (~100 times) compared with mock-treated mice and viruses were cleared at 9 dpi only in the MA-128 treated groups. This study demonstrated the potential of the novel herbal medicine, MA-128, as an herbal remedy against influenza A viruses.

      • KCI등재

        Space-Time Quantization and Motion-Aligned Reconstruction for Block-Based Compressive Video Sensing

        ( Ran Li ),( Hongbing Liu ),( Wei He ),( Xingpo Ma ) 한국인터넷정보학회 2016 KSII Transactions on Internet and Information Syst Vol.10 No.1

        The Compressive Video Sensing (CVS) is a useful technology for wireless systems requiring simple encoders but handling more complex decoders, and its rate-distortion performance is highly affected by the quantization of measurements and reconstruction of video frame, which motivates us to presents the Space-Time Quantization (ST-Q) and Motion-Aligned Reconstruction (MA-R) in this paper to both improve the performance of CVS system. The ST-Q removes the space-time redundancy in the measurement vector to reduce the amount of bits required to encode the video frame, and it also guarantees a low quantization error due to the fact that the high frequency of small values close to zero in the predictive residuals limits the intensity of quantizing noise. The MA-R constructs the Multi-Hypothesis (MH) matrix by selecting the temporal neighbors along the motion trajectory of current to-be-reconstructed block to improve the accuracy of prediction, and besides it reduces the computational complexity of motion estimation by the extraction of static area and 3-D Recursive Search (3DRS). Extensive experiments validate that the significant improvements is achieved by ST-Q in the rate-distortion as compared with the existing quantization methods, and the MA-R improves both the objective and the subjective quality of the reconstructed video frame. Combined with ST-Q and MA-R, the CVS system obtains a significant rate-distortion performance gain when compared with the existing CS-based video codecs.

      • KCI등재

        Sodium Alginate-Assisted Synthesis of PdAg Bimetallic Nanoparticles and their Enhanced Activity for Electrooxidation of Ethanol

        Yanru Yin,Changna Wen,Ning Ma,Baoyan Wang,Lianying Zhang,Hongliang Li,Peizhi Guo 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2019 NANO Vol.14 No.9

        Palladium and palladium-silver bimetallic nanocrystals have been synthesized hydrothermally by using environmental-friendly sodium alginate as the stabilizer and reducing agent. The pure palladium nanoparticles were spherical-like possibly due to the principle of the lowest surface energy, however, the formation of bimetallic palladium-silver nanoparticles was much more complicated, which was thinner and more irregular nanostructures than pure palladium nanoparticles. Electrochemical measurements showed that the electrocatalytic activity toward ethanol oxidation was increased first with the increase of silver content in bimetallic nanoparticles, from pure palladium of around 1070 mA/mg, to PdAg-20 of 1160 mA/mg and to PdAg-10 of 1750 mA/mg, and declined greatly at a high content of silver, approximately 279 mA/mg. Electrochemical stability test showed that PdAg-10 and PdAg-5 were the best and worst among four palladium-based samples, respectively. Based on the experimental data, the formation mechanism of pure palladium and palladium-silver bimetallic nanoparticles and the structure-property relationship of these samples have been discussed.

      • KCI등재

        서어에서의 COMP 범주 분석

        마상영 한국서어서문학회 1998 스페인어문학 Vol.13 No.1

        En esta tesis hemos propuesto nuestras opiniones sobre las estructuras de las oraciones compueatas que todavi′a tienen sin solucio′n muchas caracteri′sticas sinta′ctico-sema′nticas. Las grama′ticas tradicional y funcional distinguen entre las oraciones nominales, las relatives y las interrogativas segu′n las funciones que desempen~an en la oracio′n materna. En la grama′tica generativa se ha detallado el ana′lisis de la categori′a COMP con los cambios de contenido, pero todavi′a no ha aparecido una solucio′n complete. En esta situacio′n, hemos optado la idea de la categrori′a COMP de Chomsky(1986) que consideramos relativamente ma′s refinada. La conjuncio′n que introduce la oracio′n nominal ocupa la posicio′n nuclear de COMP, mientras los relativos y los interrogativos se trasladan a la posicio′n Espec de COMP dejando sue huellas respectivas en su posicio′n originaria. Pero, la oracio′n relative de funcio′n adjetiva se caracteriza par [-C, -θ] y no requiere la inversion Verbo-Sujeto durante la relativizacio′n, mientras que la oracio′n interrogativa de funcio′n nominal tiene los rasgos [+C, +θ] y exige la inversio′n Verbo-Sujeto durante el proceso de interrogacio′n. Asi′ tales diferencias son relevantes coma se ve: a. Oracio′n nominal : SCOMP ⇒ [+C,+θ] Quiero [sc[c$quot;[c que] [SF te vayas]]]. b. Oracio′n relativa : SCOMP ⇒ [-C,-θ] Esa es la chica [sc a que] [c[cθ] [SF queri′a visitar]]]. c. Oracio′n interrogativa : SCOMP ⇒ [+C, +θ] No se′ [sc cua′l pluma [c$quot;[c Φ] [SF pro prefieres]]]. Para solucionar estos problemas, Emonds(1976) nos ha propuesto que $quot;que$quot;(that en ingle′s) es un tipo de preosicio′n oracional. Pero como hemos viato en esta tesis, su solucio′n no es perfecta y tambie′n provoca problemas teo′ricos. De acuerdo con J. M. Brucart (en prensa), hemos comprobado la validez del ana′lisis de la categori′a COMP de Chomsky(1986) criticando los problemas pendientes de las propuestas de varios lingu¨i′stas : Mari′a Luisa Rivero(1980), Susan Plann(1982), M. Sun~er(1986, 1991). Tambie′n hemos analizado las relaciones entre la misma categori′a y los rasgos sema′nticos del verbo principal, y sus caraceri′sticas sinta′ctico-sema′nticas en el discurso indirecto. Lo que se ha argumentado en esta tesis nos muestra que le conviene ma′s al espan~ol el ana′lisis de COMP de Chomsky(1986) que los otros parame′trioos. El contraejemplo aparente de la secuencia $lt;que+S-qu$gt; no deteriora las suposiaones universales sino que las apoya, lo que hemos comprobado mediante el ana′lisis discursivo en que se seleocionan a la vez dos categori′as COMP. Sin embargo, todavi′a no vemos soluaonadas las diferencias sinta′ctico-sema′nticas de los componentes de la categori′a COMP. En unas propuestas anteriores la parti′cula QUE se divide en dos categori′as(relativo y conjuncio′n) en Rivero(1981) y en otras se considera so′1o como la u′nica categori′a : complementante (o mejor dicho, conjuncio′n). Pero siguiendo a esta u′ltima opinio′n, nos quedan la cuestio′n de que la preposicio′n, en el caso de las construcciones relativas EN QUE, DE QUE, aparece sin complemento, lo que viola la generalidad de la preposicio′n : La preposicio′n requiere la presencia obligatoria de su complemento, y la de que en el caso de EN EL QUE, DEL QUE, ..., no aparece el nu′cleo nominal del SN asi′ que ocurre la violacip′n del principio X'. A pesar de estas diferencias claras, haste ahora se ha tratado de analizar la categori′a COMP con el mismo criterio sinta′ctico, lo que consideramos problema′tico y deberi′amos esforzarnos a crear otras propuestas nuevas ma′s detalladas y de gran credibilidad.

      • KCI등재

        THE ASIAN ORGANIC FERTILIZER INDUSTRY

        Ma,Khristine T,Helera,Jimmy B,Williams,Jeanette Angeline B,Madamba,Normito R,Zapata Jr 한국무역연구원 2013 貿易 硏究 Vol.9 No.2

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 9시까지 원문보기가 가능합니다.

        Over the years, the market for organic fertilizers has expanded rapidly. The number of commercially produced organic fertilizers has increased in a number of Asian countries. In the Philippines, considerable advancements have already been achieved relative to organic fertilizer production. The demand for organic fertilizer is largely influenced by the development in the organic agriculture industry. Consumers have placed so much value on the nutritive and safety aspect of organically produced foods. In Asia, China has the largest production capacity when it comes to organic fertilizer. The largest importer of organic fertilizer in Asia, on the other hand, is Japan. The pelletized chicken manure fertilizer is one product Philippine poultry producers can bank on to enter the export market. This paper not only showed that it is feasible to put up a pelletized poultry manure fertilizer production plant in the country, but that the potentials for this underexplored product have tremendous profit implications for the Philippines.

      • Double-Deck Inverse Opal Photoanodes: Efficient Light Absorption and Charge Separation in Heterojunction

        Ma, Ming,Kim, Jung Kyu,Zhang, Kan,Shi, Xinjian,Kim, Sung June,Moon, Jun Hyuk,Park, Jong Hyeok American Chemical Society 2014 Chemistry of materials Vol.26 No.19

        <P>For the first time, double-deck WO<SUB>3</SUB>/BiVO<SUB>4</SUB> inverse opal photoanodes (DDIO-WO<SUB>3</SUB>/BiVO<SUB>4</SUB>) were prepared by swelling–shrinking mediated polystyrene template synthetic routes, and the use of the photoanodes in photoelectrochemical cells under simulated solar light was investigated. The double-deck photoanodes represented the compact interface between WO<SUB>3</SUB> and BiVO<SUB>4</SUB>, inheriting the periodically ordered macroporous nanostructure. More significantly, the DDIO-WO<SUB>3</SUB>/BiVO<SUB>4</SUB> inverse opal photoanodes prepared from the optimized fabrication condition demonstrated a photocurrent that was ∼40 times higher than that of the pure inverse opal WO<SUB>3</SUB> photoanodes at a bias of 1.23 V vs RHE. Even without an added catalyst, they produce an outstanding photocurrent density of ∼3.3 mA/cm<SUP>2</SUP> at a bias of 1.23 V vs RHE, which profits from improving the poor charge carrier mobility of BiVO<SUB>4</SUB> by combining it with a WO<SUB>3</SUB> skeleton and a shrouded bilayer inverse opal structure with a large surface area and good contact with the electrolyte.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/cmatex/2014/cmatex.2014.26.issue-19/cm502073d/production/images/medium/cm-2014-02073d_0008.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/cm502073d'>ACS Electronic Supporting Info</A></P>

      • KCI등재

        STRONG AND Δ-CONVERGENCE THEOREMS FOR A COUNTABLE FAMILY OF MULTI-VALUED DEMICONTRACTIVE MAPS IN HADAMARD SPACES

        Ma’aruf Shehu Minjibir 경남대학교 기초과학연구소 2022 Nonlinear Functional Analysis and Applications Vol.27 No.1

        In this paper, iterative algorithms for approximating a common fixed point of a countable family of multi-valued demicontractive maps in the setting of Hadamard spaces are presented. Under different mild conditions, the sequences generated are shown to strongly convergent and Δ-convergent to a common fixed point of the considered family, accordingly. Our theorems complement many results in the literature.

      • KCI등재

        A Study on Korean College Students’ Awareness in the Passive Voice

        Ma,Sun Mi 한국통번역교육학회 2019 통번역교육연구 Vol.17 No.1

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 9시까지 원문보기가 가능합니다.

        This study aims to investigate Korean students’ syntactic knowledge and their awareness of the passive over the active voice. A total of 44 Korean college students and 4 native speakers of English participated in the research. Findings revealed that Korean students considered the passive and the active possess the same meanings while native speakers of English responded that both structures have different meanings. It is partly because some of grammar textbooks students study with do not provide proper explanations and contexts; therefore the publishers should pay attention to the contents of their books. Since EFL students do not have such intuition, proper grammar explanations in context should be provided with the help of correct translation. The implication of the study discusses the importance of explicit, correct grammar instructions in English classes in order to build awareness in the passive voice.

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