유기발광다이오드를 이용한 Photobiomodulation 기반 스킨케어 효과

김홍빈,정혜정,진석근,이병일,안재성,Kim, Hongbin,Jeong, Hyejung,Jin, Seokgeun,Lee, Byeongil,Ahn, Jae Sung 한국광학회 2021 한국광학회지 Vol.32 No.5

Photobiomodulation (PBM) 치료법은 특정 파장대역의 광원이 미토콘드리아에서 ATP 생성을 촉진하는 현상을 이용하는 치료법으로서 상처 치유, 염증 감소, 통증 완화 효과가 있는 것으로 알려져 생물 및 의학 분야에서 많은 관심을 받고 있다. PBM 치료법에 대한 연구는 주로 레이저, 발광다이오드(LED)를 광원으로 사용하였고, 유기발광다이오드(OLED)가 가지는 장점에도 불구하고 PBM 치료법에 사용된 사례는 제한적이다. 본 연구에서는 적색(λ = 620 nm), 녹색(λ = 525 nm), 청색(λ = 455 nm) OLED 조명모듈을 사용하여 PBM에 의한 피부관리 효과를 분석하고 LED에 의한 PBM 효과와 비교하였다. OLED 조명모듈의 PBM에 의한 피부미용효과는 적색 OLED 조명모듈에 의한 collagen type 1 합성량 증가, 녹색 OLED 조명모듈에 의한 melanin 합성 억제, 청색 OLED 조명모듈에 의한 nitric oxide 생성 억제를 각각 측정하여 입증되었다. Photobiomodulation (PBM)-based therapy, which uses a phenomenon in which a light source of a specific wavelength band promotes ATP production in mitochondria, has attracted much attention in the fields of biology and medicine because of its effects on wound healing, inflammation reduction, and pain relief. Research on PBM-based therapy has mainly used lasers and light-emitting diodes (LEDs) as light sources and, despite the advantages of organic light-emitting diodes (OLEDs), there have been only a few cases where OLEDs were used in PBM-based therapy. In this research, the skin-care effect of PBM was analyzed using red (λ = 620 nm), green (λ = 525 nm), and blue (λ = 455 nm) OLED lighting modules, and was compared to the PBM effect of LEDs. We demonstrated the PBM-based skin-care effect of the red, green, blue OLED lighting modules by measuring the increase in the amount of collagen type-1 synthesis, the inhibition of melanin synthesis, and the suppression of nitric oxide generation, respectively.

한국에서 지역에 따른 Helicobacter pylori 균주 내성

김재연 ( Jae Yeon Kim ),김나영 ( Na Young Kim ),김성중 ( Sung Jung Kim ),백광호 ( Gwang Ho Baik ),김광하 ( Gwang Ha Kim ),김정목 ( Jung Mogg Kim ),남령희 ( Ryoung Hee Nam ),김홍빈 ( Hong Bin Kim ),이동호 ( Dong Ho Lee ),정현채 ( H 대한소화기학회 2011 대한소화기학회지 Vol.57 No.4

Background/Aims: This study was performed to compare the prevalence rates of primary antibiotic resistance in Helicobacter pylori (H. pylori) isolates among different regions of Korea. Methods: H. pylori were isolated from gastric mucosal biopsy specimens of 99 Koreans who lived in Gyeonggi (n=40), Kangwon province (n=40) and Busan (n=19) from April to August in 2008. All the patients had no history of H. pylori eradication therapy. The susceptibilities of the H. pylori isolates to amoxicillin, clarithromycin, metronidazole, tetracycline, azithromycin, ciprofloxacin, levofloxacin, and moxifloxacin were tested according to the agar dilution method. Results: There was a difference in resistance to clarithromycin in three institutes located among Gyeonggi (32.5%), Kangwon province (12.5%) and Busan (42.1%) by One way ANOVA test (p=0.027) and nonparametric Kruskal Wallis test (p=0.027). However, by post-hoc analysis, there was no statistically significant difference among three regions. Similarly, the other 7 antibiotics (amoxicillin, metronidazole, tetracycline, azithromycin, ciprofloxacin, levofloxacin and moxifloxacin) did not show any significant difference. Conclusions: There was no significant regional difference of the primary antibiotic resistance of H. pylori. However, the included patient number might not be enough for this conclusion demanding further evaluations. (Korean J Gastroenterol 2011;57:221-229)

안면마비 등급을 통한 관련 질병 확률 예측 머신러닝 알고리즘 형성

김홍빈(H. B. Kim),박지연(J. Y. Park),기범근(B. G. Ki),김형원(H. W. Kim),권덕호(D. H. Kwon),박용재(Y. J. Park),주창화(J. C. Hwa),김현욱(H. W. Kim),임광석(K. S. Lim) 한국생산제조학회 2022 한국생산제조시스템학회 학술발표대회 논문집 Vol.2022 No.7

Evaluation of Vancomycin TDM Strategies: Prediction and Prevention of Kidney Injuries Based on Vancomycin TDM Results

Kim Byungwook,황세정,Heo Eunjeong,Kim Hyung-sook,Jung Jongtak,Kim Eu Suk,김홍빈,Lee Kyunghoon,Park Jeong Su,송정한,Lee Joon Hee,Chung Jae-Yong,Song Kyoung-Ho,Yoon Seonghae 대한의학회 2023 Journal of Korean medical science Vol.38 No.14

The current guidelines for therapeutic drug monitoring (TDM) of vancomycin suggest a target 24-hour area under the curve (AUC0-24) of 400 to 600 mg*h/L for serious methicillinresistant Staphylococcus aureus infections. In this study, the predictabilities of acute kidney injury (AKI) of various TDM target parameters, target levels, and sampling methods were evaluated in patients who underwent TDM from January 2020 to December 2020. The AUC0-24 and trough values were calculated by both one- and two-point sampling methods, and were evaluated for the predictability of AKI. Among the AUC0-24 cutoff comparisons, the threshold value of 500 mg*h/L in the two sampling methods was statistically significant (P = 0.042) when evaluated for the predictability of AKI. Analysis by an receiver operating characteristic curve estimated an AUC0-24 cutoff value of 563.45 mg*h/L as a predictor of AKI, and was proposed as the upper limit of TDM target.

호텔식음료업장의 정규직과 비정규직 직원의 직무특성과 조직몰입의 차이

김홍빈(Hong Bin Kim) 한국호텔외식관광경영학회 2006 호텔경영학연구 Vol.15 No.5

The purpose of this study is to find out difference of recognition on job characteristics and organizational commitment to both full time and part time employees working in food and beverage department of hotels. Also, this study suggested skill of control the part time employees organizational behavior. In order to achieve the purpose, this study reviewed previous researches and conducted survey as well. Results of the study are as followings: First, part time employees showed rack of recognition about self-control factor of job characteristics. Self control factor can be defined that employees are able to make themselves decision to act. Therefore, hotels need to enlarged self-control to part time employees. Second, full time employees showed greater organizational commitment than part timers. This result that full timers indicate that they have satisfaction, pride and happiness with working in a hotel. Third, self-control factor and feed back factor made positive effect on organizational commitment for part time employees. Only self-control factor made positive effect on it for full time employees. Thus, hotel is required to provide proper feed back to part time employees about their job performance especially. In consequence, to improve outcome of organizational, hotels need to develop specific plans or incentive programs for part time employees so that part timers are able to keep themselves from misunderstanding that they are unfairly treated in working places. Also, hotel need to hire part time employees who high motivation on duty.

Anti-Alpha-Toxin Antibody Responses and Clinical Outcomes of Staphylococcus aureus Bacteremia

Kim Nak-Hyun,Choi Yunjung,Kwon Kyungmi,Park Jeong Su,Park Kyoung Un,Moon Song Mi,Song Kyoung-Ho,Kim Eu Suk,Park Wan Beom,김홍빈 대한의학회 2023 Journal of Korean medical science Vol.38 No.16

Background: Alpha-toxin (AT), a major virulence factor of Staphylococcus aureus, is an important immunotherapeutic target to prevent or treat invasive S. aureus infections. Previous studies have suggested that anti-AT antibodies (Abs) may have a protective role against S. aureus bacteremia (SAB), but their function remains unclear. Therefore, we aimed to investigate the association between serum anti-AT Ab levels and clinical outcomes of SAB. Methods: Patients from a prospective SAB cohort at a tertiary-care medical center (n = 51) were enrolled in the study from July 2016 to January 2019. Patients without symptoms or signs of infection were enrolled as controls (n = 100). Blood samples were collected before the onset of SAB and at 2- and 4-weeks post-bacteremia. Anti-AT immunoglobin G (IgG) levels were measured using an enzyme-linked immunosorbent assay. All clinical S. aureus isolates were tested for the presence of hla using polymerase chain reaction. Results: Anti-AT IgG levels in patients with SAB before the onset of bacteremia did not differ significantly from those in non-infectious controls. Pre-bacteremic anti-AT IgG levels tended to be lower in patients with worse clinical outcomes (7-day mortality, persistent bacteremia, metastatic infection, septic shock), although the differences were not statistically significant. Patients who needed intensive care unit care had significantly lower anti-AT IgG levels at 2 weeks post-bacteremia (P = 0.020). Conclusion: The study findings suggest that lower anti-AT Ab responses before and during SAB, reflective of immune dysfunction, are associated with more severe clinical presentations of infection.

소매점 유형별 상품구매행동 차이 및 선택속성의 중요도와 만족도 비교분석

김홍빈(Hong-Bin Kim),김현(Hyun Kim) 한국콘텐츠학회 2012 한국콘텐츠학회논문지 Vol.12 No.9

본 논문은 소매점 유형별 소비자의 상품선택행동과 선택속성의 중요도와 만족도에 대한 비교 분석을 통해 유형별 특성을 파악하고, 전통시장의 경쟁력 강화방안을 제시하기 위한 목적으로 서울과 수도권 거주자를 대상으로 설문하여 IPA 분석이 수행되었다. 본 연구의 분석결과에 따른 시사점은 다음과 같다. 첫째, 전통시장의 경우 상대적으로 이용시간이 긴 반면 사용금액은 크게 작은 것으로 나타났다. 이는 전통시장의 점포구성과 배치가 점포탐색을 어렵게 하는 것으로 품목별 점포의 재구성과 집중화가 필요하다 둘째, 전통시장과 대형 할인매장, 백화점 모두 중요도에 비하여 만족도가 낮아 전통시장의 활성화를 위해서는 대형 할인매장과 동일 선상에서의 경쟁보다는 취급하지 않는 품목의 구성 또는 전문화를 통하여 고객이 생각하지 못했던 곳에서 만족을 강화하는 것이 중요할 것으로 판단된다. 셋째, 소매점 유형별 선택속성에 대한 IPA 결과 상품품질에 따른 응답자의 기대치가 반영되어 대형할인마트와 백화점은 가격에 대한 신뢰성과 상품 품질우수성이 개선되어야 할 사항으로 제시되었으며, 전통상권은 저렴한 가격과 가격에 대한 신뢰, 상품품질우수성이 강점으로 파악되었으며, 시설적 측면의 항목들은 개선사항으로 나타나 시설현대화 사업의 지속적 지원이 필요한 것으로 나타났다. This study is to investigate consumer’s purchasing behavior by types of retail store and to conduct Importance-Performance Analysis(IPA) to exhort adequate competitive strategy to the traditional market. The results of this study are as follows. First, the result shows that consumer spends more time and less money at the traditional market due to the difficulties of store searching by store arrangement and construction of the market. Second, this study suggest that the traditional market needs to change their competitive strategy in same level with the discount stores, the traditional market can concentrate their capability on specialization and uniqueness of their product to meet the consumer’s needs. Third, according to the result on quadrant(concentrate here) of IPA, traditional market is marked on ease of refund, convenience of after service and parking facility, and cleanliness of bathroom while the discount store and the department store are marked on high credibility level and quality of product.

IoT 디바이스 블루투스 통신을 이용한 미아방지 시스템 개발

김홍빈(Hong-Bin Kim),김태운(Taewoon Kim),최우열(Wooyeol Choi) 대한전자공학회 2018 대한전자공학회 학술대회 Vol.2018 No.11

초정밀 스테이지를 위한 리니어 모터의 비선형 적응제어

김홍빈(Hongbin Kim),이병휘(Byonghuee Lee),허건수(Kunsoo Huh) 대한기계학회 2005 대한기계학회 춘추학술대회 Vol.2005 No.5

Linear motors are easily affected by load disturbance, force ripple, friction, and parameter variations because there is no mechanical transmission to reduce the effects of model uncertainties and external disturbance. These nonlinear effects have been reduced for high-speed/high-accuracy position control either through better motor design or via the better control algorithm that can compensate the nonlinear effects. In this paper, a nonlinear adaptive control algorithm is designed and applied for the position control of permanent magnet linear synchronous motor (PMLSM). In order to estimate and compensate the nonlinear effects such as friction and force ripple, the estimation and the nonlinear adaptive control laws are derived based on the virtual control input and a suitable Lyapunov function. The proposed controller is evaluated through the computer simulations. The control algorithm is also implemented to a DSP board and interfaced to the PMLSM for verifying the real-time control performance.

부유식 해상 풍력⦁파력 발전기의 동적운동응답에 관한 연구

김홍빈(Hongbhin Kim),구원철(Woncheol Koo) 한국해양환경·에너지학회 2021 한국해양환경·에너지학회 학술대회논문집 Vol.2021 No.10

부유식 해상풍력 발전 NREL-MIT Tension Leg Platform에 점 흡수식 파력 발전 장치인 Wave Star Platform을 통합한 부유식 해상 풍력 파력 발전 플랫폼의 동적 거동에 관한 연구를 수행하였습니다. 본 수치해석은 포텐셜 유동 이론을 바탕으로 한 경계요소법 기반 프로그램인 Ansys Aqwa를 통해서 이루어졌습니다. 풍력, 파력 발전기 간의 유체역학적 상호작용에 관한 효과를 구현하기 위해 선형 중첩 이론을 기반으로 하여 속도 포텐셜을 계산하였습니다. 계류선의 운동으로 부유식 해상 풍력 파력 복합 발전 플랫폼에 작용되는 힘을 구현하기 위해 계류선의 운동을 유한요소법 기반으로 계산 하였습니다. 또한 NREL의 오픈 소스 프로그램인 FAST의 Aerodyn 모듈을 사용하여, 풍력⦁파력 발전 플랫폼에 적용되는 풍하중을 계산하여, 본 수치해석에 사용하였습니다. 파력 발전 장치의 동력 인출 장치에 관한 부분은 쿨룽 감쇠력을 사용하여 구현하였습니다. 앞선 수치해석 기법을 바탕으로 Cummins 방정식을 기반으로 한 시간영역에서 정규파 에서의 파력 발전기의 유무에 따른 풍력 발전기의 운동응답을 계산하였고,파력 발전기의 파랑 에너지 추출을 계산하였습니다. A study was conducted on the dynamic motion response of a Floating Offshore Wind Platform that integrates the Wave Star Platform, a point absorption wave energy converters. This numerical analysis was performed through Ansys Aqwa, a multi-body hydrodynamics program based on the boundary element method. To implement the effect on the hydrodynamic interaction between Floating Offshore Wind Platform and wave energy converters , the velocity potential was calculated based on the linear superposition theory. The motion of the mooring lines was calculated based on the Finite Element Method to implement the force acting on the floating platform by the motion of the mooring lines. In addition, using the ‘Aerodyn’ module of FAST, an open source program of NREL, the wind load applied to the Floating Offshore Wind Platform was calculated and used for this numerical analysis. The part about the power take-off of the wave energy converter was implemented using the Coulomb damping force. Based on the previous numerical analysis technique, the motion response of the Offshore Wind Platform was calculated according to the presence or absence of the wave power generator at the regular wave in the time domain based on the Cummins equation, and wave energy extraction of the wave energy converter was calculated.