남자 만성 정신분열병환자에서 Haloperidol과 Nimodipine의 병합사용이 혈장 HVA와 5-HIAA에 미치는 영향

김형섭,최애경,지성학,김수동,박성덕,김광현,Kim, Hyeong-Seob,Choi, Ai-Kyung,Jee, Sung-Hak,Kim, Soo-Dong,Park, Sung-Deok,Kim, Kwang-Hyeon 대한생물정신의학회 1996 생물정신의학 Vol.3 No.1

본 연구는 난치성 만성 정신분열병 남자환자 20명을 대상으로 항정신병약물인 haloperidol 올 2주간 일정량으로 유지한후 중추신경계에 비교적 선택적으로 작용하는 칼슘차단제인 nimodipine을 5주간 병합투여하였고 BPRS, Simpson-Angus Scale Averse events-Somatic Symptoms 등을 이용하여 nimodipine투여전, 투여후 1주, 3주, 5주에 임상반응을 평가하고 혈장 HVA, 5-HIAA농도를 투여전과 투여후 1주, 3주, 5주에 측정하여 다음과 같은 결과를 얻었다. 1) Nimodipine과 haloperidol의 병합투여시 전체 BPRS점수 및 사고소검사점수, 편집성소검사점수는 용량에 관계없이 기간에 따라 감소하는 추세를 보였으나, 특히 nimodipine 90mg을 병용투여하는 군의 경우 nimodipine투여전과 비교하여 3, 5주째에서 통계적으로 의미있게 감소하는 결과를 나타냈다(p<0.05). 2) Nimodipine과 haloperidol의 병합투여에 따른 부작용등은 통계적으로 의미는 없었으나 기간에 따라 감소하는 추세를 보였고, 임상적으로 관찰된 소견상 추체외로증상, 안구동통, 정서적 불안정, 심혈관계 부작용 등의 심각한 부작용은 없었다. 3) Nimodipine의 투여량 및 기간에 따른 혈장 HVA와 5-HIAA의 농도변화는 없었다. 4) BPRS점수가 20% 이상 감소하는 경우를 호전된 것으로 간주했을때 호전군과 비호전군간의 혈장 HVA 및 5-HIAA는 차이를 나타내지 않았고, 각 군에서 측정시기에 따른 차이도 보이지 않았다. 상기 결과로 보아 nimodipine이 혈장 HVA와 5-HIAA의 농도변화에 영향을 미치지 않으나 임상적인 호전은 나타내는 바 난치성 정신분열병환자, 노인환자나 항정신병 약물에 대해 부작용이 심한 정신분열병환자에서 nimodipine 병합사용이 유용할 것으로 사료된다. In an open labeled study, two fixed doses of nimodipine(45mg and 90mg daily) were added to the usual antipsychotic drug treatment (Haloperidol : mean dose=25mg/day) in 20 male chronic schizophrenics for 5 weeks. The purposes of this study were to evaluate the therapeutic effects and the effect an the changes of plasma homovanillic acid(HVA) and 5-hydroxyindoleacetic acid(5-HIAA) levels. The results were as follows : 1) Total BPRS score and thought cluster, paranoid cluster subscores showed linear decreasing trend over the course of the study(P<0.05). Especially the thought cluster and paranoid cluster subscores were significant difference between 45mg and 90mg dose of nimodipine(P<0.05). The improvement rates were 45,45% of 90mg and 11.11% of 45mg, but there was no significant difference between the 45mg and 90mg dose of nimodipine. 2) The scores of extrapyramidal symptoms and adverse events-somatic symptoms showed a linear decreasing trends over the course of study. 3) The changes in the mean plasma HVA and 5-H1AA concentrations by the dosages and durations of combining of nimodipine were not statistically significant. 4) There was no statistical significance in plasma HVA and 5-HIAA of the improved, non-improved goroup. Nimodipine has a possibility os on adjunctive agent for treatment resistant schizophrenics, elderly patients and liable patients for the Side effects to usual antipsychotic drugs. So we suggest that the dosage of nimodipine must be above 90mg/day in the treatment of schizophrenia.

분말 압축 공정의 탄소성 유한 요소 해석

김형섭,이동녕 ( Hyoung Seop Kim & Dong Nyung Lee ) 대한금속재료학회 1991 분말야금 Vol.3 No.-

제3대구치의 발치가 인접 2대구치의 치주에 미치는 영향

김형섭,김태균,허수례,조익현,Kim, Hyung-Seop,Kim, Tae-Kyun,Heo, Soo-Rye,Cho, Ik-Hyun 대한치주과학회 2003 Journal of Periodontal & Implant Science Vol.33 No.3

The aim of this study was to investigate the effect of third molar extraction on the periodontal status of the adjacent second molar. A total of 61 second molars in 31 adult periodontitis patients were examined. Among them, 27 second molars without adjacent third molars were included in the test group, and 34 second molars with third molar were included in the control group. Clinical parameters including plaque index, gingival index, and pocket depth and radiographic bone loss were measured around the second molar both in test and control group. The result showed that: (1) the mean plaque index and gingival index of control group were higher than these of the test group but the difference was not statistically significant, (2) the mean pocket depth of the control group was higher than the test group significantly at distal and buccal surface, (3) radiographic hone loss was greater in control group than test group significantly, (4) in Pearson correlation analysis between the age of extraction and radiographic bone loss in the test group, a positive relationship was shown(p<0.01). Within limitation of this study, it may be concluded that third molar extraction in periodontitis patients showed an improvement in periodontal status in contrast the patients group having third molar, therefore earlier a removal of third molar may minimize radiographic hone loss of the adjacent second molar.

치주 치료 후 치아 상실에 관한 연구

김형섭,석정진,김현철,이수정,최승환,Kim, Hyung-Seop,Seok, Jeong-Jin,Kim, Hyun-Chul,Lee, Su-Jeong,Choi, Seoung-Hwan 대한치주과학회 2003 Journal of Periodontal & Implant Science Vol.33 No.2

The main goal of periodontal treatment is the long-term maintenance of teeth. Periodic maintenance program is need to prevent periodontal disease and maintain healthy periodontium. Hirschfeld and Wasserman(1978) studied 600 treated periodontal patients. This study categorized periodontal patients using well-maintained, downhill, extreme downhill groups. The purpose of our study is to evaluate effect of periodontal treatment and analyse tooth loss after periodontal treatment using this classification. The study population of j9 patients had been treated and maintained for mean 5.8 years. All patients were on a periodic maintenance program at 2-, 3-, 4, or 6-month intends. The avenge age of the patients at the time of original therapy was 49.6 years. To analyse tooth loss, modified classification was used on the basis of response to therapy using by Hirschfeld and Wasserman in 1978. The results were as follows : 1. 59 treated patients were lost mean 1.42 teeth per patient for 5.8 years of maintenance period. 2. Maxillary first molars were most frequently lost but mandibular lateral incisors were lost no tooth during maintenance period. 3. Tooth mortality received surgical treatment had similar to received nonsurgical treatment. 4. Tooth loss was more frequent in maxillary teeth than mandibular teeth, and posterior teeth than anterior teeth, and more frequent tendency in male than female.

회원작품 - 서쪽 하늘 게스트하우스

김형섭,Kim, Hyeong-Seop 대한건축사협회 2016 建築士 Vol.2016 No.5

PSRC 기둥공법의 현장 적용성 평가

김형섭,이창남,이승환,Kim, Hyoung-Seop,Lee, Change-Nam,Lee, Seung-Hwan 한국공간구조학회 2012 한국공간구조학회지 Vol.12 No.3

게껍질에서 추출한 chitosan 필름의 이용에 관한 연구 2. Chitosan 코팅처리한 토마토의 품질변화

김형섭,손병일,박성민,이근태,KIM Hyonng-Seub,SON Byung-Yil,PARK Seong-Min,LEE Keun-Tai 한국수산과학회 1999 한국수산과학회지 Vol.32 No.5

제조한 chitosan용액을 이용하여 토마토를 코팅처리하여 저장기간에 따른 중량, pectin함량 및 침입강도, 유리당, 유리산 및 pH등의 변화를 조사한 결과는 다음과 같다. $2\%$ chitosan용액으로 도포한 토마토(도포구)와 도포하지 않은 토마토 (대조구)의 중량감소는 대조구인 경우 저장 9일째 $4.6\%$인 반면 도포구인 경우 18일째 $4.8\%$로 2배 정도의 저장기간이 연장되었다. 저장 18일째 대조구와 도포구의 침입강도와 pectin 함량을 측정한 결과, 대조구인 경우 침입강도는 1.03kg, pectin 함량은 $0.44g\%$이었으며, 도포구는 각각 1.63kg, $0,58g\%$로 도포한 토마토의 침입강도와 pectin 함량이 대조구에 비해 높았다. 저장일수가 경과함에 따라 유리당의 변화는 전체적으로 증가하였으며, 저장 18일째에 대조구와 도포구는 각각 $2.24g\%$, $1.62g\%$로 증가폭은 대조구가 더 크게 나타났다. 또한 유기산과 pH의 변화는 저장 18일째 대조구 $0.15g\%$, 도포구 $0.17g\%$로 도포구가 높게 나타났으며, pH의 경우 대조구가 도포구보다 다소 높게 나타났다. 이상의 결과로 볼 때 대조구에 비해서 도포구가 저장기간을 연장하는데 효과적인 것으로 생각된다. Coating with chitosan ($2\%$, pH: 5.0) had a beneficial effect such as less weight loss, flesh firmness and maintenance of sugar content of tomatoes stored at the normal temperature. The weight loss of chitosan-coated tomatoes was $4.8\%$ during the storage-period (18days) while that of control was $10.2\%$. When it was stored for 18 days, the tomatoes coated with chitosan showed higher in firmness (1.63 kg) and pectin content ($0,58g\%$) than the control (1.03 kg, $0.44g\%$). For the total soluble acid and pH, the tomatoes coated with chitosan were higher in oxalic acid ($0.17 g\%$) than the control ($0.15 g\%$) and the latter were higher in the pH than the former, when they were stored for 18 days.

연마방법에 따른 복합레진의 활택도에 관한 연군 -Atomic Force Microscope를 이용한 연구

김형섭,우이형,Kim, Hyeong-Seob,Woo, Yi-Hyung 대한치과보철학회 1997 대한치과보철학회지 Vol.35 No.4

This study was undertaken to compare by Atomic Force Microscope the effects of various finishing and polishing instruments on surface roughness of filling and veneering composite resins. Seven composite resins were studied : Silux Plus (3M Dental Products, U.S.A.), Charisma (Heraeus Kulzer, Germany), Prisma THP (L.D.Caulk, Dentsply, U.S.A.), Photoclearfil (Kuraray, Japan), Cesead (Kuraray, Japan), Thermoresin LC (GC, Japan), Artglass (Heraeus Kulzer, Germany). Samples were placed and polymerized in holes (2mm thick and 8.5mm in diameter) machined in Teflon mold under glass plate, ensuring excess of material and moulded to shape with polyester matrix strip. Except control group (Polyester matrix strip), all experimental groups were finished and polishied under manufacturer's instructions. The finishing and polishing procedure were : carbide bur (E.T carbide set 4159, Komet, Germany), diamond bur (composite resin polishing bur set, GC, Japan), aluminum-oxide disc (Sof-Lex Pop-On, 3M Dental Products, U.S.A.), diamond-particle disc (Dia-Finish, Renfert Germany), white stone bur & rubber point( composite finishing kit, EDENTA, Swiss), respectively. Each specimens were evaluated for the surface roughness with Atomic Force Microscope (AutoProbe CP, Park Scientific Instruments, U.S.A.) under contact mode and constant height mode. The results as follows : 1. Except Thermoresin LC, all experimental composite resin groups showed more rougher than control group after finishing and polishing(p<0.1). 2. A surface as smooth as control group was obtained by $Al_{2}O_{3}$ disc all filling composite resin groups except Charisma and all veneering composite resin groups except Thermoresin LC(p<0.05). 3. In case of Thermoresin LC, there were no statistically significant differences before and after finishing and polishing(p>0.1). 4. Carbide bur, diamond bur showed rough surfaces in all composite resin groups, so these were inappropriate for the final polishing instruments.

제 2 발표장 : 나노결정 구리의 기계적 성질의 복합재료모델에 관한 연구

김형섭,조성석,천병선 ( H . S . Kim,S . S . Cho,B . S. Chun ) 한국복합재료학회 1996 한국복합재료학회 학술발표대회 논문집 Vol.- No.2

우울증 치료에 있어서 약물의 Combination과 Augmentation 전략

김형섭,Kim, Hyeong-Seob 대한생물정신의학회 2000 생물정신의학 Vol.7 No.2

Even the pharmacotherapy is more effective than placebo for the treatment of depression, the outcome of pharmacoltherapy remains unsatisfactory for many patients. Apart from side effects, there are two major limitations of antidepressant therapy. One is the delayed onset of improvement and another is partial response. In order to address these clinical dilemmas, many psychiatrists more commonly employ add-on therapy. In past, the practice of using multiple drugs to enhance treatment response was called polypharamcy, and was disparaged as poor clinical practice. However, with improved understanding of how drugs affects the central nervous system and increased communication in journals and on computer networks about the relative merits of specific combinations, the scientific basis for the combining drugs is being defined. Indeed, the use of multiple medications as a stratege to enhance response has become both acceptable and widespread now a days. It is now referred to more positively as add-on therapy, co-medication, combination therapy, or drug augmentation. Thus, as the methods of practical strategies for treatment of depression, switching classes antidepressant drugs, combination therapy, augmentation strategies and brief treatment algorithm will be presented with items of considerations. However, when combination of drugs being tried, knowledges about the action of mechanism, pharamcokinetics, and pharmacodynamics are essential to cope with the possible adversive reactions and to get the appropriate responses for the treatment of depressive symptoms.