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Panax ginseng as an adjuvant treatment for Alzheimer’s disease
김현중,Seok-Won Jung,김석영,조익현,Hyoung Chun KIM,Hyewhon Rhim,김만호,나승열 고려인삼학회 2018 Journal of Ginseng Research Vol.42 No.4
Longevity in medicine can be defined as a long life without mental or physical deficits. This can be prevented by Alzheimer’s disease (AD). Current conventional AD treatments only alleviate the symptoms without reversing AD progression. Recent studies demonstrated that Panax ginseng extract improves AD symptoms in patients with AD, and the two main components of ginseng might contribute to AD amelioration. Ginsenosides show various AD-related neuroprotective effects. Gintonin is a newly identified ginseng constituent that contains lysophosphatidic acids and attenuates AD-related brain neuropathies. Ginsenosides decrease amyloid b-protein (Ab) formation by inhibiting b- and g-secretase activity or by activating the nonamyloidogenic pathway, inhibit acetylcholinesterase activity and Abinduced neurotoxicity, and decrease Ab-induced production of reactive oxygen species and neuroinflammatory reactions. Oral administration of ginsenosides increases the expression levels of enzymes involved in acetylcholine synthesis in the brain and alleviates Ab-induced cholinergic deficits in AD models. Similarly, gintonin inhibits Ab-induced neurotoxicity and activates the nonamyloidogenic pathway to reduce Ab formation and to increase acetylcholine and choline acetyltransferase expression in the brain through lysophosphatidic acid receptors. Oral administration of gintonin attenuates brain amyloid plaque deposits, boosting hippocampal cholinergic systems and neurogenesis, thereby ameliorating learning and memory impairments. It also improves cognitive functions in patients with AD. Ginsenosides and gintonin attenuate AD-related neuropathology through multiple routes. This review focuses research demonstrating that ginseng constituents could be a candidate as an adjuvant for AD treatment. However, clinical investigations including efficacy and tolerability analyses may be necessary for the clinical acceptance of ginseng components in combination with conventional AD drugs.
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김현중 ( Hyun Jung Kim ),김형식 ( Hyoung Sik Kim ),이홍 ( Hong Lee ),문성기 ( Seok Tae Lim ),임석태 ( Sung Gi Moon ),박지현 ( Ji Hyun Park ),이흥범 ( Heung Bum Lee ),이용철 ( Yong Chul Lee ),이양근 ( Yang Keun Rhee ) 대한결핵 및 호흡기학회 1997 Tuberculosis and Respiratory Diseases Vol.44 No.5