피부화상에 의한 피부 및 간의 조직학적 변화에 관한 연구

김한수,김상수,김용권,Kim, Han-Soo,Kim, Sang-Soo,Kim, Yong-Kwon 대한물리치료과학회 2001 대한물리치료과학회지 Vol.8 No.1

In order to investigate a pathogenesis of liver damage induced by skin burn, thermal injury was induced by scald burn on entirely dorsal surface in rats (total body surface area 30%) except for inhalated injury. At 5 and 24 h after scald bum, biochemical assay and morphological changes in skin tissue, serum and liver tissue were examined. The effects of bum injury on the levels of glutathione, lipid peroxide and on the activities of oxygen free radical generating and scavenging enzymes have been determined in association with observing of histologic and ultrastructural changes, measuring the protein concentration in plasma, and counting the number of intravascular polymorphonuclear leukocytes. The activity of xanthine oxidase, an enzyme of oxygen free radical generating system. was elevated (p<0.01) in serum, but not in skin and in liver tissue. Futhermore, thermal injury decreased not only the protein concentration in plasma but also the number of leukocytes, that indicates induction of edema formation with protein exudation and inflammation by neutrophil infiltration into the internal organs. These data suggest that acute dermal scald burn injury leads to liver damage, that is related to elevation of xanthine oxidase activity in serum. Xanthine oxidase may be a key role in the pathogenesis of liver damage induced by skin burn.

몰로키아 분말을 첨가한 밀·보리 혼합 식빵의 제조 및 생리활성 평가

김한수,김영호,김애정,Kim, Han soo,Kim, Young Ho,Kim, Ae Jung 한국식품영양학회 2015 韓國食品營養學會誌 Vol.28 No.4

This study was performed to produce WBM (wheat and barley mixture) bread containing molokhia powder with quality characteristics and antioxidant activities. Analysis of the chromaticity of WBM prepared with molokhia powder showed that; the lightness and redness were decreased, but yellowness was increased. In mechanical properties, hardness, gumminess, and chewiness were significantly increased as the amount of molokhia powder was increased. However, cohesiveness was significantly decreased. In sensory evaluation, WBM bread containing 1.5% of molokhia powder (MB1.5) showed an overall high preference level. The total polyphenol content of molokhia powder EtOH extract and MB1.5 were 29.19 and 58.18 mg TAE/g, respectively. The total flavonoid contents of molokhia powder EtOH extract and MB1.5 were 20.62 mg and 33.25 mg RE/g, respectively. The radical scavenging ability ($IC_{50}$) of DPPH ($IC_{50}$) for molokhia powder EtOH extract and MB1.5 was 31.04 and $58.18{\mu}g/mL$, respectively while that of ABTS was 33.25 and $54.15{\mu}g/mL$, respectively. The ${\alpha}-glucosidase$ inhibitory effects of molokhia powder EtOH extract and MB1.5 were 494.88 and $814.88{\mu}g/mL$, respectively. MB bread containing 1.5% molokhia powder showed antioxidative effects and ${\alpha}-glucosidase$ inhibitory activity, meaning that not only molokhia but also MB1.5 bread has the potential to prevent chronic degenerative diseases such as diabetes.

위식도접합부선암의 임상병리학적 특성

김한수,정오,박영규,김동의,류성엽,김영진,Kim, Han-Su,Jeong, Oh,Park, Young-Kyu,Kim, Dong-Yi,Ryu, Seong-Yeop,Kim, Young-Jin 대한위암학회 2008 대한위암학회지 Vol.8 No.4

목적: 위식도접합부선암의 임상병리학적 특성은 서구와 아시아 간의 많은 차이를 보인다고 알려져 있다. 그러나, 한국의 경우 위식도접합부선암의 유병율이 매우 낮고 이에 대한 연구 또한 부족하다. 따라서 저자들은 우식도접합부선암의 Siewert 분류에 따른 임상병리학적 특성을 조사하여 서구와 다른 국내 위식도접합부선암의 특성을 연구하고자 하였다. 대상 및 방법: 2004년 5월부터 2008년 2월까지 본원에서 위암으로 수술을 시행 받은 환자들을 대상으로 수술소견 및 병리 사진을 토대로 Siewert 분류법에 따라 위식도접합부선암을 분류하고, 의무기록을 바탕으로 환자들의 임상병리학적 특성들을 조사하였다. 결과: 위식도접합부선암은 전체 1,778예 중 70예(3.9%)였다. Siewert 1형은 3예(4.3%)로 매우 드물었으며, 2형과 3형이 각각 30예(42.8%) 37예(52.8%)였다. 2형이 3형에 비하여 평균연령이 높았으나(64세 vs 59세, P=0.049), 남녀비에는 차이가 없었다. 2형과 3형간에 Barrett 식도의 발현 정도나 Lauren 분류의 차이는 없었으나, 저분화암의 빈도는 3형에서 유의하게 높았다(P=0.045). 68예(97.1%)에서 근치적 절제가 시행되었으며, 각 아형간에 TNM 병기의 차이는 없었다. 결론: 국내의 위식도접합부선암은 매우 드물며 특히 1형의 유병율이 매우 낮다. 본 연구에서 서구의 보고와 부분적으로 일치하지 않는 병리학적 특성을 보였다. 향후 보다 많은 환자들을 대상으로 한국인의 위식도접합부선암의 특성을 연구할 필요가 있다. Purpose: Siewert's classification of adenocarcinoma of the esophagogastric junction (AEG) has been widely adopted, but there is a wide discrepancy of the clinicopathological features of AEG of the Asian patients as compared to that of the Western patients. The aim of this study was to investigate the clinicopathological characteristics of AEG according to the Siewert classification. Materials and Methods: Among the patients who underwent surgery for gastric carcinoma in our institution between May 2004 and February 2008, the AEG patients were selected based on their operation records and the photographs according to Siewert's classification. Results: There were 70 AEG patients (3.9%) among the total of 1,778 patients. There were 3 patients (4.3%) with type I, 30 patients (42.8%) with type II and 37 patients (52.8%) with type III. Curative resection (R0) was achieved in 68 cases (97.1%). No significant differences in gender, stage, Barrett's esophagus and the proximal margin were found between the patients with type II and type III AEG. The patients with type III were younger than the patients with type II (59 vs 64 years, respectively, P=0.049). Well differentiated histology (P=0.045) and the intestinal type (P=0.055) were significantly more frequent in the patients with type II as compared with that in the patients with type III. Conclusion: There was a striking difference of the Asian patients from the Western patients for the incidence of AEG (and especially type I). Some of the differences between type II and type III patients were similar to those of the previous Western studies. A large study is needed to investigate whether these features are typical in the Korean population.

가정운동 훈련프로그램이 노인의 균형증진에 미치는 영향

김한수,구봉오,김상수,Kim, Han-Soo,Goo, Bong-Oh,Kim, Sang-Soo 대한물리치료과학회 2002 대한물리치료과학회지 Vol.9 No.1

The purpose of this study was to investigate the effects of home exercise program on the improvement of balance in the elderly. Subjects were twenty members living in Daegu (10 males, 10 females), between 65 and 81 years of age. The subjects for the experimental group were participated in the home exercise program for 8 weeks, between April 2001 and June 2001. The results of this study were as follows: After the exercise program, balance ability by CTSIB in the experiment group improved with no statistical significance. On the other hand, balance ability by OLST was significantly improved in the condition with open eyes than dosed eyes. Balance ability by OLSTR was improved 37.2% (p<0.001) on the hard surface with open eyes and improved 41.1% (p<0.01) on the soft surface with open eyes. Balance ability by OLSTL improved 37.1% (p<0.001) on the hard surface with open eyes and improved 72.5% (p<0.001) on the soft surface with open eyes. Balance ability by BBT also improved 1.7% (p<0.05).

영국 정부의 공공 건설사업 효율화 전략

김한수,Kim, Han-Su 한국건설관리학회 2014 한국건설관리학회 논문집 Vol.15 No.3

발성장애: 후두내시경 검사에서 놓치기 쉬운 성대점막질환

김한수,Kim, Han-Su 대한후두음성언어의학회 2010 대한후두음성언어의학회지 Vol.21 No.1

Dysphonia is a medical terminology for voice disorders characterized by hoarseness, harshness, weakness, or even loss of voice ; any impairment in ability to produce voice sounds using the vocal organs, larynx, The causes of dysphonia can be classified into two groups, organic and functional. Functional dysphonia includes spasmodic dysphonia, muscle tension dysphonia, mutational dysphonia and conversion dysphonia, etc, The findings of laryngoscopy in these dysphonia are almost normal. Therefore, physicians should diagnosis these diseases from careful history taking and abundant understandings about the phonation pattern, Organic dysphonia is caused by anatomical problems in the larynx, especially on the vocal fold, Some lesions, however, are not easily found because these lesions are too small, or located on the lower lip of vibrating vocal fold. Laryngopharyngeal reflux induced laryngitis, vascular lesions, sulcus vocalis, vocal atropy including presbylaryngis, and mucosal tears are common lesions easily missed in laryngoscopy, Therefore, a high index of suspicion is necessary to avoid missing vocal fold mucosal lesions, and the strobovideolaryngoscopy is indispensable in making the diagnosis,

다운제품의 선택과 취급

김한수,Kim, Han-Su 기술표준원 2005 기술표준 Vol.37 No.-

신 전기설비기술기준에 근거한 전기설비 적합성평가시스템 운영방안

김한수,Kim, Han-Su 대한전기협회 2006 전기저널 Vol.- No.351

전산해석을 이용한 부분 보강된 CFT 기둥의 폭발저항성능 평가

김한수,위해환,Kim, Han-Soo,Wee, Hae-Hwan 한국전산구조공학회 2015 한국전산구조공학회논문집 Vol.28 No.5

In this paper, the blast resisting performance of partially reinforced CFT columns was compared with the normal CFT columns to evaluate the effect of reinforcing with steel plates. Autodyn which is a specialized hydro-code for analysis of explosion and impact was used to simulate the structural behavior of the CFT columns under the blast loadings. The interaction between concrete and surrounding steel plates was modeled with friction and join option to represent the realistic damage of columns. According to the analysis, the partially reinforced CFT column showed enhanced blast resisting performance than the normal CFT columns. Also the improvement of blast resisting performance was depended on the height of reinforcing steel plates. 본 논문에서는 부분 보강된 CFT 기둥의 폭발저항성능을 일반 CFT 기둥과 비교하여 강판 보강의 효과를 확인하였다. 폭발하중을 받는 CFT 기둥의 구조해석에는 폭발과 충돌 해석을 위한 특수한 하이드로코드인 Autodyn을 사용하여 수치해석을 수행하였다. 콘크리트와 이를 둘러싸고 있는 강판 사이의 상호작용을 모델링하는 여러 방법이 있다. 본 연구에서는 기둥의 실제 파괴를 표현하기 위해 마찰 옵션 및 조인 옵션으로 모델링하였다. 해석에 따르면, 부분 보강된 CFT 기둥은 일반 CFT 기둥에 비해 더 나은 폭발저항효과를 나타내었다. 보강 CFT 기둥의 폭발저항성능은 콘크리트를 둘러싸고 있는 부분 보강된 강판의 높이가 높을수록 향상되었으며 CFT 기둥의 단면 크기 이상으로 보강할 것을 추천한다.

음성인식프로그램을 이용한 무후두 음성의 말 명료도와 병적 음성의 수술 전후 개선도 측정

김한수,최성희,김재인,임재열,최홍식,Kim, Han-Su,Choi, Seong-Hee,Kim, Jae-In,Lee, Jae-Yol,Choi, Hong-Shik 대한후두음성언어의학회 2004 대한후두음성언어의학회지 Vol.15 No.2

Background and Objectives : The purpose of this study was to examine objectively pre and post operative voice quality evaluation and intelligibility of alaryngeal voice using speech recognition program, HUVOIS. Materials and Methods : 2 laryngologists and 1 speech pathologist were evaluated 'G', 'R', 'B' in the GRBAS sclae and speech intelligibility using NTID rating scale from standard paragraph. And also acoustic estimates such as jitter, shimmer, HNR were obtained from Lx Speech Studio. Results : Speech recognition rate was not significantly different between pre and post operation for pathological vocie samples though voice quality(G, B) and acoustic values(Jitter, HNR) were significantly improved after post operation. In Alaryngeal voices, reed type electrolarynx 'Moksori' was the highest both speech intelligibility and speech recognition rate, whereas esophageal speech was the lowest. Coefficient correlation of speech intelligibility and speech recognition rate was found in alaryngeal voices, but not in pathological voices. Conclusion : Current study was not proved speech recognition program, HUVOIS during telephone program was not objective and efficient method for assisting subjective GRBAS scale.