온담탕 수성엑기스 중추억제작용에 관한 연구

김창덕(Chang Duck Kim),서성훈(Sung Hoon Seo),김수억(Soo Uck Kim) 경희대학교 동서약학연구소 1981 경희약대 논문집 Vol.9 No.-

N/A

산화질소가 Guinea Pig 의 Oddi 괄약근 운동에 미치는 영향에 관한 연구

김재선(Jae Seon Kim),현진해(Jin Hai Hyun),박영태(Young Tae Bak),김창덕(Chang Duck Kim) 대한내과학회 1996 대한내과학회지 Vol.50 No.1

Objectives: Recent studies indicate that intric oxide (NO) is a novel inhibitory neurotransmitter involved in several functions of many gastrointestianl organs. But only a few studies regarding its effect on sphincter of Oddi (SO) function were done until now. The aims of this study were to determine the effect of NO on motility of SO in L-arginine, a substrate of NO, inhibits SO motility, if NO is an important transmitter controlling the motility of SO. Methods: After laparotomy, a pressure-monitoring perfusion catheter was introduced into the lumen of SO through common bile duct and another catheter into the 2nd portion of duedenum through low body of stomach, and tonic pressure and phasic contractions of SO were monitored with TDS 8000 Manometry System(Sandhill Scientific, USA) during baseline period and after infusing a specific NO synthase inhibitor, N-nitro-L-arginine(Sigma: L-NNA, 5 mg/kg body weight), and cholecystokinin-8(Squibb: CCk, 25 or 50pmol/kg body weight). Results: 1) Tonic pressure and phasic contractions were significantly increased after administration of the NO synthase inhibitor. The response to CCk was enhanced by the NO synthase inhibitor. 2) Addigion of the substrate of NO suppressed the NO synthase inhibitor-induced increase of the tonic pressure and phasic contractions, and also suppressed the NO synthase inhibitor-induced enhancement of the response to CCK. 3) Administration of only NO substrate did not significantly change the tonic pressure and phasic contractions of resting stage and the response to CCK. Conclusion: These findings suggest that NO is an important neurotransmitter that is responsible for the inhibitory neural regulation of the SO motility. But the administration of the substrate of NO, L-arginine, alone does not seem to be useful for the management of SO dysfunction

식도정맥류 경화요법과 위점막 변화

김재선,김창덕,현진해 ( Jae Seon Kim,Chang Duck Kim,Jin Hai Hyun ) 대한소화기학회 1992 대한소화기학회지 Vol.24 No.5

Endoscopic features of gastric mucosa in patients with various kinds of liver diseae have caught the attention of investigators in recent past. Gastric mucosal changes are frequently observed in cirrhotic patients and have been related with portal hypertension. Although controversial results have recently been reported, much evidence exists suggesting that the underlying alteration is a mucosal vasculopathy characterized by vascular ectasis, whereas mucosal inflammation have been reported to be infrequent. In evaluating gastric mucosal changes and assuming gastric mucosal blood flow as its cause, the author observed the fiderscopic mucosal findings in 71-liver cirrhosis patients with portal hypertension. The aim of study was to investigate the relationship between variceal form and incidence of gastric mucosal changes, mucosal findings before and after sclerotherapy, gastric mucosal changes according to degree of mucosal destructions of esophageal varices, duration of disappearance of gastric mucosal changes, There was no singificant relationship between the presence of gastropathy and the degree of esophageal varices. Before sclerotherapy, incidence of gastropathy was mosaic pattern 46.4%, hyperemia 15.5%. Sclerotherapy of esophageal varices was significantly increased the incidence and severity of gastropathy. The more destructions of esophageal varices by sclerotherapy were severe, the more time that mucosal changes of post0sclerot herpy returned to those of pre-sclerotherpay were significantly delayed. In conclusion, these observation suggests that the endoscopic changes of the gastric mucosa in patienst with portal hypertension were influenced by the gastric mucosal blood flow.

췌장염 췌장염 - 원인과 발생기전 -

김창덕 ( Chang Duck Kim ) 대한소화기학회 2005 대한소화기학회지 Vol.46 No.5

대장 용종에서 cyclooxygenase - 2 와 vascular endothelial growth factor ( VEGF ) 의 발현

이창우(Chang Woo Lee),이구(Goo Lee),김동훈(Dong Hoon Kim),전훈재(Hoon Jai Chun),서정일(Jeong Ill Suh),양창헌(Chang Heon Yang),김수근(Soo Keun Kim),김창덕(Chang Duck Kim),류호상(Ho Sang Ryu),현진해(Jin Hae Hyun),김한겸(Han Kyeon Kim) 대한내과학회 2001 대한내과학회지 Vol.61 No.3

Background : Recent studies showed that non-steroidal antiinflammatory drug may reduce the risk of colorectal cancers. So its potential target, cyclooxygenase (COX)-2 in colorectal cancers has been widely investigated. However, the rate and patterns of COX-2 expression in colorectal polyps have been quite variable among study groups. Furthermore, its role has not been established. The study aim is to investigate the expressions of COX-2 and vascular endothelial growth factor (VEGF) and to evaluate the role of COX-2 in colorectal polyps. Methods : Fifty-seven colorectal polyps from endoscopic polypectomy or surgical resection were enrolled. Polyps were as follows; 9 were hyperplastic polyps, 14 mild, 26 moderate dysplasia, 8 high grade adenomas (5 severe dysplasia, a carcinoma in situ, and two intramucosal carcinomas). They were stained for COX-2 and VEGF by immunohistochemistry. The intensity of staining according to histologic grades and size of polyp was semi-quantitatively assessed. Results : COX-2 was expressed in 18 cases (31.8%) by dysplastic epithelium and 29 cases (50.9%) by interstitial cells. Epithelial COX-2 expressions were significantly related to histologic grades and size, and begun at moderate dysplasia actually. Interstitial COX-2 was little related to histologic grades and size. VEGF was expressed in 35 cases (61.4%). There was close relationship between epithelial COX-2 and VEGF expressions. Conclusion : COX-2 is expressed both in dysplastic epithelium and interstitial cells of colorectal polyps. Our results suggest that epithelial COX-2 expression may be playing a role in tumorigenesis of colorectal polyp, possibly involved in angiogenesis with VEGF.(Korean J Med 61:240-248, 2001)

췌장염에서 발생한 가성동맥류의 임상 양상: 단일기관 경험 및 국내문헌 고찰

김지현 ( Ji Hyun Kim ),김재선 ( Jae Seon Kim ),김창덕 ( Chang Duck Kim ),이홍식 ( Hong Sik Lee ),조영직 ( Young Jig Cho ),이종섭 ( Jong Sup Lee ),최도원 ( Do Won Choi ),한우식 ( Woo Sik Han ),김연호 ( Youn Ho Kim ),연종은 ( Jong E 대한소화기학회 2007 대한소화기학회지 Vol.50 No.2

Background/Aims: Pseudoaneurysm is a life-threatening complication of chronic or acute pancreatitis. This study was undertaken to evaluate the clinical features of pseudoaneurysm complicating pancreatitis. Methods: We reviewed the medical records of 7 patients diagnosed as pseudoaneurysms with chronic pancreatitis in Korea University Guro and Anam Hospital from January 1995 to March 2006 and analyzed their demographics, clinical courses and outcomes. Results: All patients were men and mean age was 54.6 years (range, 43-67 years). All the cases occurred in the setting of chronic alcoholic pancreatitis complicated by pseudocyst. Abdominal pain was the unique initial clinical symptom in 5 cases, hematemesis in 1 case, and simultaneous abdominal pain with hematemesis in 1 case. Bleeding into pseudocyst developed in 5 cases, flowing into duodenum through pancreatic duct in 1 case and rupture into the descending colon in 1 case. Mean duration between onset of symptom and diagnosis of pseudoaneurysm was 7.8 days (range, 1-23 days). Six cases were diagnosed by abdominal computed tomography disclosing characteristic finding of focal high density area in the pseudocyst. Pulsed doppler abdominal sonography was performed before computed tomography in 3 cases and results were negative in 2 cases. Transcatheter arterial embolizations were initially performed in 6 cases, and there was no recurrent bleeding except one case of splenic infarction. Distal pancreatectomy was initially performed in 1 case. Conclusions: Pseudoaneurysms complicating chronic pancreatitis shows various clinical features. Transcatheter arterial embolization can be recommended as a primary therapeutic modality. (Korean J Gastroenterol 2007;50:108-115)

백서에서 날콩 투여에 따른 췌장 외분비 기능의 변화

김광희 ( Kwang Hee Kim ),김영식 ( Young Sik Kim ),김창덕 ( Chang Duck Kim ),현진해 ( Jin Hai Hyun ) 대한소화기학회 1999 대한소화기학회지 Vol.33 No.3

Background/Aims: The aim of this study was to examine pancreatic exocrine function in the ra treated with raw soybean (RS). Methods: There were six groups as follows: Group 1 was the contro group. Group 2 and 3 were given RS diet for 1 and 2 weeks, respectively. Group 4, 5 and 6 wer given normal chow diet for 5, 7, and 14 days, respectively, after RS diet for 2 weeks. Thei pancreatic juice was collected in basal and cholecystokinin (CCK, 50, 100, and 200 pmol ·kg-1 ·hr-1 stimulation period. Apoptosis was confirmed with TUNEL stain. Results: Feeding RS significantly increased wet weight of pancreas and basal pancreatic exocrine secretion. When the diet was changed to a normal chow diet, the pancreas was regressed and basal seretion was decreased. The responses of pancreatic flow to CCK stimulation in both grown and atrophic groups were not different from that of the control. However, pancreatic amylase response to CCK in both groups was significantly reduced. Apoptosis was increased in atrophic groups. Conclusions: RS administration increased pancreatic exocrine secretion, but the secretion was decreased after changing to normal diet Pancreatic amylase response to exogenous CCK stimulation in both grown and atrophic states was significantly reduced. (Kor J Gastroenterol 1999;33:395 - 403)

우리나라 담석증의 역학에 관한 연구 ; 전국적 다기관 협동 조사 성적

김명환 ( Myung Hwan Kim ),오희철 ( Hee Choul Ohrr ),정재복 ( Jae Bock Chung ),김창덕 ( Chang Duck Kim ),강진경 ( Jin Kyung Kang ),고문수 ( Moon Soo Koh ),김남재 ( Nam Jae Kim ),김대곤 ( Dae Ghon Kim ),김성국 ( Sung Kook Kim ),김 대한소화기학회 1999 대한소화기학회지 Vol.32 No.5

Background/Aims: To understand the epidemiologic characteristics of gallstone disease in Korea and to evaluate the chronological changes of gallstone disease, the authors performed this prospective nationwide cooperative study. Methods: The subjects were 1,263 patients with gallstone. They were hospitalized at 19 hospitals in Korea from February to July, 1997. The study protocals were recorded on 1,263 patients and gallstones were removed from 1,133 patients and their chemical compositions were analyzed. Results: Among total patients with gallstone, the proportions of patients with gallbladder, common bile duct (CBD) and intrahepatic duct (IHD) stones were 64.0%, 21.9%, and 14.1%, respectively. Male to female ratio was 1 versus 1.3. The gallbladder stones were categorized as cholesterol (58.1%), black pigment (25.2%) and brown pigment (12.1%) stones. The CBD stones were classified into brown pigment (76.1% ), cholesterol (18.4%) and black pigment (3.5%) stones.

건강 성인에서 라니티딘(300mg)과 오메프라졸(10mg, 20mg)의 위식도역류 및 위내 pH에 대한 효과

김영선(Young Sun Kim),송치욱(Chi Wook Song),김윤홍(Yoon Hong Kim),김혜랑(Hye Rang Kim),김윤배(Yun Bae Kim),허병원(Byung Won Hur),이정환(Jung Whan Lee),진윤태(Yoon Tae Jeen),김창덕(Chang Duck Kim),류호상(Ho Sang Ryu),현진해(Jin Hai Hy 대한소화기기능성질환·운동학회 2000 Journal of Neurogastroenterology and Motility (JNM Vol.6 No.2

N/A Background/Aims : This study was done to compare the effects of Omeprazole (OMD) 10 or 20 mg with Ranitidine(RAN) 300 mg on intragastric acidity and gastroesophageal reflux in healthy subjects. Methods : Ten healthy male volunteers were studied after administrations of 5 days dosing with either RAN 300 mg, OMD 10 mg or 20 mg, once each morning. On the 5th day, intragastric pH and lower esophageal pH were measured by a dual channel antimony pH catheter for 10 hours. Results : Gastroesophageal reflux was reduced after administrations of RAN 300 mg, OMD 10 mg or 20 mg (p<0.05) and there was no significant difference among the three drugs (p>0.05). The gastric holding time of pH >4 was significantly prolonged over fasting and postprandial periods after RAN 300 mg, OMD 10 mg or 20 mg administrations (p<0.05). OMD 20 mg showed the most potent effect on gastric acid suppression (p<0.05), but there was no significant difference between RAN 300 mg and OMD 10 mg (p>0.05). OMD administrations (10 mg or 20 mg) exhibited a more potent effect on gastric acid suppression during the postprandial period than RAN 300 mg (p<0.05). Conclusions : OMD 10 mg was as potent as RAN 300 mg on inhibition of gastric acid, but less potent than OMD 20 mg. There was no difference among the three drugs in regard to gastroesophageal reflux in healthy subjects.

보리수나무 뿌리혹으로부터 Frankia EuIKI 공생균주의 분리

김성천(Sung Chun Kim),구창덕(Chang Duck Ku),박민철(Min Chul Park),김준호(Chun Ho Kim),송승달(Seung Dal Song),안정선(Chung Sun An) 한국식물학회 1993 Journal of Plant Biology Vol.36 No.2

The root nodules of Elaeagnus umbellata were coralloid-shape due to repeated dichotomous branching of nodule meristem. The filamentous endophyte with vesicle cluster ranging from 30 ㎛ to 60 ㎛ in diameter was present only in the cortical cells. The isolated endophytes in vitro culture showed typical Frankia morphology, consisting of highly branched hyphae ranging from 0.8 ㎛ to 1.0 ㎛ in diameter, terminal and intraphyphal sporangia varing in shape and size up to 60 ㎛ in length and laminated vesicles. Its infectivity and effectivity were confirmed by induction of nitrogen-fixing root nodules on the inoculated seedlings of two Elaeagnus species. Consequently, the isolate was confirmed as a true symbiont of Elaeagnus umbellata root nodule and named Frankia EuIK1.