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김종윤,서정기,고광욱,최용,정해일,윤회상,김용일 대한신장학회 1985 Kidney Research and Clinical Practice Vol.4 No.1
The following results were obtained by the retrospective clinicopathological analysis of 20 cases of membranous nephropathy associated with hepatitis B antigenemia in children. 1) The mean age of onset was 5 years 9 months, and male to female ratio was 18 to 2 with marked male preponderance. 2) Hepatitis Be antigen was positive in all 17 cases tested, reasonably high enough to speculate that the subepithelial deposit of the membranous nephropathy is related to hepatitis Be antigen. 3) Edema(65%), edema and gross hematuria(30 %) were the most common presenting symptoms. 4) 19 out of 20 cases showed nephrotic syndrome during the clinical courses, and 8 cases(40%) showed hypocomplementemia. 5) Pathologically, hepatitis B virus antigenemia associated membranous nephropathy was different from the idiopathic membranous nephropathy by its presence of election dense deposits in the sites other than subepithelial portion. 6) Steroid did not provide any prolonged beneficial effect. Because there is an increased risk of persistent hepatitis B virus antigenemia with steroid treatment, steroid seems not be recommended in hepatitis B virus antigenemia associated membra- nous nephropathy at present.
김종윤,문희선,이병권,윤성보,최의영,윤영원,홍범기,임세중,권혁문,민필기 연세대학교의과대학 2010 Yonsei medical journal Vol.51 No.5
Purpose: Metabolic syndrome (MS) has been reported as a potential risk factor of coronary artery disease (CAD). The aims of this study were to assess whether there was a relationship between MS score and CAD angiographic severity, and to assess the predictive value of individual components of MS for CAD. Materials and Methods: We retrospectively enrolled 632 patients who underwent coronary angiography for suspected CAD (394 men, 61.0 ± 10.6 years of age). MS was defined by the National Cholesterol Education Program criteria with the waist criterion modified into a body mass index (BMI) of more than 25 kg/m2. The MS score defined as the number of MS components. CAD was defined as > 50%luminal diameter stenosis of at least one major epicardial coronary artery. CAD angiographic severity was evaluated with a Gensini scoring system. Results: Of the patients, 497 (78.6%) had CAD and 283 (44.8%) were diagnosed with MS. The MS score was significantly related to the Gensini score. High fasting blood glucose (FBG) was the only predictive factor for CAD. A cluster including high FBG,high blood pressure (BP), and low high-density lipoprotein cholesterol (HDL-C)showed the highest CAD risk. Conclusion: The MS score correlates with the angiographic severity of CAD. The predictive ability of MS for CAD was carried almost completely by high FBG, and individual traits with high BP and low HDLC may act synergistically as risk factors for CAD.
김종윤,엄효숙,김연희,김두한 대한피부과학회 2004 大韓皮膚科學會誌 Vol.42 No.4
Pigmeted spindle cell nevus (PSCN) is often interpreted as a Spitz nevus or misdiagnosed as a malignant melanoma. Some authors consider PSCN as a pigmented variant of Spitz nevus, but many dermatologists classify it as a separate disease. We report a case of pigmented spindle cell nevus which occurred in a 4-year-old boy. The lesion was a well-demarcated, 3×3㎜ sized, black macule on the dorswn part of the 4th finger, left hand. The histopathologic findings of the excisional biopsy specimen revealed the proliferation of uniform, spindle shaped, pigmented melanocytes at the dermoepidermal junction and sharply defined lateral margins. The pathologic features were consistent with PSCN. (Korean J Dermatol 2004;42(4):482~484)