애엽(艾葉) (Artemisia asiatica Nakai)의 혈압강하작용(血壓降下作用)

김윤호,신홍기,김기순,Kim, Yun-Ho,Shin, Hong-Kee,Kim, Kee-Soon 대한생리학회 1981 대한생리학회지 Vol.15 No.2

The wormwood is one of the plants which occur widely throughout the world. Though the precise data on the entire chemical composition of mugwort leaves are not available, the major principles which have been found so far include inulin, alkaloid, thujon, sesquiterpene and several vitamins. Santonin, a parasiticide, is one of the glucosides extracted from the limited species of wormwood. It has long been known in herb medicine that the plants of this family has not only strong hemostatic, analgesic and parasiticidal actions but also therapeutic effects for diarrhea, stomachache and asthma. In recent pharmaceutical botany the wormwood is introduced to have antipyretic and astringent actions also. The mugwort(Artemisia asiatica Nakai) is the most common species of wormwood that occurs in Korea. The usage of this edible leaves of mugwort is rather various. It is used not only for wormwood bath but also as forage, moxa and medicinal agents. Recently Kim et al reported from their study on the effect of mugwort on the motility of isolated intestine of rabbits that tonus and motility were markedly enhanced by mugwort but this effect of mugwort on intestinal motility was almost completely blocked by atropine suggesting that activity of mugwort was exerted through its cholinergic effect. It was the findings of Kim et al that prompted the authors to do the present experiment. The present study was undertaken to investigate effects of mugwort(Artemisia asiatica Nakai) juice on the respiration and blood pressure in cats. And also studied was the mechanism of depressor action of Artemisia asiatica Nakai Juice (AAJ). The results obtained are as follows; 1) It was observed that mean arterial blood pressure and heart rate were decreased markedly by AAJ. Following administration of 0.15 ml/kg and 0.3 ml/kg AAJ into cats the maximum depressor responses observed were $77.5{\pm}2.2\;mmHg$ and $94.0{\pm}3.7\;mmHg$ respectively. 2) Depressor responses to AAJ were blocked markedly by atropine whereas the responses were not affected by propranolol and dibenamine. Therefore it is strongly inferred that depressor action of AAJ results mainly from its cholinergic effect. This inference was further substantiated by the fact that heart rate change which invariably accompanies depressor responses to AAJ was almost completely abolished by atropinization. 3) After administration of AAJ into cats frequency of respiration was markedly increased while depth of respiration decreased during first 2-3 seconds.

중소기업의 기술혁신 지원을 위한 전문가(Project-Specialist)제도 도입 방안

김윤호,Kim Yoon-ho 한국정보통신학회 2004 한국정보통신학회논문지 Vol.8 No.7

IT중소기업(Small and Medium-size Enterprises)의 기술개발은 대학, 출연연구소 및 대기업의 기술 개발과는 달리 인력, 재원, 규모 둥에서 환경이 매우 열악하다. 중소기업들이 열악한 환경은 정부가 지원하는 기술개발 출연사업에 대한 과열경쟁을 불러오고, 기술개발 규모는 과제당 3억원 내외로 적은 예산을 다수의 기업에 나누어 지원하는 현상이 발생하고 있다. 다수 소액과제를 지원관리하면서 연구개발 내용보다는 기업의 부실화 둥 기술개발 외적인 관리에 치중하게 된다. 따라서 실태조사 등 불필요한 현장 감사가 진행될 수밖에 없는데, 감독목적의 실태조사보다 기술개발을 주관하는 중소기업의 기술애로 해소 및 상업화 등 노하우 지원이 시급한 실정이다. 따라서 중소기업의 실질적인 기술개발 지원을 위해서 대학이나 연구소 등에 근무하는 기술개발 및 상용화 전문가들을 중소기업의 기술개발 지원 전문가로 활용하는 방안을 제안한다. Small and Medium-size Enterprises's R & D Program progress is hard than the university, government R & D agency and big enterprises. this environment make heat competition among the small and medium-size enterprises and subsidies little budget for many enterprises. from the management agency of the Institute of Information Technology Assessment(IITA)'s most of the activities focusing to the enterprises management not R & D Program. so, this paper suggestion an adaption on the project specialist system for the small and mediumlTenterprises'stechnologyinnovation'.

압축공격에 강인한 칼라영상의 워터마킹

김윤호,Kim Yoon-Ho 한국정보통신학회 2005 한국정보통신학회논문지 Vol.9 No.3

본 논문에서는 변환영역 기반과 인간의 시각특성을 적용하여 압축에 강한 칼라 영상의 디지털 워터마킹 알고리즘을 제안하였다. 원영상을 RGB 채널로 분리한 후, HVS 특성을 고려하여 명암대비와 텍스처 특징을 분석한 후, 최적의 주파수영역을 선택하여 워터마크를 삽입하였다 전처리 과정은 2D DCT를 사용하였고, 워터마크는 시각적으로 인지가 가능한 특정 로고 형태의 이진 영상을 사용하였다. 외부공격 유형으로 JPEG 압축을 수행하여 실험한 결과, JPEG 압축 $60\%$까지 워터마크의 추출이 가능하였고 $90\%$ 이상의 상관도를 보였다. In this paper. digital watermarking algorithm based on human visual system and transform domain is presented. Firstly, original image is separated into RGB thannels, watermark is embedded into the coefficients of DCT so as to consider a contrast sensitivity and texture degrees. In preprocessing, DCT domain based transform is involved and binary image of visually recognizable patterns is utilized as a watermark. Consequently, experimental results showed that proposed algorithm is robust and imperceptibility such destruction attack as JPEG compression.

인후두역류질환 환자에서 8주 간의 양성자 펌프 억제제 사용에 따른 역류성 인후두염의 증상지수 및 소견점수의 변화양상에 대한 연구

김윤호,조일권,이상준,정필상,Kim, Yun-Ho,Cho, Il-Kwon,Lee, Sang-Joon,Chung, Phil-Sang 대한기관식도과학회 2009 大韓氣管食道科學會誌 Vol.15 No.1

Background and Objectives : Proton pump inhibitors(PPIs) improve the symptoms of laryngopharyngeal reflux(LPR). But there is little reports about the changes of each items in reflux symptom index (RSI) and reflux finding score (RFS) after PPIstreatment. The purpose of this study is to analyze the changes of pre- and post-treatment score in each RSI and RFS items after 8 weeks medication with proton pump inhibitors in laryngopharyngeal reflux patients. Methods : Prospective study. Among the patients who had visited the department of otolaryngology from January 2007 to December 2008, 91 patients who had shown scores greater than 13 on the RSI and/or 7 on the RFS were studied. All patients received PPIs once daily before breakfast for 8 weeks. RSI and RFS were assessed at initial, four weeks and eight weeks after medication. Result: All RSI items were improved (p < 0.05). The globus sense followed by throat clearing, heartburns and hoarseness showed high initial RSI score than other items. And globus sense, throat clearing, hoarseness and heartburn were improved significantly more than others items. But only posterior commissure hypertrophy of RFS was improved significantly more than others items. Conclusion: Empiric PPIs therapy reduced the RSI scores and more effective for symptoms such as globus sense, throat clearing, hoarseness and heartburn among suspected LPR patients. In RFS, only posterior commissure hypertrophy has improved significantly. However, the changes of each categories of RFS were minimal (average: 0.16), therefore clinical significance is restricted in RFS.

UML 다이어그램 도구를 위한 다이어그램 정보의 구축과 설계

김윤호,Kim, Yun-Ho 한국정보통신학회 2020 한국정보통신학회논문지 Vol.24 No.2

본 논문에서는 UML 다이어그램의 정보를 구문적으로 분석하여 클래스들의 정보를 구조적으로 구축하는 정보 저장소인 '메타 클래스 레포지토리 (MCR)'의 구현 방법을 제시한다. 구문적으로 분석된 클래스의 정보를 구조적으로 구축하기 위하여 수퍼 클래스인 '메타 클래스 (meta-class)'를 정의하고, 이들 메타 클래스들의 컬렉션으로 구성된 레포지토리를 구축하여 정보를 관리한다. 또한, MCR이 보유하고 있는 메타 클래스 정보에 기반하여 클래스에 상응하는 코드를 생성하기 위하여 '코드 생성 엔진 (CGE)'을 설계하여 제시한다. 코드 생성 엔진의 로직을 구성함에 있어서는 클래스에 대한 정보와 프로그래밍 언어의 구문 규칙이 합법적으로 조합되어 코드가 생성되어야 한다. 따라서, 이러한 클래스 다이어그램으로부터 코드를 생성하는 데에 MCR과 CGE가 통합적으로 협력하여 수행될 수 있도록 구현하는 방법을 제시한다. CGR의 동작 메커니즘에 대한 알고리즘을 유한 상태 머신 형태로 제시함으로써 CGE의 로직을 형식화하여 표현함과 동시에 구현 상의 용이함을 취할 수 있게 하였다. This paper presents a design of the Meta-Class Repository (MCR) which maintain syntactically analyzed and structured meta-class information from UML diagrams, and then proposes 'meta-class,' also known as super-class, to construct structured information analyzed syntactically. The MCR is a collection of these meta-classes which contains the information extracted from diagrams. This paper also presents a design of the Code Generation Engine (CGE) which roles generating codes corresponding classes from UML diagrams based on the MCR maintaining a collection of meta-classes which is syntactically-analyzed and constructed in previous process. The logics of CGE are designed to generate codes collaborated with MCR and CGE with integration. The logics of CGE mechanism is presented with the form of finite state machine to present the algorithms of code generation formally and have the advantages of simplicity and easiness in development.

판형열교환기의 세브론각에 따른 증발 열전달특성 및 압력강하에 대한 실험적 연구

김윤호,이규정,Kim, Yun-Ho,Lee, Gyu-Jeong 대한기계학회 2002 大韓機械學會論文集B Vol.26 No.2

Experiments on the evaporation heat transfer and pressure drop in the brazed type plate heat exchangers were performed using refrigerants R410A and R22. To investigate the geometric effect, plate heat exchangers with the same pitch and height but different 45$^{\circ}$, 35$^{\circ}$and 20$^{\circ}$chevron angles are used. Tests were conducted fur the ranges of the mass flux of refrigerant from 13 kg/m$^2$s to 34 kg/m$^2$s, the evaporation temperatures of 15$^{\circ}C$, 1$0^{\circ}C$ and 5$^{\circ}C$, vapor quality from 0.15 to 0.95 and the heat flux from 2.5 kW/m$^2$to 8.5 kW/m$^2$. The evaporation heat transfer coefficients and pressure drops were measured. Most of flow patterns are in the chum flow regime and become close to the annular flow for increasing the mass flux and the vapor quality. The heat transfer coefficient increases with increasing the evaporation temperature at a given mass flux in all plate heat exchangers. Also, the pressure drop increases with increasing the mass flux and the quality and decreasing the evaporation temperature and the chevron angle.

서비스 지향 아키텍처를 위한 경량 ESB 엔진의 설계 및 구현

김윤호,조성환,Kim, Yoon-Ho,Cho, Seong-Hwan 한국인터넷방송통신학회 2014 한국인터넷방송통신학회 논문지 Vol.14 No.6

Service Oriented Architecture(SOA) is a flexible structure which does not affect other services even when a specific service is changed. It provides the platform with neutral interfaces independent of any others, where services are loosely coupled in a standard way. While ESB (Enterprise Service Bus) is a key technology for service-oriented architecture, few research and development for ESB has been done. In this paper, we designed and implemented the key components of ESB such as mediation service, message oriented middleware service, operation service, monitoring service, application connection service, and database connection service. The performance evaluation was done by measuring the message processing time for the number of messages with various sizes. 서비스 지향 아키텍처란 서비스들이 표준 방식에 의해 서로 느슨하게 연결(loosely coupled)되어 특정 구현에 종속되지 않은 중립적인 인터페이스를 제공함으로써, 특정 서비스를 변경 하더라도 연결된 다른 서비스에는 영향을 주지 않는 유연한 구조를 의미한다. ESB(Enterprise Service Bus)는 서비스 지향 아키텍처를 실현하기 위한 중요한 관련 기술 중 핵심요소로서 위치를 확보해가고 있으나, 국내 서비스 지향 아키텍처를 위한 ESB에 대한 개발과 연구는 부족한 실정이다. 본 논문에서는 ESB의 중계 서비스, 전송서비스, 운영서비스, 모니터링 서비스, 애플리케이션 접속 서비스, 데이터 접속 서비스를 가능하게 하는 각 주요 응용 컴포넌트의 설계 및 구현을 하였으며, 메시지 건수에 대한 데이터의 크기별에 따른 처리시간을 측정하여 성능평가를 실시하였다.

저온 Cu/Ag-Ag/Cu 본딩에서의 Ag 나노막 효과

김윤호,박승민,김사라은경,Kim, Yoonho,Park, Seungmin,Kim, Sarah Eunkyung 한국마이크로전자및패키징학회 2021 마이크로전자 및 패키징학회지 Vol.28 No.2

차세대 반도체 기술은 이종소자 집적화(heterogeneous integration)를 이용한 시스템-인-패키징(system-inpackage, SIP) 기술로 발전하고 있고, 저온 Cu 본딩은 SIP 구조의 성능 향상과 미세 피치 배선을 위해서 매우 중요한 기술이라 하겠다. 본 연구에서는 porous한 Ag 나노막을 이용하여 Cu 표면의 산화 방지 효과와 저온 Cu 본딩의 가능성을 조사하였다. 100℃에서 200℃의 저온 영역에서 Ag가 Cu로 확산되는 것보다 Cu가 Ag로 확산되는 것이 빠르게 관찰되었고, 이는 저온에서 Ag를 이용한 Cu간의 고상 확산 본딩이 가능함을 나타내었다. 따라서 Ag 나노막을 이용한 Cu 본딩을 200℃에서 진행하였고, 본딩 계면의 전단 강도는 23.27 MPa로 측정되었다. System-in-package (SIP) technology using heterogeneous integration is becoming the key of next-generation semiconductor packaging technology, and the development of low temperature Cu bonding is very important for high-performance and fine-pitch SIP interconnects. In this study the low temperature Cu bonding and the anti-oxidation effect of copper using porous Ag nanolayer were investigated. It has been found that Cu diffuses into Ag faster than Ag diffuses into Cu at the temperatures from 100℃ to 200℃, indicating that solid state diffusion bonding of copper is possible at low temperatures. Cu bonding using Ag nanolayer was carried out at 200℃, and the shear strength after bonding was measured to be 23.27 MPa.

메시지 패턴에 기반한 UML 시퀀스 다이어그램의 자동 코드 생성 방법

김윤호,Kim, Yun-Ho 한국정보통신학회 2020 한국정보통신학회논문지 Vol.24 No.7

본 논문에서는 시퀀스 다이어그램의 메시지 패턴에 기반하여 자바 코드를 생성하는 방법을 제시하고자 한다. 시퀀스 다이어그램에서 메시지는 몇 가지 유형이 전형적으로 나타낸다. 따라서 이들 유형을 분류하여 패턴으로 정의하고, 이들 각 패턴의 메시지에 대한 정보를 분석하여 코드 변환을 하기 위한 메타 정보를 구축한다. 시퀀스 다이어그램 메시지의 구조적 정보를 분석한 '메타 메시지' 정보를 MetaMessage 데이터스토어에 구축하고, 이들 메타 메시지 정보로부터 구성되는 '메타 메소드' 정보를 MetaMethod 데이터스토어에 구축한다. 이 과정에서 메타 클래스 정보와 메타 오브젝트 정보가 함께 구축되고 사용된다. 각 패턴의 메타 정보에 기반하여 타겟 프로그래밍 언어의 문법에 따라 메시지에 상응하는 코드를 생성하게 된다. 또한, 기존 연구에서는 통합적으로 잘 다루지 않았던 분기와 반복에 대한 복합 패턴을 제시함으로써 기본 패턴과 통합된 코드 생성을 가능하게 한다. This paper presents a method for code generation of UML sequence diagrams based on message patterns. In the sequence diagrams, it is shown that messages are some types of forms typically. This paper classifies according to type as three patterns, and construct meta-information for code generation analysing structural infomation for each patterns. The meta-message of structural information (MetaMessage) is stored in the MetaMessage datastore and the meta-method information from the MetaMessage is stored in the MetaMethod datastore. And then, the structural information of MetaClass and MetaObject is constructed in each datastore too. For each pattern, this paper presents a method for code generation based on the meta information of message patterns and the syntax of target progamming language. Also, branching and looping that has been seldom handled integratedly in the previous works are handled as same as the basic patterns by classifying the branching pattern and the looping pattern for code generation integratedly.

Maxent 모델을 이용한 양봉꿀벌의 서울시 수분 잠재환경 분석

김윤호,조용현,배양섭,김다윤,Kim, Yoon-Ho,Cho, Yong-Hyeon,Bae, Yang-Seop,Kim, Da-Yoon 한국환경복원기술학회 2020 한국환경복원기술학회지 Vol.23 No.4

The honeybee serves for most entomophilous flowers. They are a core species for maintaining the ecological system. Though the urban ecological system needs bees' mediation of pollination as well, we have little understanding on how the honeybee reacts to the physical environments of an urban city. This study is a basic research to enhance the potential environment for pollination in an urban area and aims to review the urban environmental variables which are highly linked to the pollination mediations by the honeybee. The study composed a Maxent model by adopting nine urban environmental variables and the locations of the Apis mellifera's appearances around 52 spots in Seoul. The variables reflect the ecology of the Apis mellifera. Of the urban environmental variables used for the model composition, six variables were found as not having meaningful correlations with the Apis mellifera's appearances and finally, building coverage, actual vegetation and land cover were selected as the appearance variables of the Apis mellifera. The AUC, the reliability indicator of the final model was 0.791 (sd=0.077). And the importance data of the variables used for the model were 55.6%, 27.9%, and 16.5% for building coverage, actual vegetation and land cover, respectively. The result of the study showed that the building coverage has the highest correlation with the appearance of the honeybee. And, as per the actual vegetation, the artificially tree planted area as well as the cultivated field and meadow in an urban area were functioning as the most important environmental conditions for the honeybee to be inhabitable. The study is expected to be utilized as the base material for the urban planning and park green area planning to enhance the potential environment for pollination in an urban area.