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탄소층으로 캡슐화된 Ni나노입자 촉매의 CO<sub>2</sub> 메탄화 반응
김혜정,김승보,김동현,윤재랑,김민재,전상구,이경자,이규복,Kim, Hye Jeong,Kim, Seung Bo,Kim, Dong Hyun,Youn, Jae-Rang,Kim, Min-Jae,Jeon, Sang Goo,Lee, Gyoung-Ja,Lee, Kyubock 한국재료학회 2021 한국재료학회지 Vol.31 No.9
Carbon-encapsulated Ni catalysts are synthesized by an electrical explosion of wires (EEW) method and applied for CO<sub>2</sub> methanation. We find that the presence of carbon shell on Ni nanoparticles as catalyst can positively affect CO<sub>2</sub> methanation reaction. Ni@5C that is produced under 5 % CH<sub>4</sub> partial pressure in Ar gas has highest conversions of 68 % at 350 ℃ and 70 % at 400 ℃, which are 73 and 75 % of the thermodynamic equilibrium conversion, respectively. The catalyst of Ni@10C with thicker carbon layer shows much reduced activity. The EEW-produced Ni catalysts with low specific surface area outperform Ni catalysts with high surface area synthesized by solution-based precipitation methods. Our finding in this study shows the possibility of utilizing carbon-encapsulated metal catalysts for heterogeneous catalysis reaction including CO<sub>2</sub> methanation. Furthermore, EEW, which is a highly promising method for massive production of metal nanoparticles, can be applied for various catalysis system, requiring scaled-up synthesis of catalysts.
체외수정 환자에서의 난포액 및 혈중 혈관 내피 성장인자
박성재 ( Sung Jae Park ),기경도 ( Kyung Do Ki ),이효원 ( Hyo Won Lee ),이보연 ( Bo Yon Lee ),이선경 ( Seon Kyung Lee ),허주엽 ( Chu Yeop Huh ),김승보 ( Seung Bo Kim ) 대한산부인과학회 2006 Obstetrics & Gynecology Science Vol.49 No.9
목적: 난포생성에서 황체기능의 작용까지 여성생식과정의 여러 단계가 혈관생성에 관련되어 있다. 본 연구는 체외수정을 시행하는 환자에서 혈액 및 난포액내 VEGF (Vascular endothelial growth factor) 농도를 측정하고자 하였다. 연구 방법: 2003년 8월부터 2005년 7월까지 본원 불임클리닉에서 체외수정시술을 받은 29명의 환자를 대상으로 하였으며 과배란 유도는 GnRH agonist를 이용한 단기투여법 (short protocol)을 사용하였다. 난자 채취시에 혈액과 난포액을 채취하여 -60℃에서 보관하였다가 효소면역 정량법 (ELISA, enzyme-linked immunosorbent assay)으로 혈청과 난포액의 VEGF 농도를 측정하였다. 결과: 총 29명의 환자중 10명의 환자에서 임신이 되었다 (34.5%). 난포액내 VEGF 농도와 혈청내 VEGF 농도 및 연령 사이에는 상관계수 0.428로 유의한 양의 상관관계를 보였고, 난포액내 VEGF 농도와 난포수 및 채취된 난자수 사이에는 상관계수 -0.493로 유의한 음의 상관관계가 나타냈다. 하지만 난포액내 VEGF 농도와 혈청내 VEGF 농도는 상관관계를 보이지 않았다. 대상 여성 중 임신군과 비임신군을 비교하였을 때 난포액내 VEGF 농도는 비임신군에서 1468.38±727.33으로 임신군의 676.48±542.07에 비해 유의하게 높게 나타났다. 결론: 본 연구의 결과를 바탕으로 황체기에서의 호르몬 생성부전이나 난포액내 부적절한 환경으로 인하여 상승된 VEGF의 농도가 체외수정 (IVF-ET)의 결과와 연관되어 있는 것으로 사료된다. Objective: Several aspects of female reproduction, from folliculogenesis to corpus luteum function, are related to angiogenesis. The purpose of this study is to measure the concentrations of vascular endothelial growth factor (VEGF) in follicular fluid and serum in patients during In Vitro Fertilization - Embryo Transfer (IVF-ET) cycles. Methods: In our prospective study, twenty-nine patients who underwent in vitro fertilization by GnRH agonist short protocol were assessed at the our infertility clinic from Aug. 2003 to July 2005. Serum VEGF and follicular fluid VEGF levels were measured in all patients at the time of oocytes retrieval. The assay technique used in this study was ELISA for serum and follicular fluid VEGF. Results: Of 29 cycles, 10 cycles were pregnant (34.5%). A positive correlation existed for follicular fluid VEGF and chronologic age (r=0.428, p-value=0.021). Follicular fluid VEGF concentration showed an inverse relationship with the total number of oocytes retrieved and follicles (r=-0.493, p-value=0.007; r=-0.474, p-value=0.009). But there was no statistically significant relationship between follicular fluid VEGF concentration and serum VEGF concentration (ρ=0.347). Follicular fluid VEGF concentration was significantly higher in the non-pregnant group (1468.38±727.33 pg/mL) compared to the pregnant group (676.48±542.07 pg/mL) (p-value=0.003). Conclusion: Our data provide some of the evidences that elevated VEGF concentrations in the follicular fluid are associated with poor conception rates in the IVF-ET cycles.
자궁경부암에서 혈관 내피 성장인자 ( VEGF ) 및 VEGF Mrna 의 발현에 대한 연구
이선경(Seon Kyung Lee),김승보(Seung Bo Kim),지성길(Sung Gil Chi),염윤석(Yoon Seok Yum),이주희(Ju Hee Lee) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.1
N/A Objective : Angiogenesis, the formation of blood vessels by sprouting from pre-existing ones, is essential for the growth of solid tumors beyond 2~3mm in diameter and for tumor metastasis. Vascular endothelial growth factor (VEGF), is known as vascular permeability factor(VPF) and mediates vascularization and tumor-induced angiogenesis. This study examined the potential of growth, invasion, and metastasis of uterine cervical carcinomas associated with neovascularization. Methods : From January 1996 to December 1999, at the Department of Obstetrics and Gynecology, Kyung-Hee University Hospital, 37 uterine cervical carcinomas and 7 normal cervical tissues were obtained and the samples were immediately frozen and stored at -70℃. Immunohistochemical staining for VEGF was carried out to study VEGF localization, and the levels of VEGF subtype mRNAs were determined by quantitative RT-PCR in specimens. The relation between VEGF subtypes expression of cervical cancers was analysed. Results : The positive staining for VEGF is seen dominantly in the cytoplasm of the cancer cells, and faintly in interstitial cells. The intensity of staining was stronger in squamous carcinomas than in adenocrcinomas, but there was no significant difference (p>0.05). Quantitative RT-PCR analysis demonstrated significantly increased VEGF121/VEGF165 mRNA expression levels (>0.56/>0.72) in 21 (56.8%) and 15 (40.5%) of 37 cervical carcinomas comparing to control groups (mean: 0.28/0.36). There was no obvious relationship between VEGF121/VEGF165 mRNA expression levels and the clinical parameters examined including age, pathology, differentiation, tumor size, lymphovascular space invasion, LN involvement and invasion depth except clinical stage (p<0.05). Conclusions : The overexpression of VEGF mRNA may be an important contributing factor in cervical carcinomas. There is no significant differenece of VEGF mRNAs levels according to clinical parameters, so it seems that the expression of VEGF is involved in the promotion of angiogenesis on cervical cancer and plays an important role in early invasion.
김성훈(Seong Hoon Kim),진규섭(Kyu Seob Jin),이상욱(Sang Uk Yi),이선경(Seon Kyung Lee),허주엽(Ju Yeop Huh),김승보(Sung Bo Kim) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.2
Uterine torsion is defined as the mtation of more than 45。 around the long axis of the uterus or a rotation which is severe enough to produce symptoms. Torsion of the human pregnant uterus is a very rare complication. The diagnosis is problematic and is often made during a cesrean section due to inhibited labor. Torsion of the human pregnant uterus can be caused by myoma or other uterine abnormalities, ovarian cysts, adhesions, abnormal fetal presentations, or fetal abnormalities ( though no cause can be found in about 20% of cases ). Uterine torsion produces symptoms of varying severity depending on the degree of rotation, and duration of the pregnancy. High mortality rates for both mother and infant have been reported. We experienced one case of the torsion of term pregnant uterus and report this case with a brief review of the concerned literature.
선행 제왕절개 후의 질식 분만시 성공군과 실패군의 비교연구
최현수(Hyun Soo Choi),이상욱(Sang Wook Yi),오영승(Young Seung Oh),진규섭(Kyu seop Jin),이보연(Bo yon Lee),이선경(Seun Kyung Lee),허주엽(Chu Yeop Huh),김승보(Seung Bo Kim) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.10
제왕 절개의 비율은 최근 까지 지난 20년동안 증가되어 왔으며 이러한 증가는 반복 제왕 절개의 증가와 관련된 것이다. 최근 제왕 절개후 질식 분만에 관한 연구에서는 반복 제왕절개시 올 수 있는 수술 후 합병증, 산모 및 태아의 이환율의 증가 등과 비교해 이 시도가 비교적 안전한 방법으로 등을 보고 하고있는 반면 또한 제왕 절개후 질식 분만시 올 수 있는 자궁 파열과 이로 인한 태아와 산모의 위험성에 관한 보고도 있다. 이에 본원에서는 제왕 절개후 질식 분만을 원해 내원한 산모를 대상으로 성공군과 실패군 사이에 여러 요인을 비교 분석하여 성공에 관여한 인자를 예측하고자 하였다. 연구 대상은 1997년 3월부터 1999년 3월까지 선행 제왕 절개 후 질식 분만을 위해 내원한 환자중 질식 분만 시도시 위험성이 적다고 판단되는 120명의 산모를 대상으로 했으며 성공군과 실패군 사이에 산모의 나이, 제태 연령, 질식 분만한 과거력의 유무, 선행 제왕 절개의 적응증, 초음파로 예측한 태아 몸무게, 신생아 몸무게, 입원시 자궁 경부 상태, Bishop score, CPD index(Cephalopelvic disproportion Index)를 비교 분석 하였다. 120명의 산모중 87명(72.5%)이 성공 하였으며 33명(27.5%)이 실패 하였고 자궁 파열이나 열개와 같은 합병증은 발견되지 않았다. 두 대조군 사이에 산모의 나이(P=0.012), Bishop score(P=0.002), CPD index(P=0.015)에서 의미있는 차이를 보였으며 기타 요인에서는 의미있는 차이를 보이지 않았다. 결론적으로 선행 제절 이후 질식 분만 시도 시에 금기가 아닌 경우 입원시 X선 골반 계측을 통한 CPD index와 Bishop score을 통해 성공 가능성에 대한 예측에 도움을 줄 수 있으며 앞으로 이 요인들과 함께 다른 요인들과의 연관성에 대한 연구를 통해 선행 제왕 절개후 질식 분만 시도시에 올 수 있는 위험성을 줄일 수 있을 것으로 생각된다. 이상과 같은 연구 결과로 또한 추후 성공의 예후 인자로 사용되어 질 수 있고, 앞으로 이 시도의 성공과 관련된 다른 인자와의 연관성을 통한 면밀한 검토가 필요할 것으로 사료된다. Objectives: Vaginal birth or trial of labor after previous cesarean section has become one of the most remarkable changes in obstetric practice. The safety and efficacy of a trial of labor and vaginal birth after previous cesarean are well documented. The purpose of this report is to predict the likelihood of vaginal birth in patients undergoing a trial of labor after previous cesarean delivery using factors known at the time of hospital admission. Method: In this retrospective study, 120 women who attempted vaginal birth at Kyung-Hee University Hospital from March 1997 to March 1999. An attempt to identify possible prognostic factors for success of such a trial was made and we evaluated the variables of significant predictive value and the patients' characteristics in the success group and failure group of women who attempted VBAC. Result: 87 cases(72.5%) in 120 cases succeeded in VBAC and 33 cases(27.5%) failed. In this comparative groups in VBAC, there was significant difference in CPD index(cephalopelvic disproportion index) and Bishop score, but no significant difference in gestational age, the estimated fetal weight by sonography and newborn birth weight. Conclusion: In this study, Bishop score and CPD index and age may be useful and valid predictor of success in VBAC and this information could be particularly valuable. The CPD index may prove most important in determining if a vaginal birth should occur after a cesarean section because it can clearly identify some patients who need a repeat cesarean section.