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일개 이차 병원에서 치료한 소아 급성 세균성 위장염 원인 및 특징
김성윤 ( Sung Yoon Kim ),김현정 ( Hyun-jung Kim ),신은혜 ( Eun Hye Shin ),은병욱 ( Byung Wook Eun ),안영민 ( Young Min Ahn ),송미옥 ( Mi Ok Song ) 대한소아감염학회 2017 Pediatric Infection and Vaccine Vol.24 No.2
목적: 소아 급성 세균성 위장염은 흔히 급성 바이러스성 위장염에 비해 더 심각한 증상을 일으킬 수 있다. 본 연구는 소아 급성 세균성 위장염 환자의 원인을 조사하고, 임상 양상을 알아보고자 하였다. 방법: 2011년 1월부터 2014년 12월까지 서울에 위치한 1개 이차 병원에서 급성 위장염 증상으로 진료받은 소아 환자들의 대변을 서울시 보건환경연구원으로 보내어 원인균 검사를 시행하였다. 결과에 따른 임상적인 특성은 소아 환자들의 의무기록을 통해 후향적으로 조사하였다. 결과: 총 664 대변 샘플 중 183개(27.6%)에서 원인균이 분리되었다. 2012년부터 검사가 시행되었음에도 불구하고, 황색포도알균이 가장 흔한 원인균이었다(39.3%). 월별 검출률은 8월이 24.6%로 가장 높았다. 캄필로박터균의 연령군에 따른 검출률은 12-19세 군에서 가장 높았다(16.7%, P =0.04). 혈변을 보인 환자들 중에서 캄필로박터균이 가장 흔하게 분리되었다(31.0%, P =0.04). C-반응단백질을 비교 시 살모넬라속균 또는 캄필로박터균이 분리된 군이 황색포도알균 또는 병원성 대장균이 분리된 군에 비해서 더 높았다(5.7±0.6 mg/dL vs. 2.1±0.3 mg/dL, P<0.01). 결론: 황색포도알균, 병원성 대장균, 캄필로박터균, 살모넬라속균이 소아 세균성 위장염의 중요한 원인 균이었다. 연령에 따른 원인균 차이, 임상 증상, 염증 지표를 고려하는 것이 원인균을 추정하는 데 도움이 될 수 있겠다. Purpose: Acute bacterial gastroenteritis (ABG) can cause more severe symptoms than acute viral gastroenteritis in children. This study was aimed at determining the etiologic trends and to examine the clinical characteristics of ABG in children. Methods: We sent stool samples from the children with acute gastroenteritis who were treated at a secondary hospital located in Seoul, Korea between January 2011 and December 2014 to Seoul Metropolitan Government Research Institute of Public Health and Environment to find the causative organisms. Clinical characteristics of patient were analyzed through a medical records review. Results: Out of 664 stool samples, 183 (27.6%) yielded bacterial pathogens. Staphylococcus aureus was the most common bacterial pathogen, found in 72 cases (39.3%), even though it was only tested for since 2012. The monthly isolation rate was the highest (24.6%) in August. The isolation rate of Campylobacter spp. by patient`s age group was high (16.7%) in the 12- to 18-year-age group (P =0.04). In patients with bloody stool, Campylobacter spp. was the most commonly isolated (31.0%, P =0.04). When comparing C-reactive protein, the Salmonella spp.- or Campylobacter spp.-isolated group showed higher values than the S. aureus - or pathogenic Escherichia coli -isolated group (5.7±0.6 mg/dL vs. 2.1±0.3 mg/dL, P <0.01). Conclusions: S. aureus, Salmonella spp., pathogenic E. coli , and Campylobacter spp. were important pathogens of ABG among children. Considering the differences in pathogens found according to age, a clinical symptom and inflammation index might be helpful in assuming the causative organism.
다발성 관절염으로 발현된 혈관 면역 아구성 임파선증 1 예
송관규(Gwan Gyu Song),황선호(Seon Ho Hwang),김지훈(Ji Hoon Kim),이인홍(In Hong Lee),정성수(Sung Soo Jung),배상철(Sang Cheol Bae),유대현(Dae Hyun Yoo),고영혜(Young Hae Ko),김인순(In Soon Kim),김성윤(Seong Yoon Kim) 대한내과학회 1993 대한내과학회지 Vol.45 No.3
Angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) is a lymphoproliferative disorder with characteristic clinical features and lymph node histology. Arthritis is a uncommon clinical finding of AILD. We describert a patient with AILD whose initial presentation was a symmetrical polyarthritis. Radiograph of involved joints revealed soft tissue swelling and periarticular osteoporosis without bony erosions. Lymph node biopsy showed characteristic findings. The patient was treated with systemic chemotherapy with C-MOPP regimen and showed partial remission. Since prognosis is greatly altered and treatment with high dose steroid or cytotoxic agents is indicated, AILD should be considered as a diagnostic possibility in patients with apparent systemic connective tissue disease in whom marked lymphadenopathy, weight loss, or steady deterioration developed.
배양된 연골세포에서 각종 Cytokine과 성장인자가 β1-integrin 및 ICAM-1의 발현에 미치는 영향
송관규 ( Gwan Gyu Song ),노영무 ( Young Moo Ro ),유대현 ( Dae Hyu Yoo ),김성윤 ( Seong Yoon Kim ) 대한류마티스학회 1995 대한류마티스학회지 Vol.2 No.1
Objective: The cell-cell and cell-extracellular matrix interactions are critical to the embryogenesis, morphogenesis, maintenance of tissue integrity, and function of cells. This interactions are mediated by membrane glycoproteins called adhesion molecules. βl-integrins are heterodimeric transmembrane glycopro-teins which play critical roles in the ability of cells to elaborate and maintain extracellular matrix. ICAM-l is a sialylated glycoprotein and mediates various cell-cell interactions in immunity and inflammation. Articular cartilage consists of chondrocytes embedded in an extensive extracellular matirx. In normal tissue, the chondrocytes actively effect the stable equili-brium between the synthesis and degradation of matrix components, so that a constant concentration of these components is maintained. In osteoarthritis, the stable equilibrium is disrupted and the rate of loss of proteoglycan exceeds the rate of depositon of newly synthesized moleclues. This equilibrium is influenced by cytokines and growth factors such as IL-I, TNF-α, IGF-1 and TGF-β. Integrins and their ligands may mediate some of the interactions of chondrocytes and cellular matrix, and the cytokines and local growth factors may affect the expression of integrins on chondrocytes. ICAM-1 may mediate interactions with other cells in osteoarthritic joint, and also may be modulated by cytokines and growth factors. The effect of IL-I, TNF-α, IGF-1 and TGF-β in the expression of, β1-integrin (CD29) and ICAM-1(CD54) on chondrocytes was investigated. Methods: Cultured chondrocytes(3rd passages) from 2 osteoarthritc patient were used. Cells were incubated for 24hours with and without IL-1β 25U/ml, IL-l 50U/ml, TNF-α 1ng/ml, TNF-α 10ng/ml, IFN-γ 100U/ml, IGF-1 10ng/ml, IGF-1 50ng/ml, IGF-1 100ng/ml, TGF-β 10ng/ml, and TGF-β 30ng/ml. Chondrocytes were stained with monoclonal antibodies against, β1-integrin (CD29) and ICAM-1 (CD54), and positve cells were counted under the light microscpe. Results: 1) Cultured chondrocytes readily expressed, β1-integrin (82.9%). 2) β1-integrin was down-regulated by IL-1β(75.4%), TNF-α(61.2%), and TGF-β (77.0%), and was slightly up-regulated by IFN-γ(85.0%) and IGF-1 (88.9%). 3) ICAM-1 was presented in only 18.0% of cells. 4) Expression of ICAM-1 was readily up-regulated by IL-1β(84.0%) and TNF-α(80.3%), and mildly up-regulated by IFN-γ(33.0%), IGF-1(35.0%), and TGF-β(29.3%). Conclusions: The presence of, 81-integrin and ICAM-1 on chondrocytes and the modulation of their expression by cytokines and local growth factors suggest that they have important roles in the interaction of chondrocytes with cartilage matrix and with other cells of osteoarthritic joints. Their roles should be elucidated by further researches.
일 농촌지역에서 알코올 남용 및 의존의 유병률 및 연관 변수
홍진표(Jin-Pyo Hong),김성윤(Seong-Yoon Kim),이무송(Mu-Song Lee),안준호(Jun-Ho Ahn),이창화(Chang-Hwa Lee),최명기(Myung-Gee Choi),강혜영(Hae-Young Kang),이군희(Gun-Hee Lee),이철(Chul Lee) 한국중독정신의학회 1998 중독정신의학 Vol.2 No.2
Objective:The purpose of this study was to investigate the prevalence of alcohol abuse and alcohol dependence in a rural area of Korea and to examine the relationship between those prevalences and sociodemographic characteristics of subjects. Method:This study was done as a part of the chronic disease survey of rural area by the Asan Foundation. Among 30 years or older population from Jung Eup, a rural area of Korea, 1734 subjects was sampled using a cluster probability sampling method. Trained interviewers visited and interviewed subjects aged 30 years or older with the alcoholism part of Composite International Diagnostic Interview (CIDI). Response rate was 68.1% (N=1191). Results:The lifetime prevalence of alcohol abuse and dependence in male subjects were 36.0% and 17.5%, respectively. Those of female subjects were 6.7% and 1.6%, respectively. These estimate are similar to those of previous community study. The frequency of alcohol intake in male respondents was 10 times or more a month, but the amount of alcohol intake was dramatically dropped in group 60 years old and over. According to the logistic regression analysis, male and 50 to 69 aged group were significantly more likely to report lifetime or 12 month alcohol dependence. Low education seemed to be correlated with alcoholism, but did not reach statistically significant level. Conclusion:Alcohol abuse and dependence were highly prevalent in the rural community of Korea. Further study about the influence of the alcohol on brain and other organs in community indwellers will be needed for further understanding of the severity of alcohol use and related problems in Korea.
배상철(Sang Cheol Bae),송관규(Gwan Gyu Song),이인홍(In Hong Lee),유대현(Dae Hyun Yoo),김성윤(Seong Yoon Kim),김신규(Thin Kyou Kim) 대한내과학회 1993 대한내과학회지 Vol.45 No.4
Objectives: Among a variety of nuclear antigens, extractable nuclear antigens(ENA) which can be extracted from nuclei by homogenization in neutral saline contain ribonucleoprotin, Sm, SS-A/Ro, SS-B/La and other antigens. Characterization of anti-ENA anti-bodies provides information about nosology, subset definition within diseases, clinical activity, specific organ involvement and prognosis. Methods: Authors have used double immunodiffusion test to detect antibodies to ENAs and studied the frequencies of autoantibodies to these antigens and their correlation with clinical and laboratory features in systemic rheumatic diseases. Results: 1) 1,063 patients were investigated for the presence of serum antibodies to ENAs and 180 out of 1,063 patients (16.9%) had anti-ENA antibodies. 3,412 tests were performed for the presence of antibodies to Sm, RNP, Ro, La, Scl-70 and Jo-1 respectively and 230 out of 3,412 tests (6.7%) were positive. 2) The profiles of 137 patients who had anti-ENA antibodies are systemic lupus erythematosus (61), rheumatoid arthritis with secondary Sj6gren's syndrome (26) and without secondary Sjogren's syndrom (9), mixed connective tissue disease (18), scleroderma (10), polymyosits/dermatomyositis (6), undifferentiated connective tissue diease (4), gout (1), fibromyalgia syndrome (1) and Hashimoto's thyroiditis (1). 3) The frequencies of antibodes to ENAs were 73.5% in patiets with systemic lupus erythemtosus, 9.6% in rheumatoid arthritis, 100% in mixed connective tissue disease, 71.4% in scleroderma and 46.2% in polymyostis/dermatomyositis. 4) The frequencies of antibodies to Sm, RNP, Ro and La in patients with systemic lupus erythematosus were 18.1%, 41.5% 43.9% and 4.9% respectively. (1) Patients with anti-Sm antbodies had a higher incidence of pleuritis than those without anti-Sm antibodies(p=0.029). (2) Patients with anti-RNP anibodies had a higher incidence of Raynaud's phenomenon and pleuritis and a lower incidence of renal disease than those without anti-RNP antibodies (p=0.008, p=0.019, p=0.029). (3) Patients with anti-Ro antibodies had a higher incidence of thrombocytopenia than those without anti- Ro antibodies. (4) There were no clinical and laboratory differences between patients with anti-La antibodies and without anti-La antibodies. 5) In patients with rheumatoid arthritis, anti-Ro anti-body was likely to be associated wih secondary Sjogren syndrome, although statistically significant association was not found (p=0.063). Conclusions: These results showed that the detection of antibodies to ENAs by double immunodiffusion test was expected to be a useful diagnostic marker and predict some clinical features in systemic rheumatic diseases.