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복합한방처방 SH21-B의 랫드와 Beagle 견에 대한 단회 경구투여 독성시험
김선형,박성진,윤유식,Kim, Seon-Hyeong,Park, Seong-Jin,Yoon, Yoo-Sik 한국한의학연구원 2003 한국한의학연구원논문집 Vol.9 No.2
This study was performed to evaluate the acute oral toxicity of an oriental medical prescription for obesity treatment, SH21-B, in Sprague-Dawley rats and Beagle dogs. SH21-B was administered in rats at does of 0mg/kg, 2,000mg/kg, and 5,000mg/kg. And also SH21-B was administered in Beagle dogs at does of 150mg/kg, 300mg/kg, and 600mg/kg. The rats and dogs of both sexes were observed daily for 14 days after single oral administration. Two female rats, one administered at 2,000mg/kg and the other administered at 5,000mg/kg, died, but no dead animal was observed among male rats. Therefore LD50 in the female rat is observed to be 8,710mg/kg, and MLD(Minimum Lethal Dose) of the male rat is observed to be more than 5,000mg/kg. Among dogs, no dead animal was observed up to 600mg/kg and MLD is observed to be more than 600mg/kg.
인공지능 기반 중독 질환자 대상 디지털 치료제 시스템 설계
김선형(Seon-Hyeong Kim),최광준(Kwang-June Choi),장유선(Yu-Seon Jang),이재준(Jae-Jun Lee),오하영(Hayoung Oh) 한국정보통신학회 2024 한국정보통신학회논문지 Vol.28 No.5
본 연구는 중독(약물, 마약) 질환자를 대상으로 기존의 약물 치료의 한계를 극복하기 위하여 디지털 치료제 시스템을 설계하는 데 목적이 있다. 이에 인공지능을 기반한 게임 디지털 치료제 시스템을 제안한다. 본 연구는 첫째, 게임 디지털 치료제 시스템을 위하여 마음 챙김 기반 게임 디자인 원칙을 설계하였다. 둘째, 디지털 치료제 시스템에 중독 질환자 대상 마음 챙김 요소별 게임 전략을 도입하였다. 셋째, 디지털 치료제 시스템에 사용자의 생리학적 데이터를 처리하고 치료를 보조할 수 있는 인공지능 기술을 도입하였다. 이를 바탕으로 마음 챙김 기반 중독 질환자 대상 게임 디지털 치료제 시스템 구현 방안을 제안하였다. 거대 언어 모델을 활용한 치료 가이드형 챗봇과 절차적 콘텐츠 생성을 통하여 개인화 및 맞춤화된 개입이 가능하며 개발 및 연구 비용 절감도 도모할 수 있다. 이는 디지털 치료의 다양한 접근 방식을 제시하여 중독으로 인한 사회•경제적 부담 감소에 기여할 수 있을 것이다. This research aims to design a digital therapeutics system for patients with addictive disorders, addressing the limitations of existing medication treatments. In this regard, we present a game-based digital therapeutics system incorporating artificial intelligence. First, this study designed the mindfulness-based game design principle for the game digital therapeutics system. Second, game strategies were established for each mindfulness factor. Third, artificial intelligence technology was introduced to analyze users’ physiological data and assist treatment. Based on this framework, we proposed a plan to implement a mindfulness-based game digital therapeutics system for patients with addictive disorders. By utilizing treatment-guided chatbots and procedural content genearation using large language models, personalized and tailored interventions, as well as reducing development and research costs is feasible. This research is expected to contribute to alleviate the social and economic burdens caused by addiction by offering diverse digital therapeutics approaches.
김선형 ( Seon Hyeong Kim ),유희철 ( Hee Chul Yu ),조백환 ( Baik Hwan Cho ),채수완 ( Soo Wan Chae ),정미진 ( Mi Jin Jeong ),최영란 ( Yeong Ran Choi ),김행순 ( Haeng Sun Kim ),김주신 ( Ju Sin Kim ),김숙배 ( Sook Bae Kim ) 한국정맥경장영양학회 2012 한국정맥경장영양학회지 Vol.5 No.1
Purpose: An accurate determination of energy expenditure is needed to prevent postoperative complications and provide effective medical care for surgical patients. The aim of this study was to compare measured resting energy expenditure (REE) in patients undergoing pancreaticoduodenectomy (PD) using an indirect calorimetry (IC) with the help of five predictive equations. Methods: The subjects chosen for the study were 18 patients (12 males, 6 females) who underwent PD at Chonbuk National University Hospital between March 2010 and October 2011. REE was measured by IC (ICREE) and calculated with the following five predictive equations - (eqREE)-Harris-Benedict (HB), Mifflin St. Jeor (MI), American College of Chest Physician (AC), Ireton- Jones (IJ) and Cunningham (CU) equation - on postoperative day 3. Results: The mean measured REE by IC was 1,117.9 ±180.2, whereas the mean predicted REE by HB, MI, AC, IJ and CU equations were 1,241.3±156.1, 1,226±153.0, 1,401.7±188.0, 1,355.1±342.7, and 1,324.8±188.7 kcal/ day, respectively. The mean predicted REE by HB, MI, AC, IJ, and CU were found to be significantly different from the measured ICREE. The intraclass correlation coefficient ICC), which describes the degree of agreement with the ICREE, was significantly highest in CUeq REE (r= 0.679). The rate of accuracy of HBeq REE, MIeq REE, ACeq REE, IJeq REE, and CUeq REE for ICREE was 27.8%, 50.0%, 27.8%, 22.2%, and 23.5%, respectively, in individual subjects. Conclusion: The intraclass correlation coefficient (r= 0.124∼0.679) and accuracy rate (22.2∼50.0%) determined from the results of REE measured by IC and that calculated by five predictive equations were low in overall. The low accuracy rate of energy expenditure by equations, which apply uniform indicators, can be explained by ongoing metabolic changes of the patient. Thus, the use of IC is recommended to assess energy requirements in PD; when this method is not practical in clinical settings, nutrition intervention is needed through regular monitoring because of the low accuracy rate of the predictive methods and ICREE that can cause inappropriate energy management, leading to metabolic disorders. (JKSPEN 2013;5(1):24-30).
췌십이지장절제술 환자의 간접열량측정기로 측정한 휴식대사량 변화를 이용한 스트레스 계수의 산정
김선형 ( Seon Hyeong Kim ),조백환 ( Baik Hwan Cho ),김숙배 ( Sook Bae Kim ),정미진 ( Mi Jin Jeong ),유희철 ( Hee Chul Yu ) 한국정맥경장영양학회 2017 한국정맥경장영양학회지 Vol.9 No.2
Purpose: To predict the energy expenditure using the stress factor representing the ratio of the metabolic variation between pre-operation and post-operation in a pancreaticoduodenectomy (PD). Methods: This was a prospective study conducted on 17 patients (11 males and 6 females) who underwent PD at Chonbuk National University Hospital between March 2010 and October 2011. The rest energy expenditure was measured by indirect calorimetry 1 day before and 3 days after surgery. The height, weight, and fat free mass were also measured 1 day before surgery. Results: The mean measured rest energy expenditure 1 day before PD (mREE<sup>pre</sup>) and 3 days after PD (mREE<sup>post</sup>) were significantly different (16.8±2.6 vs. 18.8±3.5 kcal/kg/d, P=0.0076). The stress factor, representing the ratio of the metabolic changes between pre- and post-PD, was 1.12±0.17. The recommended energy requirement for PD patients is estimated to be 23∼24 kcal/ideal body weight/d [determined from the measured preoperative rest energy expenditure (16.8±2.6 kcal/kg/d)×activity factor (1.2∼ 1.3)×stress factor (1.12)]. Conclusion: PD patients maintained a hypermetabolic status and the applicable stress factor was 1.12.
조군식,이순흠,임해진,김선형,Jo, Gun-Sik,Lee, Sun-Heum,Im, Hae-Jin,Kim, Seon-Hyeong 한국정보처리학회 1997 정보처리학회논문지 Vol.4 No.2
This paper presents the fundamental study to implement wirdless data link system in the subway.Thepropagation characteristics of the electromangnetic wave in the tunnel are analyzed to determine the proper radio frequncics for our system.The tunnel is modeled as a circular waveguide and then, its path loss is obtained.The dfficient communication control procesure is proposed, which is well suited to our system architecture and the subway environment.The prototype systrm shows a good performance in the data communication. 본 논문은 지하철에서의 무선 데이타 링크 시스템을 구현하기 위한 기초 연구를 수행하였다. 먼저 주파수 선정을 위해서 터널래의 전파전파 특성을 이론적으로 분석하였고, 터널을 원형도파관으로 간주하여 진행과 방향의 거리에 따른 감쇄량을 계산하였다. 시스템 구현에 따른 새로운 통신 알고리즘을 제안하여, 간이 실험실 모델에서 데이타, 총, 수신을 수행한 결과 만족한 결과를 얻을 수 있었다.