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김미래,이유미,최동희,윤대환,나창수,Kim, Mirae,Lee, Yumi,Choi, Donghee,Youn, Daehwan,Na, Changsu 경락경혈학회 2019 대한침구의학회지 Vol.36 No.4
Objectives : This study aimed to investigate the effects of electroacupuncture (EA), the laser acupuncture (LA) and the combination therapy (LA+EA) in a collagenase-induced osteoarthritis rat model. Methods : Osteoarthritis rat model was induced by injection of collagenase into left lower articular cavity (50 μl to knee and 10 μl to ankle). In order to assess the anti-osteoarthritic effects of EA, the 650 nm LA and 650 nm LA+EA, the histopathological findings and plantar withdrawal responses were analyzed. Results : All of the treatment methods used in this study were effective in reducing pain. All treatment groups were effective in decreasing inflammatory cytokines of TNF-a and IL-6; the 650 nm LA and 650 nm LA+EA groups significantly reduced IL-1β. Conclusions : 650 nm LA and EA inhibit the production of collagenase-induced inflammatory mediators of osteoarthritis.
특발성 망막전막에서 내경계막 제거 시 인도시아닌그린 염색의 용매에 따른 수술결과 비교
김미래,박주홍,사공민,장우혁,Mi Rae Kim,Ju Hong Park,Min Sagong,Woo Hyok Chang 대한안과학회 2014 대한안과학회지 Vol.55 No.6
Purpose: This study was designed to compare the outcomes in idiopathic epiretinal membrane (ERM) surgery according to solvents of indocyanine green (ICG) for internal limiting membrane (ILM) peeling. Methods: The medical records of 27 patients (27 eyes) with idiopathic ERM who had undergone pars plana vitrectomy with ICG staining for ILM peeling were retrospectively reviewed. The patients were divided into two groups according to solvents of 0.25% ICG solutions. Solvents used were balanced salt solution (BSS) in group I (15 eyes) and 5% glucose in group II (12 eyes). The severity of ERM, the duration of symptoms, the preoperative and postoperative best corrected visual acuity (BCVA) values, the visibility of the stained ILM (Good, Fair, Poor), and the postoperative complications were compared in the two groups. Results: There was no statistically significant difference in the severity of ERM, the duration of symptoms and the preoperative BCVA in the two groups. The postoperative BCVA was significantly improved in both groups, and the difference was not statistically significant (<em>p</em> = 0.675). There was a significantly smaller number of eyes with poor ILM staining in group II than in group I (<em>p</em> = 0.014). No complications such as recurrence of ERM, atrophy of the retinal pigment epithelium (RPE) or retinal detachment were observed in the two groups. Conclusions: The higher specific gravity of 5% glucose compared with that of BSS as ICG solvents allows for improved ILM visualization. Therefore using the 5% glucose-ICG solution for staining ILM improved the visibility of ILM compared BSS-ICG solution and led to comparable visual recovery. J Korean Ophthalmol Soc 2014;55(6):847-853
BaTiO<sub>3</sub> 분말과 분산제 첨가에 따른 Fe계 나노결정 P/M시트의 전자파흡수 특성변화
김미래,조현정,박원욱,Kim, Mi-Rae,Cho, Hyeon-Jeong,Park, Won-Wook 한국분말야금학회 2008 한국분말재료학회지 (KPMI) Vol.15 No.1
The amorphous $Fe_{73}Si_{16}B_7Nb_3Cu_1$(at%) alloy strip was pulverized using a jet mill and an attrition mill to get flake-shaped powder. The flake powder was mixed with dielectric $BaTiO_3$ powder and its dispersant to increase the permittivity. The powders covered with dielectric powders and its dispersant were mixed with a binder and a solvent and then tape-cast to form sheets. The absorbing properties of the sheets were measured to investigate the roles of the dielectric powder and its dispersant. The results showed that the addition of $BaTiO_3$ powders and its dispersant improved the absorbing properties of the sheets noticeably. The powder sheet mixed with 5 wt% of $BaTiO_3$ powder and 1 wt% of dispersant showed the best electromagnetic wave absorption rate because of the increase of the permittivity and the electrical resistance.
그람양성세균각막염에 대한 임상적, 미생물학적 분석: 15년 연구
김미래,이상범,Mi Rae Kim,Sang Bumm Lee 대한안과학회 2014 대한안과학회지 Vol.55 No.10
Purpose: To investigate the shifting trends of pathogenic organisms, antibiotic resistance, and clinical characteristics of patients with Gram-positive bacterial keratitis and to elucidate the prognostic factors. Methods: We performed a retrospective chart review of 152 isolates in 146 eyes with Gram-positive bacterial keratitis between January 1998 and December 2012. The study was divided into 5 periods for analysis of the bacteriological profiles and in vitro antibiotic resistance. The epidemiological and clinical characteristics were compared according to bacterial isolates. Logistic regression analysis was performed to determine the risk factors. Results: Gram-positive bacterial keratitis tended to decrease and significant change in the distribution of isolates was not observed. Commonly isolated organisms were S. epidermidis (48.7%), S. aureus (25.0%), and S. pneumoniae (7.2%) in order of frequency. The resistance to fluoroquinolone tended to increase (<EM>p </EM>= 0.104) and resistance to gentamicin was significantly decreased (<EM>p </EM>= 0.01). S. epidermidis had the shortest corneal epithelium healing time (<EM>p </EM>= 0.035) and the most favorable visual outcome after treatment (<EM>p </EM>= 0.035) compared with the other species. Risk factors for poor visual outcomes included a best corrected visual acuity less than 0.1 at initial evaluation and an epithelial healing time greater than 10 days. Conclusions: Gram-positive bacterial keratitis tended to decrease and S. epidermidis was the most common isolate. The clinical prognosis was most favorable in S. epidermidis. The BCVA less than 0.1 at initial evaluation was an important risk factor for poor visual outcome and surgical treatment in Gram-positive bacterial keratitis.J Korean Ophthalmol Soc 2014;55(10):1432-1444
김민석(Min Seok Kim),김미래(Mi Rae Kim),김원제(Won Jae Kim),김명미(Myung Mi Kim) 대한안과학회 2015 대한안과학회지 Vol.56 No.12
목적: 속발외사시의 수술 결과에 따른 임상양상을 비교하여 수술 예후인자를 분석해 보고자 한다. 대상과 방법: 1988년 7월 1일부터 2013년 12월 31일 사이에 내사시 수술 후 발생한 속발외사시로 수술을 시행 받은 환자 65명을 대상으로 처음에 있었던 내사시의 분류와 진단 나이, 내사시 수술의 방법과 시기, 외사시 수술의 방법과 시기, 내전장애의 유무, 약시의 유무, 외사시 수술 전후의 사시각 등을 분석하였다. 결과: 속발외사시 수술 후 평균 경과관찰 기간은 5.1 ± 5.2년(0.5-17.4년)으로, 최종 경과관찰 시 50명(76.9%)에서 수술성공을 보였으며 속발외사시의 누적성공률은 수술 후 7.7년부터 68.2%로 일정해지는 양상을 보였다. 정위군과 재발군을 비교한 결과, 외사시 수술을 시행한 나이가 10세 이하인 경우가 재발군에서 많았으며(14.0% vs. 41.7% p=0.044), 외사시 수술 후 경과관찰 기간이 유의하게 길었고(3.9년 vs. 8.6년, p=0.014) 재발하기까지 기간은 평균 16.9개월이었다. 수술 후 1주일째의 사시각이 정위군은 평균 0.5프리즘 디옵터(prism diopters, PD)의 내편위, 재발군에서는 평균 4.5PD의 외편위로 유의한 차이를 보였다(p=0.047). 결론: 내사시 수술 후 속발외사시가 일찍 발생하여 어린 나이에 수술이 필요하였던 경우와 속발외사시 수술 후 1주일째 외편위가 있을때 속발외사시의 재발이 더 많은 것으로 나타났으며 속발외사시의 재발이 아주 늦게 발생하는 경우도 있으므로 장기적인 경과관찰이 필요하다. Purpose: In this study we evaluated the prognostic factors by comparing the clinical manifestation of consecutive exotropia after consecutive exotropia surgery. Methods: We performed a retrospective study of 65 patients who had surgery due to consecutive exotropia after esotropia surgery in Yeungnam University Medical Center between July 1988 and December 2013. The type of esotropia, age at diagnosis of esotropia, type of esotropia surgery, age at esotropia surgery, type of consecutive exotropia surgery, age at consecutive exotropia surgery, presence of adduction limitation, presence of amblyopia, and preoperative and postoperative angles of strabismus were analyzed. Results: The mean follow-up time after consecutive exotropia surgery was 5.1 ± 5.2 years and 50 of 65 patients showed successful surgical outcomes at the last follow-up. Cumulative success rate of consecutive exotropia remained stable postoperatively in 68.2% of patients after 7.7 years. When comparing the success group and the recurrent group, the age at consecutive exotropia surgery was significantly younger and mean follow-up time was significantly longer in the recurrent group. The mean interval between consecutive exotropia surgery and recurrence of exotropia was 16.9 months in the recurrent group. The mean angle of strabismus at postoperative 1 week was significantly different between the 2 groups; 0.5 prism diopters (PD) esodeviation in the success group and 4.5 PD exodeviation in recurrent group. Conclusions: Recurrence of consecutive exotropia frequently developed with younger age at consecutive exotropia surgery and exodeviation at postoperative 1 week. Recurrent consecutive exotropia should be observed for an extended period, thus requiring periodic long-term postoperative follow-ups.