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아래눈꺼풀에 발생한 원발성 피부 역형성 대세포 림프종 1예
김미랑,지준영,고영혜,김윤덕,Mi-Rang Kim,Jun-Young Chi,Young-Hyeh Ko,Yoon-Duck Kim 대한안과학회 2005 대한안과학회지 Vol.46 No.12
Purpose: Primary cutaneous anaplastic large cell lymphoma is rarely encountered in the lower eyelids. We report a patient with primary cutaneous anaplastic large cell lymphoma arising from the lower eyelid. Methods: A 39-year-old man presented with a relatively fast growing mass on the center of his left lower eyelid for one month. The mass did not respond to local injection of triamcinolone at a local clinic. The lesion appeared as a solitary reddish nodule with ulceration, was non-tender, round, crusted, and measured 13 mm×11 mm×5 mm. Well- developed superficial vessels were found on the surface of the nodule. An incisional biopsy was performed. Results: Histologic examination revealed that the bulk of the infiltrate was in the papillary and reticular dermis. Tumor cells had abundant, well-defined cytoplasm and pleomorphic nuclei with multiple nucleoli. The majority of the neoplastic cells showed immunoreactivity for CD 30 (Ki-1) along the cell membrane. A histopathological diagnosis of primary cutaneous anaplastic large cell lymphoma was made. Conclusions: Most cases of primary cutaneous anaplastic large cell lymphoma arise from the body and extremities. However, since primary cutaneous anaplastic large cell lymphoma may occur in the eyelid, it should be differentiated from nodular and relatively fast growing inflammatory tumors despite local steroid treatment.
김미랑,정의상,Mi-Rang Kim,Eui-Sang Chung 대한안과학회 2005 대한안과학회지 Vol.46 No.9
Purpose: To evaluate the surgical outcome of deep anterior lamellar keratoplasty (DALKP) in patients with corneal opacity with an intact corneal endothelium. Methods: We transplanted partial thickness donor cornea, devoid of endothelium and Descemet’s membrane, on to a recipient bed of which the deep stromal area had been dissected to expose the smooth surface of Descemet’s membrane. We evaluated the visual acuity, refractive error, endothelial cell density, intraocular pressure, complication and graft rejection after a follow-up period of at least 6 months. Results: Twelve eyes of 11 patients (M:F=7:4) were enrolled in this study, with a mean age of 39 years (17~60). The mean follow-up period was 9.8 months. The underlying diseases were keratoconus in 6 eyes, corneal dystrophy in 4 and herpetic corneal lesion in 2. The mean postoperative visual improvement was 5 lines of Snellen chart. Microperforations occurred during operation in 4 eyes, and were treated with intracameral gas injection. One of them underwent penetrating keratoplasty due to persistent double anterior chamber. Transient elevation of intraocular pressure was noted in 7 eyes, but no case of graft rejection was observed during the follow-up period. Conclusions: Even though intraoperative microperforation may require an additional procedure such as gas injection which increases the possibility of intraocular pressure elevation, deep anterior lamellar keratoplasty is thought to be a good option for the primary surgery in patients with corneal opacity with an intact corneal endothelium due to its relatively fast recovery, reduced risk of rejection and preservation of endothelium without ongoing loss.
김미랑,손세운,기창원,Mi Rang Kim,M,D,Sae Woon Sohn,M,D,Changwon Kee,M,D 대한안과학회 2006 대한안과학회지 Vol.47 No.1
Purpose: We attempted to detect the herpes virus using a polymerase chain reaction (PCR) technique from the aqueous humor of patients who were suspected of having herpetic uveitis. Methods: We obtained aqueous humor from four patients who suffered from elevated intraocular pressure and uveitis but did not respond to steroid and intraocular pressure depressants. We employed the PCR technique for to detect herpes-virus specific DNA. Patients were treated with oral and topical acyclovir. Results: Uveitis of varying severity and progressive iris atrophy was observed in all patients. Varicella zoster virus (VZV) specific DNA was detected in two of four patients. Two patients showed a favorable course but the other two patients showed an unfavorable course due to advanced peripheral anterior synechia and corneal decompensation. Conclusions: Diagnosis of herpetic uveitis was difficult because it was not usually accompanied by dendritic corneal lesions. Herpetic uveitis should be considered whenever anterior uveitis and elevated intraocular pressure accompanies the characteristic iris atrophy. PCR was very useful in detecting the virus DNA in the aqueous humor to enable rapid diagnosis and adequate treatment.
김미랑,서운교,신정인,Kim, Mi-Rang,Seo, Un-Kyo,Shin, Jeong-In 대한한방내과학회 2002 大韓韓方內科學會誌 Vol.23 No.1
Clinical symptoms of herpes zoster include red rash, burning pain, tingling or extreme sensitivity in the affected area, usually limited to one side of the body. There might be a fever or a headache. The pain of acute herpes zoster may be severe, but it is usually temporary. Some of old patients are likely to develop postherpetic neuralgia. We treated a 73 year-old male patient who had severe pain and a headache after acute herpes zoster. In the point of Differentiation of Syndromes(辯證), this subject was diasgnosed as wind-heat syndrome(風熱證) and was administered Bangpungtongsung-san. For the purpose of making the pain easier, we used the western medication as well. After six days of treatment, pain and the other symptoms improved. Besides postherpetic neuralgia dissipated. Based on this experience, both oriental medicine and western medicine have a good effect on acute herpes zoster.
Heo Haejeong,Kim Jong-Hwan,Lim Hyun Jung,Kim Jeong-Hwan,Kim Miso,Koh Jaemoon,Im Joo-Young,Kim Bo-Kyung,Won Misun,Park Ji-Hwan,Shin Yang-Ji,윤미란,Cho Byoung Chul,Kim Yong Sung,Kim Seon-Young,김미랑 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Acquired resistance to inhibitors of anaplastic lymphoma kinase (ALK) is a major clinical challenge for ALK fusion-positive non-small-cell lung cancer (NSCLC). In the absence of secondary ALK mutations, epigenetic reprogramming is one of the main mechanisms of drug resistance, as it leads to phenotype switching that occurs during the epithelial-to-mesenchymal transition (EMT). Although drug-induced epigenetic reprogramming is believed to alter the sensitivity of cancer cells to anticancer treatments, there is still much to learn about overcoming drug resistance. In this study, we used an in vitro model of ceritinib-resistant NSCLC and employed genome-wide DNA methylation analysis in combination with single-cell (sc) RNA-seq to identify cytidine deaminase (CDA), a pyrimidine salvage pathway enzyme, as a candidate drug target. CDA was hypomethylated and upregulated in ceritinib-resistant cells. CDA-overexpressing cells were rarely but definitively detected in the naïve cell population by scRNA-seq, and their abundance was increased in the acquired-resistance population. Knockdown of CDA had antiproliferative effects on resistant cells and reversed the EMT phenotype. Treatment with epigenome-related nucleosides such as 5-formyl-2′-deoxycytidine selectively ablated CDA-overexpressing resistant cells via accumulation of DNA damage. Collectively, our data suggest that targeting CDA metabolism using epigenome-related nucleosides represents a potential new therapeutic strategy for overcoming ALK inhibitor resistance in NSCLC.
김미랑 ( Mirang Kim ),유정아 ( Jeonga Yu ),배은경 ( Eunkyoung Bae ),석웅 ( Woong Seok ),하범만 ( Beomman Ha ),최병섭 ( Byungseop Choi ) 국군의무사령부 2020 대한군진의학학술지 Vol.51 No.1
Objective; This study aims to check adequacy of current obesity classification in Korea among young male soldiers. Method; We surveyed 316 military personnel who agreed this study with structured questionnaire. They answered voluntarily the questionnaire and also wrote down their data of medical examination, body composition and army physical fitness test. Results; Subjects were classified as by Body Mass Index(BMI): underweight(<18.5) 1, normal(18.5-22.9) 129(40.8%), overweight(23-24.9) 91(28.8%), obese(25-29.9) 78(24.7%), severe obese (30≤) 17(5.4%). Obesity rate was 30.1% by BMI 25, 14.6% by Body fat(25%) and 18.7% by waist cimcumference(90cm), respectively. This classification by BMI presents 87% of sensitivity, 79.6% of specificity based on 25% Body fat. When we analysed BMI ROC curve by Body fat(25%), sensitivity and specificity were 80.4% and 90% at the point of BMI 26.05. Almost two-third(67%) of Overweight group and one-third(30.8%) of Obese group showed more than 45% of muscle ratio. All of them had less than 25% body fat. In the over obese group, there were statistically significant differences when analyzing the abnormality of medical examination and passing the physical fitness test by dividing into 45% muscle ratio and 25% body fat, respectively. Conclusion; This study shows that it may be appropriate to reclassify some of overweight(23≤BMI<25) and Obese(25≤BMI<30) young men as normal or overweight in Republic of Korea Army considering possibility of muscle excess. If we study more subjects in the future, new and appropriate cut-off values from normal to obese could be suggested.