상표동향 보고서 - 글로벌 브랜드

김미라,Kim, Mi-Ra 한국특허정보원 2005 Patent 21 Vol.62 No.-

동남아 호스피스기관 연수 보고서

김미라,Kim, Mi-Ra 한국가톨릭호스피스협회 2003 호스피스 Vol.26 No.-

우슬 중 ${\beta}-Ecdysone$의 초임계추출법(SFE)과 용매추출법의 비교

김미라,김명석,심재한,Kim, Mi-Ra,Kim, Myong-Seok,Shim, Jae-Han 한국응용생명화학회 2001 Applied Biological Chemistry (Appl Biol Chem) Vol.44 No.3

우슬(Achyranthis radix)중 ${\beta}-ecdysone$의 초임계추출법과 용매추출법의 비교를 위해 초임계유체추출(SFE) 및 용매추출 후 초임계유체크로마토그래피(SFC)에 의한 우슬 중 ${\beta}-ecdysone$ 분석을 실시하였다. SFE에 있어서 추출 최적압력은 300 atm이었으며, 온도는 $80^{\circ}C$, 추출량은 100 ml, 보조제인 methanol 함량비율은 20%였다. 우슬에서 ${\beta}-ecdysone$의 분석시 SFC의 최소검출량은 5 ng이었고, SFE의 회수율은 줄기에서는 $90.7{\sim}93.5%$였으며, 뿌리에서는 $77.8{\sim}81.9%$였다. 용매추출의 회수율은 줄기에서는 $76.4{\sim}93.0%$였고 뿌리에서는 $80.6{\sim}93.1%$였다. 우슬의 생육기별 조사에서 ${\beta}-ecdysone$은 주로 뿌리에서 많이 검출되었고 1년생이면서 8월에 수확한 것이 654.9 ppm으로 가장 많이 함유한 것으로 나타났다. Extraction efficiency of ${\beta}-ecdysone$ in Achyranthis radix was investigated using the methods of solvent extraction and supercritical fluid extraction (SFE). The optimum SFE conditions for the analysis of ${\beta}-ecdysone$ in A. radix were 300 atm, $80^{\circ}C$, 100 ml of extraction volume, and 20% ratio of modifier(methanol). As revealed through SFE, detection limit of ${\beta}-ecdysone$ in A. radix was 5 ng and recoveries of ${\beta}-ecdysone$ in A. radix shoots and root were $90.7{\sim}93.5%$ and $77.8{\sim}81.9%$, respectively. Recoveries of ${\beta}-ecdysone$ in A. radix shoots and root through solvent extraction were $76.4{\sim}93.0%$ and $80.6{\sim}93.1%$, respectively. ${\beta}-Ecdysone$ content was determined to be highest at 654.9 ppm in the first year A. radix roots harvested in August.

주제어 분석에 의한 해상·수중 분야 군사과학기술 동향 분석

김미라,Kim, Mi-Ra 한국군사과학기술학회 2013 한국군사과학기술학회지 Vol.16 No.5

The purpose of this study is to investigate trends of characteristics and changes in the field of marine/naval/underwater military science and technology in Korea. This study analyzed the keywords that appeared in marine/naval/underwater section of the "Journal of the Korean Military Science and Technology" during the period, 1998~2012. One hundred and seven articles were analyzed by keywords in English. Four hundred and fifty four keywords in English were analyzed by appearance frequency. Finally those results of source literatures and keywords were compared with each other and a better direction for the future of the field with further studies was suggested.

밀리미터파 GaAs 건 다이오드의 설계 및 제작

김미라,이성대,채연식,이진구,Kim, Mi-Ra,Lee, Seong-Dae,Chae, Yeon-Sik,Rhee, Jin-Koo 대한전자공학회 2007 電子工學會論文誌-SD (Semiconductor and devices) Vol.44 No.8

We designed and fabricated the planar graded-gap injector GaAs Gm diodes with $1.6{\mu}m$ active length for operation at 94 GHz. The fabrication of the Gunn diode is based on MESA etching, Ohmic metalization, and overlay metalization. The measured negative resistance characteristics of the graded-gap injector GaAs Gunn diodes are examined for two different device structures changing the distance between the cathode and the anode electrodes. Also, we discuss the DC results under the forward and the reverse biases concerning the role of the graded-gap injector. It is shown that the structure having the shorter distance between the cathode and the anode electrode has higher peak current, higher breakdown voltage, and lower threshold voltage than those of the larger distance. [ $1.6{\mu}m$ ]의 활성층을 가지는 planar형태의 94 GHz graded-gap injector GaAs 건 다이오드를 설계, 제작하였다. 이 다이오드는 반 절연 기판에 성장된 에피 구조를 바탕으로 메사 식각, 오믹 금속 접촉형성 및 overlay metalization의 주요 공정을 통하여 두가지 형태의 planar 구조로 제작되었다. 제작된 건 다이오드의 부성저항 특성을 anode와 cathode 금속전극들의 배치를 달리 한 두 소자 구조에서 고찰하였고 graded-gap injector의 역할을 순방향과 역방향에서의 직류거동으로부터 살펴보았다. 결과적으로, 금속전극의 배치에 있어서, cathode와 anode 전극사이의 거리가 감소된 소자 구조에서 증가된 peak 전류와 breakdown 전압, 그리고 감소된 문턱전압을 얻었다.

의료서비스충성도에 대한 QR정보서비스의 효과

김미라,황윤용,Kim, Mi Ra,Hwang, Yoon Yong 한국산업정보학회 2022 한국산업정보학회논문지 Vol.27 No.5

This study investigated the influence relationship of information service using QR code on customer's service quality perception and loyalty behavior for medical service in the physical environment. As a result of the study, when medical institutions provide location information services about the physical environment by utilizing the usefulness and reliability of QR codes, the perceived quality of customers' QR information will be strengthened, and furthermore, loyalty behavior toward medical services will increase in the future. Considering the spread of smartphones as a popular digital medium today, marketers use QR codes to connect and provide four-dimensional information services without time and place restrictions, thereby strengthening the interactive experience with customers. And these efforts suggest that it can contribute to improving service image and strengthening loyalty beyond simply providing service information to companies.

소아에서 단순형 및 천공형의 급성 충수염에 대한 복강경하 충수절제술 적용의 적합성 연구

김미라,정재희,김응국,송영택,Kim, Mee-Ra,Chung, Jae-Hee,Kim, Eung-Kook,Song, Young-Tack 대한소아외과학회 2004 소아외과 Vol.10 No.2

Appendectomy is the most common emergency surgical operation in children. The laparoscopic treatment of pediatric appendicitis is controversial, particularly in complicated cases. The purpose of this study is to evaluate laparoscopic appendectomy (LA) and open appendectomy (OA) for simple and perforated appendicitis (SA, PA) in children. A total of 188 patients, operated from January 1992 to September 2003, were reviewed. Ninety-one patients underwent OA (65 SA and 26 PA) and 97 had LA ( 67 SA, 30 PA). There was one conversion of LA to OA in PA. Operative time for LA was longer for OA in PA (55.8 vs. 45.7 min; p=0.0467). Recovery of bowel movement, diet starting time, length of hospital stay for LA were significantly shorter than those for OA. Postoperative complication rate was not different between LA and OA in each group. Laparoscopic appendectomy is a safe and effective method for both simple and perforated appendicitis.

입 안의 생명수 침 건강법

김미라,Kim, Mi-Ra 한국상하수도협회 2007 한국상하수도협회지 Vol.20 No.-

Tumor Necrosis factor-α Promotes Osteogenesis of Human Bone Marrow-derived Mesenchymal Stem Cells through JNK-dependent Pathway

김미라,송해영,김재호,Kim, Mi-Ra,Song, Hae-Young,Kim, Jae-Ho Korean Society of Life Science 2006 생명과학회지 Vol.16 No.7

Tumor necrosis $factor-{\alpha}\;(TNF-{\alpha})$는 염증성 골질환에서의 골조직의 손실과 밀접한 관련이 있다. 본 연구에서는 인체 골수 유래 중간엽 줄기세포의 골세포로의 분화과정에 대한 $TNF-{\alpha}$의 영향을 조사하였다. $TNF-{\alpha}$는 골수 유래 중간엽 줄기세포의 골세포로의 분화를 나타내는 표시인 세포외 무기질 축적과 alkaline phosphatase의 발현의 증가를 일으켰으며 2ng/ml의 농도에서 최대의 증가를 나타내었다. $TNF-{\alpha}$에 의한 골세포로의 분화는 $NF_kB$의 저해제에 의해서는 영향받지 않았으나 JNK 특이 저해제인 SP600125에 의해 완벽하게 억제되었다. 이는 $TNF-{\alpha}$에 의한 골수 유래 중간엽 줄기세포의 골세포로의 분화과정에 JNK가 중요한 역할을 한다는 것을 제시한다. Tumor necrosis $factor-{\alpha}\;(TNF-{\alpha})$ has been implicated in skeletal diseases by promoting bone loss in inflammatory bone diseases. In the present study, we examined the effects of $TNF-{\alpha}$ on osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells (hBMSCs). $TNF-{\alpha}$ dose-dependently promoted matrix mineralization of hBMSCs with a maximal stimulation at 2ng/ml. $TNF-{\alpha}$ increased expression of alkaline phosphatase, which plays a crucial role for the matrix deposition. The $TNF-{\alpha}-stimulated$ osteoblastic differentiation was not affected by $NF_kB$ inhibitors, BAY and SN50. However, a JNK-specific inhibitor, SP600125 completely abolished the $TNF-{\alpha}-stimulated$ matrix mineralization and expression of alkaline phosphatase. These results suggest that $TNF-{\alpha}$ enhances osteoblastic differentiation of hBMSCs through JNK-dependent pathway.

GnRH agonist 사용 중 심한 자궁출혈 환자에서의 자궁의 모세혈관확장증

김미라 ( Mi La Kim ),김주명 ( Joo Myung Kim ),이원식 ( Won Sik Lee ),주관영 ( Kwan Young Joo ),이인국 ( In Kook Lee ),김혜선 ( Hye Sun Kim ),홍성란 ( Sung Ran Hong ) 대한산부인과학회 2008 Obstetrics & Gynecology Science Vol.51 No.1

Telangiectasis of the uterus is an extremely rare but life-threatening disease because of massive uterine bleeding. The usage of GnRH agonist can cause regression and atrophy of the endometrium through induction of hypoestrogenism by pituitary down-regulation. But there is no clear explanation or report in the literature showing the relationship between uterine telangiectasis and GnRH agonist usage. We have experienced a patient with uncontrolled massive uterine bleeding after GnRH agonist treatment, who needed emergency hysterectomy. Pathologic tissue examination showed telangiectasis of the endometrium and myometrium. This is the first case report of telagiectasis of the uterus without other organ involvement. We report this case with a brief review of the literatures.