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무슬림 여성의 외상 후 스트레스장애 수준이 건강요인, 불안 및 우울지수, 그리고 심근 자율신경계에 미치는 영향
김만성(Kim, Man-Sung),김성대(Kim, Seong-Dae),김아란(Kim, Ah-Ran),김선휘(Kim, Sun-Hwi),한동유(Han, Dong-Yoo),정일규(Jeong, Il-Gyu) 한국사회체육학회 2016 한국사회체육학회지 Vol.0 No.65
The purpose of this research was to investigate the effects of muslim women’s post traumatic stress disorder(PTSD) level on health, anxiety·depression index, and cardiac autonomic system. The subjects of this study were ninety seven college women(age 21.18±1.70 yrs) in Peshawar, Pakistan. Participants were assigned into four groups according to Posttraumatic stress Diagnosis Scale(PDS): high PTSD level(HP), middle PTSD level(MP), low PTSD level(LP), and no PTSD level(NP). Measurement of anxiety·depression index was conducted by Beck Anxiety Inventory(BAI) and Beck Depression Inventory-Ⅱ(BDI-Ⅱ). For the factors of health status total cholesterol(TC), triglyceride(TC), blood sugar, body fat, hypertension were also measured. The heart rate variability parameters such as low frequency(LFnu), high frequency(HFnu), and total power(TP) were also measured by Pulse-wave HRV analyzer(ubplus T1). In order to find any difference of health-related factors according to PTSD level, one way ANOVA analysis was applied and LSD post-hoc test. Futhermore, Simple regression analysis was applied for subjects in PTSD groups to evaluate the effects of PTSD level on anxiety·depression index and cardiac autonomic system. The results were shown as follows: First, there was no significant difference among four groups in health-related parameters. Second, PTSD level had a significant corelation with depression index(R²=.402, p<.001). Third, PTSD level had a significant corelation with anxiety index(R²=.244, p<.001). Finally, PTSD level had a significant but low corelation with TP index(R²=.103, p<.05). These results suggest that without direct effect of PTSD on physiological factors in young Muslim women, high level of PTSD might induce the negative psychological or emotional response such as depression and anxiety and the changed cardiac autonomic status.
대장선암에서 p53과 c-erbB-2의 표출 및 상관관계에 관한 연구
양승하,강상균,김대중,김의한,김만성 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.2
Colorectal adenocarcinoma is relatively common malignant tumor in korea and various oncogenes has found in tumor cells. Colorectal adenocarcinoma show overexpression of p53 and c-erbB-2. The relation between expression of p53 and c-erbB-2 and prognosis of patients in colorectal adenocarcinoma has studied recently, but that is controversy. To evaluate relation between expression of p53 and c-erbB-2 and histopathologic finding prognostic factors, we have performed immunohistochemical staining, using mouse anti-p53 and anti-human c-erbB-2, for 52 cases of colorectal adenocarcinoma. The results were as follows; 1) Expression rate of p53 and c-erbB-2 in colorectal adenocarcinoma were 71.2% and 51.9%, respectively. 2) Expression rate of p53 in left side(70.4%), differentiated(75.6%) and invasion to serosa and surrounding adipose tissue(72.5%) were higher than in right side(37.5%), poorly differnetiated(42.9%) and invasion to muscle(50%). 3) Expression rate of c-erbB-2 in left side(51.9%), differentiated(57.8%) and invasion to serosa and surrounding adipose tissue(54.5%) were higher than in right side(37.5%), poorly differnetiated(14.3%) and invasion to muscle(37.5%). 4) The expression of p53 and c-erbB-2 showed coexpression in colorectal adenocarcinoma. 5) The expression of p53 and c-erbB-2 showed no differenece according to presence or absence of lymphatic metastasis. Above result revealed that p53 and c-erbB-2 are coexpression in colorectal adenocarcinoma. The expression of each p53 and c-erbB-2 and the simultaneous expression of p53 and c-erbB-2 may be related to left side and differentiated cases. Our studies for relation with prognosis of patients in colorectal adenocarcinoma showed different results according to depth of invation and metastasis to lymph node and we should be followed for them.
위선암에서 조직면역학적 방법을 이용한 P-glycoprotein의 분포에 관한 연구
김만성,양승하,김의한,강상균 순천향의학연구소 1995 Journal of Soonchunhyang Medical Science Vol.1 No.1
P-glycoprotein, as a pleotropic membrane transport protein, shows specific localization in many normal tissue and malignant tumor. It act as an energy dependent drug pump in malignant tumors and makes difficulty for treating these tumors with anticancer drugs. Many malignant tumors such as colon carcinoma, renal cell carcinoma, hepatoma, islet cell tumor of pancreas, and adrenal cortical carcinoma, show high expression of P-glycoprotein and resistance to chemotherapy. However reports for P-glycoprotein in gastric adenocarcinoma is rare. The difference of its expression according to differentiation of gastric adenocarcinoma has been studied and its results are controversial. To observe the relationship of P-glycoprotein positivity according to differentiation of carcinoma, age and sex, adenocarcinoma 82 cases and dysplastic lesions 12 cases were analysed then processed for immunohistochemical stain by avidin-biotin complex using mAB JSB-1. The results were as followings : 1. Positive rate of P-glycoprotein in gastric adenocarcinoma and dysplastic lesions were 48.78%(40/82) and 50%(6/12). 2. Well, moderate and poorly differentiated adenocarcinoma showed positive reaction of P-glycoprotein in 51.28%(20/39), 46.43%(13/28) and 46.67%(7/15) respectively. 3. Positive reaction of P-glycoprotein in male was 53.85%(35/65) and female in 29.41%(5/7) which indicate high positive rate in male. 4. Positive rate of P-glycoprotein according to age distribution were 25%(1/4) in 20-30 decade, 42.8%(6/14) in 40 decade, 44.83%(13/29) in 50 decade, 57.14(12/21) in 60 decade and 57.14%(8/14) in 70 decade. It indicate that P-glycoprotein positivity is increased with age. The above results reveal that the expression of p-glycoprotein in gastric adenocarcinoma as related with sex and age but not with differentiation of carcinoma. These results implies that P-glycoprotein may be implicated with hormone dependent.
김만성(MS Kim),주활(H Joo),이정일(JI Lee),황호연(HY Hwang) 대한산부인과학회 1982 Obstetrics & Gynecology Science Vol.25 No.4
Umbilical cord complications have been practical interest to physicians for years because of their frequent occurence in routine obstetric practice, yet there are few comprehensive discussions on the subject. True knots, which result from active movements of the fetus distinguished from false knots, which result from kinking of the vessels to accomodate to the length of the cord. True knots of umbilical cord are not infrequent and are occasionally of complicated nature a case of true knot of umbilical cord which coming fetal death is presented with brief review of the literature.