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한국 성인 남녀에서 주관적 체형 인식과 대사증후군과의 연관성: 2015–2016년 국민건강영양조사 자료 이용
김리연,심경원,이홍수,이상화,최지윤 대한가정의학회 2020 Korean Journal of Family Practice Vol.10 No.4
Background: Obesity has become a concern globally. The incidence of metabolic syndrome has increased rapidly in Korea over the past decades. Previous studies have reported obesity as a major cause of metabolic syndrome. Body mass index (BMI) and body weight perception have been widely used as indirect predictors of the risk of metabolic syndrome. Therefore, we aimed to evaluate subjective body weight perception and the risk of metabolic syndrome in adults over 20 years of age and confirm the gap between body weight perception and the objective measure of BMI. Methods: This study was conducted aming 9,842 Korean adults over 20 years of age using data from the VI-3 (2015) and VII-1 (2016) Korea National Health and Nutrition Survey. The BMI criteria were set according to the WHO Asia Pacific Standard criteria. Perceived body weight status was measured according to the question, “How would you describe your body shape?”. The patients were grouped as “obese,” “slightly obese,” “right weight,” and “under weight” according to the original responses (“very obese,” “slightly obese,” “normal,” “slightly thin,” and “very thin”). Data analysis was performed using chi-square test, analysis of variance, and logistic regression. Results: Among the participants, the risk of metabolic syndrome was progressively higher with the body weight perception as obese. Additionally, the risk of metabolic syndrome was higher in those with a higher BMI than in those with subjective body weight perception. Conclusion: In this Korean population, increased risk of metabolic syndrome showed higher associated with higher BMI than with body weight perception. 연구배경: 비만은 전세계적으로 문제가 되고 있으며, 지난 수십 년간 대사증후군은 한국에서 빠르게 증가하였다. 많은 선행연구에서 비만이 대사증후군의 주요 원인임이 밝혀졌으며, 체질량지수(body mass index, BMI), 체형 인식을 대사증후군의 위험도를 평가하는 간접적인 예측인자로 널리 이용했다. 그리고 주로 체형 인식에 대한 연구는 성인이 아닌 청소년에 국한되어 연구된 내용이 많아 성인으로 일반화하기에는 어려움이 있었다. 따라서 20세 이상의 성인을 대상으로 개인의 주관적 체형 인식 정도와 대사증후군의 위험도를 평가하고, 나아가서 BMI라는 객관적인 척도를 이용하여 주관적 체형 인식과의 간극을 확인하여 대사증후군의 위험도의 변화를 확인하고자 한다. 방법: 본 연구는 국민건강영양조사 제6기 3차년도(2015년), 제7기 1차년도(2016년) 자료를 적용하여 20세 이상의 한국 성인 9,842명을 대상으로 하였다. 체질량지수 기준은 세계보건기구 아시아태평양 지역 기준과 대한비만학회 비만 기준을 따랐으며, 주관적 체형 인식에 대한 분류는 국민건강영양조사에서 분류한 매우 마른편, 약간 마른편을 마른편으로 간주하였고, 보통, 약간 비만, 매우 비만으로 나누어 분석하였다. 분석 프로그램은 SPSS 23.0을 사용하였고 카이제곱 검정, 분산분석, 로지스틱 회귀분석을 실시하였다. 결과: 주관적 체형 인식이 과체중(OR, 4.039; 95% CI, 3.486–4.679), 비만(OR, 11.840; 95% CI, 9.625–14.565)에 해당하는 군에서 정상인 군에 비해 대사증후군 위험도가 증가하였으며, 객관적인 BMI 지표보다 주관적 체형 인식에서 덜 비만하다고 생각하는 군이 체형 인식이 올바른 군에 비해 대사증후군의 위험도가 증가하는 것으로 나타났다(OR, 1.622; 95% CI, 1.438–1.830). 결론: 한국 성인에서 객관적인 BMI 지표가 주관적인 체형 인식보다 높은 경우 대사증후군의 위험도가 증가한다.
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양훈주,송윤미,김리연,오지혜,조태형,김인숙,황순정,Yang, Hoon Joo,Song, Yoon Mi,Kim, Ri Youn,Oh, Ji Hye,Cho, Tae Hyung,Kim, In Sook,Hwang, Soon Jung 대한악안면성형재건외과학회 2013 Maxillofacial Plastic Reconstructive Surgery Vol.35 No.1
Purpose: Maxilla and mandible have different patterns of cortical and trabecular bone and different bone mineral densities, even though both are components of the jaw bone. However, cellular differences between maxilla- and mandible derived osteoblasts (OBs) have rarely been studied. We hypothesize that maxilla- and mandible-derived OBs show different responses to $17{\beta}$-estradiol (E2), which is one of the critical factors for bone formation. This study compares skeletal site-specific cell responses between maxilla- and mandible-derived human OBs to E2. Methods: Maxilla- and mandible-derived OBs derived from an identical donor were separately isolated from a total of five normal healthy subjects aged 18~44 years old, cultured with a treatment of 100 nM estrogen. The responses between maxilla- and mandible-derived OBs to E2 were evaluated and compared using cell proliferation, alkaline phosphatase (ALP) activity and gene expression of osteoprotegerin (OPG), ALP, insulin-like growth factor-1 (IGF-1), and estrogen receptor ${\alpha}$ ($ER{\alpha}$). Results: E2 did not have any distinct effects on the proliferation of both types of OBs. Mandible-derived OBs exhibited higher ALP activity than maxilla-derived OBs in the non-treated condition, which was common in all tested individuals. ALP activities of both types of OBs showed a minor increasing tendency with the treatment of E2, even though there was no statistical significance in some specimens. The gene expression of OB by E2 was diverse, depending on the individuals. There was increased expression of OPG, IGF-1, or $ER{\alpha}$ gene in the part of subjects, which was more repeated in maxilla-derived OBs. In particular, OPG or ALP induction by E appeared less frequently in mandible-derived OBs. Conclusion: Current results revealed that E2 affects maxilla- and mandible-derived OBs into facilitating the osteogenic process despite individual differences. Mandible-derived OBs are less sensitive to bone-forming gene expression by E2.
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이성훈,이동훈,박봉우,김리연,황안득,우상근,Wenjun Xiong,이용진,반기원,박훈준 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
Vascular regeneration in ischemic hearts has been considered a target for new therapeutic strategies. It has been reported that ETV2 is essential for vascular development, injury-induced neovascularization and direct cell reprogramming of non-endothelial cells into endothelial cells. Thus, the objective of this study was to explore the therapeutic potential of ETV2 in murine models of myocardial infarction in vivo. Direct myocardial delivery of lentiviral ETV2 into rodents undergoing myocardial infarction dramatically upregulated the expression of markers for angiogenesis as well as anti-fibrosis and anti-inflammatory factors in vivo. Consistent with these findings, echocardiography showed significantly improved cardiac function in hearts with induced myocardial infarction upon ETV2 injection compared to that in the control virus-injected group as determined by enhanced ejection fraction and fractional shortening. In addition, ETV2-injected hearts were protected against massive fibrosis with a remarkable increase in capillary density. Interestingly, major fractions of capillaries were stained positive for ETV2. In addition, ECs infected with ETV2 showed enhanced proliferation, suggesting a direct role of ETV2 in vascular regeneration in diseased hearts. Furthermore, culture media from ETV2-overexpressing cardiac fibroblasts promoted endothelial cell migration based on scratch assay. Importantly, intramyocardial injection of the adeno-associated virus form of ETV2 into rat hearts with induced myocardial infarction designed for clinical applicability consistently resulted in significant augmentation of cardiac function. We provide compelling evidence that ETV2 has a robust effect on vascular regeneration and enhanced cardiac repair after myocardial infarction, highlighting a potential therapeutic function of ETV2 as an efficient means to treat failing hearts.
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