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권혁찬(Hyuk Chan Kwon),김재석(Jae Seok Kim),김효진(Hyo Jin Kim) 대한내과학회 2001 대한내과학회지 Vol.61 No.4
N/A Background: There are few therapeutic options in patients with colorectal cancer that progressed or recurred after initial 5-fluorouracil (5-FU) therapy. Many different 5-FU-based regimens and biochemical modulations that can potentiate the cytotoxic effects of 5-FU have been investigated in these patients. We evaluated the efficacy and toxicity of combination of 5-FU, leucovorin, levamisole and cisplatin (FLLP) salvage combination chemotherapy in progressive or recurrent colorectal cancer after 5-FU/leucovorin chemotherapy. Methods: Twenty-eight patients were enrolled in this study from April 1995 to July 1999. Patients received cisplatin (60 mg/㎡) administered on day 1, followed by leucovorin (20 mg/㎡) and 5-FU (375 mg/㎡) by rapid intravenous push for 5 consecutive days on day 1∼5. Levamisole was given or ally at a dose 50 mg three times a day on day 1∼3 & day 15∼17. Treatment courses were repeated in 4-week intervals. Results: Twenty-two patients were evaluable after treatment . Objective tumor response was in 4 of 22 (18.2%). The complete response, partial response, stable disease were 4.5% (1/22), 13.7% (3/22), 31.8% (7/22) respectively. The median response duration was 5.5 months. The median time to progression was 5.8 months. The overall median survival duration was 8.7 months and response group lived significantly longer than non-response group (not yet reached vs. 7.9 month, p=0.03). WHO grade 3-4 leukopenia occurred in 14%, nausea and vomiting 9%, but there was no treatment related death. Conclusion: We concluded that evaluation of this regimen appears relatively safe, with modest response as a salvage chemotherapy in patients who were previously exposed to 5-FU containing regimen. (Korean J Med 61:424-429, 2001)
심자도의 P-Q 구간과 T-P 구간에서 설정한 베이스 라인의 효과에 대한 연구
임현균,권혁찬,김태은,이용호,김진목,김인선,김기웅,박용기,Lim, Hyun-Kyoon,Kwon, Hyuk-Chan,Kim, Tae-En,Lee, Yong-Ho,Kim, Jin-Mok,Kim, In-Seon,Kim, Ki-Woong,Park, Yong-Ki 한국초전도학회 2007 Progress in superconductivity Vol.9 No.1
The baseline selection is the first and important step to analyze magnetocardiography (MCG) parameters. There are no difficulties to select the baseline between P- and Q-wave peak (P-Q interval) of MCG wave recorded from healthy subjects because the P-Q intervals of the healthy subjects do not much vary. However, patients with ischemic heart disease often show an unstable P-Q interval which does not seem to be appropriate for the baseline. In this case, T-P interval is alternatively recommended for the baseline. However, there has been no study on the difference made by the baseline selection. In this study, we studied the effect of the different baseline selection. MCG data were analyzed from twenty healthy subjects and twenty one patients whose baselines were alternatively selected in the T-P interval for their inappropriate P-Q interval. Paired T-test was used to compare two set of data. Fifteen parameters derived from the R-wave peak, the T-wave peak, and the period, $T_{max/3}{\sim}T_{max}$ were compared for the different baseline selection. As a result, most parameters did not show significant differences (p>0.05) except few parameters. Therefore, there will be no significant differences if anyone of two intervals were selected for the MCG baseline. However, for the consistent analysis, P-Q interval is strongly recommended for the baseline correction.
문용혁 ( Yong-hyuk Moon ),권혁찬 ( Hyeokchan Kwon ),서동일 ( Dong-il Seo ),윤찬현 ( Chan-hyun Youn ) 한국정보처리학회 2011 한국정보처리학회 학술대회논문집 Vol.18 No.2
본 고에서는 최근 주목 받고 있는 비디오 스트리밍 보안 기술과 관련한 ITU-T 표준화 내용에 대하여 살펴보고자 한다. 특히, SVC (Scalable Video Coding) 기술을 위해 제안된 안전한 트랜스코딩 메커니즘 (Secure Transcodable Mechanism)을 위한 보안 정책 모델에 대하여 논의한다.
문용혁 ( Yong-hyuk Moon ),권혁찬 ( Hyeokchan Kwon ),서동일 ( Dong-il Seo ),윤찬현 ( Chan-hyun Youn ) 한국정보처리학회 2011 한국정보처리학회 학술대회논문집 Vol.18 No.1
본 고에서는 다양한 공유 환경에서 사용자의 콘텐츠 이용을 저해하지 않으면서, 콘텐츠의 중립적 사용과 안정성을 동시에 충족시킬 수 있도록 고안된 플랫폼 독립적 콘텐츠 공유 시스템에 대하여 논의한다. 특히, 본 시스템은 별도로 정의된 Bytecode 형태의 보안 코드를 플랫폼 독립적으로 해석하는 기능의 Secure Virtual Machine 기반으로 구현되는 제안상의 특징이 있다.
임현균,김기웅,권혁찬,이용호,Lim, Hyun-Kyoon,Kim, Ki-Woong,Kwon, Hyuk-Chan,Lee, Yong-Ho 한국초전도학회 2008 Progress in superconductivity Vol.10 No.1
Magnetocardiography (MCG) is a non-contact, non-invasive, and harmless diagnostic tool to detect the abnormal electrical conductivities of the heart caused by the various coronary artery disease or cardiac muscular disease. The purpose of this study is to identify whether MCG signals and MCG parameter values vary depending on the location of sensor assembly. It will be an important reference for the standard measurement. Four healthy male subjects (33.3$\pm$6.3 years) participated in this study. Basal recording was made at 20 mm apart from the chest surface. All subjects were requested to take a regular breathe while MCG was taken. The gap between the chest surface and the bottom of the sensor assembly was 20, 40, 60, and 80 mm. Recording was made using 64 channel MCG system (Axial type, first order gradiometer) developed by Korea Research Institute of Standards and Science (KRISS). After resting for two minutes in a supine position on the bed in magnetically shielded room, MCG were recorded for 30 s. As the sensor location is getting away from the chest surface signal, the amplitude of R and T wave peak decreases to 70% (at 40 mm gap), 50% (at 60 mm), and 37% (at 80 mm) of the reference strength measured (y = $1.3903e^{-0.0169x}$, $R^2$ = 0.99; where y=amplitude remained after reduction, x=distance between chest surface and sensor location). The regression equations may be used as a good reference to calculate how much strength will be decreased by the distance. In MCG parameters, most values of parameters were decreased as the gap was increased. As an example, the current moment at T-wave peak reduced to 52% (at 40 mm gap), 33% (at 60 mm), and 19% (at 80 mm). However, the difference caused by the gap could be reduced by considering the distance when the MCG parameters were calculated. The study results can be used as a useful reference to design the baseline and the sensor location.
Multi-Class Job 모델을 위한 Size-Interval 기반 할당 시스템 분석
문용혁 ( Yong-hyuk Moon ),권혁찬 ( Hyeokchan Kwon ),윤찬현 ( Chan-hyun Youn ) 한국정보처리학회 2011 한국정보처리학회 학술대회논문집 Vol.18 No.1
본고에서는 Multi-class Jobs 을 Dispatching system 에서 처리하는 경우, Cost performance 을 점근적으로 해석하는 과정에 대해 논의한다. 구체적으로, Job 할당 시스템은 Size-Interval 기반의 스케줄링 기법을 이용하고, Resource failure 에 대비하여 Job duplication 전략을 활용하는 것으로 가정한다.