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임현균 대한기계학회 2000 기계저널 Vol.40 No.9

Blood Pressure Differences between a Mercury Sphygmomanometer and Two Automatic Devices

임현균,도일,안봉영 대한의용생체공학회 2015 Biomedical Engineering Letters (BMEL) Vol.5 No.4

Purpose Blood pressure (BP) is one of the most importantpieces of information to diagnose cardiovascular diseases butthe measurement readings could be easily changed by variousfactors. If these readings are wrong, it may ultimately lead toa misdiagnosis. In addition, there is a problem when thereare different devices used to read blood pressure becausethese devices may give different readings. Methods Four different BP measurement devices were used,including two mercury sphygmomanometers and twoautomatic digital devices. Thirty-eight healthy young people(mean age = 27.1±6.1 years) stayed one night at a clinicalcenter and the BPs were measured from their right arms onthe following day. Factors such as exercise, food, and smokingthat may affect the BP were controlled and prohibited. Alltests were repeated three times and all devices were calibratedbefore the test. Absolute BP value difference between amercury sphygmomanometer and an automatic digital devicewas counted for the BP difference between devices ≥ 5 mmHgand ≥ 10 mmHg of each measurement. Results Significant inter-device BP differences were foundbetween a mercury sphygmomanometer and two automaticdevices (p<0.01) while no significant difference was foundbetween mercury sphygmomanometers (p>0.5); all subjectsshowed BP difference less than 5 mmHg between twomercury sphygmomanometers while only 32% and 38% ofsubjects showed BP difference less than 5 mmHg for two outof three repeated tests between a mercury sphygmomanometerand an automatic device, and even 26% ~ 36% of subjectsshowed BP difference ≥ 10 mmHg. Conclusions This study result stresses that it is necessary tocheck the reliability of automatic blood pressure devicesused in the hospitals. In addition, an easier and moreconvenient protocol should be developed for the routinecalibration of automatic devices.

경직의 정량 평가를 위한 진자실험의 변수분석 ( A Study on the Parameter Analysis for the Quantitative Evaluation of Spasticity Implementing Pendulum Test )

임현균,이영신,조강희,채진목,김봉옥 대한기계학회 2000 대한기계학회 춘추학술대회 Vol.- No.-

운동과 약물에 의한 심장 부하의 심자도 양상 비교

임현균,김기웅,권혁찬,이용호,김진목,유권규,김인선,김원식,임청무,이상길,정남식,고영국 한국감성과학회 2009 춘계학술대회 Vol.2009 No.-

심장의 박동수 자율신경계에 있어서 매우 중요한 감성 지표가 되어 왔다. 정상인 심장박동수의 개인간 차이는 유의하게 다르지 않다. 그러나 심장병 환자는 건강한 사람들과 유의한 차이를 보이게 된다. 특히 허혈 초기에는 증상이 잘 나타나지 않기 때문에 일부러 심장에 부하를 주어서 허혈 유무를 판정하기도 한다. 부하를 주는 방법은 운동에 의한 운동부하검사, 약물에 의한 약물부하검사로 나뉜다. 신체조건 및 안정상 운동부하 검사가 불가능한 경우에는 약물을 이용한다. 심전도를 이용한 심장부하 연구는 많이 수행되어 왔으나 심자도 연구는 초기단계이다. 본 연구에서는 20 대 정상인 20 명과 협심증 환자들 27명에게 약물 부하를 유도하여 나타난 심박수, 심자도의 차이를 비교하였다. 또한 8 명의 정상인을 대상으로 가혹한 운동부하를 일으켜 최대 부하상태에선 안정 상태까지 이르는 과정을 심자도로 관찰하였다. 결과로서 운동부하 검사에서 야기되는 스트레스의 정도는 약물로 얻어지는 부하에 비해 유의하게 큼을 알 수 있었다. 또한 약물 스트레스는 정상인의 심장 전기생리학적 변화는 미미하지만 일부 허혈 환자들에게서는 유의한 차이를 보였다. 미약한 약물 스트레스에 대해 변화되는 정도가 심자도에 관찰되어 허혈 검사에 사용 가능성을 보였다.

HPLC-MS를 이용한 생체시료 중 니세르골린의 주대사체인 10${\alpha}$-Methoxy-9,10-dihydrolysergol(MDL)의 분석 및 이를 이용한 한국인 성인 남성에 대한 생체이용률 응용

임현균,유선동,김경호,한상범,염정록,Lim, Hyon-Kyun,Yoo, Sun-Dong,Kim, Kyeong-Ho,Han, Sang-Beom,Youm, Jeong-Rok 대한약학회 2007 약학회지 Vol.51 No.2

A simple and sensitive HPLC-MS method for quantitation of 10${\alpha}$-methoxy-9,10-dihydrolysergol (MDL), the main metabolite of nicergoline, in human plasma was developed and the bioavailability parameters of MDL was assessed in Korean healthy male volunteers. Clomipramine was used as an internal standard. MDL and internal standard in plasma sample were extracted using ethyl acetate. A centrifuged upper layer was then evaporated and reconstituted with mobile phase of 10 mM ammonium acetate-acetonitrile (10 : 90, v/v). The reconstituted samples were injected into a Zorbax SB-C8 column (2.1${\times}$150 mm,5 ${\mu}$m) at a flow-rate of 0.3 ml/min. Using MS with selected ion monitoring (SIM) mode, MDL and clomipramine were detected without severe interference from human plasma matrix. MDL produced a protonated molecular ion ([M+H]$^+$) at m/z 287. Internal standard produced a protonated molecular ion ([M+H]$^+$) at m/z 315. A linear relationship for MDL was found in the range of 2.5${\sim}$100 ng/ml. The lower limit of quantitation (LLOQ) was 2.5 ng/ml with acceptable precision and accuracy. The intra- and inter-day validation for all coefficients of variation (R.S.D.%) were found less than 15%. Main pharmacokinetic parameters of 30 mg of nicergoline were revealed as follows: AUC$_t$ 321.1${\pm}$64.5 ng${\cdot}$hr/ml, C$_{max}$, 51.2${\pm}$25.3 ng/ml, T$_{max}$ 3.6${\pm}$1.5 hr, K$_{el}$ 0.12${\pm}$0.07 hr$^{-1}$ and t$_{1/2}$ 7.6${\pm}$3.4 hr. Inter subject variations and race differences were shown in comparison with the published data in the literature.

리피토정^® (아토르바스타틴 20 mg)에 대한 아토르바정^®의 생물학적동등성

임현균,이태호,이재현,염정록,송진호,한상범,Lim, Hyun-Kyun,Lee, Tae-Ho,Lee, Jae-Hyun,Youm, Jeong-Rok,Song, Jin-Ho,Han, Sang-Beom 한국약제학회 2008 Journal of Pharmaceutical Investigation Vol.38 No.2

The present study describes the evaluation of the bioequivalence of two atorvastatin tablets, Lipitor $Tablet^{(R)}$ (Pfizer, reference drug) and Atorva $Tablet^{(R)}$ (Yuhan, test drug), according to the guidelines of Korea Food and Drug Administration (KFDA). Forty-nine healthy male Korean volunteers received each medicine at the atorvastatin dose of 40 mg in a $2{\times}2$ crossover study with a two weeks washout interval. After drug administration, serial blood samples were collected at a specific time interval from 0-48 hours. The plasma atorvastatin concentrations were monitored by an high performance liquid chromatography -tandem mass spectrometer (LC-MS/MS) employing electrospray ionization technique and operating in multiple reaction monitoring (MRM) and positive ion mode. The total chromatographic run time was 4.5 min and calibration curves were linear over the concentration range of 0.1-100 ng/mL for atorvastatin. The method was validated for selectivity, sensitivity, linearity, accuracy and precision. $AUC_t$ (the area under the plasma concentration-time curve from time zero to 48hr) was calculated by the linear log trapezoidal rule method. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were complied trom the plasma concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_t$ and $C_{max}$. No significant sequence effect was found for all of the bioavailability parameters indicating that the crossover design was properly performed. The 90% confidence intervals of the $AUC_t$ ratio and the $C_{max}$ ratio for Atorva $Tablet^{(R)}$ / Lipitor $Tablet^{(R)}$ were ${\log}\;0.9413{\sim}{\log}\;1.0179$ and ${\log}\;0.831{\sim}{\log}\;1.0569$, respectively. These values were within the acceptable bioequivalence intervals of ${\log}\;0.8{\sim}{\log}\;1.25$. Based on these statistical considerations, it was concluded that the test drug, Atorva $Tablet^{(R)}$ was bioequivalent to the reference drug, Lipitor $Tablet^{(R)}$.

Flexible Transparent Conducting Hybrid Film Using Surface-embedded Copper Nanowire (CuNW) Network

임현균,진정호,장준호,배병수 한국고분자학회 2015 한국고분자학회 학술대회 연구논문 초록집 Vol.2015 No.4

진자실험을 통한 경직의 정량적 평가에 관한 연구 II - 대표변수를 이용한 새로운 척도 개발

임현균,조강희,김봉옥,이영신 대한의용생체공학회 2001 의공학회지 Vol.22 No.1

본 연구에서는 진자 실험을 통하여 중추신경계 질환인 경직을 정량적으로 판정할 수 있는 새로운 LCL(Logically Classified Level) 척도(scale)가 개발되었다. 새로운 척도개발에는 총 30개의 변수가 사용되었다. 이를 위하여 실험결과의 통계적 분석이 수행되었고 이들 중 진자 실험에서 경직의 특성이 가장 잘 반영되는 변수가 대표변수로 선정되었다. 사용된 30개의 변수 중 20개는 새로 도출된 변수이며 10개는 선행된 연구자들에 의하여 개발된 변수이다. 새로운 20개의 변수들은 진자 실험에서 발생되는 특성들인 각도, 각속도, 근육 모델, EMG가 고르게 반영될 수 있도록 이들의 조합으로 도출되었다. 이변량 상관분석결과 총 30개의 변수들 중 11개의 변수들은 서로 밀접한 상관성이 있음이 파악되었다. 11개의 서로 강한 상관성을 보이는 변수 중 논리적인 모순이 없는 L11이 대표변수로 선택되었다. 28명의 환자 데이터는 대표변수인 L11를 기준으로 4개의 그룹으로 분리되었고 최종으로 이들 그룹의 경향을 예측할 수 있는 회귀 방정식을 유도하였다. 새로운 척도에 사용된 대표변수인 L11은 환자들에게서 나타날 수 있는 여러 경우에 적합한지 검토되었는데 미소한 환자의 상태까지 잘 반영하고 있음이 드러났다. 따라서 새로운 LCL 척도는 기존의 준 정량적인 척도인 MAS(Modified Ashworth Scale)를 대체할 수 있을 것으로 기대된다. 특히 환자의 초기 진단뿐만 아니라 동일한 환자의 치료전후, 병적 호전에 대하여 정밀하게 파악할 수 있어 약물의 처방량 조절, 치료기간 등 치료의 전략에 사용될 수 있을 것으로 기대된다. A new scale named LCL(Logically Classified Level) has been developed to judge the status of the spasticity quantitatively implementing a pcndulum test in this study. Total 30 parameters have been used to develop the new scale. One representative parameter that can represent the dominant characteristics of spasticity has been chosen through statistical analysis. 20 parameters among 30 parameters uscd in the statistical analysis were newly developed and 10 parameters were from previous studies. The new 20 parametcrs were developed using combinations of pcndulum test characteristics. ie anglc, angular velocity. musclo midel. and EMG. 11 parameters among 30 parameters have showed strong correlations each other, Finally. L11 that showed consistency at every case has been chosen to be a representative parameter among the 11 parameters. 28 patients data were separated into 4 groups. A regression equation to predict the trend of patients of L11 has been made. The paramcter L11 was tested to prove its usabilitics for various cases of patients. The new LCL scale is expected to be a quantitative scale, and to replace the MAS(Modified Ashworth Scale) that is not a quantitative scale. Especially it is also expected that the new scale could be used to plan a treatmcnt period. methods, and intensity. as it can evaluate the status of patient's in detail.

관상동맥질환을 진단하기 위한 R파와 T파의 크기에 대한 연구

임현균,유권규,김진목,김인선,강찬석,박용기,Lim, Hyun-Kyoon,Yu, Kwon-Kyu,Kim, Jin-Mok,Kim, In-Seon,Kang, Chan-Seok,Park, Yong-Ki 한국초전도학회 2008 Progress in superconductivity Vol.10 No.1

Multi-channel magnetocardiography (MCG) has been proposed to detect ischemic heart disease because its sensitivity is quite high comparing with other conventional diagnostic tools. Especially, current map and magnetic field map of MCG provide crucial information on whether myocardiac muscles maintain the normal conduction pathway. In addition, MCG parameters derived from repolarization are useful to detect coronary artery disease. Recently, there was a study reporting that R- and T- wave amplitude are highly correlated with ischemic heart disease. In this study, we studied R- and T-wave amplitude and their ratio as well as MCG parameters. MCG data from 20 young, 20 age-matched controls, and 20 myocardial infarction (MI) patients were analyzed. As a result, MCG parameters showed significant change in MI patients comparing to those of controls. R- and T-wave amplitude of MI patients showed a feature of severe ischemic heart disease even though it was difficult to find consistent values. Further study is needed to reveal the relations between small T-wave amplitude and coronary artery disease.

심자도 센서의 위치 효과에 대한 연구

임현균,김기웅,권혁찬,이용호,Lim, Hyun-Kyoon,Kim, Ki-Woong,Kwon, Hyuk-Chan,Lee, Yong-Ho 한국초전도학회 2008 Progress in superconductivity Vol.10 No.1

Magnetocardiography (MCG) is a non-contact, non-invasive, and harmless diagnostic tool to detect the abnormal electrical conductivities of the heart caused by the various coronary artery disease or cardiac muscular disease. The purpose of this study is to identify whether MCG signals and MCG parameter values vary depending on the location of sensor assembly. It will be an important reference for the standard measurement. Four healthy male subjects (33.3$\pm$6.3 years) participated in this study. Basal recording was made at 20 mm apart from the chest surface. All subjects were requested to take a regular breathe while MCG was taken. The gap between the chest surface and the bottom of the sensor assembly was 20, 40, 60, and 80 mm. Recording was made using 64 channel MCG system (Axial type, first order gradiometer) developed by Korea Research Institute of Standards and Science (KRISS). After resting for two minutes in a supine position on the bed in magnetically shielded room, MCG were recorded for 30 s. As the sensor location is getting away from the chest surface signal, the amplitude of R and T wave peak decreases to 70% (at 40 mm gap), 50% (at 60 mm), and 37% (at 80 mm) of the reference strength measured (y = $1.3903e^{-0.0169x}$, $R^2$ = 0.99; where y=amplitude remained after reduction, x=distance between chest surface and sensor location). The regression equations may be used as a good reference to calculate how much strength will be decreased by the distance. In MCG parameters, most values of parameters were decreased as the gap was increased. As an example, the current moment at T-wave peak reduced to 52% (at 40 mm gap), 33% (at 60 mm), and 19% (at 80 mm). However, the difference caused by the gap could be reduced by considering the distance when the MCG parameters were calculated. The study results can be used as a useful reference to design the baseline and the sensor location.