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한국 폐경 후 여성에서 유전자 다형성과 골밀도의 연관성 ; 유전자 상호작용
권인순(In Soon Kwon),김인규(In Gyu Kim),강창모(Chang Mo Kang),유태우(Tai Woo Yoo),박병주(Byung Joo Park),강홍식(Heung Sik Kang),이행신(Haeng Shin Lee),김초일(Cho Il Kim),조현찬(Hyun Chan Cho),배상훈(Sang Hoon Bae),박상철(Sang Chul Pa 대한내과학회 2001 대한내과학회지 Vol.60 No.5
N/A Results : There was no significant relationship of VDR or ER genotypes to lumbar or femoral neck BMD, hormones, and bone turnover markers. However, after controlling for potential confounding factors, a statistically significant ER X genotype effect on femoral neck BMD (p=0.038) , but not on lumbar BMD was observed . Moreover, there was more significant effect on femoral neck BMD by an interaction of VDR B * ER X genotype (p=0.013) in multiple regression analysis . Conclusion : The ER X genotype was associated with femoral neck BMD in Korean postmenopausal women . This association was more significant with the VDR B genotype interaction .(Korean J Med 60:421-431, 2001)