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권오덕(Oh-Deog Kwon),정규용(Kyu-Yong Jung) 한국독성학회 2003 Toxicological Research Vol.19 No.4
This study was carried out to investigate the effect of chitosan on lead metabolism in SD rats. Ten male rats were divided into a experimental group and a control group. Each experimental and control rats were administered by water contaminated with 100 mg/l of lead for 4 weeks, respectively. Experimental group received diets supplemented artificially with 5% of chitosan for 4 weeks. Body weight change, food and water consumption, fecal and urinary excretion, and fecal and urinary lead excretion were measured. There were no significant differences in body weight gain, food<br/> and water consumption, and fecal and urinary excretion between the two groups. However, fecal lead excretion of rats fed the diet containing 5% of chitosan were higher than the control group. Whereas urinary lead excretion of rats fed the diet containing 5% of chitosan were lower than the control group. The results suggested that the oral administration of chitosan prevents the gastrointestinal lead absorption in rats.
마우스에서 Interleukin-2가 RD-995 종양세포에 미치는 항암효과
권오덕 ( Oh Deog Kwon ) 한국가축위생학회 2002 韓國家畜衛生學會誌 Vol.25 No.3
Recombinant interleukin-2(IL-2) has demonstrated as an antineoplastic agent in mice and human, hut the relatively low response rates observed in clinical trials. Therefore, the present study was undertaken in order to evaluate therapeutic activities of IL-2 for the establishment of therapeutic applications. At the onset of the experiment, normal C3H/HeN mice were injected with 5×10(6) RD-995 tumor cells, murine ultraviolet radiation-induced fibrosarcoma, intraperitoneally. Beginning on day 6, experimental groups were treated with a 5-day course of IL-2(subcutaneous injection of 30,000 IU every 12 hours for 5 days). The result of this experiment revealed that body weight gradually decreased from 20th day in control mice. Subcutaneous IL-2 therapy prevented partially decrease body weight, and prolonged survival of mice compared with control group.
권오덕 ( Oh Deog Kwon ) 한국가축위생학회 2001 韓國家畜衛生學會誌 Vol.24 No.1
Squamous cell carcinoma of the skin was diagnosed in an 11-year-old, Australian shepherd dog with a hard mass on the right rump area. On histopathological examination of the tumor showed laminated keratin "pearls" surrounded by proliferated squamous cells, and mitotic figures. The dog was treated by surgical excision and chemotherapy with vinblastine sulfate, cyclophosphamide and prednisolone for 4 weeks. The tumor was effectively treated with a combination of surgery and chemotherapy.
수송 스트레스 및 영양결핍에 기인한 일본원숭이의 집단 폐사
권오덕 ( Oh Deog Kwon ),정규식 ( Kyu Shik Jeong ),이근우 ( Keun Woo Lee ),이창민 ( Chang Min Lee ),임채웅 ( Chae Woong Lim ),도재철 ( Jae Cheul Do ) 한국가축위생학회 2003 韓國家畜衛生學會誌 Vol.26 No.2
There was a mass outbreak of death caused by transport stress and malnutrition in Japanese macaques imported from Japan at a farm stock in Korea, which were diagnosed on the ground of history taking, clinical finding, hematological examination and necropsy. Twenty eight Japanese macaques imported from Japan died suddenly from the 4th day after arrival in a farm. These animals were confined very small cages individually and lose the appetite for 10 days from shipping. Main clinical findings observed from alive Japanese macaques consisted of hypothermia and dehydration. On hematological observation for typical 4 cases showed increased erythrocytes and packed cell volume. On serum biochemical examination for 3 cases showed hypoglycemia, whereas blood urea nitrogen, aspartate aminotransferase and alanine aminotransferase were increased. On necropsy for 3 cases, hemorrhage and congestion were observed on the lung and the walls of stomach and intestine were thinned. Histologically, hemorrhagic pneumonia and enteritis with loss of villi were seen. The death of these animal was caused by poor management during transport, which was resulted in transport stress and malnutrition.
전북지방에저 생산된 가축사료내 카드뮴 함량에 관한 조사연구
권오덕,Kwon Oh-Deog 한국임상수의학회 1992 한국임상수의학회지 Vol.9 No.1
Present study was undertaken in order to evaluate the cadmium contents of various feedstuffs produced in Chonbuk area. Fifty-five samples were collected from 5 regions. All of the samples were dry-ashed and analyzed for cadmium content using atomic absorption spectrophotometer. The results obtained were summarized as followed : 1. The cadmium content in $\mu\textrm{g}$/g of agriculture by-products were measured with the following mean values and ranges : soybean pod 3.15${\pm}$0.51(2.40∼3.81), rice bran 2.87${\pm}$0.23(2.50∼3.09), rice straw 1.66${\pm}$0.85(1.08∼3.14), rice hull 0.86${\pm}$0.45(0.41∼1.35). 2. The cadmium content in $\mu\textrm{g}$/g of pasture plants were measured with the following mean values and ranges : kudzu 5.65${\pm}$1.00(4.87∼7.29), sagebrush 4.86${\pm}$1.24(2.89∼6.24), clove, 4.28${\pm}$0.75(2.99∼4.86), lespedeza 3.99${\pm}$1.21(2.38∼4.94), Korean lawn grass 2.24${\pm}$1.04(1.33∼3.44), reed 1.99${\pm}$0.95(0.88∼2.91), cornstalk 1.61${\pm}$0.99(0.38∼3.12). 3. The regional mean values for all kinds of samples were Okgu-gun 3.19${\pm}$2.09$\mu\textrm{g}$/g, Mooju-gun 3.15${\pm}$1.73$\mu\textrm{g}$/g, Wanju-gun 3.05${\pm}$1.76$\mu\textrm{g}$/g, Namwon-gun 2.85${\pm}$1.70$\mu\textrm{g}$/g, Jeongup-gun 2.85${\pm}$1.25$\mu\textrm{g}$/g.
산양의 실험적 납중독에 관한 임상병리학적 관찰 I. 임상학적 관찰(증상, 혈액, 뇨)
권오덕,이현범,이주묵,채준석,Kwon, Oh-deog,Lee, Hyun-beom,Lee, Joo-mook,Chae, Joon-seok 대한수의학회 1992 大韓獸醫學會誌 Vol.32 No.1
Present experiments were undertaken in order to clarify the clinico-pathological characteristics of lead poisoning in goats. Twenty goats were divided into three experimental groups(A, B and C) and a control(D). The three experimental groups received diets contaminated artificially with 10(A group), 200(B group) and 1,000(C group) ${\mu}g/$ of lead, for 70 days respectively. The control group received normal diets. Blood samples were collected 1 or 2 weeks interval and were examined for anemia(erythrocyte counts, hemoglobin concentrations and hematocrit values) and lead contents of erythrocyte and serum. Urine samples collected similarly with blood were examined for delta-aminolevulinic acid and lead content. Collected samples were analyzed for lead content by atomic absorption spectrophotometry. From these experiments following results were obtained : In group B and C, marked decreases in body weight and feed intake, and diarrhea were observed from the $30^{th}$ day of experimental periods. The B and C groups showed pronounced anemia(decrease in erythrocyte count, hemoglobin concentration and hematocrit value) from the $21^{st}$ or $42^{nd}$ day. In group B and C, the lead content of erythrocytes was increased significantly from the $28^{th}$ or $14^{th}$ day. The lead content of serum was increased significantly from the $42^{nd}$ or $14^{th}$ day in B and C groups. The lead content of urine was increased significantly from the first day in both B and C groups. The urinary delta-aminolevulinic acid content was increased significantly from $14^{th}$ day in both B and C groups.