Effect of Jaeumkanghwatang (JEKHT), a Polyherbal Formula on the Pharmacokinetics Profiles of Tamoxifen in Male SD Rats (1) - Single Oral Combination Treatment of Tamoxifen 50mg/kg with JEKHT 100 mg/kg within 5 min -

곽민아,박수진,박성환,이영준,구세광 대한한의학회 2016 대한한의학회지 Vol.37 No.2

Objectives: The objective of this study was to elucidate the effect of Jaeumkanghwatang (JEKHT) on the plasma concentration and pharmacokinetics of tamoxifen in combination therapy as a process of the comprehensive and integrative medicine against breast cancer. Methods: After 50 mg/kg of tamoxifen treatment, JEKHT 100 mg/kg was orally administered within 5 min. The plasma were collected at 30 min before administration, 30min, 1, 2, 3, 4, 6, 8 and 24 hrs after end of JEKHT treatment, and plasma concentrations of tamoxifen were analyzed using LC-MS/MS methods. PK parameters of tamoxifen (Tmax, Cmax, AUC, t1/2 and MRTinf) were analysis as compared with tamoxifen single administered rats. Results: JEKHT did not influenced on the plasma concentrations and pharmacokinetics of tamoxifen after single oral co-administration, within 5min except for some negligible effects on plasma concentration. The Tmax, Cmax, AUC, t1/2 and MRTinf of tamoxifen in co-administered rats were quite similar to those of tamoxifen single treated rats. Conclusions: Based on the results of the present study, JEKHT did not influenced on the oral bioavailability of tamoxifen, when they were single co-administered within 5min. However, more detail pharmacokinetic studies should be tested to conclude the possibilities that can be used as comprehensive and integrative therapy with JEKHT and tamoxifen for breast cancers, when they were co-administered, like the effects on the pretreatment of JEKHT and after repeat co-administrations.

腹痛 및 下腹冷이 主訴인 만성췌장염 의증 환자 치험 1례

곽민아,황희정,변준석,박순달 대한한방내과학회 2002 大韓韓方內科學會誌 Vol.23 No.3

칼 안드레(Carl Andre, 1935∼)의 원소(elements)박물관

곽민아 미술사문화비평학회 2013 미술사문화비평 Vol.4 No.-

Andre’s floor pieces can be summarized as a simple pattern of repeating the unit of geometrical shape. Andre defined that the purpose of his work was to find and select an independent particle and make a work piece based on it. The unit is a unit that composed the whole piece and this concept corresponds to how Andre referred the particle therefore the unit is the root of his floor piece. Andre’s modular unit is fundamental and has singular size and properties. The modular unit are made to be simplest form with minimum requirements. This modualr units can be combined and form anxial symmetry that are free to exchange, add and remove - which is an important feature of Andre’s work. For this reason, Andre’s unit is the part of floor piece but, at the same time, it exists as the floor piece by itself. Andre wanted to make his unit to be most fundamental ones and noted basic materials : elements material. The element material cannot be splitted into any subordinate unit. Andre selected the Periodic table of the elements which organized by Dmitrii Ivanonichi Mendeleev, Russian chemist, as the theoretical basis. Since Andre was a child, he was interested in chemistry. Andre wanted to build a museum to exhibit samples of all materials. Andre’s floor pieces that are made of elements material show a desire for the museum. In the choosing the material, Andre followed the Periodic table of the elements outright. To emerge from the limitation on the selection of material, Andre used the method to place his units by intersection. The pieces are made with pure materials provided various experiences for visitors beyond the visual experience. Without dazzling visual stimuli, Andre’s floor pieces which made of element materials are active and free existence and does not lose its own identity and value always.

운동과 이침요법을 병행한 체중조절 프로그램이 비만아동의 체성분, 혈액구성 및 체력에 미치는 영향

곽민아,김대준,변준석 대한침구의학회 2009 대한침구의학회지 Vol.26 No.2

Objectives : The purpose of this study was to investigate the changes of obesity, blood composition and physical ability in obese children on body weight control program. Methods : The body weight control program included exercise, nutrition education and auricular acupuncture was performed 4 times a week during 12 weeks. 32 obese children whose body fat ratio were over 30% participated in this study. Measuring materials were body composition(weight, muscle mass, fat mass, fat ratio, BMI), physical measurement(height, waist circumference, chest circumference, hip circumference), physical ability(grip strength, sit-ups, sitting trunk flexion, sit-down stand-up test, standing long jump, opened eyes foot balance, side step), blood composition(WBC, Hb, ESR, Total Cholesterol, TG, GOT, GPT, BUN, Creatinine, Glucose) and survey(changes of eating habits, changes of living habits, knowledge of obesity, self-confidence, self-esteem). Results : From the results, positive changes were made in BMI, height, waist circumferences, chest circumferences, hip circumferences, sit-ups, sitting trunk flexion, sit-down stand-up test, standing long jump, opened eyes foot balance, side step, Hb, ESR, GOT, GPT and changes of eating habits through the body weight control program. Conclusions : This results suggest that body weight control program including exercise, nutrition education and auricular acupuncture may be effective for helping obese children.

正傳加味二陳湯과 clarithromycin의 倂用이 Helicobacter pylori에 미치는 영향

곽민아,서부일,변준석 대한본초학회 2004 大韓本草學會誌 Vol.19 No.3

Objectives : To evaluate the antibacterial and synergic effects of Jengjengamiygin-tang(JJGM) with clarithromycin by in Vitro and in Vivo methods. Methods : The minimal inhibitory concentration(MIC), MIC50 and MIC90 of single use of clarithromycin, JJGM and their concomitant treatment against Helicobacter pylori were observed. In addition, the changes of ulcerative lesions and viable cell numbers were also monitored after having experimented gastric infected mice models with Helicobacter pylori. Results : 1. The concomitant treatment of clarithromycin and JJGM showed relatively more favorable antibacterial effects than those of each. 2. The numbers of ulcerative lesions were more effectively inhibited by combination use of clarithromycin and JJGM. 3. The numbers of viable Helicobacter pylori were more effectively inhibited by combination use of clarithromycin and JJGM. Conclusions : The concomitant treatment of clarithromycin and JJGM showed relatively more favorable antibacterial effects than those of each.

Fabrication of Polyphenol-incorporated Hyaluronic Acid Hydrogels for Tissue Adhesives

곽민아,박원호 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.1

히알루론산(HA)은 D-glucuronic acid와 N-acetyl-D-glucosamine을 반복 단위로 가지는 음이온성 천연 다당류로 인체의 피부나 연골에 주로 존재한다. 우수한 생체적합성, 생분해성, 무독성 및 보습성 등의 특성을 가지기 때문에 조직공학 및 의약학 분야에서 다양하게 응용되고 있으며, 특히 사슬의 친수성 및 유연성이 우수하여 수화젤 형태로의 적용을 위한 연구가 많이 진행되고 있다. 하지만, 히알루론산 수화젤은 기계적 강도가 낮아 사용에 제한이 있어, 본 연구에서는 히알루론산 고분자에 다양한 기질에 우수한 접착력을 발현하는 카테콜기를 도입하여 이를 보완하고자 하였다. 제조된 히알루론산의 카테콜 유도체(HA-Cat)를 사용하여 산화가교에 의한 수화젤의 형성거동을 분석하였고, 접착력을 향상시키기 위해 식물에서 추출한 폴리페놀 화합물인 탄닌산(TA)을 추가로 첨가하였다. 첨가한 탄닌산 함량에 따른 HA-Cat 수화젤의 물리·화학적 특성 및 조직 접착력 등의 특성 분석을 통해 의료용 조직접착제로의 적용 가능성을 검토하였다.

Self-Crosslinkable Chitosan-Gallol Conjugate Hydrogels for 3D Bioprinting

곽민아,이수진,박원호 한국고분자학회 2022 한국고분자학회 학술대회 연구논문 초록집 Vol.47 No.1

Enhancement in Tissue Adhesion of Catechol-modified Hyaluronic Acid Hydrogels by Tannic Acid Treatment

곽민아,홍보민,박원호 한국고분자학회 2020 한국고분자학회 학술대회 연구논문 초록집 Vol.45 No.2

Hyaluronic Acid/Tannic Acid Blend Hydrogels with UV-Blocking, Antioxidant and Cooling

곽민아,이수진,박원호 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.2

수화젤은 다량의 수분을 함유할 수 있는 3 차원 망상구조물로 세포외기질(extracellular matrix, ECM)과의 유사성, 유연성, 보습성, 생체적합성을 가져 화장품 및 의·약학 등 다양한 분야에서 응용되고 있다. 한편, 기존의 수화젤형 자외선 차단제는 복잡한 공정조건, 비싼 비용, 낮은 생체적합성을 나타낸다. 본 연구에서는 간단한 공정으로 식물 유래 천연 자외선 차단제를 제조하고자 하였다. 식물성 폴리페놀 화합물인 탄닌산은 우수한 자외선 차단효과를 지니며 항산화능, 향균성, 항원 활성과 같은 생리활성 기능을 갖는다. 이처럼 다기능성을 갖는 탄닌산과 천연 고분자인 히알루론산을 단순히 혼합함으로써 수소결합 등에 의한 물리적 가교를 통해 수화젤을 형성하였다. 이후, 탄닌산 함량에 따른 수화젤의 물리·화학적 특성, 자외선 차단능 및 항산화 활성을 분석하였다. 또한 자일리톨을 첨가하여 흡열반응에 의한 냉감효과와 피부에 대한 보습성을 평가하였다. 따라서, 천연 재료 기반의 수화젤을 단순공정을 통해 제조함으로써 다기능성을 갖춘 자외선 차단제로의 적용 가능성을 확인하였다.

Gallol-modified Chitosan Hydrogels with Self-Crosslinking Capability for 3D Bioprinting

곽민아,박원호 한국고분자학회 2022 한국고분자학회 학술대회 연구논문 초록집 Vol.47 No.2