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Chlorpromazine이 家兎卵巢와 子宮 및 肝組織의 水分과 電解質에 미치는 影響
朴東欽 고려대학교 의과대학 1974 고려대 의대 잡지 Vol.11 No.2
Chlorpromazine, one of the antihistamine drugs, has been used for hypertensive disorders of the pregnancy, the menopausal syndrome, dysmenorrhea, and pre-menstrual tension. The drug is able to induce a number of untoward side effects, such as deleterious side effects to the hypothalamus-pituitary-gonadal-uterine axis, pituitary-thyrotropic axis, and the growth hormone. An attempt was made to clarify the effect of chlorpromazine to the gonads, water and electrolyte contents in the uterine and hepatic tissue of mature female rabbits weighing about 2.0 kg of body weight. A group of rabbits preconditioned with 50 I.U./kg of HCG for 5 days and another with 50 mg/kg of chlorpromazine plus 50 I.U./kg of HCG for 5 days were observed in 24 hours after conditioning. The results obtained are as follows: 1. The HCG preconditioned mature female rabbits showed acceleration of the follicles and ovulation in the ovaries, and the chlorpromazine plus HCG preconditioned group showed no definite evidence of the inhibition of ovulation. 2. The electrolyte levels in the serum of HCG preconditioned rabbits showed an increase of potassium and magnesium, and a decrease in chloride, sodium, and calcium levels. The levels of potassium and magnesium, on the contrary, were decreased and the sodium and calcium levels were increased in the chlorpromazine plus HCG preconditioned group. 3. The water, sodium, and calcium levels in the uterine tissue of the HCG preconditioned group were increased in comparison to its levels of the normal group and chloride and magnesium levels were decreased. In the chlorpromazine plus HCG preconditioned group, water, chloride and potassium levels of the uterus were decreased below the normal level and the calcium and magnesium levels showed further increase than the HCG preconditioned group. 4. The water content in the hepatic tissue was decreased, and chloride, sodium, and potassium levels were increased in the HCG preconditioned group. The water content was increased and chloride, sodium, potassium, and magnesium contents were remarkably decreased in chlorpromazine plus HCG preconditioned group. 5. The water contents in the hepatic tissue of the normal, HCG and chlorpromazine plus HCG preconditioned group were lower than that of the uterine tissue. 6. The chloride levels in the hepatic tissue of the normal, HCG, and chlorpromazine plus HCG preconditioned group were remarkably reduced. 7. The sodium contents in the hepatic tissue of normal, HCG, and chlorpromazine plus HCG preconditioned group were lower than that of the uterine tissue. 8. The potassium contents in the hepatic tissue of normal, HCG. and chlorpromazine plus HCG preconditioned group were higher than that of the uterine tissue. 9. There showed markedly decreased IeveIs o f the calcium in the hepatic tissue of the normal, HCG, and chlorpromazine plus HCG preconditioned group in comparison to the uterine tissue level. 10. Equally the magnesium showed decreased levels in all groups compared to the uterine tissue.
朴東欽 우석대학교 의과대학 1969 우석의대잡지 Vol.6 No.1
A statistical survey was conducted on infertile women of 306 cases who visited to outpatient clinic of Woo-Sok Medical College Hospital with chief complaint of infertility during the period of Jan. 1966 to Dec. 1968. This study includes all of the cases who has had a period of involuntary infertility of more than 3 years. This result revealed as follows : 1. Among the total outpatient of 4,771, the frequency of infertile women is 6.41%. Among them primary affection is 3.92% and secondary 2.49%. 2. In the age distribution the highest incidence is noted at the age of 25 to 30 in primary infertility and 31 to 35 in secondary infertility. 3. Infertility within 6 years occupies 49.98% of the total number of the infertile women and those with a period of infertility within 9 years are 65.38%. 4. Delayed tendency of menarche is not seen and there is no significant difference between primary and secondary infertility The cases who had regular menstrual history are predominant. 5. Most of the chief complaints were lower abdominal pain, genital discharge and lumbago which are seemed to be related to chronic pelvic inflammatory disease which might have caused infertility. Underdevelopment of genital organs and dysfunctions are the highest figure of 31.44% in primary affection and inflammation of genital organ is the highest figure in secondary affection respectively. 6. 46.37% of secondary infertility had abortions in their last pregnancy. 7. Hysterosalpingography showed tubal patency in 54.55% with primary infertility and 38.4% in secondary infertility. 8. Diagnostic endometrial curettage revealed secretory phase in 69.5% and endometrial tuberculosis was found in 8.5%.
변미권,김진영,심성흠,김기탁,김종득,박동일,감철우,Byun, Mi-Kwon,Kim, Jin-Young,Sim, Sung-Heum,Kim, Ki-Tak,Kim, Jong-Deuk,Park, Dong-Il,Kam, Cheol-Woo 대한한방내과학회 2007 大韓韓方內科學會誌 Vol.28 No.4
Amyotrophic lateral sclerosis (ALS) is a progressive disorder that causes degeneration of motor neurons of the brain and spinal cord. ALS is a progressive, fatal neuromuscular disease characterized by loss of motor neurons leading to muscle weakness. Sensation and mental function stay intact during the course of the disease. ALS is characterized by both upper and lower motor neuron damage. Diagnosis includes magnetic response imaging (MRI) electromyogram (EMG), muscle biopsy, and blood test. There is no cure for ALS. We recently observed three cases of ALS. The patients were diagnosis with ALS by EMG and symptoms. This report was conducted to evaluate how oriental medical treatment can affect ALS. We report the change of their symptoms through oriental medical treatment compared with taking riluzole.
인체폐암세포 NCI-H460 및 A549의 apoptosis 유발에 미치는 삼기보배탕의 영향
허만규,허태율,김기탁,변미권,김진영,심성흠,김광록,감철우,박동일,Heo, Man-Kyu,Heo, Tae-Yool,Kim, Ki-Tak,Byun, Mi-Kwon,Kim, Jin-Young,Sim, Sung-Heum,Kim, Koang-Lock,Kam, Cheol-Woo,Park, Dong-Il 대한한방내과학회 2007 大韓韓方內科學會誌 Vol.28 No.3
Objectives : This study was designed to investigate the antiproliferative activity of the water extract of Samgibopae-tang (SGBPT) in NCI-H460 and A549 non-small-cell lung cancer cell lines Methods : In this study, we measured the subsistence, form of NCI-H460 and A549 non-small-cell lung cancer cell by hemocytometer and DAPI staining. In each cell, we analyzed DNA fragmentation. reverse transcription-polymerase chain reaction and measured activity of caspase-3, caspase-8 and caspase-9. Results and Conclusions : We found that exposure of A549 cells to SGBPT resulted in growth inhibition in a dose-dependent manner. butSGBPT did not affect the growth of NCI-H460 cells. The antiproliferative effect by SGBPT treatment in A549 cells was associated with morphological changes. SGBPT treatment partially induced the expression of DR5 cells and the expression of Faswas markedly increased in both transcriptional and translational levels in A549 cells. SGBPT treatment partially induced the expression of Bcl-2, Bcl-XL and the expression of Bid was markedly decreased in translational levels in A549 cells. However, SGBPT treatment did not affect the expression of IAP family in A549 orNCI-H460 cells. SGBPT treatment partially induced the expression of caspase-3, caspase-8, caspase-9 activity which markedly increased in a dose-dependent manners in A549 cells. The fragmental development of PARP and ${\beta}$-catenin protein was observed in A549 cells by SGBPT treatment. SGBPT treatment induced the expression of PLC-${\gamma}1$ protein which decreased in A549 cells. SGBPT treatment partially induced the expression of DFF45/ICAD which markedly increased in a dose-dependent manner in A549 cells. Taken together. these findings suggested that SGBPT-induced inhibition of human lung carcinoma did not affect NCI-H460 cell growth. However, SGBPT-induced inhibition of human lung carcinoma A549 cell growth was associated with the induction of death receptor and mitochondrial pathway. The results provided important new insights into the possible molecular mechanisms of the anti-cancer activity of SGBPT.