자연과학분야 / 통합연구 : 기독교와 유전공학 ( 초록 )

서민호 통합연구학회 1989 통합연구 Vol.2 No.4

암의 분자생물학적 진단

서민호 啓明大學校 醫科大學 1991 계명의대학술지 Vol.10 No.3

1982年 大邱地方에서 分離된 Salmonell의 抗菌劑 感受性

徐民濩,李裕澈,趙東澤 대한화학요법학회 1983 대한화학요법학회지 Vol.1 No.1

1982年 1月부터 12月까지 慶北醫大 微生物學敎室과 大邱 東山의료원에 檢査의뢰된 가검물에서 分離 동정된 83株의 Salmonella paratyphi A 와 185株의 Salmonella typhi를 利用하여 chloramphenicol(Cm), terracycline(Tc), streptomycin(Sm), kanamycin(Km), amikacin(Ak), sulfisomidine(Su), nalidixic acid(Na), ampicillin (Ap), cephaloridine(Cr), gentamicin(Gm), trimethoprim(Tp), rifampicin(Rf) 等 12種의 抗菌劑에 대한 minimal inhibitory concentration(MIC)의 분포 및 耐性양상과 耐性의 接合에 의한 傳達 等을 관찰하였다. S. prartyphi A는 95% 억제 MIC가 Cm에는 8㎍/㎖, Ap에는 4㎍/㎖, Tp에는 0.5㎍/㎖로 나타났고 S. typhi는 95% 억제 MIC가 Cm에는 8㎍/㎖, Ap에는 2㎍/㎖, Tp에는 0.25㎍/㎖로 나타났다. S. paratyphi A는 총 83株 중 5株가 耐性이어서 耐性率이 6.0%였고 S. typhi는 총 185株 中 7株가 耐性이어서 耐性率이 3.8%였다. 특히 S. typhi 중에는 Tc, Sm, Ap, Cr, Km, Gm, Ak 等 7劑耐性菌과 Cm, Tc, Sm, Su, Ap, Tp 혹은, Tc, Sm, Cr, Km, Gm, Ak 等 6濟耐性菌이 各各 1株씩 있었다. 12주의 耐性菌들을 E. coli ML 1410 및 RG 176 그리고 RG488과 接合시켜 耐性의 傳達性여부를 조사한 바 12株 모두에서 耐性傳達을 볼 수 없었다. Eighty-three strains of Salmonella paratyphi A and 185 strains of Salnionella typhi isolated in Taegu area during 1982 were tested for the antimicrobial susceptibility to 1 2 drugs including chloramphenicol (Cm), tetracycline (Tc) , sulfisomidine (Su) , streptomycin (Srn) , nalidixic acid (Na) , ampicillin (Ap) , cephaloridine(Cr) , kanamycin(Km) , gentamicin (Gm), amikacin(Ak), trimethoprim(Tp), and rifampicin (Rf). Minimal inhibitory concentrations (MIC) t o 957; of strains (MIC957;) of S. typhi were 8 ,ucg/ml of Cm, 1 of Tc, 16 of Sm, 236 of Su, 4 of Na, 2 of Ap, 2of Cr,4 of Km, 1 of Gm, 2 of Ak, 0.25 of Tp, and 16 of Rf. MESS,";, of S. paratyphi A were 32,ag/ml of Sm, 4 of Ap, 0.5 of Gm, 1 of Km, 1 of Ak, and 0.5 of Tp. MIC95a/o of S. paratyphi A to other drugs were the same as those of S.typhi. There were 5(6. Oyh) strains of S. paratyphi A and 7(3.8%) of S. typhi resistant to one or more drugs. Among resistant strains of S. typhi, 3 strains were multiply resistant to 6 or more drugs. So strains carrying transferable plasmid was demonstrated in 12 resistant strains by conjugation to E. coli ML141.0, E. coli RG176, and/or E. coli RG488.

분산 스트림 처리 시스템의 데이터 손실방지를 위한 적응적 Upstream Backup 알고리즘

서민호,백성하,정원일,이순조,배해영 한국차세대컴퓨팅학회 2010 한국차세대컴퓨팅학회 논문지 Vol.6 No.5

분산 스트림 처리 시스템을 위한 고가용성 알고리즘에는 Passive Standby, Active Standby, Upstream Backup 알고리즘 등이 있다. 기존의 고가용성 알고리즘은 복구 시 필요한 데이터의 백업을 위한 bandwidth overhead가 크며 노드의 연산결과를 다수의 downstream 노드들이 공유하며 데이터의 유입률이 폭발적으로 증가하는 경우에 출력 큐의 오버플로우로 인한 데이터의 손실 문제가 발생 할 수 있다. 본 논문은 이러한 문제들을 해결하기 위해 데이터 스트림의 유입량과 노드들의 연산처리율 모니터링을 통해 백업 방법을 유동적으로 변경시키는 적응적 Upstream Backup 알고리즘을 제안한다.

임상가검물에서 분리된 Gram음성 간균의 항균제감수성

백원기,서성일,서민호 啓明大學校 醫科大學 1990 계명의대학술지 Vol.9 No.4

One hundred and one Gram negative bacilli isolated from various clinical specimens were tested for antimicrobial susceptibility to 21 drugs including quinolones. P. aeruginosa(35 strains) was most frequently isolated and followed by Proteus(27),E. coli(20), Klebsiella(16), Citrobacter(2), Serratia(1) in the decreasing order. The majority of strains isolated except P. aeruginosa were very susceptible to quinolone antibiotics tested. In P. aeruginosa all strains were resistant to nalidixic acid, and 11.4-17.1% to enoxacin, norfloxacin(NF), and ciprofloxacin. The other species had no resistant strains to Nf, and especially E. coli was very highly susceptible to all quinolone antibiotics tested. 90%MICs of quinolones against P. aeruginosa were 32->64 and the other species was <0.25-16. Resistance frequency of P. aeruginosa to beta-lactam antibiotics were 42.9-60% and 90% MICs of these drugs were also high. To amikacin, 51.4% of P. aeruginosa was resistant, but all strains of the other species were susceptible except one strain. The majority of isolated strains were susceptible to chloramphenicol, tetracycline, sulfisomidine, and trimethoprim. Organisms multiply resistant to drugs were noted in almost all isolates tested. The strain numbers of multiply resistant to 6 or more drugs were 16 strains of E. coli, 24 strains of P. aeruginosa, 16 strains of Proteus, 3 strains of Klebsiella.

이하선에 발생한 악성 근상피종 1예_

서민호,변남철,조준호,김광태 대한이비인후과학회 2006 대한이비인후과학회지 두경부외과학 Vol.49 No.3

Myoepitheliomas of salivary gland occur infrequently and are generally benign. Malignant myoepitheliomas of salivary gland are extremely rare tumor, and increasing number of case reports have shown that malignant myoepitheliomas may either arise de novo or develop in a pre-existing pleomorphic adenoma. In our case, myoepitheliomas was located in the parotid gland, and tumor cells displayed morphological features of spindle & epithelioid cells. Their clinical behavior by literature seems variable. This case dealt with malignant myoepithelioma of the parotid gland in a 65-year-old man with a relatively favourable course, and was followed up for 2 years and 5 months. In addition, this case illustrates some of the characteristic clinical and pathological features of this rare tumor. (Korean J Otolaryngol 2006;49:349-52)

한국 연안에 출현하는 부유성 요각류의 종다양성과 주요 종의 분포특성

서민호,최서열,박은옥,정달상,서호영 한국환경생물학회 2018 환경생물 : 환경생물학회지 Vol.36 No.4

The Korean coast is divided into the West Korea Coastal zone (WKC), the South Coastal zone of Korea (SCK), the East Korea Coastal zone (EKC), and Jeju Coastal zone of Korea (JCK). Each coastal zone has different marine environment characteristics. This study analyzed zooplankton data of KOEM (Korea Environment Management Corporation) collected in the Korean coastal waters the spring and summer of 2015 and 2016. In spring, water temperature was lowest in the JCK, and gradually increased in the order of EKC, SCK, and WKC, while in summer lowest in WKC and increased in the order of EKC, SCK, and JCK. Salinity was lowest in WKC which had many rivers flowing inland, and increased in the order of SCK, EKC and JCK in spring. In summer it was lowest in JCK and increased toward WKC, SCK, and EKC. In summer, Chlorophyll-a concentrations were generally low, but was lowest in JCK in spring. In the study area, a total of 77 species occurred, of which 50 species did in spring and 65 species in summer. The number of species was lowest in JCK and highest in SCK in spring and summer, respectively. Paracalanus parvus s. l. was the most dominant species or the second dominant species in Korean coastal areas in spring, but it was predominant in summer. In addition, in spring Acartia hongi, Calanus sinicus, Oithona similis were predominant in WKC, Oithona similis and Corycaeus affinis in SCK, O. similis and Corycaeus sp. in EKC, C. affinis and O. setigera in JCK. In summer Corycaeus spp., O. similis, A. hongi, Tortanus forcipatus were predominant in WKC, C. affinis, Pseudodiaptomus marinus in SCK, O. similis, A. omorii, Corycaeus sp. in EKC, and A. steueri, A. pacifica, Oithona sp., C. sinicus in JCK. The copepod community in the Korean coastal areas were classified into four areas, WKC-western SCK, eastern SCK, EKC and JCK according to differences in environmental factors such as water temperature, salinity, Chl-a concentration, and suspended matter concentration of each coastal area. 각기 다른 해양 환경 특성을 보이는 서해, 남해, 동해, 제주 연안역을 대상으로 춘계 (5월)와 하계 (8월)에 출현한 부유성 요각류의 군집구조에 대하여 분석하였다. 봄과 여름에 출현한 부유성 요각류는 총 73종이었으며, 이 중 연안종이 28종이었다. 봄 (49종)에 비해 여름 (58종)에 출현 종이 다양하였다. 요각류 출현 개체수는 봄과 여름 Chl-a 농도가 낮게 나타난 동해연안해역에서 가장 낮았으며, 봄에 Chl-a 농도가 높게 나타난 서해연안해역에서 출현 개체수가 높게 나타났다. 그러나 여름에 제주연안해역에서 Chl-a 농도가 0.6 μg L-1으로 낮게 나타났으나, 높은 출현 개체수를 보였다. 봄에 한국 연안에서 우점적으로 출현하는 요각류는 Acartia hongi, A. ohtsukai, Paracalanus parvus s. l., Oithona similis이었다. 여름에는 이들 종 이외에 A. omorii, A. pacifica, A. steueri, Calanus sinicus, Corycaeus affinis, Corycaeus sp., Pseudodaiptomus marinus, Tortanus forcipatus이었다. Paracalanus parvus s. l.은 봄에 조사 해역에서 최우점종 또는 차우점종으로 생태적 지위를 달리하였으나, 여름에는 전 조사해역에서 최우점종으로 출현하였다. 요각류 군집특성은 수온, 염분, Chl-a 농도 등의 환경 요인에 따라 서해, 남해, 동해, 제주 4구역으로 명확하게 구분되었다.

Triamcinolone Acetonide가 배양 켈로이드 섬유아세포의 G1 세포주기 관련 유전자 발현에 미치는 영향

설정현,우상현,백원기,서성일,서민호 大韓成形外科學會 1998 Archives of Plastic Surgery Vol.25 No.2

The effect of triamcinolone acetonide(TA) on the expression of Gl related genes was investigated the cultured keloid fibroblast. The addition of TA to the culture medium resulted in growth inhibition of keloid fibroblast. TA reduced the expression of cyclin A, B, E and cyclin dependent kinase(CDK) 2 mRNA, but unexpectedly, the expression of cyclin C, Dl and CDK4 mRAN was not affected significantly as compared with those of normal fibroblast. Expressions of p16, p21 and p27, the wellestabilished CDK-inhibitors, were also investigated. The level of p16 was not detected in both normal and keloid fibroblasts and the expression of p27 was significantly decreased in keloid fibroblast. The expression of p21 was dramatically increased in keloid fibroblast but not significantly changed in normal fibroblast. Also the expressions of p53 and pRb, the well known tumor suppressor genes, were increased by the addition of TA. These data suggested that the observed growth inhibitory effect of TA may be related to transcriptional inactivation of cyclin A, B, E and CDK2 and to the transcriptional activation of p21, but the mechanisms of unchanged expression of cyclin C, Dl and CDK4 mRNA remain to be elucidated.

W-CDMA 방식 기저대역 MODEM Chip Set 아키텍쳐 구현 연구

서민호,서승모 대한전자공학회 1998 전자공학회지 Vol.25 No.5

소형 인공위성 추력기용 정밀 유량제어 밸브 개발

서민호,김은수,김길영,김치붕,이성택 한국항공우주학회 2006 한국항공우주학회 학술발표회 논문집 Vol.- No.-