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      • KCI등재

        Anti-Inflammatory Effects of Methanol Extract of Codium fragile in Lipopolysaccharide-Stimulated RAW 264.7 Cells

        강창희,최영현,Sung-Yong Park,김기영 한국식품영양과학회 2012 Journal of medicinal food Vol.15 No.1

        The methanol extract of Codium fragile (MECF) has been reported to possess bioactive properties such as antidegranulation in eosinophils, as well as anti-edema, antibacterial, and antiviral activities. However, little is known about the molecular effects of MECF on lipopolysaccharide (LPS)-induced inflammation. Therefore, we investigated whether MECF affects the expression of inflammatory mediators in LPS-stimulated RAW 264.7 cells. To evaluate the anti-inflammatory effects of MECF, the cells were pretreated with MECF for 1 hour and then cultured with LPS for 24 hours. Our results indicate that MECF significantly attenuated secretion of LPS-induced inflammatory mediators nitric oxide (NO), prostaglandin E2 (PGE2), and tumor necrosis factor (TNF)-a in RAW 264.7 cells. Additionally, LPS-induced mRNA and protein expression of inducible NO synthase (iNOS), cyclooxygenase (COX)-2, and TNF-a was decreased by pretreatment with MECF. These data indicate that MECF attenuates the expression of these inflammatory mediators at the transcriptional level. Therefore, we also investigated the effects of MECF on nuclear factor-jB (NF-jB) activity, which may be an important transcriptional factor for regulating the expression of iNOS, COX-2, and TNF-a mRNA. Our results showed that MECF reduced LPS-induced NF-jB activity via the suppression of nuclear translocation of the p50 and p65 NF-jB subunits and degradation of inhibitor of jB. In conclusion, we propose that MECF treatment down-regulates the expression and secretion of LPS-induced inflammatory mediators by inhibiting NF-jB activity.

      • 開心術 70례 보고 ―1985년도―

        노중기,남충희,이길노,이철세,강창희 순천향대학교 1986 논문집 Vol.9 No.1

        Seventy cases of the open heart surgery were performed in the Department of Thoracic and Cardiovascular surgery of Soonchunhyang University in 1985. Of them, 52 cases were congenital anomalies which were classified as 43 acyanotic patients and 9 cyanotic patients, and 18 cases were aquired valvular diseases which contained 17 rheumatic valvular diseases and 1 mitral valve prolaps syndrome . The most common anomaly of acyanotic congenital group was VSD(22cases) and the one in cyanotic group was TOF(5 cases). In 18 cases of the acquired valvular diseases, open mitral commissuratomy was done in 2 patients, tissue valve replacement(Carpentier-Edwards Bioprosthesis) in 9, mechanical valve replacement(Medtronic-Hall) in 6, and mitral valvulo-plasty with Carpentier ring in 1 patients. The most frequent complications during postoperative course were arrhythmia and low cardiac output syndrome, Perioperative mortality rate was 5.7%.

      • 1999-2000년 제주시 지역 강수의 유기산 함량 분석

        강창희,김원형 濟州大學校 基礎科學硏究所 2001 基礎科學硏究 Vol.14 No.1

        The precipitation samples at Cheju city were collected during the period of January in 1999 to December in 2000, and the organic acids as well as the major soluble ions were analyzed. The confidence of analytical data was confirmed by using the comparison methods such as ion-balance, electric conductivity and acid fraction, all of whose correlation coefficients were over 0.97. The ionic strengths lower than 10^(-4)M, the basis for the pure rainwater, were 46% and 30% in 1999 and 2000 respectively. The acidity contribution was mostly by SO₄^(2-) and NO₃^(-) with 90% in 1999 and 93% in 2000, and the organic acids have contributed to the acidity with only 4%. The neutralization factors by NH₃were about 0.48 and 0.34 in 1999 and 2000, whereas those by CaC0₃ were 0.22 and 0.26 respectively. The sources of the precipitation components in Cheju city were also studied with a factor analyzing method. The most probable factors were found to be anthropogenic and soil-sourced, and the second influencing factor was to be oceanic.

      • 제주도 고산에서의 대기오염물질 측정 및 분석에 관한 연구

        박경윤,이동섭,이상훈,홍민선,강창희 濟州大學校 基礎科學硏究所 1993 基礎科學硏究 Vol.6 No.1

        Measurements of sulfur dioxide, ozone and meteorological parameters at Korean, Cheju island show clear indications of the influence of the source areas of both Korean Peninsular and Mainland China. Monthly mean levels in February of SO₂and O₃were 1.4 and 44 ppb, respectively. These Values are 2-30 times higher than those measured in remote are as such as Bermuda Island and Uto Island in Finland. Ozone loss in February and March were found to be 0.2 and 0.36 ppb/hr and correlation coefficient between ozone and solar radiation was 0.48. Also it was found that SO₂levels were more than 2 times higher when the prevailing winds were from WSW-NNE than from the rest.

      • 청정 지역 강우의 분석 : 1997-1998년 한라산 1100 고지와 제주시 강우의 특성 Characteristics of Rainwater at 1100 Site of Mt. Halla and Cheju City in 1997-1998

        강창희,김원형,홍상범,이기호,홍민선,심상규 濟州大學校 基礎科學硏究所 2000 基礎科學硏究 Vol.13 No.1

        The rainwater samples were collected from the 1100 Site of hlt. Halla and Cheju city during the period of March in 1997 to August in 1998. and the major soluble ions were analyzed. The confidence of analytical data was confirmed by using the comparison methods such as ion-balance, electric conductivity and acid fraction. all of which correlation coefficients were above 0.94. The ionic strengths lower than 10^(-4)M, the basis for the pure rainwater, were found in 47% and 38% at 1100 Site and Cheju city, respectively. The precipitations in Cheju city were more influenced by the oceanic effect than those in 1100 Site. The acidity contribution was mainly by SO_(4)^(2-) and NO_(3)^(-) in both areas. and the organic acids have contributed to the acidity with only 5-7%. The neutralization factors by NH_(3) were about 46% at both 1100 site and Cheju city, whereas those by CaCO_(3) were 11% and 15% at 1100 site and Cheju city respectively, and the free acidity were both about 35% in average. From the MSA analysis. it was found that the air in Cheju island has been influenced by the pollution from the other areas. The sources of the rainwater components in 1100 Site and Cheju city were also studied with a factor analyzing way and the most probable factors were found to be anthropogenic, oceanic, and soil-sourced. The results of multiple regression analysis have shown that SO_(4)^(??) was dissolved mostly in the form of H_(2)SO_(4), CaSO_(4) and (NH_(4))_(2)SO_(4). and NO_(3)^(-) was in the form of HNO_(3), Ca(NO_(3))_(2) and NH_(4)NO_(3).

      • KCI등재

        '학교교육 수준 및 실태 분석 연구: 중학교' 자료를 이용한 사교육비 지출의 성적 향상효과 분석

        강창희,Kang, Changhui 한국개발연구원 2012 韓國 開發 硏究 Vol.34 No.2

        본 논문은 한국교육개발원의 '학교교육 수준 및 실태 분석 연구: 중학교' 자료를 이용하여 중학교 3학년 학생에 대한 사교육비 지출이 어느 정도의 성적 향상효과가 있는지를 추정한다. 사교육비의 내생성을 통제하기 위해 본 논문은 도구변수법과 비모수 구간추정법(nonparametric bounds analysis)을 사용한다. 분석 결과, 두 방법에서 공통적으로 사교육비 지출의 증가가 유의미한 정도의 성적 향상으로 연결된다는 확실한 증거가 발견되지 않는다. 도구변수법의 결과에 의하면, 10% 높은 사교육비 지출은 국어, 영어, 수학 성적을 각각 약 1.24%, 1.28%, 0.75% 향상시킨다. 구간추정법에서는 국어, 영어, 수학 과목에서 모두 10% 증가된 사교육비 지출의 효과가 0보다 크다는 증거를 찾기 어렵다. 본 논문의 실증 결과는 내생성을 통제한 여타의 연구들과 비슷한 결과를 보여준다. This paper examines the effect of private tutoring expenditures on academic performance of middle school students in South Korea, using data from "Analysis of the Level of School Education and Its Actual condition: Middle School". In the face of endogeneity of private tutoring expenditures, the paper employs an instrumental variable (IV) method and a nonparametric bounding method. Using both methods we show that the true effect of private tutoring on middle school students remains at most modest in Korea. The IV results suggest that a 10 percent increase in tutoring expenditure for Korean, English and math raises a student's test score of the subject at the largest by 1.24, 1.28, and 0.75 percent, respectively. The bounding results also fail to show evidence that an increase in tutoring expenditure leads to economically and statistically significant improvements in test score.

      • 고성능 액체 크로마토그래피에 의한 금속 : Diethyldithiocarbamate Chelates의 용리거동에 관한 연구

        강창희,李垣 慶熙大學校 1987 論文集 Vol.16 No.-

        The separation behavior of Pb(Ⅱ), Co(Ⅱ), Cu(Ⅱ), Hg(Ⅱ)-diethyldithiocarbamate metal chelates gave been studied by high performance liquid chromatography. The optimum conditions for the separation of four metal-DDTC chelates were determined. As the following conclusions have been obtained. 1. The four metal-DDTC chelates were quantitatively extracted into 2ml of MIBK by shaking for 20-25mins. 2. Metal-DDTC cheltes were successfully separated on Nova-Pak C_18 column (3.9㎜ I. D. x 15㎝, particle size 4μm) using methanol/acetonitrile/water/(40:35:25) as the eluent. And the eluted metal chelates were detected by UV detector (at 254nm). 3. The optimum pH range for the formation of metal-DDTC chelates were from 9.0 to 9.5. 4. The elution-order of the metal-chelates in several extracting solvents is as follows : Pb(Ⅱ)>Co(Ⅱ)>Cu(Ⅱ) Hg(Ⅱ) It was found that these elution-order agreed well the stability of metal-DDTC chelates.

      • 요한복음의 말씀의 意味

        강창희 아세아연합신학대학교 1999 ACTS 神學과 宣敎 Vol.3 No.-

        우리는 요한복음의 “말씀”을 다른 학자들과 마찬가지로 구약 창세기 1장의 말씀과 잠언 8장의 창조하는 지혜, 그리고 1세기 유대교의 말씀에 대한 이해 등을 배경으로 설명할 수 있었다. 한마디로 요한복음의 말씀은 하나님의 세계 창조의 능력이 나사렛예수를 통해서 다시 나타나서 세상을 새로운 질서를 따라 재창조하는 구원 역사를 시작하였는데, 사람들은 예수를 믿고 따름으로 하나님의 영생을 얻을 수 있음을 의미한다. 하나님의 재창조적 능력은 다름 아닌 예수의 구원사역을 통하여만 이루어지는 것임으로 요한복음은 예수를 아예 창조적 능력을 나타내는 “말씀”으로 지칭하고 있다. 우리는 하나님의 구원의 능력인 “말씀”의 의미를 몇 가지 나누어 논하였다. 그리고 “말씀”의 의미가 상호 연결되어 있음을 보았는데 이것은 예수 한분의 인격과 사역을 다양하게 설명 할 수 있기 때문이다. “말씀”의 신성은 곧 창조성이요, 중보적 성격을 나타내며, 이런 성격은 곧 “말씀”이신 그리스도를 증거하는 것이다. 사람들은 이 그리스도를 믿어서 그와 인격적 관계를 맺어야 하며, 그의 말씀을 지켜야 한다. “말씀”을 지키는 제자도는 기독론적 의미를 제자들의 삶에 대한 적용하는 것이다. 예수를 “말씀”이라고 유비적으로 표현한 것은 요한복음의 다른 유비적 기독론적 표현과 관련되어 이해할 수 있다. 즉 빛, 하나님의 어린양, 생명의 떡, 선한 목자, 포도나무, 길, 진리, 생명, 부활, 등의 표현은 “말씀”이라는 한 가지 표현 안에 통일된다. 물론 이런 점을 우리가 각기 토의 하지는 않았으나, 말씀의 나타난 의미와 이런 유비적 의미를 관련시켜 볼때 무리 없이 이해할 수 있을 것이다. 이런 표현 모두 한분 예수의 신분과 사역을 나타내기 때문이다. 이렇게 볼 때, “로고스”는 요한복음의 기독론을 총망라하는 포용적이고 통전적인 기독론적 호칭이다. 그러므로 요한은 그의 복음서의 초두에 예수를 “말씀”으로 표현하고 있는 것이다. 영존하시는 예수는 요한복음을 읽는 사람들에게 말씀으로서의 자신을 증거하고 믿기를 권면하고 있다. 그러므로 예수님 자신이 말씀이시오. 요한복음 자체가 예수의 말씀이다.

      • KCI등재

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