압력제어방식 CVT의 모델기준제어

남주현(Juhyun Nam),류완식(Wansik Ryu),김현석(Hyunsuk Kim),김현수(Hyunsoo Kim) 한국자동차공학회 2003 한국자동차공학회 춘 추계 학술대회 논문집 Vol.- No.-

In this paper, a model based control algorithm for pressure control type CVT has been developed. Model based controller was designed based on Kpsi map and steady state primary pressure model for a ratio control valve. It was found from the experiments thai the model based controller has similar tracking performance compared with the PID controller. However, model based controller showed superior robustness to the PID controller especially for the overdrive range. It is expected that the model based controller can be used to prevent the belt slippage and improve the shift speed.<br/>

상피성난소암에서 p53 유전자변이 및 난소암의 발생기원에 관한 연구

남주현(CH Nam),송규영(KY Song),조성원(SW Cho),김종혁(JH Kim),김용만(YM Kim),목정은(JE Mok) 대한산부인과학회 1996 Obstetrics & Gynecology Science Vol.39 No.5

Although ovarian cancer is the most lethal tumor of the female genital tract, molecular mechanism of tumor development have not yet fully been understood. The loss of heterozygosity on chromosome 3, 6, 11 and 17 has been reported to occur frequently in ovarian cancer, suggesting the involvement of tumor suppressor gene inactivation in the development of ovarian cancer. I became clear that p53 tumor suppressor gene could be a prime target form genetic alteration in sporadic human malignancies such as lung, colo, brreast and ovary. Activating mutations seem to concentrate in a portion of the gene spanning codons 132-281, corresponding to exons 5-8, and do not seem to conform to a particular parttern, since they range from nucleotide substitution to deletions of variable length. The objectives of this study were to define the sites, nature and incidence of the mutations of p53 tumor supressor gene in epithelial ovarian cancer and the stage(early or late event) of the genetic alterations by comparing these mutations in primary tumors with those in metastases. Using polymerase chain reaction with primers form exon 5, 6, 7 and 8 followed by direct DNA sequencing technique, we analysed 61 fresh frozen ovarian cancer samples(primary tumor and metastases) from 23 patients with epithelial ovarian cancer who were surgically treated in Asan Medical Center. Twelve point mutations were indentified from five(21.7%) of the patients tested. Mutations were shown in exons 5 and 8, but no preferential pattern of nucleotide substitution could be observed. In the cases showing twon or more sites with mutation(case 7, 10, 16) the natures of nucleotide substitution in DNA from different sites within the same patient were identical. This suggests that ovarian carcinomas have unifocal orgin. And it was noticeable that mutations were observed in all primary lesions(ovaries), but in only a few sites of metastatic lesions, suggesting that p53 mutations may occur late during ovarian cancer evolution.

AITSC-NET: COVID19 진단을 위한 밝기보정, 객체 분할 및 분류 신경망

남주현(Ju-Hyeon Nam),김수정(Su-Jeong Kim),이상철(Sang-Chul Lee) 한국정보과학회 2020 한국정보과학회 학술발표논문집 Vol.2020 No.12

임신성 융모성질환 환자에서 혈청 Hman Chorionic Gonadotropin과 이의 이형체인 Free B-subunit 및 Urivary Gonadotropin Fragment의 측정

남주현(CH Nam),목정은(JE Mok) 대한산부인과학회 1996 Obstetrics & Gynecology Science Vol.39 No.3

To evaluate the value of serum hCG, its free B-subunit and urinary gonadotropin gragment(UGF) for early differentiation of gestational trophoblastic disease(GTD) from normal pregnancy and possible prediction for metastatic GTD, serum levels of total B-hCG and its free B-subunit and urine levels of UGF were measured in 15 normal early pregnant women and 36 patients with GTD before treatment and during follow-up. The ratio(R) of free B-subunit to total B-hCG(gn/1000mIU) were compared in each groups-normal pregnancy(NP), molar pregnancy(MP), non-metastatic(NMGTD) and metastatic GTD(MGTD). Compared to NP group(R=1.12), the mean ratio of pretreatment samples of MP(R=3.03), NMGTD(R=2.95) and MGTD(R=6.36) groups were significantly higher(p

난소암의 예후인자

남주현(CH Nam) 대한산부인과학회 1996 Obstetrics & Gynecology Science Vol.39 No.1

N/A

모션캡쳐 시스템의 효율적인 모션 데이터 편집에 관한 연구

남주현(Nam, Ju-Hyun) 한국게임학회 2014 한국게임학회 논문지 Vol.14 No.3

양질의 콘텐츠를 제공하기 위해 게임 제작사에서는 신기술을 도입하고 있으며 이중 하나는 게임 캐릭터 애니메이션에 모션캡쳐를 활용하는 것이다. 그러나 소규모 업체들은 경제적 부담으로 인해 모션캡쳐를 활용할 수 있는 기회조차 얻지 못하고 있다. 이에 본 논문은 게임 캐릭터 애니메이션 제작을 위한 모션캡쳐 시스템을 활용한 적용사례를 중심으로 기존의 제작방법을 단순화하여 시간적 경제적 이득을 추구할 수 있는 방법을 찾고 키 프레임 애니메이션을 적용할 수 있는 방안을 모색하여 게임 콘텐츠 개발에 도움이 되고자 한다. To provide high quality contents, game companies are introducing a new technology. One of the ways is the game character animation would utilize the motion capture. However, because of the economic burden, small businesses do not have a chance to take advantage of the motion capture. The purpose of this study is to derive benefit from cost and time saving by simplifying the existing production method based on a case of utilize to motion capture system. In addition this study has find ways to apply the key frame animation, so that is will be help to develop game contents.

한국여성에서 난소암 진단을 위한 혈청 CA 125 측정의 유용성

남주현(CH Nam),김상순(SS Kim),조윤경(YK Cho),이수미(SM Lee),김영탁(YT Kim),목정은(JE Mok) 대한산부인과학회 1992 Obstetrics & Gynecology Science Vol.35 No.12

Objective: Our objectives were to define the optimal threshold level of CA 125 in Korean women for early detection of ovarian cancer and to evaluate the efficacy of this marker for differentating malignant from benign pelvic masses. Study Design: Serum CA 125 levels were measured by immunoradiometric assay in total 1,049 samples which were collected from 550 apparently healthy women, 388 patients with benign pelvic masses, and 111 patients with gynecologic cancers. Results: CA 125 levels were above 35 U/ml in 24(4.4%) of 550 healthy women, however only one exceeded 35 U/ml among women 50 years or older (specificity: 99.1%). Of women younger than age 50, 4(0.9%) had elevated CA 125 levels above 65 U/ml. Among 388 patients with benignpelvic masses, CA 125 levels above 35, and 65 U/ml were detected in 115 (29.6%), and 67 (17.3%) patients respectively. Using both cut-offs of CA 125, the rates of sensitivity were 91.1% and 88.9%, respectively, for patients with epithelial ovarian cancer. Using threshold of 126 U/ml which is the level of the 95th percentile for 216 patients with benign ovarian tumor, the rates of sensitivity and specificity for differentiating epithelial cancer from begnign ovarian tomor were 88.2% and 95.4%, respectively. Conclusion: In terms of ovarian cancer screening, different threshold levels of CA 125 should be applied by age. Using 35 U/ml threshold for women age 50 or older and 65 U/ml threshold for those under 50 years of age, the specificityes of CA 125 are adequate for screening. In differentiating malignant from benign pelvic masses, using 126 U/ml cut-off could obtain the acceptable sensitivity and the better specificity.

진행된 상피성난소암에서 p53 유전자변이와 DNA 배수성의 예후인자로서의 의의 및 이들의 상관관계

남주현(CH Nam),김종혁(JH Kim),김용만(YM Kim),김영탁(YT Kim),목정은(JE Mok) 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.4

Ovarian cancer has a higher mortality rate than any other gynecologic malignancy and the majority of the patients are in an advanced stage at the time of diagnosis. However, well-estagblished clinicopahtological prognostic factiors such as stage, hisgologic type, grade of differentiation, amonut of residual tumor, and age are insufficient for prediction survival, thus necessitating new, more objective, and reproducible biological prognostic varialbes. Mutation of p 53 tumor suppressor gene and DNA aneuploidy are known to be associated with development and progression of ovarian cancer, but their prognostic sinificance is not yet conclusive. The objectives of this study were to define the nature and the prevalence of p53 gene mutation and DNA aneuploidy, and to deteirmine thier prognostic implications and their correlation in advanced epithelial ovarian cancer. the study population implications and of p53 tumor suppressor gene and DNA anuuploidy, and to determine their prognostic implications and their correlation in advanced epithelial ovarian cancer. The study population comprised tiryty-two patients with stage II to IV epithelial ovarian cancer who were mangaged at Asan Medical Center between may 1993 and April 1996. Fresh frozen tumor samples of primary lesion were analysed by direct DNA sequencing technique using ploymerase chain reaction with primers for exon 5,6,7 and 8. Measurerements of the nuclear DNA content were performed on the same cytometry. Twelve (37.5%) point mutations were identified in all exons, 3,2,2and 5 cases in exon 5,6,7and 8 of p 53 gene respectively without any preferential pattern of nucleotide substitution. Twenty-Three (71.9%) cased of tumors were revealed to be aneuploid (DNA index >1.05). there was no correlation between p53 gene mutation and DNA ploidy. The presence or absence of p53 gene mutation had no signficant correlation with FIGO stge, histologic grade, serum CA 125 level after second chemotherapy and residual tumor size after debulking surgery. Two-year survival rates of patients with and with out mutation showed no difference. On the other hand, patients with aneuploid tumors revealed to be significantly associated with more advanced stage (P=0.46) and higher level of serum CA 125 after second chemotherapy (P=0.18) and had shorter 2-year survival rate than shose with diploid tumor, although the statistical significance was marginal (P=0.057). In conclusion, p53 gene mutation and DNA ploidy show no correlation, and p53 gene mutation does not appear to be a marker prediction the biological behavior or the outcome of the disease. However, DNA ploidy was shown to be utilized as a prognostic fatoc for survival in advanced epithelial ovarian cnacer, althour further studies for longer period of time are required to confirm.

부인암에서 종양표시물질 UGF , CA125 , LSA , NB/70K 및 SCC의 이용

남주현(CH Nam) 대한산부인과학회 1991 Obstetrics & Gynecology Science Vol.34 No.6

Tumor markers are useful tools that aids the clinician in the early diagnosis and efficacy of treatment of cancers. I investigated values of 5 tumor markers - UGF(urinary gonadotropin fragment), CA125, LSA(lipid-associated sialic acid), and NB/70K in ovarian and endometrial cancers and UGF, LSA, and SCC(TA-4) in cervical cancer. I obtained 98 samples from 53 patients of ovarian cancer with clinical evidence of disease(CED) and 145 samples 53 patients with no evidence of disease(NED). In endometrial cancer, 90 samples from 52 patients with CED and 69 samples from 30 patients with NED were obtained. In cervical cancer, 85 samples from 50 patients with CED and 62 samples from 23 patients with NED were obtained. In patients with clinical evidence of ovarian cancer, sensitivities of UGF, CA125, LSA and NB/70K were 74.5, 78.1, 53.5, and 67.7%, respectively. False positive rate of above 4 markers in patients with NED were 7.5, 14.5, 30.6 and 44.7%, respectively. Using UGF and CA125 together, sensitivity increased significantly to 93.9%(p<0.005). Using 3 markers in combination, sensitivity of UGF/CA125/NB/70K was significantly higher than that of UGF/CA125 and other 3 combinations(p<0.05). In patients with clinical evidence of endometrial cancer, sensitivities of UGF, CA125, LSA, and NB/70K were 63.1, 64.4, 53.0, and 60.5%, respectively. False positive rate of these 4 markers in patients with NED were 10.7, 8.7, 27.7, and 27.5%, respectively. Using UGF and CA125 together, sensitivity increased significantly to 78.9%(p<0.005). Using 3 markers together, sensitivities of UGF/CA125/NB/70K and CA125/LSA/NB/70K were significantly higher than those of 2 and other 3 combinations(p<0.001). In patients with clinical evidence of cervical cancer, sensitivities of UGF, SCC and LSA were 53.2, 56.5, and 50.7%, respectively. False positive rate of these 3 markers in patients with NED were 4.8, 3.3, and 20.4%, respectively. Using UGF and SCC together, sensitivity increase significantly to 75%(p<0.01). However, sensitivity of 3 markers in combination did not increase significantly.

Sphingosine and FTY720 Modulate Pacemaking Activity in Interstitial Cells of Cajal from Mouse Small Intestine

남주현,김병주,김우경 한국분자세포생물학회 2013 Molecules and cells Vol.36 No.3

Interstitial cells of Cajal (ICCs) are the pacemakers of the gastrointestinal tract, and transient receptor potential melastatin type 7 (TRPM7) and Ca2+ activated Cl- channels (ANO1) are candidate the generators of pacemaker potentials in ICCs. The effects of D-erythro-sphingosine (SPH) and structural analogues of SPH, that is, N,N-dimethyl-D-erythro-sphingosine (N,N-DMS), FTY720, and FTY720-P on the pacemaking activities of ICCs were examined using the whole cell patch clamp technique. SPH, N,N-DMS, and FTY720 decreased the amplitudes of pacemaker potentials in ICC clusters, but resting membrane potentials displayed little change. Also, perfusing SPH, N,N-DMS, or FTY720 in the bath reduced both inward and outward TRPM7-like currents in single ICCs, and inhibited ANO1 currents. The another structural analogue of SPH, FTY720-P was ineffective at the pacemaker potentials in ICC clusters and the TRPM7-like currents in single ICCs. Furthermore, FTY720-P had no effect on ANO1. These results suggest that SPH, N,N-DMS, and FTY720 modulate the pacemaker activities of ICCs, and that TRPM7 and ANO1 channels affect intes-tinal motility.