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Cimiside E Arrests Cell Cycle and Induces Cell Apoptosis in Gastric Cancer Cells
Lian Yu Guo,Eun Ji Joo,손건호,Su Jin Jeon,Sehyun Jang,신은명,Hong Yu Zhou,Yeong Shik Kim 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.10
Cimiside E was isolated from the Cimicifuga heracleifolia Komarov extract, which has been previously demonstrated to possess apoptotic action on gastric cancer cells. The IC50 value of cimiside E on gastric cancer cells for 24 h was 14.58 μM. The mechanism of apoptosis was further elucidated through western blot, RT-PCR, morphology, Annexin V-FITC/PI staining and cell cycle analysis. Cell cycle arrest was induced by cimiside E in S phase at a lower concentration (30 μM) and G2/M phase at higher concentrations (60 and 90 μM). Cimiside E mediated apoptosis through the induction of the caspase cascade for both the extrinsic and intrinsic pathways. These findings suggest that cimiside E may be an effective chemopreventive agent against cancer.
김련옥 ( Lian Yu Jin ) 문창어문학회 2008 문창어문논집 Vol.45 No.-
The comparative study of Korean and Chinese shows vigorous progress in the field of linguistics as the exchange of the economy and cultural between Korea and China becomes intimate. Especially, the departmentalizing works are increased and the explanation ability of grammar is improved according to the characteristics of the cognitive meaning in specified individual language. As a part of such research, it takes the first step on the comparative study of Korean and Chinese by means of making lexical fields by restricting the object. The open-close verbs show the meaning opposition as the cognitive semantics of the view. To make the lexical fields, it is primarily to consult open-close verbs through synonym and antonym of the dictionaries for Korean and Chinese, and the lexical correspondence relation between Korean and Chinese such as ``開``, ``閉`` in Chinese and ``yeol-da(열다)``, ``dat-da(닫다)`` in Korean. And the lexical fields are made by through a semantic analysis of dictionaries. Then, the open-close verbs are restricted based on the above lexical fields and the common points and the differences of the open-close verbs in Korean and Chinese corresponding to their meanings. As a result, it shows many differences in the expansion of their meanings whereas the original meanings of the ``yeol-da(열다)`` and ``dat-da(닫다)``. It considers the meaning opposition revealing Open verbs and close verbs as ``Open-close verbs``. In general, the extension of the internal meaning in Chinese open-close verbs is progressed vigorously by comparing with Korean. And the Korean open-close verbs extends its meaning by increasing the number of the external lexical fields. Moreover, we see that both the Korean and Chinese extends the meanings by using the more great store of learning in the lexical fields of the ``yeol-da(열다)`` than that of ``dat-da(닫다)``. The concrete discussion will be done in the next research. In addition, the differences of the cognitive meaning between Korea and China can be explained through the different aspects of the usage in Korean and Chinese open-close verbs. It also remained as the next research topic.
Performances of the Effervescent Atomizer for Water Mist Fire Extinguishing
( Jin Xiang Wu ),( Qiang Liang ),( Lian Sheng Liu ),( Yun Zhong Yan ),( En Yu Wang ),( Qing Miao ) 한국액체미립화학회 2005 한국액체미립화학회 학술강연회 논문집 Vol.2005 No.-
Based on the mechanism of effervescent atomization, a new effervescent atomization system of water mist was designed. In this system, the gas medium is carbon dioxide, which is soluble and can be used in fire suppression. High pressure saturated carbon dioxide-water solution flowed through the throttle orifice, carbon dioxide was bubbled, and the two-phase flow was formed in the mixing chamber of nozzle. At last, the water mist was formed downstream of the exit orifice of nozzle. In order to examine the feasibility of this system, data were collected, processed and analyzed with DUAL PDA. The velocity profile and drop-size distribution (D10, D32, Dv0.9) downstream of the effervescent atomizer were gained. The efficiency of fire suppression of this system were experimentally investigated by putting out the fire of industry alcohol and diesel oil. The experimental results showed that this water mist system is feasible for fire suppression.
Mite and Booklouse Fauna From Vacuumed Dust Samples From Beijing
Jin-Lu Sun,Lian Shen,Jun Chen,Jin-Miao Yu,Jia Yin 대한천식알레르기학회 2014 Allergy, Asthma & Immunology Research Vol.6 No.3
A significant-source of allergens come from house dust that contain particles derived from arthropods, molds, and pet dander. This study evaluatedmite and booklouse fauna from vacuumed dust samples in Beijing China (a temperate zone). Our survey was carried out in Beijing in the homes ofmite allergic patients who visited our Allergy Department. In total, 38 homes were selected for the collection of dust samples by vacuuming, fromDecember 2008 to January 2010. The flotation method was used to isolate mites from house dust. Permanent slides were prepared for mite specimensand mites were identified and counted under a microscope. In total, 1,798 separate mite and insect specimens were found in 345 dust samplestaken from 38 homes. A total of 95 individual Dermatophagoides (D) siboney were detected in 35 dust samples from 19 homes (representing5.3% of all mite and insect species found in house dust); in addition, this mite was found to co-exist with D. farinae (Hughes, 1961) in 33 dust samples. Our results demonstrated the presence D. siboney that co-existed with D. farinae in house dust in Beijing China (a temperate zone).
Plasma Folate and Vitamin B <sub>12</sub> Levels in Patients with Hepatocellular Carcinoma
Cui, Lian-Hua,Quan, Zhen-Yu,Piao, Jin-Mei,Zhang, Ting-Ting,Jiang, Meng-Hui,Shin, Min-Ho,Choi, Jin-Su MDPI 2016 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.17 No.7
<P>Folate and vitamin B<SUB>12</SUB> involved in the one-carbon metabolism may play a key role in carcinogenesis and progression of hepatocellular carcinoma (HCC) through influencing DNA integrity. The purpose of this study is to evaluate the association of plasma folate and vitamin B12 levels with HCC in a case-control study on 312 HCC patients and 325 cancer-free controls. Plasma concentrations of folate and vitamin B<SUB>12</SUB> in all the subjects were measured by electrochemiluminescence immunoassay. Meanwhile, the information of HCC patients’ clinical characteristics including tumor-node-metastasis (TNM) stage, tumor size and tumor markers were collected. The patients of HCC had significantly lower folate levels than those of controls; there was no significant difference in the mean of plasma vitamin B<SUB>12</SUB> levels. We also observed an inverse association between the levels of plasma folate and HCC: the adjusted odds ratios (OR) (95% confidence intervals (CI)) of HCC from the highest to lowest quartile of folate were 0.30 (0.15–0.60), 0.33 (0.17–0.65), and 0.19 (0.09–0.38). Compared to the subjects in the lowest quartile of plasma vitamin B<SUB>12</SUB>, only the subjects in the highest quartile of vitamin B<SUB>12</SUB> exhibited a significant positive relationship with HCC, the adjusted OR was 2.01 (95% CI, 1.02–3.98). HCC patients with Stage III and IV or bigger tumor size had lower folate and higher vitamin B<SUB>12</SUB> levels. There was no significant difference in the mean plasma folate levels of the HCC cases in tumor markers status (AFP, CEA and CA19-9 levels), whereas patients with higher CEA or CA19-9 levels retained significantly more plasma vitamin B<SUB>12</SUB> than those with normal-CEA or CA19-9 level. In conclusion, plasma folate and vitamin B<SUB>12</SUB> levels could be associated with HCC, and might be used as predictors of clinical characteristics of HCC patients. However, further prospective studies are essential to confirm the observed results.</P>
Association of XPD and XRCC1 Genetic Polymorphisms with Hepatocellular Carcinoma Risk
Guo, Lian-Yi,Jin, Xu-Peng,Niu, Wei,Li, Xiao-Fei,Liu, Bao-Hai,Wang, Yu-Lin Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.9
Aim: XRCC1 and XPD are two major repair genes involved in nucleotide excision repair (NER), which is reported to be associated with risk of several cancers. We explored the association of XRCC1 and XPD polymorphisms with the risk of HCC. Methods: A total of 410 cases with HCC and 410 health controls were collected. XRCC1 Arg194Trp, XRCC1 Arg399Gln, XPD Lys751Gln and XPD Asp312Asn genotyping was performed by duplex polymerase-chain-reaction with the confronting-two-pair primer (PCR-CTPP) method. Results: XRCC1 194Trp/Trp was strongly significantly associated with an increased risk of HCC cancer when compared with the wide-type genotype (OR=2.26, 95% CI=(1.23-5.38). Individuals carrying the XRCC1 399Gln/Gln showed increased risk of HCC (OR=1.74, 95%CI=1.06-2.74). The XPD 751Gln/Gln and Gln allele genotype were associated with strong elevated susceptibility to HCC (OR=3.51 and 1.42, respectively). Conclusion: These results suggest that polymorphisms in XRCC1 and XPD may have functional significance in risk of HCC.
Xiang Xu,Yu-Nan Lu,Jia-Hui Cheng,Hui-Wen Lan,Jing-Mei Lu,Guang-Nan Jin,Guang-Hua Xu,Cheng-Hua Jin,Juan Ma,Hu-Nan Piao,Xuejun Jin,Lian-Xun Piao 고려인삼학회 2022 Journal of Ginseng Research Vol.46 No.1
Background: Maternal Toxoplasma gondii (T. gondii) infection during pregnancy has been associated with various mental illnesses in the offspring. Ginsenoside Rh2 (GRh2) is a major bioactive compound obtained from ginseng that has an anti-T. gondii effect and attenuates microglial activation through toll-like receptor 4 (TLR4)/nuclear factor-kappa B (NF-kB) signaling pathway. GRh2 also alleviated tumor-associated or lipopolysaccharide-induced depression. However, the effects and potential mechanisms of GRh2 on depression-like behavior in mouse offspring caused by maternal T. gondii infection during pregnancy have not been investigated. Methods: We examined GRh2 effects on the depression-like behavior in mouse offspring, caused by maternal T. gondii infection during pregnancy, by measuring depression-like behaviors and assaying parameters at the neuronal and molecular level. Results: We showed that GRh2 significantly improved behavioral measures: sucrose consumption, forced swim time and tail suspended immobility time of their offspring. These corresponded with increased tissue concentrations of 5-hydroxytryptamine and dopamine, and attenuated indoleamine 2,3-dioxygenase or enhanced tyrosine hydroxylase expression in the prefrontal cortex. GRh2 ameliorated neuronal damage in the prefrontal cortex. Molecular docking results revealed that GRh2 binds strongly to both TLR4 and high mobility group box 1 (HMGB1). Conclusion: This study demonstrated that GRh2 ameliorated the depression-like behavior in mouse offspring of maternal T. gondii infection during pregnancy by attenuating the excessive activation of microglia and neuroinflammation through the HMGB1/TLR4/NF-kB signaling pathway. It suggests that GRh2 could be considered a potential therapy in preventing and treating psychiatric disorders in the offspring mice of mothers with prenatal exposure to T. gondii infection.