Surface Quality Controlling Research on High Speed Milling Nickel-Based Superalloy Inconel 718

Yubo Liu,Xu Yanfeng,Xi Wang,Wang Xufeng 보안공학연구지원센터 2016 International Journal of Multimedia and Ubiquitous Vol.11 No.7

Nickel based superalloy Inconel 718 is difficult to machine as a material. The prediction model of surface roughness in high speed milling of Nickel-based Superalloy Inconel 718 was developed based on multiple regression analysis. The model is established from the experiments conducted on a XH714D matching center. The predicted results by using this model agree very well with those obtained from experiments, and the Prediction model of surface roughness of nickel based superalloy can provide a foundation to optimize cutting parameters and control surface quality.

Economic Dispatching Strategy of Double Lead-acid Battery Packs Considering Various Factors

Yubo Wang,Qingwu Gong 대한전기학회 2021 Journal of Electrical Engineering & Technology Vol.16 No.1

In this paper, a new energy storage economic dispatch strategy is proposed. Firstly, the equivalent life of a battery is evaluated based on its discharge of depth, and the optimal operation state of the battery is determined. Then, a mathematical model of double battery packs operation is established, which can make the battery closer to the optimal operation state. According to diff erent demand of power supply, two dispatching strategies are proposed. The fi rst strategy considers the reliability of power supply and maximum wind and photovoltaic energy consumption, and the second strategy considers the life of battery energy storage itself. The simulation operations in IEEE33 bus system. And it results show that the above two strategies can prolong the battery life, reduce the energy storage cost, and bring more benefi ts to the energy storage system. The second strategy gains more benefi ts because of more consideration of energy storage itself. Therefore, energy storage equipment, as an auxiliary service equipment, can make the price diff erentials between purchase and sale of electricity lower. So the price more fl exible when it gains profi ts by purchasing electricity at a low price and selling electricity at a high price.

Evolutionary Algorithm Based Feature Optimization for Multi-Channel EEG Classification

Wang, Yubo,Veluvolu, Kalyana C. Frontiers Media S.A. 2017 Frontiers in neuroscience Vol.11 No.-

<P>The most BCI systems that rely on EEG signals employ Fourier based methods for time-frequency decomposition for feature extraction. The band-limited multiple Fourier linear combiner is well-suited for such band-limited signals due to its real-time applicability. Despite the improved performance of these techniques in two channel settings, its application in multiple-channel EEG is not straightforward and challenging. As more channels are available, a spatial filter will be required to eliminate the noise and preserve the required useful information. Moreover, multiple-channel EEG also adds the high dimensionality to the frequency feature space. Feature selection will be required to stabilize the performance of the classifier. In this paper, we develop a new method based on Evolutionary Algorithm (EA) to solve these two problems simultaneously. The real-valued EA encodes both the spatial filter estimates and the feature selection into its solution and optimizes it with respect to the classification error. Three Fourier based designs are tested in this paper. Our results show that the combination of Fourier based method with covariance matrix adaptation evolution strategy (CMA-ES) has the best overall performance.</P>

고령자와 비만집단을 위한 헬스기구의 디자인에 관한 연구

왕우박 ( Yubo Wang ),조광수 ( Kwangsoo Cho ) 한국산업디자이너협회 2019 산업디자인학연구 Vol.13 No.2

Along with the annually increasing problem of aging population, whereas the condition of physical nutrition has been enhanced due to the improvement of economic conditions, obesity group has risen as a social issue as a result of reduced activity level. Both of these two issues are health related, and every year a number of the elderly and obesity group are trying to keep their health through exercise. Many them are using fitness equipment to gain a healthy life, but it's hard to say that the design of this equipment is optimized for these users. The purpose of this study was to design a fitness equipment that has no negative influence on the use of fitness equipment as well as that the elderly and obesity group did not disapproval to it. The aim of this study is to investigate the kind of design that every general, elderly, and obesity group can use without any resistance. Found in study, figure, and the body‘s positive and negative reaction of every general, elderly, and obesity group of people through preceding research, by surveying 50 people, we have collected data on the degree of approval and disapproval reaction toward fitness equipment in terms of body, meaning, and figure, and investigated the reason why certain equipment received negative reaction. The conclusion of the study is that the design considering all the characteristics of the all general, the elderly and the obesity group propose solutions that can solve the disapproval of the all general, the elderly and the obesity group to the fitness equipment.

헬스기구의 인클루시브 디자인을 위한 고령자의 거부감에 관한 연구

왕우박(Yubo Wang),조광수(Kwangsoo Cho) 한국디자인학회 2018 한국디자인학회 학술발표대회 논문집 Vol.2018 No.11

유니버설디자인 관점의 헬스기구 디자인에 관한 연구

왕우박(Yubo Wang),김원섭(Wonsup Kim) 한국디자인학회 2021 한국디자인학회 학술발표대회 논문집 Vol.2021 No.5

Light-Chain Cardiac Amyloidosis: Cardiac Magnetic Resonance for Assessing Response to Chemotherapy

Guo Yubo,Li Xiao,Gao Yajuan,Shen Kaini,Lin Lu,Wang Jian,Cao Jian,Zhang Zhuoli,Wan Ke,Zhou Xi Yang,Chen Yucheng,Zhang Long Jiang,Li Jian,Wang Yining 대한영상의학회 2024 Korean Journal of Radiology Vol.25 No.5

Objective: Cardiac magnetic resonance (CMR) is a diagnostic tool that provides precise and reproducible information about cardiac structure, function, and tissue characterization, aiding in the monitoring of chemotherapy response in patients with lightchain cardiac amyloidosis (AL-CA). This study aimed to evaluate the feasibility of CMR in monitoring responses to chemotherapy in patients with AL-CA. Materials and Methods: In this prospective study, we enrolled 111 patients with AL-CA (50.5% male; median age, 54 [interquartile range, 49–63] years). Patients underwent longitudinal monitoring using biomarkers and CMR imaging. At followup after chemotherapy, patients were categorized into superior and inferior response groups based on their hematological and cardiac laboratory responses to chemotherapy. Changes in CMR findings across therapies and differences between response groups were analyzed. Results: Following chemotherapy (before vs. after), there were significant increases in myocardial T2 (43.6 ± 3.5 ms vs. 44.6 ± 4.1 ms; P = 0.008), recovery in right ventricular (RV) longitudinal strain (median of -9.6% vs. -11.7%; P = 0.031), and decrease in RV extracellular volume fraction (ECV) (median of 53.9% vs. 51.6%; P = 0.048). These changes were more pronounced in the superior-response group. Patients with superior cardiac laboratory response showed significantly greater reductions in RV ECV (-2.9% [interquartile range, -8.7%–1.1%] vs. 1.7% [-5.5%–7.1%]; P = 0.017) and left ventricular ECV (-2.0% [-6.0%–1.3%] vs. 2.0% [-3.0%–5.0%]; P = 0.01) compared with those with inferior response. Conclusion: Cardiac amyloid deposition can regress following chemotherapy in patients with AL-CA, particularly showing more prominent regression, possibly earlier, in the RV. CMR emerges as an effective tool for monitoring associated tissue characteristics and ventricular functional recovery in patients with AL-CA undergoing chemotherapy, thereby supporting its utility in treatment response assessment.

SLC39A10 promotes malignant phenotypes of gastric cancer cells by activating the CK2-mediated MAPK/ERK and PI3K/AKT pathways

Ren Xiaojuan,Feng Chao,Wang Yubo,Chen Pu,Wang Simeng,Wang Jianling,Cao Hongxin,Li Yujun,Ji Meiju,Hou Peng 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-

Solute carrier family 39 member 10 (SLC39A10) belongs to a subfamily of zinc transporters and plays a key role in B-cell development. Previous studies have reported that its upregulation promotes breast cancer metastasis by enhancing the influx of zinc ions (Zn2+); however, its role in gastric cancer remains totally unclear. Here, we found that SLC39A10 expression was frequently increased in gastric adenocarcinomas and that SLC39A10 upregulation was strongly associated with poor patient outcomes; in addition, we identified SLC39A10 as a direct target of c-Myc. Functional studies showed that ectopic expression of SLC39A10 in gastric cancer cells dramatically enhanced the proliferation, colony formation, invasiveness abilities of these gastric cancer cells and tumorigenic potential in nude mice. Conversely, SLC39A10 knockdown inhibited gastric cancer cell proliferation and colony formation. Mechanistically, SLC39A10 exerted its carcinogenic effects by increasing Zn2+ availability and subsequently enhancing the enzyme activity of CK2 (casein kinase 2). As a result, the MAPK/ERK and PI3K/AKT pathways, two major downstream effectors of CK2, were activated, while c-Myc, a downstream target of these two pathways, formed a vicious feedback loop with SLC39A10 to drive the malignant progression of gastric cancer. Taken together, our data demonstrate that SLC39A10 is a functional oncogene in gastric cancer and suggest that targeting CK2 is an alternative therapeutic strategy for gastric cancer patients with high SLC39A10 expression.

IRI estimation using analysis of dynamic tire pressure and axle acceleration

Yubo Zhao,J. Gregory McDaniel,Ming L. Wang 국제구조공학회 2017 Smart Structures and Systems, An International Jou Vol.19 No.2

A new method is developed to estimate road profile in order to estimate IRI based on the ASTM standard. This method utilizes an accelerometer and a Dynamic Tire Pressure Sensor (DTPS) to estimate road roughness. The accelerometer measures the vertical axle acceleration. The DTPS, which is mounted on the tire\' s valve stem, measures dynamic pressure inside the tire while driving. Calibrated transfer functions are used to estimate road profile using the signals from the two sensors. A field test was conducted on roads with different quality conditions in the city of Brockton, MA. The IRI values estimated with this new method match the actual road conditions measured with Pavement Condition Index (PCI) based on the ASTM standard, images taken from an onboard camera and passengers\' perceptions. IRI has negative correlation with PCI in general since they have overlapping features. Compared to the current method of IRI measurement, the advantage of this method is that a) the cost is reduced; b) more space is saved; c) more time is saved; and d) mounting the two sensors are universally compatible to most cars and vans. Therefore, this method has the potential to provide continuous and global monitoring the health of roadways.

Diagnostic Performance of HPV E6/E7 mRNA and HPV DNA Assays for the Detection and Screening of Oncogenic Human Papillomavirus Infection among Woman with Cervical Lesions in China

Wang, Hye-young,Lee, Dongsup,Park, Sunyoung,Kim, Geehyuk,Kim, Sunghyun,Han, Lin,Yubo, Ren,Li, Yingxue,Park, Kwang Hwa,Lee, Hyeyoung Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.17

Background: Human papillomavirus (HPV) is the most common sexually transmitted infection worldwide and it is responsible for most cases of cervical uterine cancer. Although HPV infections of the cervix do not always progress to cancer, 90% of cervical cancer cases have been found to be associated with high risk HPV (HR-HPV) infection. HPV DNA testing is widely used, along with Papanicolaou (Pap) testing, to screen for cervical abnormalities. However, there are no data on the prevalence of genotype-specific HPV infections assessed by measuring HPV E6/E7 mRNA in women representative of the Chinese population across a broad age range. Materials and Methods: In the present study, we compared the results with the CervicGen HPV RT-qDx assay, which detects 16 HR-HPV genotypes (Alpha-9: HPV 16, 31, 33, 35, 52, and 58; Alpha-7: HPV 18, 39, 45, 51, 59, and 68; and Alpha-5, 6: HPV 53, 56, 66, and 69), and the REBA HPV-ID assay, which detects 32 HPV genotypes based on the reverse blot hybridization assay (REBA) for the detection of oncogenic HPV infection according to cytological diagnosis. We also investigated the prevalence and genotype distribution of HPV infection with a total of 324 liquid-based cytology samples collected in western Shandong province, East China. Results: The overall HPV prevalences determined by HPV DNA and HPV E6/E7 mRNA assays in this study were 79.9% (259/324) and 55.6% (180/324), respectively. Although the positivity of HPV E6/E7 mRNA expression was significantly lower than HPV DNA positivity, the HPV E6/E7 mRNA assay showed greater specificity than the HPV DNA assay (88.6% vs. 48.1%) in normal cytology samples. The prevalence of Alpha-9 (HPV 16, 31, 33, 35, 52, and 58) HPV infection among these women accounted for up to 80.3% and 76.1% of the high-grade lesions detected in the HPV mRNA and DNA tests, respectively. The HR-HPV genotype distribution, based on HPV DNA and E6/E7 mRNA expression by age group in patients with cytologically confirmed lesions, was highest in women aged 40 to 49 years (35.9% for cytologically confirmed cases, Pearson correlation r value=0.993, p<0.001) for high-grade lesions. Among the oncogenic HR-HPV genotypes for all age groups, there was little difference in the distribution of HPV genotypes between the HPV DNA (HPV -16, 53, 18, 58, and 33) and HPV E6/E7 mRNA (HPV -16, 53, 33, 58, and 18) assays. HPV 16 was the most common HPV genotype among women with high-grade lesions. Conclusions: Our results suggest that the HPV E6/E7 mRNA assay can be a sensitive and specific tool for the screening and investigation of cervical cancer. Furthermore, it may provide useful information regarding the necessity for early cervical cancer screenings and the development of additional effective HPV vaccines, such as one for HPV 53 and 58. Additionally, gaining knowledge of HPV distribution may also inform us about ecological changes in HPV after the vaccination.