Sensitivity Alterable Biosensor Based on Gated Lateral BJT for CRP Detection

Heng Yuan,Byoung-Ho Kang,Jae-Sung Lee,Hyun-Min Jeong,Se-Hyuk Yeom,Kyu-Jin Kim,Dae-Hyuk Kwon,Shin-Won Kang 대한전자공학회 2013 Journal of semiconductor technology and science Vol.13 No.1

In this paper, a biosensor based on a gated lateral bipolar junction transistor (BJT) is proposed. The gated lateral BJT can function as both a metaloxide-semiconductor field-effect transistor (MOSFET) and a BJT. By using the self-assembled monolayer (SAM) method, the C-reactive protein antibodies were immobilized on the floating gate of the device as the sensing membrane. Through the experiments, the characteristics of the biosensor were analyzed in this study. According to the results, it is indicated that the gated lateral BJT device can be successfully applied as a biosensor. Additionally, we found that the sensitivity of the gated lateral BJT can be varied by adjusting the emitter (source) bias.

Effects of Propranolol on the Left Ventricular Volume of Normal Subjects During CT Coronary Angiography

Yuan Heng Mo,Fu Shan Jaw,Yung Cheng Wang,Chin Ming Jeng,Shinn Forng Peng 대한영상의학회 2011 Korean Journal of Radiology Vol.12 No.3

Objective: The purpose of this study is to determine the effects of propranolol on the left ventricular (LV) volume during CT coronary angiography. Materials and Methods: The LV volume of 252 normal Chinese subjects (126 subjects with propranolol medication and 126 age- and gender-matched Chinese subjects without medication) was estimated using 64 slices multi-detector CT (MDCT). The heart rate difference was analyzed by the logistic linear regression model with variables that included gender, age, body height, body weight, systolic blood pressure (SBP), diastolic blood pressure (DBP) and the dosage of propranolol. The following global LV functional parameters were calculated: the real-end diastolic volume (EDV), the real-end systolic volume (ESV) and the real-ejection fraction (EF). Results: The female subjects had a greater decrease of heart rate after taking propranolol. The difference of heart rate was negatively correlated with the dosage of propranolol. The real-EDV, the real-ESV and the real-EF ranged from 48.1 to 109 mL/m2, 6.1 to 57.1 mL/m2 and 41% to 88%, respectively. There was no significant difference in the SBP and DBP between the groups without and with propranolol medication (123 ± 17 and 80 ± 10 mmHg; 120 ± 14 and 80 ± 11 mmHg, respectively). The real-EDV showed no significant difference between these two groups, but the real-ESV and real-EF showed significant differences between these two groups (69.4 ± 9.3 and 70.6 ± 8.9 mL/m2; 23.5 ± 5.7 and 25.6 ± 3.7 mL/m2, 66.5 ± 5.1% and 63.5 ± 4.6%, respectively). Conclusion: The difference of heart rate is significantly influenced by gender and the dosage of propranolol. Propranolol will also increase the ESV, which contributes to a decreased EF, while the SBP, DBP and EDV are not statistically changed. Objective: The purpose of this study is to determine the effects of propranolol on the left ventricular (LV) volume during CT coronary angiography. Materials and Methods: The LV volume of 252 normal Chinese subjects (126 subjects with propranolol medication and 126 age- and gender-matched Chinese subjects without medication) was estimated using 64 slices multi-detector CT (MDCT). The heart rate difference was analyzed by the logistic linear regression model with variables that included gender, age, body height, body weight, systolic blood pressure (SBP), diastolic blood pressure (DBP) and the dosage of propranolol. The following global LV functional parameters were calculated: the real-end diastolic volume (EDV), the real-end systolic volume (ESV) and the real-ejection fraction (EF). Results: The female subjects had a greater decrease of heart rate after taking propranolol. The difference of heart rate was negatively correlated with the dosage of propranolol. The real-EDV, the real-ESV and the real-EF ranged from 48.1 to 109 mL/m2, 6.1 to 57.1 mL/m2 and 41% to 88%, respectively. There was no significant difference in the SBP and DBP between the groups without and with propranolol medication (123 ± 17 and 80 ± 10 mmHg; 120 ± 14 and 80 ± 11 mmHg, respectively). The real-EDV showed no significant difference between these two groups, but the real-ESV and real-EF showed significant differences between these two groups (69.4 ± 9.3 and 70.6 ± 8.9 mL/m2; 23.5 ± 5.7 and 25.6 ± 3.7 mL/m2, 66.5 ± 5.1% and 63.5 ± 4.6%, respectively). Conclusion: The difference of heart rate is significantly influenced by gender and the dosage of propranolol. Propranolol will also increase the ESV, which contributes to a decreased EF, while the SBP, DBP and EDV are not statistically changed.

Design and Evaluation of Nanorods Assembling Based on Dielectrophoresis

Yuan, Heng,Kim, Kyu Jin,Yeom, Se Hyuk,Kang, Byoung Ho,Wang, Bo,Kwon, Dae Hyuk,Kang, Shin Won Trans Tech Publications, Ltd. 2011 Advanced materials research Vol.320 No.-

<P>In this study, for assembling the nanorods which are synthesized by electrochemical deposition (ECD) method, computer simulation tool (Ansys<SUP>TM</SUP>) was used basis of dielectrophoresis (DEP) principle. Following the simulation results, the nanorods assembly device was designed and fabricated using semiconductor technology. Furthermore, an electric field was applied on the assembly electrode with AC bias and DC bias hybrid. The nanorods assembling experiments were carried out as the frequency of the electric field changed. The assembly results were confirmed using optical microscope.</P>

Volatile Organic Compound Gas Sensor Using a Gated Lateral Bipolar Junction Transistor

Yuan, Heng,Kwon, Hyurk-Choon,Yeom, Se-Hyuk,Wang, Bo,Kim, Kyu-Jin,Kwon, Dae-Hyuk,Kang, Shin-Won Korean Physical Society 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.2

Volatile Organic Compound Gas Sensor Using a Gated Lateral Bipolar Junction Transistor

Heng Yuan,Hyurk-Choon Kwon,Se-Hyuk Yeom,Bo Wang,김규진,강신원,권대혁 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.21

In this paper, we report the fabrication of a gated lateral bipolar junction transistor (LBJT) that is used as a sensor for volatile organic compound (VOC) gases. The proposed sensor was fabricated using a standard 0.35-µm process. The sensor can function as both a metal-oxide-semiconductor field-effect transistor (MOSFET) and a BJT. The floating gate of the sensor was coated with a solvatochromic dye, which exhibits charge-transfer (CT) characteristics, as the sensing membrane of the sensor. The gated LBJT was driven under emitter (source) bias and base current control. Owing to the interaction of the VOC gas with the sensing membrane, the emitter (source) current value changed; this change was detected by using a semiconductor test and analyzer (STA-EL421, ELECS). Results show that our fabricated semiconductor-based gas sensor can be effectively used under normal temperature.

Bioactive Components of Houttuynia cordata Thunb and Their Potential Mechanisms Against COVID-19 Using Network Pharmacology and Molecular Docking Approaches

Heng Yuan,Liping Liu,Junyu Zhou,Ting Zhang,James W. Daily III,박선민 한국식품영양과학회 2022 Journal of medicinal food Vol.25 No.4

We investigated the molecular mechanism by which Houttuynia cordata Thunb (HCT) may intervene in coronavirus disease 2019 (COVID-19) and COVID-19-induced cytokine storms using network pharmacology and molecular docking approaches. Using the Traditional Chinese medicine Systems Pharmacology Database and Analysis Platform (TCMSP), a “component–target–pathway” topology map of HCT for COVID-19 treatment was constructed using Cytoscape. Core target genes were analyzed using the STRING database, and the signal pathway map and biological mechanism of COVID-19 therapy were obtained using cluster profilers. Active components of HCT were docked with severe respiratory syndrome coronavirus 2 (SARS-CoV-2) 3C-like protease (3CLpro) and RNA-dependent RNA polymerase (RdRp) using AutoDockTools. Data visualization and statistical analysis were conducted using the R program. A molecular dynamic simulation was carried out with the Groningen Machine for Chemical Simulation program. HCT had six active anti-COVID-19 ingredients and 45 molecular targets. Their crucial target proteins for COVID-19 treatment were the RELA (nuclear factor kappa B [NF-κB] p65 subunit), interleukin 6, and mitogen-activated protein kinase 1. In functional enrichment analysis, the potential molecular targets of active components of HCT for COVID-19 treatment belonged to 18 signaling pathways (adjusted P = 2.12E-11). Gene ontology obtained by Kyoto Encyclopedia of Genes and Genome enrichment screening showed that the primary mechanism of COVID-19 treatment was upregulation of protein kinase C followed by downregulations of T cell differentiation and proliferation and NF-κB signaling. Molecular docking showed that the active components of HCT (quercetin and kaempferol) had similar binding affinities for SARS-CoV-2 3CLpro and SARS-CoV-2 RdRp, primary COVID-19 target proteins as did clinically used drugs. These results were confirmed with molecular dynamics simulation. In conclusion, multiple components of HCT, especially quercetin and kaempferol, have the potential to treat COVID-19 infection and COVID-19-induced cytokine storm by targeting multiple proteins.

Sensitivity Alterable Biosensor Based on Gated Lateral BJT for CRP Detection

Yuan, Heng,Kang, Byoung-Ho,Lee, Jae-Sung,Jeong, Hyun-Min,Yeom, Se-Hyuk,Kim, Kyu-Jin,Kwon, Dae-Hyuk,Kang, Shin-Won The Institute of Electronics and Information Engin 2013 Journal of semiconductor technology and science Vol.13 No.1

In this paper, a biosensor based on a gated lateral bipolar junction transistor (BJT) is proposed. The gated lateral BJT can function as both a metal-oxide-semiconductor field-effect transistor (MOSFET) and a BJT. By using the self-assembled monolayer (SAM) method, the C-reactive protein antibodies were immobilized on the floating gate of the device as the sensing membrane. Through the experiments, the characteristics of the biosensor were analyzed in this study. According to the results, it is indicated that the gated lateral BJT device can be successfully applied as a biosensor. Additionally, we found that the sensitivity of the gated lateral BJT can be varied by adjusting the emitter (source) bias.

Methylenetetrahydrofolate Reductase Gene C677T Polymorphism and Lung Cancer: an Updated Meta-analysis

Hou, Xin-Heng,Huang, Yu-Min,Mi, Yuan-Yuan Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.5

Objective: Methylenetetrahydrofolate reductase (MTHFR) catalyzes the metabolism of folate and nucleotides needed for DNA synthesis and repair. Variations in MTHFR functions likely play roles in the etiology of lung cancer (LC). So far, several studies between MTHFR C677T polymorphism and LC provide controversial or inconclusive results. Methods: To better assess the purported relationship, we performed a meta-analysis of 14 publications. Eligible studies were identified by searching the Pubmed, Embase, Web of Science and Google Scholar databases. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated to assess the association. Results: Overall, no significant association was detected between the MTHFR C677T polymorphism and LC risk, the same as in race subgroup. However, in the stratified analysis by histological type, significantly increased non-small-cell lung cancer (NSCLC) risk was indicated (T-allele vs. C-allele: OR = 1.11, 95%CI = 1.03-1.19; TT vs. CC: OR = 1.24, 95%CI = 1.09-1.41; TC vs. CC: OR = 1.11, 95%CI = 1.03-1.20 and TT+TC vs. CC: OR = 1.09, 95%CI = 1.03-1.15). At the same time, ever-smokers who carried T-allele (TT+TC) had a 10% decreased LC risk compared with CC genotype carriers. Conclusions: Our study provided evidence that the MTHFR 677T null genotype may increase NSCLC risk, however, it may protect ever-smokers against LC risk. Future studies with large sample sizes are warranted to further evaluate this association in more detail.

Poster Presentations : Basic Research, Parenteral Nutrition ; Complications Occurring During Total Parenteral Nutrition

( Heng Sim Lee ),( Chung Ping Hsu ),( Yu Ling Changen ),( Ben Yuan Chan ) 한국정맥경장영양학회 2005 The 11th PENSA Congress Vol.2005 No.-

Output common mode voltage of a newly combined three‑phase full‑bridge duplex inverter

Hengli Wang,Lei Yuan,Qiang Ren 전력전자학회 2022 JOURNAL OF POWER ELECTRONICS Vol.22 No.9

Multilevel inverters, owing to their high equivalent switching frequency, high quality of output waveforms, fast dynamic response, and high redundancy, contribute significantly to high-efficiency and high-power inverter applications. However, in practical scenarios, multilevel inverters also have negative impacts. The output common mode voltage is one of the typical problems, which may harm the reliability of systems. In this study, a combined three-phase full-bridge duplex inverter is proposed. Then, the general expression of the proposed inverter’s output common mode voltage is derived based on the numerical double Fourier series. The generation mechanism of the output common mode voltage is subsequently revealed. A common mode voltage suppression strategy, which is universal and applicable to other multiple inverter topologies, is also proposed. The effectiveness of the proposed theory and control strategy is validated through the simulation and the experiment.