http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Case Study of a Narcoleptic Patient with a Family History of Narcolepsy
YoonKyung Shin,SeungChul Hong,YounJung Cho,JongHyun Jeong,JinHee Han,SungPil Lee 대한신경정신의학회 2007 PSYCHIATRY INVESTIGATION Vol.4 No.2
Narcolepsy is characterized by excessive daytime sleepiness, and this is typically associated with cataplexy and other rapid eye movement (REM) sleep phenomena such as sleep paralysis and hypnagogic hallucinations. These narcoleptic symptoms have been occasionally misdiagnosed as depression, seizure or even schizophrenia. The female patient (age=22 years) introduced here had experienced excessive daytime sleepiness, severe cataplexy and sleep paralysis. However, she didn’t know the cause of her symptoms in spite of having visited hospitals several times for five years. Her father had also suffered from excessive daytime sleepiness since his early twenties. He had been diagnosed with depression and then took antidepressants; however, his sleepiness and fatigue didn’t improve. This case history focuses on the diagnostic and therapeutic aspects of a patient with familial excessive daytime sleepiness.
Evaluation of temperature effects on brake wear particles using clustered heatmaps
Jihoon Shin,Inhyeok Yim,Soon-Bark Kwon,Sechan Park,Min-soo Kim,YoonKyung Cha 대한환경공학회 2019 Environmental Engineering Research Vol.24 No.4
Temperature effects on the generation of brake wear particles from railway vehicles were generated, with a particular focus on the generation of ultrafine particles. A real scale brake dynamometer test was repeated five times under low and high initial temperatures of brake discs, respectively, to obtain generalized results. Size distributions and temporal patterns of wear particles were analyzed through visualization using clustered heatmaps. Our results indicate that high initial temperature conditions promote the generation of ultrafine particles. While particle concentration peaked within the range of fine sized particles under both low and high initial temperature, an additional peak occurred within the range of ultrafine sized particles only under high initial temperature. The timing of peak occurrence also differed between low and high initial temperature conditions. Under low initial temperature fine sized particles were generated intensively at the latter end of braking, whereas under high initial temperature both fine and ultrafine particles were generated more dispersedly along the braking period. The clustered correlation heatmap divided particle sizes into two groups, within which generation timing and concentration of particles were similar. The cut-off point between the two groups was approximately 100 nm, confirming that the governing mechanisms for the generation of fine particles and ultrafine particles are different.
Park, Yoonkyung,Park, Seong-Cheol,Park, Hae-Kyun,Shin, Song Yub,Kim, Yangmee,Hahm, Kyung-Soo John Wiley & Sons, etc 2007 Biopolymers Vol.88 No.2
<P>HP (2–20) (AKKVFKRLEKLFSKIQNDK) is a 19-aa antimicrobial peptide derived from N-terminus of Helicobacter pylori Ribosomal protein L1 (RpL1). In the previous study, several analogs with amino acid substitutions were designed to increase or decrease only the net hydrophobicity. In particular, substitutions of Gln<SUP>16</SUP> and Asp<SUP>18</SUP> with Trp (Anal 3) for hydrophobic amino acid caused a dramatic increase in antibiotic activity without a hemolytic effect. HP-A3 is a potent antimicrobial peptide that forms, in a hydrophobic medium, an amphipathic structure consisting of an N-terminal random coil region (residues 2–5) and extended C-terminal regular α-helical region (residues 6–20). To obtain the short and potent α-helical antimicrobial peptide, we synthesized a N-terminal random coil deleted HP-A3 (A3-NT) and examined their antimicrobial activity and mechanism of action. The resulting 15mer peptide showed increased antibacterial and antifungal activity to 2- and 4-fold, respectively, without hemolysis. Confocal fluorescence microscopy studies showed that A3-NT was accumulated in the plasma membrane. Flow cytometric analysis revealed that A3-NT acted in salt- and energy-independent manner. Furthermore, A3-NT causes significant morphological alterations of the bacterial surfaces as shown by scanning electron microscopy. Circular dichroism (CD) analysis revealed that A3-NT showed higher α-helical contents than the HP-A3 peptide in 50% TFE solution. Therefore, the cell-lytic efficiency of HP-A3, which depended on the α-helical content of peptide, correlated linearly with their antimicrobial potency. © 2007 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 88: 199–207, 2007.</P><P>This article was originally published online as an accepted preprint. The ‘Published Online’ date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com</P>
Flavanones inhibit the clonogenicity of HCT116 cololectal cancer cells.
Woo, Yoonkyung,Shin, Soon Young,Hyun, Jiye,Lee, Sung Dae,Lee, Young Han,Lim, Yoongho D.A. Spandidos 2012 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.29 No.3
<P>Naringenin has been shown to display various biological effects such as antioxidant, anticancer, anti-inflammatory, and antiviral activities. Taxifolin inhibits the production of lipopolysaccharide-induced prostaglandin?E, and fustin suppresses the activity of acetylcholinesterase. They all belong to flavanone which is a class of flavonoids with a C6-C3-C6 skeleton. Since the anticancer activities of flavanone derivatives have rarely been reported, we examined the effects of 26 flavanone derivatives on HCT116 colorectal cancer cells. Our results suggest that flavanone derivatives control the expression of cell cycle regulatory proteins, which blocks G1 cell cycle progression and inhibits the clonogenicity of HCT116 cells. In addition, in order to design flavanone derivatives that show better anticancer activity, structure-activity relationships were examined.</P>
Kim, Yoonkyung,Jung, Hye‐,youn,Choe, Yun Hui,Lee, Chaewoon,Ko, Sung‐,Kyun,Koun, Soonil,Choi, Yohan,Chung, Bong Hyun,Park, Byoung Chul,Huh, Tae‐,Lin,Shin, Injae,Kim, Eunkyoung WILEY‐VCH Verlag 2012 Angewandte Chemie Vol.124 No.12
<P><B>Mit photochromem Diarylethen vernetzte Dendrimere</B> (blau im Bild) wurden mit dem Fluoreszenzfarbstoff Cy3 (rot) zur reversiblen Fluoreszenzphotoschaltung markiert. Bestrahlt man die erhaltenen Nanocluster mit UV‐Licht, wird die Cy3‐Fluoreszenz durch das Diarylethen in seiner ring‐geschlossenen Form gelöscht, während Bestrahlung mit sichtbarem Licht die Nanocluster fluoreszieren lässt. In lebenden Zebrafischen konnten hochkontrastige Fluoreszenzbilder aufgenommen werden.</P>