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      • Blocking of Cell Proliferation, Cytokines Production and Genes Expression Following Administration of Cordyceps Sinensis in the Bronchoalveolar Lavage Fluids Cells

        Kuo,,Yuh-Chi,Wu,,Chia-Lin,Tasi,,Wei-Jern,Wang,,Jir-Yenn,Chang,,Shi-Chung,Lin,,Ching-Yuang,Shiao,,Ming-Shi 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

        Yuh-Chi Kuo¹,Chia-Lin Wn¹,Wei-jern Tasi¹,Jir-Yenn Wang²,Shi-Chung Chang₃,Ching-Yung Lin⁴,and Ming-Shi Shiao⁴¹National Research Institute of Chinese Medicine, ²Department of Biology,Fu Jen University, ³Department of Chest, ⁴Department of Pediatrics, □De[art,amt of Medical Research and Education. Taipei Veterans General Hospital, Taipei, Taiwan Yuh-Chi Kuo¹,Chia-Lin Wn¹,Wei-jern Tasi¹,Jir-Yenn Wang²,Shi-Chung Chang²,Ching-Yung Lin³,and Ming-Shi Shiao⁴.¹National Research Institute of Chinese Medicine, ²Department of Biology,Fu Jen University, ³Department of Chest, ⁴Department of Pediatrics, □De[art,amt of Medical Research and Education. Taipei Veterans General Hospital, Taipei, Taiwan. Blocking of Cell Proliferation, Cytokines Production and Genes Expression Following Administration of Cordyceps sinensis in the Bronchoalveolar Lavage Fluids Cells. Proceedings of international Symposium on East-West Medicine, Seoul. 44-64, 1999.-Cordyceps sinensis is a major parasitic fungus on larva of Lepidoptera. It is one of the well know fungi used in traditional Chinese medicine for treatment asthma, lung and kideney diseases. Many fungi belonging to the genus Cordyceps have been demonstrated to produce natural products with various biological activities. Reported biological activities of genus cordyceps include:(a)inhibition of DNA and RNA synthesis;(b)enhancement of cell differentiation;(c)restruction of cytoskeleton;(d)inhibition of protein kinase activity;(e)antitumor activity on bladder, colon, lung carcinoma as well as fibroblastoma;(f)inhibition of the infection and revers transciptase activity of human immunodeficiency virus type 1; and(g) inhibition of methylation of nucleic acid. Thus, it is suggested that the extracts of Cordyceps sp. Contain antitumor, antiviral, and many other biological activities. In our previous studies, we proved that C. sinensis contains the antitumor and immunomodulatory agents. In the present studies, effects of C. sinensis on bronchoalveolar lavage fluids(BAL)cells were demonstrated. The crude methanolic extracts of C. sinensis were fractionated into 15 fractions by silica gel column chromatography. Effects of various fraction on BAL cells proliferation and lipopolysaccharide(LPS) stimulated interleukin-1β(IL-8),platelet activating factor(PAF), interleukin-6(IL-6), tumor necrosis factor-α(TNF-α),and interleukin-8(IL-8) production on BAL cells were determined. The result indicated that the CS-19-22 fraction suppressed BAL cells proliferation activated by LPS. The median inhibitory concentration(IC50) was 6㎍/ml. The CS-19-22 fraction also decreased IL-1β,PAF,IL-6, TNF-αand IL-8 production.The results of revers transcription-polymerase chain reaction(RT-PCR) demonstrated that the CS-19-22 fraction did not affect IL-1β,PAF,IL-6, TNF-α,and IL-8 mRNAs expression in BAL cells activated by LPS. By contrast, it inhibited the IL-10 mRNA expression but enhanced IFN-γand IL-12 mRNAs expression in activated BAL cells. Moreover, the CS-19-22 fraction blocked PAF-induced platelet aggregation. It is unlikely that cytotoxicity was involved. Because no cell deths were observable. We hypothesize that inhibitory mechanisms of CS-19-22 on BAL cells proliferation may be related to the impairments of gene expression and production of cytokines in BAL cells. The explanation of C. sinensis antiasthma function may involved the following(1)C.sinenesis contained immunomodulatory agents that stimulated IFN-γand IL-12 expression in TH1cells.(2)Enhanced secretion of IFN-γand IL-12 will inhibit the Tγcells immune responses Ex. Decreasing of IL-6 and IL-10 production.(3) The impairments of cytokines production in TH2 cells suppressed th BAL cells proliferation then more cytokines production Ex.IL-1β,PAF,IL-6,TNF-αand IL-8 in activated BAL cells were decreased. (4)The suppression of TH2cells immune responses will inhibit the growth and differentiation of B cells then IgE production will be decreased. (5)Reduced production of IgE will decreased asthma attack occurring in individuals. However, the results of the present study suggested that C. sinensis may also have acted to treat asthma in part by inhibiting BAL cells proliferation and cytokine gene expression and production. Future, experiments with treatment of animals with asthma with C. sinensis will be necessary to defined whether C. sinensis can reduce asthma injury. Plans are underway for the isolation of pure principal growth inhibitors and their mechanisms of action are subjected for further study.

      • KCI등재SCOPUS

        The Production of a Gendered Space : Reading Women's Landmarks in Anping, Taiwan

        Su-lin,Yu 숙명여자대학교 아시아여성연구원 2014 Asian Women Vol.30 No.4

        This study explores how Anping, one of the most significant cultural centers in Asia, has been transformed into a gendered space. To read Anping as a gendered space, this paper, based upon news reports and intensive interviews with participating agents in the community, will focus on the only two officially designated women"s landmarks in the region as the subjects of textual analysis. I will show the process of the production and representation of Lin Mor Niang Park and the statues of Miss Jin as well as her mother. First, I will analyze how metaphors of gender inscribed in the landmarks are employed to reinforce dominant gender stereotypes. Next, I will explore how the women"s landmarks have turned into the most desirable forms of contemporary cultural capital related to a growth in tourism and a shift towards an entrepreneurial form of urban governance. Indeed, gender is not only constitutive of, but virtually indispensable to, the configuration of the place. In contrast to the current masculine version of Anping's map, which is full of military and colonial landmarks, this study seeks to enrich Anping's outlook by identifying significant sites particularly associated with female representatives of their time. My purpose is to produce a new way to understand the city's cultural landscape by locating women's stories in the mapping of Anping's history. By representing the new visual modalities such as Lin Mor Niang Park and Miss Jin's statue into the current mapping, this study can contribute to what might be called a feminist politics of place construction.

      • KCI등재후보

        Portable Laser Doppler Flowmeter for Microcirculation Detection

        Chang-Lin,Hu,Meng-Lin,Li,Zhan-Sheng,Lin,Yen-Yu,Chen,Yuan-Hsiang,Lin 대한의용생체공학회 2013 Biomedical Engineering Letters (BMEL) Vol.3 No.2

        Purpose The microcirculatory system of the human body is closely related to its physiological conditions. The laser Doppler flowmeter can detect symptoms through variations in the microcirculation; however, the present commercial Doppler flowmeter is very expensive, heavy, and inconvenient to carry. Therefore, an inexpensive, small, and portable laser Doppler flowmeter is proposed. Methods In this study, we designed a laser Doppler flowmeter transmitting receiving module based on the fundamental principles of laser Doppler, using a common computer for flow calculation. A self-designed correction system was used to validate the portable laser Doppler flowmeter. Results The coefficient of correlation between the mean frequency offset <ω> of the flowmeter and the actual mimicked blood flow rate reached a high value of R = 0.99, and the variations in microcirculation flow could be accurately measured. Conclusions The results proved that the low-cost portable laser Doppler flowmeter can be used extensively in early symptom detection for disease prevention and control.

      • KCI등재SCOPUS

        Fabrication of a Biodegradable Multi-layered Polyvinyl Alcohol Stent

        Mei-Chen,Lin,Ching-Wen,Lou,Jan-Yi,Lin,Ting,An,Lin,Yueh-Sheng,Chen,Jia-Horng,Lin 한국섬유공학회 2018 Fibers and polymers Vol.19 No.8

        This study aims to develop biodegradable vascular stents that prevent permanent damage caused by rejection of the immune system of the human body. Polyvinyl alcohol (PVA) yarns are twisted to enhance their strength. The twisted yarns are braided and then coated with chitosan (CS). The CS-coated PVA vascular stents are chemically crosslinked with genipin (GP) to improve their flexibility and biodegradability. Their morphological characteristics are also observed using a stereoscopic microscope, and their properties are evaluated through scanning electron microscopy, Fourier transform infrared, bending test, biodegradability test, drug release measurement, and MTT assay. Results reveal that wet PVA-CS-GP vascular stents coated with multiple CS layers can maintain a tubular structure when they are bent. After crosslinking is performed, the compressive strength of the PVA-CS-GP stents is 17.04 times higher than that of pure PVA. The weight loss rate of the PVA-CS-GP vascular stents as <3 % after 30 days. The PVA-CS-GP vascular stents composed of 0.10 % heparin sodium show a good drug release effect. Biological activity test indicates that these stents exhibit good proliferation, and our structural model verifies that they are good vascular stents.

      • KCI등재SCOPUS

        Effects of Heat Treatments on Puncture Resistant Properties of Polyamine and Polyamide-based Nonwoven Fabrics

        Ting,Ru,Lin,Yan-Yu,Lin,Ting,An,Lin,Jia-Ci,Jhang,Ching-Wen,Lou,Jia-Horng,Lin 한국섬유공학회 2020 Fibers and polymers Vol.21 No.9

        In countries with severe gun regulations, soldiers and police officers are commonly attacked by sharp weapons. The current personal protective equipment is too heavy, and therefore, in this study, mechanically strong Kevlar® fibers,nylon fibers, and Low-melting-point polyester (LMPET) fibers are needle punched to make thin, light, and comfortablenonwoven fabrics. Hot-baking and hot-pressing heat treatments are used for thermal bonding fibers, which subsequentlygenerate a dense and rigid surface because nonwoven fabrics are subjected to damaged structure by needle punch or aslippery state due to the fibers' properties. The results of the air permeability, tensile strength, and quasi-static stab resistancetestings verify that the dense surface is correlated with hot-pressing heat treatment.

      • KCI등재

        A retrospective analysis of 20-year data of the surgical management of ulcerative colitis patients in Taiwan: a study of Taiwan Society of Inflammatory Bowel Disease

        ( Chun-chi Lin ), ( Shu-chen Wei ), ( Been-ren Lin ), ( Wen-sy-tsai ), ( Jinn-shiun Chen ), ( Tzu-chi Hsu ), ( Wei-chen Lin ), ( Tien-yu Huang ), ( Te-hsin Chao ), ( Hung-hsin Lin ), ( Jau-min Wong ), ( Jen-kou ) 대한장연구학회 2016 Intestinal Research Vol.14 No.3

        Background/Aims: With the recent progress in medical treatment, surgery still plays a necessary and important role in treating ulcerative colitis (UC) patients. In this study, we analyzed the surgical results and outcomes of UC in Taiwan in the recent 20 years, via a multi-center study through the collaboration of Taiwan Society of IBD. Methods: A retrospective analysis of surgery data of UC patients from January 1, 1995, through December 31, 2014, in 6 Taiwan major medical centers was conducted. The patients' demographic data, indications for surgery, and outcome details were recorded and analyzed. Results: The data of 87 UC patients who received surgical treatment were recorded. The median post-operative follow-up duration was 51.1 months and ranged from 0.4 to 300 months. The mean age at UC diagnosis was 45.3±16.0 years and that at operation was 48.5±15.2 years. The 3 leading indications for surgical intervention were uncontrolled bleeding (16.1%), perforation (13.8%), and intractability (12.6%). In total, 27.6% of surgeries were performed in an emergency setting. Total or subtotal colectomy with rectal preservation (41.4%) was the most common operation. There were 6 mortalities, all due to sepsis. Emergency operation and low pre-operative albumin level were significantly associated with poor survival (P =0.013 and 0.034, respectively). Conclusions: In the past 20 years, there was no significant change in the indications for surgery in UC patients. Emergency surgeries and low pre-operative albumin level were associated with poor survival. Therefore, an optimal timing of elective surgery for people with poorly controlled UC is paramount.

      • KCI등재SCOPUS

        Shielding-benefit Evaluation of Electromagnetic Radiation and UV Radiation for Multifunctional Composite Polypropylene Woven Fabrics

        Ting,An,Lin,Yu-Chun,Chuang,Jan-Yi,Lin,Mei-Chen,Lin,Ching-Wen,Lou,Keng,Siang,Sim,Jia-Horng,Lin 한국섬유공학회 2020 Fibers and polymers Vol.21 No.10

        People have increasingly rising health consciousness in recent years and researchers are thus devoted themselvesto develop multi-functional textile products. In this study, stainless steel (SS) filaments are used for electromagnetic shieldingeffectiveness (EMSE) while polypropylene (PP) filaments are used for ultraviolet resistance and good mechanical properties. Spinning and weaving continuous formation techniques are employed to produce wrapped yarns with SS and PP filaments,after which a weaving process is employed for the preparation of SS/PP woven fabrics. The woven fabrics are tested forEMSE and UV resistance, examining the effect of the lamination-layer numbers and lamination-layer angles. Test resultsshow that the optimal EMSE and UV resistance occur when SS/PP woven fabrics are laminated with two layers at 90 °. Notonly focus on the mechanical performance, the proposed woven fabrics with good EMSE, UV resistance, and a light weight,and are good candidate for a variety of application as required. The proposed UV resistance and EMSE woven fabricssignificantly increase the additional values of traditional textiles.

      • KCI등재SCOPUS

        Polyester/Polylactic Acid/Stainless Steel Composite Bone Scaffolds Made by Electrochemical Treatment: Process Design and Property Evaluations

        Mei-Chen,Lin,Ching-Wen,Lou,Jan-Yi,Lin,Ting,An,Lin,Shih-Peng,Wen,Jia-Horng,Lin 한국섬유공학회 2019 Fibers and polymers Vol.20 No.2

        This study combines and twists 75D polyester (PET) multi-filaments and polylactic acid (PLA) multi-filaments with twist coefficients of 2, 3, 4, 5, and 6 to form 150D PET/PLA plied yarns. The 0.08-mm-diameter stainless steel (SS) fibers are made into SS braids with a 60-tooth braid gear and a take-up gear with 60, 70, 80, 90, or 100 teeth. PET/PLA plied yarn and SS braids are then combined and electrochemically treated with an electric current of 100, 200, 300, 400, or 500 mA at 60 ℃ for 24 hours, forming the PET/PLA/SS composite bone scaffolds. PET/PLA/SS composite bone scaffolds are observed by scanning electron microscope (SEM) and energy dispersive spectroscope (EDS), and tested for weight increase rate and biocompatibility. The experiment results show that the optimal twist coefficient for PET/PLA plied yarn is 4 and the optimal tooth number on the take-up gear for SS braids is 80. SEM observation result shows that hydroxyapatite (HA) deposits on the surface of PET/PLA/SS composite bone scaffolds and attaches to the PET/PLA plied yarns. Finally, regardless of electric currents, all PET/PLA/SS composite bone scaffolds possess good biocompatibility.

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