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박예수,김승현,조재림 한양대학교 의과대학 2000 한양의대 학술지 Vol.20 No.1
The purpose of this study was to evaluate the change of lumbar lordosis before and after pedicle screw fixation. Authors analyzed the change of lumbar lordosis in 100 cases of degenerative spinal stenosis, which were operated on using pedicle screws from January 1994 to July 1996. We also measured the total lordosis angle(TLA) and segmental lordosis angle(SLA) according to the fusion types and the fusion segments. Total lumbar lordosis angle was measured from the upper endplate of the first lumbar vertebra to the upper endplatee of the first sacral vertebra. And the segmental lordosis angle was measured from the upper endplate of the upper-most vertebra in fusion segments to the upper endplate of the lower-most vertebra. In all patients, mean TLA was 33.6 degrees preoperatively, 37.9 degrees postoperatively and 36.1 degrees in last follow-up. The TLA according to fusion types mostly change in the six and seven decades of two groups (floating, fixed fusion group). The TLA and the SLA according to fusion segments mostly changed in 5 segments fusion group and the change according to fusion types was not. In pedicle screw fixation, physiologic lordosis can be maintained by using the four-poster frame. Preoperative hypolordosis can be corrected into physiologic lordosis by pre-bending technique of the rod. But excessive pre-bending of the rod for correction of the lordosis increased the possibility of loosening of the sacral screws.
Park, Min-Oh,Lee, Byung-Hoo,Lim, Eunjin,Lim, Ji Ye,Kim, Yuri,Park, Cheon-Seok,Lee, Hyeon Gyu,Kang, Hee-Kwon,Yoo, Sang-Ho American Chemical Society 2016 Journal of agricultural and food chemistry Vol.64 No.23
<P>Turanose is a sucrose isomer naturally existing in honey and a promising functional sweetener due to its low glycemic response. In this study, the extrinsic fructose effect on turanose productivity was examined in Neisseria amylosucrase reaction. Turanose was produced, by increasing the amount of extrinsic fructose as a reaction modulator, with high concentration of sucrose substrate, which resulted in 73.7% of production yield. In physiological functionality test, lipid accumulation in 3T3-L1 preadipocytes in the presence of high amounts of pure glucose was attenuated by turanose substitution in a dose-dependent manner. Turanose treatments at concentrations representing 50%, 75%, and 100% of total glucose concentration in cell media significantly reduced lipid accumulation by 18%, 35%, and 72%, respectively, as compared to controls. This result suggested that turanose had a positive role in controlling adipogenesis, and enzymatic process of turanose production has a potential to develop a functional food ingredient for controlling obesity and related chronic diseases.</P>
( Ye-lim Park ),( Tae-rim Choi ),( Hyun Joong Kim ),( Hun-suk Song ),( Hye Soo Lee ),( Sol Lee Park ),( Sun Mi Lee ),( Sang Hyun Kim ),( Serom Park ),( Shashi Kant Bhatia ),( Ranjit Gurav ),( Changmin 한국미생물생명공학회(구 한국산업미생물학회) 2021 Journal of microbiology and biotechnology Vol.31 No.2
Among various species of marine bacteria, those belonging to the genus Halomonas have several promising applications and have been studied well. However, not much information has been available on their antibiotic resistance. In our efforts to learn about the antibiotic resistance of strain Halomonas socia CKY01, which showed production of various hydrolases and growth promotion by osmolytes in previous study, we found that it exhibited resistance to multiple antibiotics including kanamycin, ampicillin, oxacillin, carbenicillin, gentamicin, apramycin, tetracycline, and spectinomycin. However, the H. socia CKY01 resistance pattern to kanamycin, gentamicin, apramycin, tetracycline, and spectinomycin differed in the presence of 10% NaCl and 1% NaCl in the culture medium. To determine the mechanism underlying this NaCl concentration-dependent antibiotic resistance, we compared four aminoglycoside resistance genes under different salt conditions while also performing time-dependent reverse transcription PCR. We found that the aph2 gene encoding aminoglycoside phosphotransferase showed increased expression under the 10% rather than 1% NaCl conditions. When these genes were overexpressed in an Escherichia coli strain, pETDuet-1::aph2 showed a smaller inhibition zone in the presence of kanamycin, gentamicin, and apramycin than the respective control, suggesting aph2 was involved in aminoglycoside resistance. Our results demonstrated a more direct link between NaCl and aminoglycoside resistance exhibited by the H. socia CKY01 strain.
Park, Ye‐,Lim,Kim, Hwang‐,Phill,Cho, Young‐,Won,Min, Dong‐,Wook,Cheon, Seul‐,Ki,Lim, Yoo Joo,Song, Sang‐,Hyun,Kim, Sung Jin,Han, Sae‐,Won,Park, Kyu Joo,Kim, T John Wiley Sons, Inc. 2019 International journal of cancer: Journal internati Vol.144 No.2
<P><I>PIK3CA</I> is a frequently mutated gene in cancer, including about ~15 to 20% of colorectal cancers (CRC). <I>PIK3CA</I> mutations lead to activation of the PI3K/AKT/mTOR signaling pathway, which plays pivotal roles in tumorigenesis. Here, we investigated the mechanism of resistance of <I>PIK3CA</I>‐mutant CRC cell lines to gedatolisib, a dual PI3K/mTOR inhibitor. Out of a panel of 29 CRC cell lines, we identified 7 harboring one or more <I>PIK3CA</I> mutations; of these, 5 and 2 were found to be sensitive and resistant to gedatolisib, respectively. Both of the gedatolisib‐resistant cell lines expressed high levels of active glycogen synthase kinase 3‐beta (GSK3β) and harbored the same frameshift mutation (c.465_466insC; H155fs*) in <I>TCF7</I>, which encodes a positive transcriptional regulator of the WNT/β‐catenin signaling pathway. Inhibition of GSK3β activity in gedatolisib‐resistant cells by siRNA‐mediated knockdown or treatment with a GSK3β‐specific inhibitor effectively reduced the activity of molecules downstream of mTOR and also decreased signaling through the WNT/β‐catenin pathway. Notably, GSK3β inhibition rendered the resistant cell lines sensitive to gedatolisib cytotoxicity, both <I>in vitro</I> and in a mouse xenograft model. Taken together, these data demonstrate that aberrant regulation of WNT/β‐catenin signaling and active GSK3β induced by the <I>TCF7</I> frameshift mutation cause resistance to the dual PI3K/mTOR inhibitor gedatolisib. Cotreatment with GSK3β inhibitors may be a strategy to overcome the resistance of <I>PIK3CA</I>‐ and <I>TCF7</I>‐mutant CRC to PI3K/mTOR‐targeted therapies.</P>
Analysis of carotenoid compositions in tomato varieties with treatment methods (2021)
Ye-Lim Park,Jung-Ah Shin,Ki-Teak Lee 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
In this study, the content of carotenoids (α-carotene, β-carotene) according to the types of tomatoes (tomato, cherry tomatoes, salty tomatoes, black tomatoes, jujube cherry tomatoes) and the process (raw, blanched) was analyzed by HPLC. Alkali hydrolysis was performed for carotenoid analysis. As a result, it was shown that the carotenoid content of the 10 kinds of samples was different according to the type and treatment method. The content of α-carotene varied from 5.10 μg/100 g to 17.93 μg/100 g, and the content of β-carotene also varied from 239.14 μg/100 g to 493.00 μg/100 g. α-carotene was shown in the order of blanched black tomatoes (17.93 μg/100 g), raw black tomatoes (15.11 μg/100 g), and blanched cherry tomatoes (12.34 μg/100 g). β-carotene was shown in the order of blanched black tomatoes (493.00 μg/100 g), blanched jujube cherry tomatoes (478.20 μg/100 g), and blanched cherry tomatoes (455.80 μg/100 g). Even in the same variety, the difference between the α-carotene content and the β-carotene content between raw and blanched was confirmed.