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고호모시스테인혈증에 의한 근위심부정맥혈전증 및 폐색전증 1예
정예령 ( Ye Ryung Jung ),용석중 ( Suk Joong Yong ),신계철 ( Kye Chul Shin ),성재호 ( Jae Ho Seong ),김종환 ( Chong Whan Kim ),이명규 ( Myoung Kyu Lee ),이지호 ( Ji Ho Lee ),정세현 ( Sae Hyun Jung ),김상하 ( Sang Ha Kim ) 전북대학교 의과학연구소 2012 全北醫大論文集 Vol.36 No.2
위험인자가 없이 발생한 근위심부정맥혈전증 및 폐색전증 환자에서는 고호모시스테인혈증을 포함한 혈전성향을 확인하는 것이 필요하다. 저자들은 엽산 결핍에 의한 고호모시스테인혈증으로 인해 근위심부정맥혈전증및 폐색전증이 발생한 것을 진단하고 엽산과 항혈소판제의 투여를 유지하여 혈중 호모시스테인의 수치를 정상화하고 혈전증을 치료한 환자를 경험하여 보고하는 바이다. Most cases of venous thrombosis occur at underlying condition. If a patient is diagnosed with venous thrombosis without any apparent risk factor, evaluation of thrombophilia maybe needed. Hyperhomocysteinemia is associated with hypercoagulability and cardiovascular disease including venous thrombosis, the leading cause of it is vitamin deficiency. We report a case of pulmonary embolism and both internal iliac vein thrombosis with hyperhomocysteinemia due to folate deficiency. A 29-year-old male patient presented with chest pain. Chest and lower extremity CT scans revealed pulmonary embolism and thrombosis of both internal iliac veins. His plasma homocysteine level was elevated to 14.8μmol/L, folic acid level was decreased to 2.30 ng/mL. He was treated with folic acid and warfarin for six months. After treatment, plasma homocysteine level was normalized and the evidence of thrombosis has disappeared.
Ye-Ryung Kim,이은지,Kyong-Oh Shin,김민희,Yael Pewzner-Jung,Yong-Moon Lee,박주원,Anthony H. Futerman,Woo-Jae Park 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
The endoplasmic reticulum (ER) is not only important for protein synthesis and folding but is also crucial for lipid synthesis and metabolism. In the current study, we demonstrate an important role of ceramide synthases (CerS) in ER stress and NAFLD progression. Ceramide is important in sphingolipid metabolism, and its acyl chain length is determined by a family of six CerS in mammals. CerS2 generates C22-C24 ceramides, and CerS5 or CerS6 produces C16 ceramide. To gain insight into the role of CerS in NAFLD, we used a high-fat diet (HFD)-induced NAFLD mouse model. Decreased levels of CerS2 and increased levels of CerS6 were observed in the steatotic livers of mice fed a HFD. In vitro experiments with Hep3B cells indicated the protective role of CerS2 and the detrimental role of CerS6 in the ER stress response induced by palmitate treatment. In particular, CerS6 overexpression increased sterol regulatory elementbinding protein-1 (SREBP-1) cleavage with decreased levels of INSIG-1, leading to increased lipogenesis. Blocking ER stress abrogated the detrimental effects of CerS6 on palmitate-induced SREBP-1 cleavage. In accordance with the protective role of CerS2 in the palmitate-induced ER stress response, CerS2 knockdown enhanced ER stress and SREBP1 cleavage, and CerS2 heterozygote livers exhibited a stronger ER stress response and higher triglyceride levels following HFD. Finally, treatment with a low dose of bortezomib increased hepatic CerS2 expression and protected the development of NAFLD following HFD. These results indicate that CerS and its derivatives impact hepatic ER stress and lipogenesis differently and might be therapeutic targets for NAFLD.
A case of vaginal laceration during use of a menstrual cup
( Hae Ryung Choi ),( Gil Jae Jung ),( Ye Jin Seon ),( So Ryeong Kim ),( Hwan Shin ),( Ji Hye Kim ),( Jong Soo Kim ),( Jin Wan Park ),( Yun Dan Kang ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-
Interest in menstrual cups among Korean women increased after an environmental group reported the detection of harmful chemicals in locally sold sanitary pads in August 2017. In December 2017, the Korean Ministry of Food and Drug Safety (MFDS) approved the first menstrual cup to be imported and sold within Korea. However, consumers and clinicians should be aware of the potential complications of menstrual cups, even though such complications are rare. We report the case of a 22-year-old woman with vaginal bleeding from an anterior fornix laceration which was caused by the removal of a menstrual cup. To our knowledge, this is the first reported case of vaginal fornix laceration associated with menstrual cup use.
Kim, Ye‐,Ryung,Volpert, Giora,Shin, Kyong‐,Oh,Kim, So‐,Yeon,Shin, Sun‐,Hye,Lee, Younghay,Sung, Sun Hee,Lee, Yong‐,Moon,Ahn, Jung‐,Hyuck,Pewzner‐,Jung, Yael,Pa John Wiley and Sons Inc. 2017 JOURNAL OF CELLULAR AND MOLECULAR MEDICINE Vol.21 No.12
<P><B>Abstract</B></P><P>Ceramides mediate crucial cellular processes including cell death and inflammation and have recently been implicated in inflammatory bowel disease. Ceramides consist of a sphingoid long‐chain base to which fatty acids of various length can be attached. We now investigate the effect of alerting the ceramide acyl chain length on a mouse model of colitis. Ceramide synthase (CerS) 2 null mice, which lack very‐long acyl chain ceramides with concomitant increase of long chain bases and C16‐ceramides, were more susceptible to dextran sodium sulphate‐induced colitis, and their survival rate was markedly decreased compared with that of wild‐type littermates. Using mixed bone‐marrow chimeric mice, we showed that the host environment is primarily responsible for intestinal barrier dysfunction and increased intestinal permeability. In the colon of CerS2 null mice, the expression of junctional adhesion molecule‐A was markedly decreased and the phosphorylation of myosin light chain 2 was increased. <I>In vitro</I> experiments using Caco‐2 cells also confirmed an important role of CerS2 in maintaining epithelial barrier function; CerS2‐knockdown <I>via </I>CRISPR‐Cas9 technology impaired barrier function. <I>In vivo</I> myriocin administration, which normalized long‐chain bases and C16‐ceramides of the colon of CerS2 null mice, increased intestinal permeability as measured by serum FITC‐dextran levels, indicating that altered SLs including deficiency of very‐long‐chain ceramides are critical for epithelial barrier function. In conclusion, deficiency of CerS2 influences intestinal barrier function and the severity of experimental colitis and may represent a potential mechanism for inflammatory bowel disease pathogenesis.</P>
Hirsutism may indicate tumor etiology of the ovary: a case report of leydig cell hyperplasia
( Gil Jae Jung ),( Hae Ryung Choi ),( Ye Jin Seon ),( So Ryeong Kim ),( Hwan Shin ),( Ji Hye Kim ),( Yun Dan Kang ),( Jin Wan Park ),( Jong Soo Kim ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-
We report a case of a 59-year-old woman who complaint excessive beard. She had hypertension and obesity and had undergone a previous right salpingo-oopherectomy and total thyroidectomy. On physical examination, she had male-pattern balding and excessive beard, sternal and peri-areolar terminal hair growth. The clitoris was moderately enlarged. Only serum testosterone elevated 5.8 ng/ml which 193 times than normal. In CT and MRI scan, 7*3cm sized tumor was observed in endometrium with adenomyotic uterus and atrophic left ovary. She underwent total hysterectomy with left oophorectomy. Histopathological examination and immunohistochemistry verified the diagnosis of an leydig cell hyperplasia in left ovary. Serum testosterone normalized and the virilization progressively subsided over the following few months. This report underlined that careful research of patient history of virilization for diagnosis of androgen producing tumor after menopause.
Choi, Yeun Seoung,Lim, Jung Soo,Kwon, Woocheol,Jung, Soon-Hee,Park, Il Hwan,Lee, Myoung Kyu,Lee, Won Yeon,Yong, Suk Joong,Lee, Seok Jeong,Jung, Ye-Ryung,Choi, Jiwon,Choi, Ji Sun,Jeong, Joon Taek,Yoo, The Korean Academy of Tuberculosis and Respiratory 2015 Tuberculosis and Respiratory Diseases Vol.78 No.4
Pulmonary Langerhans cell histiocytosis is an uncommon diffuse cystic lung disease in adults. In rare cases, it can involve extrapulmonary organs and lead to endocrine abnormalities such as central diabetes insipidus. A 42-year-old man presented with polyphagia and polydipsia, as well as a dry cough and dyspnea on exertion. Magnetic resonance imaging of the hypothalamic-pituitary system failed to show the posterior pituitary, which is a typical finding in patients with central diabetes insipidus. This condition was confirmed by a water deprivation test, and the patient was also found to have type 2 diabetes mellitus. Computed tomographic scanning of the lungs revealed multiple, irregularly shaped cystic lesions and small nodules bilaterally, with sparing of the costophrenic angles. Lung biopsy through video-assisted thoracoscopic surgery revealed pulmonary Langerhans cell histiocytosis. On a follow-up visit, only 1 year after the patient had quit smoking, clinical and radiological improvement was significant. Here, we report an uncommon case of pulmonary Langerhans cell histiocytosis that simultaneously presented with diabetes insipidus and diabetes mellitus.
( Yeun Seoung Choi ),( Jung Soo Lim ),( Woocheol Kwon ),( Soon Hee Jung ),( Il Hwan Park ),( Myoung Kyu Lee ),( Won Yeon Lee ),( Suk Joong Yong ),( Seok Jeong Lee ),( Ye Ryung Jung ),( Jiwon Choi ),( 대한결핵 및 호흡기학회 2015 Tuberculosis and Respiratory Diseases Vol.78 No.4
Pulmonary Langerhans cell histiocytosis is an uncommon diffuse cystic lung disease in adults. In rare cases, it can involve extrapulmonary organs and lead to endocrine abnormalities such as central diabetes insipidus. A 42-year-old man presented with polyphagia and polydipsia, as well as a dry cough and dyspnea on exertion. Magnetic resonance imaging of the hypothalamic-pituitary system failed to show the posterior pituitary, which is a typical finding in patients with central diabetes insipidus. This condition was confirmed by a water deprivation test, and the patient was also found to have type 2 diabetes mellitus. Computed tomographic scanning of the lungs revealed multiple, irregularly shaped cystic lesions and small nodules bilaterally, with sparing of the costophrenic angles. Lung biopsy through video-assisted thoracoscopic surgery revealed pulmonary Langerhans cell histiocytosis. On a follow-up visit, only 1 year after the patient had quit smoking, clinical and radiological improvement was significant. Here, we report an uncommon case of pulmonary Langerhans cell histiocytosis that simultaneously presented with diabetes insipidus and diabetes mellitus.